| Patent application number | Description | Published |
|---|
| 20140022250 | System and Method for Patient Specific Planning and Guidance of Ablative Procedures for Cardiac Arrhythmias - A method and system for patient-specific planning and guidance of an ablation procedure for cardiac arrhythmia is disclosed. A patient-specific anatomical heart model is generated based on pre-operative cardiac image data. The patient-specific anatomical heart model is registered to a coordinate system of intra-operative images acquired during the ablation procedure. One or more ablation site guidance maps are generated based on the registered patient-specific anatomical heart model and intra-operative patient-specific measurements acquired during the ablation procedure. The ablation site guidance maps may include myocardium diffusion and action potential duration maps. The ablation site guidance maps are generated using a computational model of cardiac electrophysiology which is personalized by fitting parameters of the cardiac electrophysiology model using the intra-operative patient-specific measurements. The ablation site guidance maps are displayed by a display device during the ablation procedure. | 01-23-2014 |
| 20140024932 | Computation of Hemodynamic Quantities From Angiographic Data - Methods for computing hemodynamic quantities include: (a) acquiring angiography data from a patient; (b) calculating a flow and/or calculating a change in pressure in a blood vessel of the patient based on the angiography data; and (c) computing the hemodynamic quantity based on the flow and/or the change in pressure. Systems for computing hemodynamic quantities and computer readable storage media are described. | 01-23-2014 |
| 20140136174 | System and Method for Patient Specific Modeling of Liver Tumor Ablation - A method and system for tumor ablation planning and guidance based on a patient-specific model of liver tumor ablation is disclosed. A patient-specific anatomical model of the liver and circulatory system of the liver is estimated from 3D medical image data of a patient. Blood flow in the liver and the circulatory system of the liver is simulated based on the patient-specific anatomical model. Heat diffusion due to ablation is simulated based on a virtual ablation probe position and the simulated blood flow in the liver and the venous system of the liver. Cellular necrosis in the liver is simulated based on the simulated heat diffusion. A visualization of a simulated necrosis region is generated and displayed to the user for decision making and optimal therapy planning and guidance. | 05-15-2014 |
| 20140296842 | Patient Specific Planning and Simulation of Ablative Procedures - Patient specific temperature distribution in organs, due to an ablative device, is simulated. The effects of ablation are modeled. The modeling is patient specific. The vessel structure for a given patient, segmented from medical images, is accounted for as a heat sink in the model of biological heat transfer. A temperature map is generated to show the effects of ablation in a pre-operative analysis. Temperature maps resulting from different ablation currents and ablation device positions may be used to determine a more optimal location of the ablative device for a given patient. Other models may be included, such as accounting for the tissue damage during the ablation. | 10-02-2014 |
| 20150042646 | System and Method for Patient Specific Planning and Guidance of Electrophysiology Interventions - A method and system for patient-specific planning and guidance of electrophysiological interventions is disclosed. A patient-specific anatomical heart model is generated from cardiac image data of a patient. A patient-specific cardiac electrophysiology model is generated based on the patient-specific anatomical heart model and patient-specific electrophysiology measurements. Virtual electrophysiological interventions are performed using the patient-specific cardiac electrophysiology model. A simulated electrocardiogram (ECG) signal is calculated in response to each virtual electrophysiological intervention. | 02-12-2015 |
| 20150063649 | Method and System for Blood Flow Velocity Reconstruction From Medical Images - A method and system for blood flow velocity reconstruction from medical image data is disclosed. Flow system geometry of a flow conduit is generated from medical image data. The flow system velocity includes an inlet, walls, and one or more outlets of the flow conduit. A measured velocity field is extracted from the medical image data. Inlet and wall fluxes are estimated based on the measured velocity field or other external measurements. Outlet fluxes are estimated such that mass conservation is constrained based on the inlet and wall fluxes. A reconstructed velocity field is calculated by solving flux-constrained Poisson (FCP) equations that are constrained by the estimated output fluxes | 03-05-2015 |
| 20150065864 | Method and System for Functional Assessment of Renal Artery Stenosis from Medical Images - A method and system for non-invasive assessment of renal artery stenosis is disclosed. A patient-specific anatomical model of at least a portion of the renal arteries and aorta is generated from medical image data of a patient. Patient-specific boundary conditions of a computational model of blood flow in the portion of the renal arteries and aorta are estimated based on the patient-specific anatomical model. Blood flow and pressure are simulated in the portion of the renal arteries and aorta using the computational model based on the patient-specific boundary conditions. At least one hemodynamic quantity characterizing functional severity of a renal stenosis region is calculated based on the simulated blood flow and pressure in the portion of the renal arteries and aorta. | 03-05-2015 |
| 20160022369 | System And Method For Interactive Patient Specific Simulation Of Radiofrequency Ablation Therapy - A method and system for interactive patient-specific simulation of liver tumor ablation is disclosed. A patient-specific anatomical model of the liver and circulatory system of the liver is estimated from 3D medical image data of a patient. A computational domain is generated from the patient-specific anatomical model of the liver. Blood flow in the liver and the circulatory system of the liver is simulated based on the patient-specific anatomical model. Heat diffusion due to ablation is simulated based on a virtual ablation probe position and the simulated blood flow in the liver and the circulatory system of the liver by solving a bio-heat equation for each node on the level-set representation using a Lattice-Boltzmann method (LBM) implementation. Cellular necrosis in the liver is computed based on the simulated heat diffusion. Visualizations of a computed necrosis region and temperature maps of the liver are generated. A user input is interactively received to modify the position of the virtual ablation probe, the heat diffusion and cellular necrosis is re-simulated based on the user input, and the visualizations of the computed necrosis region and the temperature maps are updated. | 01-28-2016 |
