Sahni
Girish Sahni, Chandigarh IN
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20120213763 | MUTANTS OF STREPTOKINASE AND THEIR COVALENTLY MODIFIED FORMS - The present invention relates to novel mutants of Streptokinase, its functional fragments and covalently modified forms. Methods are provided for the preparation of the bacterial plasminogen activator protein, Streptokinase its muteins, species variants and their covalently modified variants that are characterized by improved therapeutic properties, such as increased proteolytic stability, extended plasma half-lives, reduced immuno-reactivity and enhanced fibrin clot specificity. The method involves either incorporating additional cysteine residues, or substituting cysteine residues for naturally occurring amino acids into non-essential regions of the protein such that the catalytic activity of the resultant protein remains largely unaltered. These cysteine variants were further modified by covalently attaching a cysteine reactive polymer such as polyethylene glycol (PEG) or sulfhydryl-reactive moieties from a group that includes fluorophore, spin labels or other small conjugates. Disclosed herein are site-specific biologically active conjugates of Streptokinases and its covalently modified variants. | 08-23-2012 |
20130136731 | Protein Fusion Constructs Possessing Thrombolytic and Anticoagulant Properties - The present invention discloses novel hybrid proteins that have both plasminogen activator and anti-thrombotic properties, including clot specific action, that renders these as highly advantageous for the treatment of circulatory disorders involving fibrin clot formation due to underlying tissue damage in the blood vessels leading to myocardial infarction, strokes etc. Also disclosed are new proteins, and methods of obtaining the same, that help to dissolve blood clots by activating plasminogen in a plasmin or thrombin dependent manner and also inhibit both the activity and generation of thrombin through the intrinsic pathway of blood coagulation. | 05-30-2013 |
Girish Sahni, Chandigarth IN
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20100034804 | MUTANTS OF STREPTOKINASE AND THEIR COVALENTLY MODIFIED FORMS - The present invention relates to novel mutants of Streptokinase, its functional fragments and covalently modified forms. Methods are provided for the preparation of the bacterial plasminogen activator protein, Streptokinase its muteins, species variants and their covalently modified variants that are characterized by improved therapeutic properties, such as increased proteolytic stability, extended plasma half-lives, reduced immuno-reactivity and enhanced fibrin clot specificity. The method involves either incorporating additional cysteine residues, or substituting cysteine residues for naturally occurring amino acids into non-essential regions of the protein such that the catalytic activity of the resultant protein remains largely unaltered. These cysteine variants were further modified by covalently attaching a cysteine reactive polymer such as polyethylene glycol (PEG) or sulfhydryl-reactive moieties from a group that includes fluorophore, spin labels or other small conjugates. Disclosed herein are site-specific biologically active conjugates of Streptokinases and its covalently modified variants. | 02-11-2010 |
Hirdesh Sahni, Bangalore IN
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20110190787 | IMAGE GUIDED WHOLE BODY STEREOTACTIC NEEDLE PLACEMENT DEVICE WITH FALLING ARC. - The present invention provides an Image guided whole body stereotactic needle placement device with falling arc ( | 08-04-2011 |
Hirdesh Sahni, Maharashtra IN
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20100082040 | IMAGE GUIDED WHOLE BODY STEREOTACTIC NEEDLE PLACEMENT DEVICE - The present invention provides an image guided whole body stereotactic needle placement device comprising a circular base plate ( | 04-01-2010 |
Narinder Singh Sahni, Oslo NO
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20130143761 | PRODUCT AND METHOD - The present invention relates to oligonucleotide probes, for use in assessing gene transcript levels in a cell, which may be used in analytical techniques, particularly diagnosis techniques and kits containing the same. | 06-06-2013 |
Paramjeet Singh Sahni, New Delhi IN
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20150341017 | AUTOMATIC POWER SWITCHING AND POWER HARVESTING IN THIN OXIDE OPEN DRAIN TRANSMITTER CIRCUITS, SYSTEMS, AND METHODS - A power harvesting circuit includes a new transmitter topology that ensures that no junction of thin oxide transistors forming the power harvesting circuit will experience a voltage across junctions of the transistors that is more than a maximum tolerable junction voltage. A supplemental power feed circuit operates to provide a supplemental feed current to components in a transmitter circuit when power harvested from a receiver circuit is insufficient to adequately power these components of the transmitter circuit, which may occur during high frequency operation of communications channels coupling the transmitter and receiver circuits. The supplemental power feed circuit also operates to sink a shunt current when power harvested from the receiver circuit is more than is needed to power the components in the transmitter circuit. | 11-26-2015 |
Paramjeet Singh Sahni, Bangalore IN
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20080224679 | Regulator With Improved Load Regulation - A regulator to provide an output voltage of a constant level at an output node. In an embodiment, the regulator contains a pass transistor to provide a conductive path between a pair of terminals, with the resistance offered by the path being determined by a control voltage on a third terminal of the pass transistor and the conductive path coupling a first reference potential (e.g., power supply) to the output node. An amplifier generates the control voltage based on a difference of a reference voltage and a voltage proportionate to the output voltage. A control unit turns on a current source when the voltage at the output node is below the desired constant level and turns on a current sink when voltage at said output node is above the constant level, to quickly correct for any variations in the output voltage due to load changes. | 09-18-2008 |
Saurabh Sahni, Madhya Pradesh IN
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20120296920 | METHOD TO INCREASE CONTENT RELEVANCE USING INSIGHTS OBTAINED FROM USER ACTIVITY UPDATES - Embodiments are directed towards ranking candidate pieces of content for publication based on a weighted combination of an “activity score” and a “trending score”. In one embodiment, the activity score measures social activity related to the content, such as how much the content has been shared, viewed, or commented on. In one embodiment, the trending score indicates a measure of trending topics contained in the content. In one embodiment, trending topics are keywords derived from an analysis of social activities across the internet, such as blog posts, wall posts, tweets, comments, ratings, tags, videos, pictures, and the like. In one embodiment, a topic is trending if it surpasses a minimum absolute threshold of social activity as well as a percentage increase in social activity. | 11-22-2012 |
Saurabh Sahni, Bangalore IN
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20100023399 | Personalized Advertising Using Lifestreaming Data - This patent discloses a method to increase the relevance of advertisements displayed on the Internet. An ad server may receive a request for an advertisement from a web server. The ad server may compare metadata to online advertisements within an ad database. The metadata may include data about the user obtained from at least two websites through a lifestreaming process. The comparison may seek out a best match between the advertisements and the metadata and serve the resulting advertisement to the web server. | 01-28-2010 |
20100023506 | AUGMENTING ONLINE CONTENT WITH ADDITIONAL CONTENT RELEVANT TO USER INTERESTS - A method of gathering information relevant to the interests of a user includes receiving activity history associated with the user from a network data source, where the activity history includes a description of a user action initiated by the user, generating a first metadata item based upon the activity history; and storing the first metadata item as user profile information associated with the user in a user profile database. Generating the first metadata item may include extracting text from the activity history and generating the first metadata item based upon the text. The activity history may include a description of a user action. The method may further include providing a server plugin for performing a second method in response to access of web content on a server by the user, the second method comprising retrieving a content object from the server, determining if the first metadata item is relevant to the content object, adding a web link to the web content as a reference to the content object in response to the content object being relevant to the first metadata item; and providing the web content to the user. | 01-28-2010 |
Saurabh Sahni, Indore IN
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20100114946 | ADAPTIVE WEIGHTED CRAWLING OF USER ACTIVITY FEEDS - Embodiments are directed towards determining frequencies for adaptively crawling user activity feeds, by taking into account user activity patterns, as well as a type or nature of a service to be crawled. A statistical model of activity patterns is generated for each user and user activity source based on various parameters. The activity patterns may be weighted to account for variation in relevancy of user content. Various measures are generated that are adaptive by being updated at a rate determined sufficient to detect user activity pattern changes. The statistical model produces clusters of users for each service. A crawling frequency may be assigned to the various clusters such that different users for a given service may have content crawled at different frequencies. | 05-06-2010 |
20100145939 | DETERMINING RELATED KEYWORDS BASED ON LIFESTREAM FEEDS - Embodiments are directed towards providing related keywords determined to be relevant to a search term using life-streaming data to identify the related keywords. Relevancy is determined by performing the related keyword analysis when life-stream services have been updated. Related keywords may be identified for a given search term using a combination of an aggregated life-stream analysis, a user profile based analysis, and/or a community based life-stream analysis. Each of these mechanisms identify a subset of updated life-streams or profiles to be analyzed to identify keywords that co-occur within each life-steam along with the given search term. The resulting co-occurring keywords may then be ordered based on a frequency of occurrence for the subset of life-streams. A weighted combination of the identified related keywords may be used to display related keywords to a user for use in modifying a search query. | 06-10-2010 |
20120102058 | DETERMINING RELATED KEYWORDS BASED ON LIFESTREAM FEEDS - Embodiments are directed towards providing related keywords determined to be relevant to a search term using life-streaming data to identify the related keywords. Relevancy is determined by performing the related keyword analysis when life-stream services have been updated. Related keywords may be identified for a given search term using a combination of an aggregated life-stream analysis, a user profile based analysis, and/or a community based life-stream analysis. Each of these mechanisms identify a subset of updated life-streams or profiles to be analyzed to identify keywords that co-occur within each life-steam along with the given search term. The resulting co-occurring keywords may then be ordered based on a frequency of occurrence for the subset of life-streams. A weighted combination of the identified related keywords may be used to display related keywords to a user for use in modifying a search query. | 04-26-2012 |
20130097237 | SYSTEMS AND METHODS FOR AUTOMATED LABELING OF SOCIAL CONNECTIONS - First data relating to a first user and second data relating to a second user are retrieved from a plurality of sources. A social connection is identified, by a computing device, between the first user and the second user using the first data and the second data. A label that describes the social connection is identified, by the computing device, using the first data and the second data. A first profile relating to the first user and a second profile relating to the second user is updated by the computing device to reflect the social connection and the label for the social connection. | 04-18-2013 |
Vinod Chandra Sahni, Mumbai IN
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20120094839 | NIOBIUM BASED SUPERCONDUCTING RADIO FREQUENCY(SCRF) CAVITIES COMPRISING NIOBIUM COMPONENTS JOINED BY LASER WELDING, METHOD AND APPARATUS FOR MANUFACTURING SUCH CAVITIES - Niobium or its alloy based Superconducting Radio Frequency (SCRF) Cavities involving atleast one laser beam welded components in the SCRF cavity welded from inside surface of the wall of cavity directed to achieving more than half the thickness to full depth penetration with minimum HAZ, minimizing distortion and shrinkage. The method ensures improved weld quality and surface finish substantially free of any weld defects. Also disclosed is the welding nozzle system and welding rigs adapted to facilitate such laser welding of the Niobium or its alloy based Superconducting Radio Frequency (SCRF) Cavities. The invention is thus directed to enhancing productivity, ensuring consistent quality and reliability, enhanced weld penetration with minimum HAZ, smooth finish of weld joints at possible reduced costs. | 04-19-2012 |
Vinod Chandra Sahni, Indore IN
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20110183854 | Method of qualifying niobium and/or other super conducting materials for reliable fabrication of superconducting radio frequency (SCRF) cavities - A method of qualifying Niobium and/or other super conducting materials for the reliable fabrication of SCRF cavities , which will invariably deliver high accelerating fields including: identification of the best superconducting lower critical field (H | 07-28-2011 |