Patent application number | Description | Published |
20100234827 | METHOD OF TREATING HEART FAILURE - The present invention includes methods, systems, uses, and means for the delivery of one or more anti-fibrotic agents into the pericardial space for the treatment and prevention of heart failure (HF). | 09-16-2010 |
20110245711 | METHOD AND APPARATUS FOR PERSONALIZED PHYSIOLOGIC PARAMETERS - Methods and apparatus combine patient measurement data with demographic or physiological data of the patient to determine an output that can be used to diagnose and treat the patient. A customized output can be determined based the demographics of the patient, physiological data of the patient, and data of a population of patients. In another aspect, patient measurement data is used to predict an impending cardiac event, such as acute decompensated heart failure. At least one personalized value is determined for the patient, and a patient event prediction output is generated based at least in part on the personalized value and the measurement data. For example, bioimpedance data may be used to establish a baseline impedance specific to the patient, and the patient event prediction output generated based in part on the relationship of ongoing impedance measurements to the baseline impedance. Multivariate prediction models may enhance prediction accuracy. | 10-06-2011 |
20110270049 | Method and Apparatus for Remote Detection and Monitoring of Functional Chronotropic Incompetence - Methods and apparatus to determine the presence of and track functional chronotropic incompetence (hereinafter “CI”) in an in-home setting under conditions of daily living. The functional CI of the patient may be determined with one or more of a profile of measured patient heart rates, a measured maximum patient heart rate, or a peak of the heart rate profile, such as the peak of a heart rate distribution profile. The functional CI of the patient may be determined with the measured heart rate profile, in which the measured heart rate profile may correspond to heart rates substantially less than the maximum heart rate of the patient, such that the heart rate can be safely measured when the patient is remote from a health care provider. The functional CI of the patient may be determined based a peak of the remotely measured heart rate profile, for example a peak corresponding to the mode of the heart rate distribution profile. For example, the relative amounts of the profile of heart rates above the peak and heart rates below the peak can be compared to determine the CI. The peak of the heart rate profile of the remote heart rate data may be used to determine the heart rate reserve and functional CI of the patient. The changes in HR can be measured and correlated to one or more sensor parameters such as activity to determine CI of the patient. | 11-03-2011 |
20120035432 | MEDICAL DEVICE AND METHODS OF MONITORING A PATIENT WITH RENAL DYSFUNCTION - Embodiments relate to a method of monitoring physiological parameters of a patient with renal dysfunction. The method includes electrically connecting one or more medical device electrodes with a measurement site of a patient, generating one or more first stimulation signals sufficient to provide input physiological parameters specific to the patient, measuring one or more first bioimpedance values from the generated signals, analyzing at least one of the input physiological parameters within the one or more first bioimpedance values and generating a personalized dialysis program. The systems and methods can further provide essentially real-time data of patient undergoing treatment and control of treatment to a patient. | 02-09-2012 |
20120035494 | MULTIFREQUENCY BIOIMPEDENCE DEVICE AND RELATED METHODS - Embodiments relate to a device and a method of monitoring and analyzing physiological parameters of a patient. The method includes electrically connecting one or more electrodes with a measurement site of a patient, generating a stimulation signal or signals sufficient to provide multiple stimulation frequencies, multiple waveforms or a combination thereof, measuring a one or more bioimpedance values from the generated signals and analyzing at least one of a fluid bioimpedance contribution, fat bioimpedance contribution or ion bioimpedance contribution within the one or more bioimpedance values sufficient to generate a physiological report. | 02-09-2012 |
20120136263 | DETECTION OF RELAXATION ABNORMALITY IN HEART TISSUE - A chronically implanted medical device, connected to a medical electrical lead that includes a sensor, is used to detect diastolic dysfunction. A LV accelerometer signal is sensed through the sensor. Based on the LV accelerometer signal, a determination is made as to whether diastolic dysfunction data exists. | 05-31-2012 |
20120143072 | METHOD AND APPARATUS FOR DETERMINING LEFT VENTRICULAR LUSITROPY - A chronically implanted medical device, connected to a medical electrical lead that includes a sensor, is used to detect diastolic dysfunction. A LV accelerometer signal is sensed through the sensor. Based on the LV accelerometer signal, a determination is made as to whether diastolic dysfunction data exists. | 06-07-2012 |
20120158082 | AORTIC PACING TO CONTROL CARDIAC AFTERLOAD - A chronically implanted medical device, connected to a medical electrical lead that includes a sensor, is used to detect cardiac afterload. Electrical stimulation is delivered proximate aortic arch tissue of a patient in order to reduce a patient's cardiac afterload. Electrical stimulation is terminated after a termination condition is met. | 06-21-2012 |
20120158086 | AORTIC PACING TO REDUCE HEART RATE - A chronically implanted medical device, connected to a medical electrical lead that includes a sensor, is used to detect heart rate. Electrical stimulation is delivered proximate aortic arch tissue of a patient in order to reduce a patient's heart rate. Electrical stimulation is terminated after a determination is made that continued electrical stimulation does not provide a beneficial heart rate effect to the patient. | 06-21-2012 |
20130096395 | METHOD AND APPARATUS FOR PERSONALIZED PHYSIOLOGIC PARAMETERS - Methods and apparatus combine patient measurement data with demographic or physiological data of the patient to determine an output that can be used to diagnose and treat the patient. A customized output can be determined based the demographics of the patient, physiological data of the patient, and data of a population of patients. In another aspect, patient measurement data is used to predict an impending cardiac event, such as acute decompensated heart failure. At least one personalized value is determined for the patient, and a patient event prediction output is generated based at least in part on the personalized value and the measurement data. For example, bioimpedance data may be used to establish a baseline impedance specific to the patient, and the patient event prediction output generated based in part on the relationship of ongoing impedance measurements to the baseline impedance. Multivariate prediction models may enhance prediction accuracy. | 04-18-2013 |
20130303997 | TRANSSEPTAL NEEDLE APPARATUS - In various examples, an apparatus includes a gripping member including a body and a gripping portion attached to the body. The body includes a passage configured to accept a needle cannula within the passage. The gripping portion includes an open configuration in which the needle cannula is movable within the passage and a closed configuration in which the gripping portion engages the needle cannula to inhibit movement of the needle cannula within the passage. A coupling member is rotatably attached to the gripping member. The coupling member is configured to selectively couple with a dilator. The coupling member includes a bore fluidly coupled with the passage, the bore being configured to accept the needle cannula within the bore. | 11-14-2013 |
20130304036 | TRANSSEPTAL NEEDLE APPARATUS - In various examples, an apparatus includes a needle assembly including an outer cannula including a tubular sidewall disposed around a lumen. At least a portion of the sidewall includes an exterior including a polymeric material configured to inhibit skiving of an interior of a dilator with movement of the outer cannula within the dilator. An inner cannula is disposed within the lumen and is selectively slidable with respect to the outer cannula. A handle is disposed at a proximal portion of the needle assembly. The handle includes a first handle portion coupled to and movable with the outer cannula. A second handle portion is coupled to and movable with the inner cannula, wherein the first handle portion is selectively movable with respect to the second handle portion to extend a distal end of the inner cannula from within the lumen of the outer cannula. | 11-14-2013 |
20130304051 | TRANSSEPTAL NEEDLE APPARATUS - In various examples, an apparatus includes a needle cannula including a proximal end and a distal end The needle cannula includes a lumen extending from the proximal end to the distal end. A handle is disposed at the proximal end of the needle cannula. An electrocautery receiver is associated with the handle and electrically coupled to the needle cannula, wherein, with an electrocautery device activated and placed within the electrocautery receiver, electrical energy is conducted from the electrocautery device to the distal end of the needle cannula to selectively electrocauterize tissue in contact with the distal end of the needle cannula. | 11-14-2013 |
20140257115 | APPARATUS AND METHOD FOR PATIENT ACTIVITY ESTIMATION AND CLASSIFICATION - A medical device includes a housing and an electrode arrangement coupled to the housing and configured to sense an electrical physiologic signal from a patient. The device also includes detection circuitry coupled to the electrode arrangement and configured to obtain a cardiac signal component and a non-cardiac signal component from the physiological signal. A processor is coupled to the detection circuitry. The processor is configured to detect patient activity using at least the non-cardiac signal component and discriminate between voluntary and involuntary activity of the patient based on a comparison of temporally aligned cardiac and non-cardiac signal components. | 09-11-2014 |
20140275837 | APPARATUS AND METHOD FOR DETECTION OF SLEEP DISORDERED BREATHING - An apparatus, system, and method directed to detecting a physiological signal during discrete time separated detection windows, deriving one or more respiratory disturbance indices from the physiological signal, detecting a respiratory disturbance state in response to the one or more respiratory disturbance indices deviating from a threshold value, interpolating the one or more respiratory disturbance indices between adjacent time separated detection windows, and declaring a respiratory disturbance episode based on the detected respiratory disturbance state during the detection windows and the interpolation between detection windows. | 09-18-2014 |
20140275919 | APPARATUS AND METHOD FOR ELECTROCARDIOGRAPHIC MONITORING - In various examples, an apparatus includes an apparatus configured for implantation within a body of a patient. The apparatus, in some examples, includes a housing. At least one antenna extends from the housing, the antenna being flexible such that the antenna conforms to the body of the patient. In some examples, the apparatus includes at least three electrodes, wherein at least a first electrode is disposed on the antenna and at least a second electrode is disposed on the housing. The at least three electrodes are disposed in a non-linear configuration, allowing for differential processing of signals recorded by the at least three electrodes. | 09-18-2014 |
20140276154 | CARDIAC SIGNAL RECORDING USING DYNAMICALLY GENERATED DETECTION THRESHOLDS - A medical device includes a housing configured for implantation within a body of a patient, and detection circuitry disposed in the housing and coupled to an electrode arrangement. The detection circuitry is configured to sense cardiac signals from the patient. A processor is coupled to the detection circuitry. The processor is configured to compare the cardiac signals to an initial detection threshold, automatically generate an additional detection threshold in response to a predetermined number of the cardiac signals meeting or exceeding the initial detection threshold or a previously generated detection threshold, count each occurrence of a cardiac signal meeting or exceeding each of the respective detection thresholds, and record cardiac signal data only for a cardiac signal that meets or exceeds the highest of the detection thresholds. | 09-18-2014 |
20140371604 | METHOD AND APPARATUS FOR REMOTE DETECTION AND MONITORING OF FUNCTIONAL CHRONOTROPIC INCOMPETENCE - Methods and apparatus to determine the presence of and track functional chronotropic incompetence (hereinafter “CI”) in an in-home setting under conditions of daily living. The functional CI of the patient may be determined with one or more of a profile of measured patient heart rates, a measured maximum patient heart rate, or a peak of the heart rate profile. The functional CI of the patient may be determined with the measured heart rate profile, in which the measured heart rate profile may correspond to heart rates substantially less than the maximum heart rate of the patient, such that the heart rate can be safely measured when the patient is remote from a health care provider. The functional CI of the patient may be determined based a peak of the remotely measured heart rate profile, for example a peak corresponding to the mode of the heart rate distribution profile. | 12-18-2014 |