Patent application number | Description | Published |
20120089047 | CRYOABLATION APPARATUSES, SYSTEMS, AND METHODS FOR RENAL NEUROMODULATION - Catheter apparatuses, systems, and methods for cryogenically modulating neural structures of the renal plexus by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a catheter treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver a cryo-applicator to a renal artery via an intravascular path. Cryogenic renal neuromodulation may be achieved via application of cryogenic temperatures to modulate neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. | 04-12-2012 |
20120130360 | NEUROMODULATION CRYOTHERAPEUTIC DEVICES AND ASSOCIATED SYSTEMS AND METHODS - Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state. | 05-24-2012 |
20120130458 | NEUROMODULATION CRYOTHERAPEUTIC DEVICES AND ASSOCIATED SYSTEMS AND METHODS - Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state. | 05-24-2012 |
20120136344 | NEUROMODULATION CRYOTHERAPEUTIC DEVICES AND ASSOCIATED SYSTEMS AND METHODS - Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state. | 05-31-2012 |
20120136417 | NEUROMODULATION CRYOTHERAPEUTIC DEVICES AND ASSOCIATED SYSTEMS AND METHODS - Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state. | 05-31-2012 |
20120136418 | NEUROMODULATION CRYOTHERAPEUTIC DEVICES AND ASSOCIATED SYSTEMS AND METHODS - Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state. | 05-31-2012 |
20120143294 | NEUROMODULATION CRYOTHERAPEUTIC DEVICES AND ASSOCIATED SYSTEMS AND METHODS - Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state. | 06-07-2012 |
20130324987 | Methods and Devices for Cryogenic Carotid Body Ablation - Methods and cryogenic devices for assessing, and treating patients having sympathetically mediated disease, involving augmented peripheral chemoreflex and heightened sympathetic tone by reducing chemosensor input to the nervous system via carotid body ablation. | 12-05-2013 |
20140163538 | Refrigerant Supply System for Cryotherapy Including Refrigerant Recompression and Associated Devices, Systems, and Methods - Cryotherapeutic systems configured for refrigerant recompression and associated devices, systems, and methods are disclosed herein. A cryotherapeutic system configured in accordance with a particular embodiment includes a high-pressure line, a low-pressure line, a recompression unit, and a cryo-catheter. The recompression unit increases the pressure of refrigerant from the low-pressure line to the high-pressure line to a treatment pressure sufficient for cryogenic alteration of tissue. The high-pressure line and the low-pressure line include, respectively, a first connector and a second connector. The cryo-catheter includes a shaft, a supply lumen in the shaft that is coupled to the first connector, an exhaust lumen in the shaft that is coupled to the second connector, and a cryo-applicator attached to the shaft having a cooling chamber configured to receive refrigerant from the supply lumen and to return refrigerant via the exhaust lumen to the low-pressure line. | 06-12-2014 |
Patent application number | Description | Published |
20100018618 | TIRE WITH TREAD HAVING A TWO-PLY TREAD CAP LAYER - The invention relates to a tire with a tread of a cap/base construction comprised of a two-ply (dual layered) tread cap rubber layer comprised of a combination of an outer tread cap layer and an inner tread cap layer together with an underlying tread base rubber layer which underlies the two-ply tread cap layer. The tread cap layer is of a lug and groove configuration with at least a portion of the grooves extending through the outer tread cap layer into the inner tread cap layer without extending to the tread base rubber layer. The outer tread cap rubber layer is comprised of a carbon black-rich rubber composition to promote dry traction for the tread running surface. The inner tread cap layer is comprised of a softer silica-rich rubber composition to promote wet traction for tread running surface as the outer tread cap layer wears away to expose the softer inner tread cap layer. | 01-28-2010 |
20110048599 | TIRE WITH RUBBER TREAD CONTAINING COMBINATION OF RESIN BLEND AND FUNCTIONALIZED ELASTOMER - This invention relates to a pneumatic tire with an outer, running surface containing, circumferential tread comprised of a styrene/butadiene (SBR) rich rubber composition containing two SBR's with spaced apart glass transition temperatures (Tg's), one of which is a functionalized SBR with a functional group reactive with hydroxyl groups on a precipitated silica, together with a combination of at least three resins with spaced apart softening points. The filler reinforcement is a combination of precipitated silica and specialized rubber reinforcing carbon black. | 03-03-2011 |
20120024441 | PNEUMATIC TIRE - The present invention is directed to a pneumatic tire having a rubber tread of a cap/base construction comprised of an outer rubber tread cap layer containing an outer running surface and an underlying rubber tread base layer, wherein said tread cap layer is comprised of a plurality of circumferential, longitudinal rubber tread cap zones of graduated physical properties, wherein said tread cap zones individually extend from said tread cap running surface radially inward to said tread base layer: wherein said tread cap zones are comprised of two primary tread cap zones and one central tread cap zone;
| 02-02-2012 |
20130126060 | STIFFNESS ENHANCED TREAD - A pneumatic tire includes a tread base comprised of a first material, a tread cap comprised of a second material, and a plurality of plugs comprised of a third material. The tread cap is disposed radially outward of the tread base and in operational contact with a ground surface. The plurality of plugs are disposed at least partially within the tread cap. The plurality of plugs yield a tread stiffness in one direction greater than stiffness in at least one other direction. | 05-23-2013 |
Patent application number | Description | Published |
20100181158 | Slave Cylinder for a Vibration-Damped Hydraulic Force Transmission System, Particularly a Hydraulic Clutch Actuating System for Motor Vehicles - A slave cylinder ( | 07-22-2010 |
20110094845 | ACTUATION DEVICE FOR A DUAL CLUTCH TRANSMISSION - A dual clutch actuation device generates the axial compression force required to compress a first and second set of frictional elements of a dual clutch module. Dual clutch actuation device includes a first and second annular piston. The annular pistons include a first end that is in contact with annular bearing assemblies. The annular bearing assemblies are in contact with actuation levers that are in contact with the first set of frictional elements. The annular pistons are arranged in concentric annular piston slots. Together the piston and annular slots form annular piston chambers. The piston chambers are filled with hydraulic fluid. When the hydraulic fluid is pressurized the pistons slide out of the annular slots and apply a force on the actuation levers which in turn apply an axial compression force on the frictional elements. | 04-28-2011 |
20140076681 | Slave Cylinder for a Vibration-Damped Hydraulic Force Transmission System, Particularly a Hydraulic Clutch Actuating System for Motor Vehicles - A slave cylinder for a vibration-damped hydraulic force transmission system, particularly a hydraulic clutch actuating system for motor vehicles is disclosed, comprising a cylinder housing, a piston received therein to be longitudinally displaceable and a pressure chamber which is bounded by the cylinder housing and the piston and which can be selectably acted on by a pressure medium, by way of a pressure connection provided in the cylinder housing, in order to displace the piston in the cylinder housing. An insert member which is inserted in the pressure chamber and secured in the pressure connection and which is equipped with a device for reducing pressure pulses, the device being constantly open to the pressure medium, is additionally provided. As a result, the vibration-damping measures or means are integrated in the slave cylinder in a particularly economic and space-saving manner. | 03-20-2014 |
Patent application number | Description | Published |
20090062140 | METHOD FOR IDENTIFYING CELLS BASED ON DNA REPLICATION DOMAIN TIMING PROFILES - Methods for identifying and/or distinguishing a homogeneous population of cells based on their replication domain timing profile using high resolution genomic arrays or sequencing procedures are provided. These methods may be used to compare the replication timing profile for a population of cells to another replication timing profile(s), a replication timing fingerprint, and/or one or more informative segments of a replication timing fingerprint, which may be simultaneously or previously determined and/or contained in a database, to determine whether there is a match between them. Based on such information, the identity of the population of cells may be determined, or the identity of the population of cells may be distinguished from other populations of cells or cell types. Methods for determining a replication timing fingerprint for particular cell types are also provided. | 03-05-2009 |
20120322675 | GENOME-SCALE ANALYSIS OF REPLICATION TIMING - Methods for identifying and/or distinguishing a homogeneous population of cells based on their replication domain timing profile using high resolution genomic arrays or sequencing procedures are provided. These methods may be used to compare the replication timing profile for a population of cells to another replication timing profile(s), a replication timing fingerprint, and/or one or more informative segments of a replication timing fingerprint, which may be simultaneously or previously determined and/or contained in a database, to determine whether there is a match between them. Based on such information, the identity of the population of cells may be determined, or the identity of the population of cells may be distinguished from other populations of cells or cell types. Methods for determining a replication timing fingerprint for particular cell types are also provided. | 12-20-2012 |
20130184998 | REPLICATION TIMING PROFILES FOR LEUKEMIA AND OTHER CANCERS - Described is a method for determining that a population of cells are a specific type of leukemic cell based on the replication timing fingerprint for the population of cells. | 07-18-2013 |
20140149048 | FINGERPRINT FOR CELL IDENTITY AND PLURIPOTENCY - A method for determining a replication timing footprint comprises the following steps: (a) selecting a set of chosen regions of the replication timing profile of a chromosome of an individual, (b) choosing a set of selected regions from the set of chosen regions to form a set of selected regions and a set of unused regions, (c) conducting a iterative algorithm on the set of selected regions until a domain number for the set of selected regions has decreased to a predetermined minimum, (d) determining a replication timing footprint based the set of selected regions after step (c) has been conducted, and (e) displaying the replication timing footprint to a user. | 05-29-2014 |