Patent application number | Description | Published |
20090171085 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES - The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of diseases characterized by, caused by or associated with the release of chemical mediators via degranulation and other processes effected by activation of the IgE and/or IgG receptor signaling cascades. | 07-02-2009 |
20120045454 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES - The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of diseases characterized by, caused by or associated with the release of chemical mediators via degranulation and other processes effected by activation of the IgE and/or IgG receptor signaling cascades. | 02-23-2012 |
20130150349 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES - The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of diseases characterized by, caused by or associated with the release of chemical mediators via degranulation and other processes effected by activation of the IgE and/or IgG receptor signaling cascades. | 06-13-2013 |
20140303154 | 2,4-PYRIDINEDIAMINE COMPOUNDS AND THEIR USES - The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of diseases characterized by, caused by or associated with the release of chemical mediators via degranulation and other processes effected by activation of the IgE and/or IgG receptor signaling cascades. | 10-09-2014 |
Patent application number | Description | Published |
20090017032 | MAMMALIAN CX3C CHEMOKINE ANTIBODIES - Nucleic acids encoding a new family of chemokines, the CX3C family, from a mammal, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using said reagents and related diagnostic kits are also provided. | 01-15-2009 |
20090317398 | MAMMALIAN CX3C CHEMOKINE ANTIBODIES - Nucleic acids encoding a new family of chemokines, the CX3C family, from a mammal, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using said reagents and related diagnostic kits are also provided. | 12-24-2009 |
20110189123 | MAMMALIAN CX3C CHEMOKINE ANTIBODIES - Nucleic acids encoding a new family of chemokines, the CX3C family, from a mammal, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using said reagents and related diagnostic kits are also provided. | 08-04-2011 |
20120225482 | MAMMALIAN CX3C CHEMOKINE ANTIBODIES - Nucleic acids encoding a new family of chemokines, the CX3C family, from a mammal, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using said reagents and related diagnostic kits are also provided. | 09-06-2012 |
Patent application number | Description | Published |
20110299228 | Multi-access Switchgear Assembly - A metal clad switchgear assembly comprising multiple compartments defined within an electrical enclosure is provided. The compartments interchangeably accommodate electrical components, for example, current transformers, a circuit breaker, a control power transformer, an epoxy encapsulated potential transformer, etc., electrical cables, and bus bars in predetermined positions for allowing front access and/or rear access to them. One or more compartments are configured for enabling the electrical cables to enter into and/or exit out from the electrical enclosure for allowing front and/or rear access to the electrical cables. A mounting block assembly is positioned in one or more of the compartments for mounting, enclosing, and providing front access to the electrical components. One or more infrared windows and inspection windows are positioned on a front side and/or a rear side of the switchgear assembly for scanning and providing a visual indication of the electrical components, the electrical cables, and the bus bars. | 12-08-2011 |
20140145535 | Eddy Current Torque Transfer Coupling Assembly - An electrical slip coupling assembly and method for enhancing transmission of torque are provided. The coupling assembly includes a field member (FM), an armature member (AM), and annular windings. The FM includes flux concentrating axial and radial teeth. The AM includes an interchangeable non-ferrous electrically conductive material cladding on an axial inner surface of the AM and a relatively low conductivity ferrous material cladding on a radial inner surface of the AM. The excitation of the annular windings induces the axial teeth and the radial teeth to generate flux field concentrations that create an axial eddy current zone (AECZ) in the AM across an axial air gap, and a radial eddy current zone (RECZ) in the AM across a radial air gap. During relative motion between the FM and the AM, the eddy currents in the AECZ and the RECZ create a driving torque between the FM and the AM. | 05-29-2014 |
Patent application number | Description | Published |
20080225149 | Column sample-and-hold cell for CMOS APS sensor - A sample and hold readout circuit, and method of operation which minimizes fixed pattern noise during a read out operation. The circuit improves the consistency of the pixel to pixel output of the pixel array and increases the dynamic range of the pixel output. This is accomplished by eliminating the crowbar between the storage elements in the sample and hold circuit. Switches are added to isolate the sample and hold circuit from the column line coupled to the pixel array and to short the front plates of the capacitors together. Activating these switches allows the signals stored in the sample and hold circuit to be transferred downstream without the use of a crowbar switch. | 09-18-2008 |
20090153717 | CMOS ACTIVE PIXEL SENSOR WITH A SAMPLE AND HOLD CIRCUIT HAVING MULTIPLE INJECTION CAPACITORS AND A FULLY DIFFERENTIAL CHARGE MODE LINEAR SYNTHESIZER WITH SKEW CONTROL - An CMOS active pixel sensor (APS) imaging system include circuitry to compensate for different analog offset levels from the CMOS pixel array. More specifically, the compensation is performed in the analog (charge) domain. A digital correction value, which may be measured as part of the operation or testing of the CMOS APS system, is provided to a offset correction block circuit, to generate an analog electrical signal. The analog electrical signal is supplied to a sample-and-hold circuit including a charge amplifier. The signal read from the pixel array, after conditioning through an analog signal chain, is also supplied to the charge amplifier, which has a linear transfer function and outputs the compensated signal. | 06-18-2009 |
20090266976 | AMPLIFICATION WITH FEEDBACK CAPACITANCE FOR PHOTODETECTOR SIGNALS - Signals from an imager pixel photodetector are received by an amplifier having capacitive feedback, such as a capacitive transimpedance amplifier (CTIA). The amplifier can be operated at a low or no power level during an integration period of a photodetector to reduce power dissipation. The amplifier can be distributed, with an amplifier element within each pixel of an array and with amplifier output circuitry outside the pixel array. The amplifier can be a single ended cascode amplifier, a folded cascode amplifier, a differential input telescopic cascode amplifier, or other configuration. The amplifier can be used in pixel configurations where the amplifier is directly connected to the photodetector, or in configurations which use a transfer transistor to couple signal charges to a floating diffusion node with the amplifier being coupled to the floating diffusion node. | 10-29-2009 |
20090278575 | CHARGE RECYCLING AMPLIFIER FOR A HIGH DYNAMIC RANGE CMOS IMAGER - A high dynamic range amplifier circuit for amplifying pixel signals of an imager device is disclosed. The amplifier circuit uses a read-out scheme based on a charge recycling approach, where a pixel signal is first amplified with a low gain during a first amplification phase T | 11-12-2009 |
20090322925 | PROVIDING CURRENT TO COMPENSATE FOR SPURIOUS CURRENT WHILE RECEIVING SIGNALS THROUGH A LINE - Circuits, methods, and systems are disclosed in which a current is provided to compensate for spurious current while receiving signals through a line. For example, the spurious current can be sensed and the compensating current can be approximately equal to the sensed spurious current. The spurious current could include photocurrent from a bright light, and the compensating current can prevent bright light effects. | 12-31-2009 |
20110007198 | MULTI PATH POWER FOR CMOS IMAGERS - An analog signal chain for a CMOS active pixel sensor imaging system utilizes, for each amplification stage, a plurality of fixed gain amplifiers instead of a single multi-gain amplifier. The fixed gain amplifier corresponding to the desired gain level is selected and powered on and coupled to the input/output signal paths, while the non-selected fixed gain amplifier(s) are powered off and isolated from the input/output signal paths. Each fixed gain amplifier is operated at a gain bandwidth corresponding to the timing requirements of the imaging system and the gain of the amplifier. Thus, each fixed gain amplifier (other than the one corresponding to the maximum gain of a comparable multi-gain amplifier) operates at a lower level of power consumption than the comparable multi-gain amplifier. | 01-13-2011 |
Patent application number | Description | Published |
20130102654 | RNA APTAMERS AGAINST BAFF-R AS CELL-TYPE SPECIFIC DELIVERY AGENTS AND METHODS FOR THEIR USE - In one embodiment, a B cell specific aptamer-siRNA chimera is provided. The B cell specific aptamer-siRNa chimera may include an RNA aptamer that binds BAFF-R and an siRNA molecule conjugated to the RNA aptamer via a nucleotide linker. In another embodiment, a B cell specific RNA aptamer is provided. The RNA aptamer may be a molecule that binds to BAFF-R that has the sequence SEQ ID NO:37, SEQ ID NO:38 or SEQ ID NO:39. In some embodiments, the RNA aptamer is conjugated, via a nucleotide linker, to an siRNA molecule that suppresses expression of one or more target oncogenes in one or more B cells. In one aspect, the one or more target oncogenes are selected from Bcl6, Bcl2, STAT3, Cyclin D1, Cyclin E2 and c-myc. In another embodiment, methods for treating a B cell malignancy in a cancer patient are provided. Such methods may include administering a therapeutically effective amount of a therapeutic composition, the therapeutic composition comprising a B cell specific RNA aptamer that binds BAFF-R. | 04-25-2013 |
20160076036 | RNA APTAMERS AGAINST BAFF-R AS CELL-TYPE SPECIFIC DELIVERY AGENTS AND METHODS FOR THEIR USE - In one embodiment, a B cell specific aptamer-siRNA chimera is provided. The B cell specific aptamer-siRNA chimera may include an RNA aptamer that binds BAFF-R and an siRNA molecule conjugated to the RNA aptamer via a nucleotide linker. In another embodiment, a B cell specific RNA aptamer is provided. The RNA aptamer may be a molecule that binds to BAFF-R that has the sequence SEQ ID NO:37, SEQ ID NO:38 or SEQ ID NO:39. In some embodiments, the RNA aptamer is conjugated, via a nucleotide linker, to an siRNA molecule that suppresses expression of one or more target oncogenes in one or more B cells. In one aspect, the one or more target oncogenes are selected from Bcl6, Bcl2, STAT3, Cyclin D1, Cyclin E2 and c-myc. In another embodiment, methods for treating a B cell malignancy in a cancer patient are provided. Such methods may include administering a therapeutically effective amount of a therapeutic composition, the therapeutic composition comprising a B cell specific RNA aptamer that binds BAFF-R. | 03-17-2016 |
Patent application number | Description | Published |
20150105450 | MULTI-TARGETING SHORT INTERFERING RNAs - The present invention relates to novel short interfering RNA (siRNA) molecules that are multi-targeted. More specifically, the present invention relates to siRNA molecules that target two or more sequences. In one embodiment, multi-targeting siRNA molecules are designed to incorporate features of siRNA molecules and features of micro-RNA (miRNA) molecules. In another embodiment, multi-targeting siRNA molecules are designed so that each strand is directed to separate targets. | 04-16-2015 |
20150110860 | METHODS AND COMPOSITIONS FOR THE SPECIFIC INHIBITION OF GENE EXPRESSION BY DOUBLE-STRANDED RNA - The invention is directed to compositions and methods for selectively reducing the expression of a gene product from a desired target gene in a cell, as well as for treating diseases caused by the expression of the gene. More particularly, the invention is directed to compositions that contain double stranded RNA (“dsRNA”), and methods for preparing them, that are capable of reducing the expression of target genes in eukaryotic cells. The dsRNA has a first oligonucleotide sequence that is between 25 and about 30 nucleotides in length and a second oligonucleotide sequence that anneals to the first sequence under biological conditions. In addition, a region of one of the sequences of the dsRNA having a sequence length of at least 19 nucleotides is sufficiently complementary to a nucleotide sequence of the RNA produced from the target gene to trigger the destruction of the target RNA by the RNAi machinery. | 04-23-2015 |
20150118682 | METHODS FOR PRODUCING INTERFERING RNA MOLECULES IN MAMMALIAN CELLS AND THERAPEUTIC USES FOR SUCH MOLECULES - Methods for producing interfering RNA molecules in mammalian cells are provided. Therapeutic uses for the expressed molecules, including inhibiting expression of HIV, are also provided. | 04-30-2015 |
20150197752 | RNA APTAMERS FOR THERAPEUTIC AND DIAGNOSTIC DELIVERY TO PANCREATIC CANCER CELLS - In some embodiments, aptamers that specifically bind pancreatic cancer cells are provided. Such aptamers may include an RNA molecule that specifically binds a pancreatic cancer cell surface protein. In certain embodiments, the RNA molecule that is used as an aptamer may include a nucleotide sequence of GAAUGCCC (SEQ ID NO: 8). In other embodiments, the RNA molecule may include a nucleotide sequence of SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, or SEQ ID NO:6. In certain embodiments, the aptamer may be conjugated to one or more therapeutic agents (e.g., an shRNA molecule, an siRNA molecule, an mRNA molecule, or an miRNA molecule), one or more diagnostic agents, or a combination thereof. The aptamers and their conjugates may be used to deliver therapeutic agents to a pancreatic cancer cell, and/or in methods for treating or diagnosing pancreatic cancer. | 07-16-2015 |
Patent application number | Description | Published |
20090300098 | SYNDICATING ENTERPRISE APPLICATION SYSTEM DATA - Systems and methods are provided that syndicate enterprise application system (EAS) data. A method includes creating a feed for an EAS module, generating a news item for the feed, and publishing the news item on the feed. Accordingly, employees in an organization are able to easily become aware of information about their organization by tightly coupling a syndication system to human resources management. The sharing of information throughout the organization creates a more inclusive and cohesive working environment. In one embodiment, the EAS data is enterprise resource planning (ERP) data. | 12-03-2009 |
20090319595 | Presence Mapping - Systems, methods, and associated software for detecting presence are described with respect to a number of embodiments of the present disclosure. More particularly, presence information can be displayed on a floor plan, according to the teachings herein. In one implementation, a method for monitoring the presence of a person is described in which the name of a person of interest is received from a requestor. The requestor and the person of interest are both associated with an organization. The method also includes retrieving information regarding a first work area associated with the person of interest and reproducing a section of a floor plan containing at least the first work area. Furthermore, the method includes sending the section of the floor plan to the requestor. The method also includes retrieving information regarding the person of interest associated with the first work area. A name field, which includes the name and the presence status of the person of interest, is sent to the requestor. | 12-24-2009 |
20100005085 | CREATING RELATIONSHIP MAPS FROM ENTERPRISE APPLICATION SYSTEM DATA - Systems and methods are provided that create a relationship map using enterprise application system (EAS) data. Relationship data is automatically collected from EAS modules. The EAS modules may be enterprise resource planning (ERP) modules. A relationship map is then generated from the collected relationship data. Thus, a representation of formal and informal working relationships among employees in an organization is built, where such relationship data was previously too onerous to capture manually. Further, this representation may be visually illustrated to a user, enabling the user to navigate among the relationships of their fellow coworkers. | 01-07-2010 |
20100005098 | COMBINED DIRECTORY OF PERSONAL AND ENTERPRISE APPLICATION SYSTEM DATA - Systems and methods are provided that combine private contact information and Enterprise Application System (“EAS”) data in a directory. An embodiment includes receiving private contact information regarding a first employee from a second employee, storing the private contact information regarding the first employee on an EAS server, and displaying the private contact information to the second employee upon request, wherein the private contact information is viewable only to the second employee. | 01-07-2010 |
20100011361 | Managing Task Requests - Systems and methods are disclosed herein for managing task requests. An end user device include one or several possible implementation for managing task requests. Specifically, the end user device comprises a processing device and a memory device, which is configured to store a task request managing program. The processing device is configured to execute the task request managing program. The processing device is configured to analyze a string of characters of a natural language request from a user to extract a requested task and a requested object. The processing device is further configured to check whether the user is permitted to initiate the requested task on the requested object. In addition, the processing device is configured to perform the requested task on the requested object when it is determined that the user is permitted to initiate the requested task on the requested object. | 01-14-2010 |
Patent application number | Description | Published |
20150097682 | MOBILE USER INTERFACE FOR SMART-HOME HAZARD DETECTOR CONFIGURATION - System for displaying hazard events and adjusting hazard detector settings on a mobile device includes a user interface executed on the mobile device, a hazard detector, and a computer server system communicatively coupled to the mobile device and hazard detector. The hazard detector generates hazard events indicating detection of smoke or carbon monoxide. The hazard events are transmitted to the computer server system and then to the mobile device. User interface displays the hazard events in an event group. User interface receives an adjusted value for a setting of the hazard detector and transmits the adjusted value to the computer server system. The computer server system determines that the adjusted value corresponds to the hazard detector, receives a check-in event from the hazard detector, and transmits the adjusted value to the hazard detector in response to receiving the check-in event. The hazard detector applies the adjusted value to the setting. | 04-09-2015 |
20150097688 | MOBILE USER INTERFACE FOR EVENT NOTIFICATIONS ARISING FROM SMART-HOME HAZARD DETECTION DEVICES - System for displaying hazard events and adjusting hazard detector settings on a mobile device includes a user interface executed on the mobile device, a hazard detector, and a computer server system communicatively coupled to the mobile device and hazard detector. The hazard detector generates hazard events indicating detection of smoke or carbon monoxide. The hazard events are transmitted to the computer server system and then to the mobile device. User interface displays the hazard events in an event group. User interface receives an adjusted value for a setting of the hazard detector and transmits the adjusted value to the computer server system. The computer server system determines that the adjusted value corresponds to the hazard detector, receives a check-in event from the hazard detector, and transmits the adjusted value to the hazard detector in response to receiving the check-in event. The hazard detector applies the adjusted value to the setting. | 04-09-2015 |
20150100618 | HAZARD DETECTION UNIT FACILITATING USER-FRIENDLY SETUP EXPERIENCE - A method for establishing a pairing between a hazard detector and an online account may include instantiating an application on a mobile computing device and receiving a first code from a central server. The application may receive a second code from printed material associated with the hazard detector. The hazard detector may broadcast a Wi-Fi access point, and the application may join the Wi-Fi access point. The application can be authenticated by the hazard detector using the second code, and the application can receive an identity of a home Wi-Fi network from a user. The application can then transmit the identity of the home Wi-Fi network to the hazard detector. The hazard detector can use the home Wi-Fi network to access the Internet and transmit the first code to the central server, where the central server can use the first code in completing the pairing process. | 04-09-2015 |
20150256563 | HAZARD DETECTION UNIT FACILITATING USER-FRIENDLY SETUP EXPERIENCE - A method for establishing a pairing between a smart-home device and an online account may include instantiating an application on a computing device and receiving a first code from a central server. The application may receive a second code from printed material associated with the smart-home device. The smart-home device may broadcast a first communication protocol, and the application may join the first mutation protocol. The application can be authenticated by the smart-home device using the second code, and the application can receive an identity of a second communication protocol from a user. The application can then transmit the identity of the second communication protocol to the smart-home device. The smart-home device can use the second mutation protocol to access the Internet and transmit the first code to the central server, where the central server can use the first code in completing the pairing process. | 09-10-2015 |