Robinson, MA
Barnett Joel Robinson, Newton, MA US
Patent application number | Description | Published |
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20100037876 | Two-stroke internal combustion engine with valves for improved fuel efficiency - A two-stroke cycle internal combustion engine has a cylinder with a cylinder head closing off an end of the cylinder, a crankshaft and a piston connecting with the crankshaft to move the piston in a reciprocating movement within the cylinder. Intake and exhaust valves move into and out of a combustion chamber for openings and closures of the valves. A mixture of fuel and air is forced into the cylinder during an open interval of the intake valve beginning in the middle of the upstroke and terminating in a range of 20-60 degrees before top dead center to improve efficiency and choice of fuel by minimizing compressive forces of the piston during the upstroke. Timing of the closure of the intake valve may be delayed automatically with a reduction in crankshaft angular speed. | 02-18-2010 |
20110061633 | Internal combustion engine having intake manifold combined with holding tank - An internal combustion engine with a plurality of cylinders operating in a four-stroke mode, with pistons moving with reciprocating motion, employs at least one holding tank that is formed within a branch of an intake manifold. The holding tank may be shared among a plurality of cylinders. The holding tank, in response to an opening and a closure of a holding valve within the manifold, serves alternately as a conduit and a tank to convey a pre-combustion gas (fuel-air mix in gasoline engines) to and from the cylinders. Intake valves are held open beyond termination of induction strokes for entry and extraction a quantity of pre-combustion gas from a cylinder to reduce the compression ratio to a value less than the expansion ratio. | 03-17-2011 |
Brandon Michael Robinson, Watertown, MA US
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20160066727 | CONTAINER OR UTENSIL SUPPORT STRUCTURE - A container support apparatus can include a base body having a first portion, a second portion, and a boundary region between the first and second portions. The apparatus can include a first straight lateral connector member and a second straight lateral connector member, each formed at least in part from the first portion of the base body. The apparatus can include a bottom support member disposed in a coplanar position with the first portion of the base body in an undeployed state. The first and second lateral connector members can undergo downward angular pitching in conjunction with the bottom support member undergoing simultaneous vertical translation and planar rotation relative to the second portion of the base body during transition from the undeployed state to a deployed state, and the bottom support member can maintain a parallel orientation relative to the second portion of the base body during this transition. | 03-10-2016 |
Bryan S. Robinson, Arlington, MA US
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20100104277 | MODULATOR FOR FREQUENCY-SHIFT KEYING OF OPTICAL SIGNALS - Described are an FSK modulator and a method for large-alphabet FSK modulation. The FSK modulator and the method are based on filtering of a multi-tone optical source such as a mode-locked laser which provides a comb distribution of tones. A frequency-selective component selects for transmission a subset of the tones. In various embodiments the frequency-selective component is a Mach-Zehnder interferometer filter or a microring resonator filter. A second frequency-selective component selects a subset of the tones from the comb distribution provided by the first frequency-selective component. Still more frequency-selective components can be used according to the number of tones supplied by the multi-tone optical source to the FSK modulator. The optical signal exiting the last frequency-selective component includes only a single tone which corresponds to the symbol to be transmitted. | 04-29-2010 |
20110199621 | SINGLE-TRANSDUCER, THREE-DIMENSIONAL LASER IMAGING SYSTEM AND METHOD - Disclosed herein are a system and method for three-dimensional imaging using a single transducer. A laser in a transmitter emits a sequence of short pulses, each of which is at a different center wavelength (frequency). A dispersive element in the transmitter spatially separates the pulses according to wavelength, with different pulses mapped to different spatial locations in a target volume via a lens. The pulses travel to the target, which scatters or back-reflects the pulses towards the dispersive element via the lens. The lens collects the returned pulses and transmits them to a single transducer via the dispersive element. The transducer measures the time of arrival for each returned pulse. Because the arrival time depends on the range to the object in the portion of the target illuminated by the corresponding emitted pulse, the measured arrival time can be used to reconstruct a 3D (angle-angle-range) image of the object. | 08-18-2011 |
20110274429 | METHOD AND APPARATUS FOR PHASE SHIFT KEYED OPTICAL COMMUNICATIONS - A burst-mode differential phase shift keying (DPSK) communications system according to an embodiment of the present invention enables practical, power-efficient, multi-rate communications between an optical transmitter and receiver. An embodiment of the system utilizes a single interferometer in the receiver with a relative path delay that is matched to the DPSK symbol rate of the link. DPSK symbols are transmitted in bursts, and the data rate may be varied by changing the ratio of the burst-on time to the burst-off time. This approach offers a number of advantages over conventional DPSK implementations, including near-optimum photon efficiency over a wide range of data rates, simplified multi-rate transceiver implementation, and relaxed transmit laser line-width requirements at low data rates. | 11-10-2011 |
20130148983 | MODULATOR FOR FREQUENCY-SHIFT KEYING OF OPTICAL SIGNALS - Described are an FSK modulator and a method for large-alphabet FSK modulation. The FSK modulator and the method are based on filtering of a multi-tone optical source such as a mode-locked laser which provides a comb distribution of tones. A frequency-selective component selects for transmission a subset of the tones. In various embodiments the frequency-selective component is a Mach-Zehnder interferometer filter or a microring resonator filter. A second frequency-selective component selects a subset of the tones from the comb distribution provided by the first frequency-selective component. Still more frequency-selective components can be used according to the number of tones supplied by the multi-tone optical source to the FSK modulator. The optical signal exiting the last frequency-selective component includes only a single tone which corresponds to the symbol to be transmitted. | 06-13-2013 |
Craig Robinson, Westborough, MA US
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20140154686 | BIOMETRIC DEVICE AND MEANS FOR ELECTRONIC STORAGE AND RETRIEVAL OF BIOMETRIC DATA - There is disclosed a biometric device ( | 06-05-2014 |
David R. Robinson, Hanover, MA US
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20140053083 | Application Program and Related Techniques for Organizing a Meeting Between People - A computer-implemented application program comprises various graphic user interfaces to facilitate the formation of a physical meeting between people. A computer-readable storage medium comprises instructions to implement the computer-implemented application program. | 02-20-2014 |
Don Robinson, Framingham, MA US
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20130092079 | Coated Medical Device and Method for Manufacturing the Same - The medical device of the invention comprises a surface comprising at least one outermost portion and a plurality of depressions. The depressions occupy at least about 80% of the surface area of the surface. The depressions contain a coating material that preferably comprises a biologically active material and/or polymer, and the outermost portion is substantially free of any coating material. The invention is also directed to a method for manufacturing a medical device. The method comprises applying a coating material to the surface of the medical device by using at least one roller. | 04-18-2013 |
Doran Robinson, Newton, MA US
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20150149189 | METHODS AND APPARATUS FOR ESTABLISHING A HEALTHCARE DATA INTERFACE USING A PRACTICE MANAGEMENT SYSTEM - Methods and apparatus for establishing a healthcare data interface for a healthcare provider associated with a practice management system, wherein the healthcare data interface is established between the practice management system and a healthcare trading partner to enable electronic transmission of data between the practice management system and the healthcare trading partner. The method comprises receiving a request from the healthcare provider to establish the healthcare data interface with the healthcare trading partner and prompting, via a user interface, the healthcare provider for configuration information, wherein the prompting is performed based, at least in part, on information associated with the healthcare trading partner stored by the practice management system. The method further comprises receiving the configuration information from the healthcare provider, and configuring the healthcare data interface for the healthcare provider based, at least in part, on the received configuration information. | 05-28-2015 |
Douglas Robinson, Cambridge, MA US
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20150105434 | BIOMARKERS FOR IAP INHIBITOR THERAPY - A method of selecting a subject having cancer for treatment with an IAP inhibitor. | 04-16-2015 |
Douglas K. Robinson, Mansfield, MA US
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20100154255 | SHOE WITH SENSORS, CONTROLLER AND ACTIVE-RESPONSE ELEMENTS AND METHOD FOR USE THEREOF - Active-response golf shoes are disclosed. The golf shoes include a plurality of sensors, a controller, and at least one active-response element. The sensor and controller operate to rapidly determine if a golfer is walking or swinging a golf club. Once this determination is made the controller and active-response element rapidly change the shoe's characteristics. If the controller determines that the golfer is walking, the shoe provides a soft and flexible walking platform. If the controller determines that the golfer is swinging, the shoe morphs or changes automatically to provide a stable hitting platform. The controller senses various predetermined conditions such as pressure of the user's foot to determine whether the golfer is walking or swinging. The active-response element is a lateral adjuster having an upper bracket located in the laces area and a lower bracket affixed to the side of the sole, brackets supporting a plurality of electrostrictive polymer bands; | 06-24-2010 |
20120285044 | GOLF SHOE OUTSOLE - The golf shoe outsole of the invention comprises a generally flexible forward section and a generally hard heel section, each section having a plurality of pod sections molded thereupon, preferably there are eight separate pod sections, each having at least one cleat attached thereto. Each pod section has an outer edge or perimeter that is flared quite significantly to provide a greater degree of flexibility and traction with turf, and therefore greater stability and balance to the user. The outsole has a 0.375 width to length ratio at the metatarsal area of the outsole and a pod vertical height of at least 9.1 mm and a flare angle of at least 52° from vertical on the outer edges of the pods. The pods are relatively hard with a minimum Shore A hardness of 95 and extend a minimum of 6.3 mm from the bottom surface of the outsole. The forward portion of the outsole is made from a relatively flexible thermoplastic polyurethane having a hardness between 75 to 85 Shore A. | 11-15-2012 |
Douglas Michael Robinson, Hanover, MA US
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20100184125 | BIOMARKERS AND METHODS FOR DETERMINING SENSITIVITY TO INSULIN GROWTH FACTOR-1 RECEPTOR MODULATORS - IGF1R biomarkers useful in a method for identifying and monitoring a mammal that will respond therapeutically to a method of treating cancer comprising administering an IGF1R modulator, wherein the method comprises (a) exposing the mammal to the IGF1R modulator and (b) measuring in the mammal the level of the at least one biomarker, wherein a difference in the level of the at least one biomarker measured in (b) compared to the level of the biomarker in a mammal that has not been exposed to the IGF1R modulator indicates that the mammal will respond therapeutically to the method of treating cancer and (c) wherein the level of the biomarker in a mammal after exposure to a IGF1R modulator indicates that the mammal has responded therapeutically to the method of treating cancer. | 07-22-2010 |
20110269139 | BIOMARKERS AND METHODS FOR DETERMINING SENSITIVITY TO EPIDERMAL GROWTH FACTOR RECEPTOR MODULATORS - The present invention provides methods useful for predicting the likelihood that a mammal that will respond therapeutically to a method of treating cancer comprising administering an EGFR modulator, and diagnostic methods and kits thereof. | 11-03-2011 |
20140094461 | BIOMARKERS FOR HEDGEHOG INHIBITOR THERAPY - A method of selecting a subject having cancer for treatment with a Hedgehog signaling inhibitor by determining the level of expression of at least one biomarker in a biological sample derived from the subject. | 04-03-2014 |
Gary Robinson, Framingham, MA US
Patent application number | Description | Published |
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20110274748 | CAI-Based Systems and Methods for the Localized Treatment of Ocular and Other Diseases - The subject invention provides CAI compounds and formulations thereof, and methods for their use in the localized treatment of non-life threatening diseases. Formulations of CAI compounds of the subject invention include CAI free base and CAI prodrug microcrystallines, microparticles, emulsions, and the like. The subject invention further provides methods for treating non-life threatening diseases using the CAI compounds of the invention (i.e., novel delivery systems and combination therapies) that are effective and are associated with little or no adverse side effects. | 11-10-2011 |
20140079694 | CAI-BASED SYSTEMS AND METHODS FOR THE LOCALIZED TREATMENT OF OCULAR AND OTHER DISEASES - The subject invention provides CAI compounds and formulations thereof, and methods for their use in the localized treatment of non-life threatening diseases. Formulations of CAI compounds of the subject invention include CAI free base and CAI prodrug microcrystallines, microparticles, emulsions, and the like. The subject invention further provides methods for treating non-life threatening diseases using the CAI compounds of the invention (i.e., novel delivery systems and combination therapies), that are effective and are associated with little or no adverse side effects. | 03-20-2014 |
20140154246 | CAI-BASED SYSTEMS AND METHODS FOR THE LOCALIZED TREATMENT OF OCULAR AND OTHER DISEASES - The subject invention provides CAI compounds and formulations thereof, and methods for their use in the localized treatment of non-life threatening diseases. Formulations of CAI compounds of the subject invention include CAI free base and CAI prodrug microcrystallines, microparticles, emulsions, and the like. The subject invention further provides methods for treating non-life threatening diseases using the CAI compounds of the invention (i.e., novel delivery systems and combination therapies), that are effective and are associated with little or no adverse side effects. | 06-05-2014 |
Gary L.w.g. Robinson, Framingham, MA US
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20150344413 | COMPOUNDS FOR THE TREATMENT OF SEIZURES AND OTHER CENTRAL NERVOUS SYSTEM DISORDERS AND CONDITIONS - The present application relates to novel compounds comprising a moiety that leads to the metabolic production of ketones bonded to a ketone-potentiated anti-epileptic drug, compositions comprising these compounds, and their use, for example for the treatment of epilepsy, and other CNS diseases, disorders or conditions. In particular, the present application includes compounds of Formula I, and compositions and uses thereof: | 12-03-2015 |
Hugh Michael Robinson, Cambridge, MA US
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20160110441 | DYNAMIC DETERMINATION OF FILTERS FOR FLIGHT SEARCH RESULTS - Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for providing travel itinerary filters. In one aspect, a method includes receiving a flight query including a plurality of parameters; determining a plurality of itineraries that satisfy the parameters of the flight query; clustering the plurality of itineraries into a plurality of clusters, wherein the clusters depend upon values of particular features of the plurality of itineraries that satisfy the flight query, and wherein each cluster is generated to have particular values for one or more features of a plurality of features; generating one or more filters corresponding to one or more of the clusters, wherein each filter has the particular values of the one or more features identified by the corresponding cluster; and providing the plurality of itineraries that satisfy the flight query and the one or more filters for filtering the plurality of itineraries. | 04-21-2016 |
Ian S. Robinson, Waltham, MA US
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20140354477 | Satellite Orbital Determination (OD) Using Doppler and Kepler Orbital Elements - Technology to determine a satellite's orbit is disclosed. In an example, an orbital determination (OD) device for a satellite operable to determine a satellite's orbit can include computer circuitry configured to: Receive a single global positioning system-generated (GPS-generated) signal from a GPS satellite; decode an ephemeris of the GPS satellite from the GPS-generated signal; determine a Doppler shift and a Doppler trend of the GPS-generated signal; and generate a Doppler-GPS OD using the ephemeris of the GPS satellite and the Doppler shift and the Doppler trend of the GPS-generated signal fit to Kepler orbital elements of an orbit model. | 12-04-2014 |
Jacob Robinson, Somerville, MA US
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20120094382 | MOLECULAR DELIVERY WITH NANOWIRES - A molecular delivery system including a plurality of nanowires (e.g., Si NWs), each of the nanowires having a surface layer formed of a silicon-containing material and a covalently bound linker (e.g., silane linker) attached to the surface layer and optionally including a substrate to which the nanowires are adhered or a molecule to be delivered attached to the linker. Also disclosed is a method of delivering into a cell an exogenous molecule. | 04-19-2012 |
20130260467 | MOLECULAR DELIVERY WITH NANOWIRES - A molecular delivery device including a plurality of nanowires (e.g., Si NWs) coated with an electrically conductive layer. Also disclosed are methods for delivering a molecule by nanowire-mediated electroporation. | 10-03-2013 |
20130284612 | NANOWIRES FOR ELECTROPHYSIOLOGICAL APPLICATIONS - An electrical device including a substrate that has a surface and a plurality of electrically conductive nanowires, each of which has a first end and a second end. Each of the nanowires is formed of a semiconductor, a compound semiconductor, a metal, as or a combination thereof and is coated with an electrically insulating layer except for its first and second ends, the first end being attacked to the surface and the second end being coated with an electrically conductive layer. Also disclosed is a method of sending or receiving an electrical signal to or from a biological cell using the above-described device. | 10-31-2013 |
Jason Robinson, Tewksbury, MA US
Patent application number | Description | Published |
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20080216869 | SYSTEMS AND METHODS FOR ROBOTIC GUTTER CLEANING ALONG AN AXIS OF ROTATION - In embodiments of the present invention, a gutter-cleaning device comprises a housing containing an impeller drive facility, the housing configured to fit into a gutter, an impeller, disposed at an end of the housing and driven by the impeller drive facility, and a transport facility for transporting the housing along the gutter | 09-11-2008 |
20090004055 | CONTAINER AND METHOD FOR SUPPORTING HOME TESTING AND DIAGNOSIS OF INFECTIOUS DISEASES - A container is configured to provide sequential access to contents therein, and includes an upper portion and a lower portion connected to the upper portion by a hinged portion, the lower portion defining an interior space bearing a moveable tray and an opening through which the moveable tray may move, the moveable tray defining an interior volume configured to receive at least one device therewithin. The container also includes at least one device borne by the moveable tray, at least one cavity for receiving the at least one device disposed in the upper portion and at least one insert located between the upper and lower portions, the at least one insert comprising at least written indicia thereon. | 01-01-2009 |
20090264940 | SURGICAL TOOL - A tool for use during surgery includes a housing including a distal end and a proximal end, a motor disposed within the housing, and an output shaft having a proximal end connected to the motor and a distal end extending from the distal end of the housing. The tool further includes a battery pack contained within the housing, and a passage extending from the distal end to the proximal end of the housing through the output shaft and the battery pack, wherein the passage is defined by an interior surface of the output shaft and a channel through the battery. | 10-22-2009 |
20110209726 | SYSTEMS AND METHODS FOR ROBOTIC GUTTER CLEANING ALONG AN AXIS OF ROTATION - In embodiments of the present invention, a gutter-cleaning device comprises a housing containing an impeller drive facility, the housing configured to fit into a gutter, an impeller, disposed at an end of the housing and driven by the impeller drive facility, and a transport facility for transporting the housing along the gutter | 09-01-2011 |
20140238440 | Systems And Methods For Robotic Gutter Cleaning Along An Axis Of Rotation - A gutter-cleaning device includes a body defining a forward drive direction and configured to fit into a residential gutter. The device also includes a drive system supporting the body and configured to maneuver across the gutter. A driven impeller disposed on the body defines an axis of rotation. The impeller has at least one agitator oriented about the axis of rotation. The axis of rotation is arranged at an angle to the forward drive direction to aim toward an inside corner of the gutter to eject agitated debris from the gutter and away from the impeller. | 08-28-2014 |
Justin Robinson, Cambridge, MA US
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20140201001 | DISTRIBUTION OF PRODUCTS - Among other things, information is maintained that associates competitors with respective territories for which the competitors have rights that are to be exclusive relative to other competitors for items associated with the territories. A user can enter, through a user interface, an expression of interest that can be associated with one of the territories. In response to the expression of interest, a user is automatically enabled to interact with the competitor that has the exclusive right to the territory, without automatically enabling the user to interact with a competitor that does not have the exclusive right. | 07-17-2014 |
20140201100 | CONFIRMATION OF IDENTITY - Among other things, a user of a mobile device who is delivering an ordered product from a store to a customer at a location can confirm that the customer is a proper person to receive the ordered product. | 07-17-2014 |
20140279516 | AUTHENTICATING A PHYSICAL DEVICE - Among other things, a physical device is determined to be validly issued by a party that issues physical devices that include security features. At least a portion of a photographic or video image of the physical device is processed automatically to determine if the physical device includes at least one of the security features. | 09-18-2014 |
20150186963 | DISTRIBUTION OF PRODUCTS - Among other things, information is maintained that associates competitors with respective territories for which the competitors have rights that are to be exclusive relative to other competitors for items associated with the territories. A user can enter, through a user interface, an expression of interest that can be associated with one of the territories. In response to the expression of interest, a user is automatically enabled to interact with the competitor that has the exclusive right to the territory, without automatically enabling the user to interact with a competitor that does not have the exclusive right. | 07-02-2015 |
Keith Robinson, Marshfield Hills, MA US
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20090011885 | Rotary Regenerative Heat Exchange Wheel Assembly with Improved Flexible Drive Belt Link for Easy Assembly and Disassembly - A rotary regenerative heat exchange wheel assembly of the type including a rotary wheel constructed to rotate about an axis, and driven with a belt drive, the assembly comprising: a flexible belt of a predetermined cross section, including an elongated strip terminating at two ends, each end being formed with a slot, and a flexible link sized so as to extend to each slot; and at least one fastening device for securing the flexible link to each end of the strip. | 01-08-2009 |
Larry Robinson, Pepperell, MA US
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20130272286 | Architecture For Content And Host-Centric Information Dissemination In Delay-Tolerant MANETs - An architecture to enable delay tolerant content-centric and host-centric communications in MANETs comprised of smart phones is disclosed. This architecture allows cross network communications and Internet sharing, assuming that at least one of the smart phones has internet connectivity. The architecture includes a routing mechanism for content-centric communications, as well as routing algorithms for host-centric communications. In one embodiment, a combination of OLSR and a modified variant of PRoPHET is used to create preferred routing paths for content-centric communication. In another embodiment, variations of store and forward, such as binary spray and wait, are used for host-centric communications. These communications between mobile devices utilize wireless communications, such as IEEE802.11. | 10-17-2013 |
Luke Robinson, Quincy, MA US
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20150225474 | ANTIBODY MOLECULES TO DENGUE VIRUS AND USES THEREOF - Antibody molecules that specifically bind to dengue virus are disclosed. In certain embodiments, the antibody molecule bind to dengue virus serotypes DV-1, DV-2, DV-3, and DV-4. The antibody molecules can be used to treat, prevent, and/or diagnose dengue virus. | 08-13-2015 |
20160046697 | ANTIBODY MOLECULES TO DENGUE VIRUS AND USES THEREOF - Antibody molecules that specifically bind to dengue virus are disclosed. In certain embodiments, the antibody molecule bind to dengue virus serotypes DV-1, DV-2, DV-3, and DV-4. The antibody molecules can be used to treat, prevent, and/or diagnose dengue virus. | 02-18-2016 |
Luke Nathaniel Robinson, Cambridge, MA US
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20140056913 | ANTI-DENGUE VIRUS ANTIBODIES AND USES THEREOF - The present invention provides, among other things, antibody agents (e.g., antibodies, and/or antigen-binding fragments thereof) that bind to DV epitopes, as well as compositions containing them and methods of designing, providing, formulating, using, identifying and/or characterizing them. In some embodiments, provided antibody agents show significant binding to a plurality of DV serotypes. In some embodiments, provided antibody agents show significant binding to all four DV serotypes. Such antibody agents are useful, for example, in the prophylaxis, treatment, diagnosis, and/or study of DV. | 02-27-2014 |
Mark Robinson, Uxbridge, MA US
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20130232474 | TECHNIQUES FOR AUTOMATED SOFTWARE TESTING - Described are techniques for testing an application. A test script including one or more instructions is received to test an application. A user interaction with a user interface of the application is emulated. Emulating includes executing a first portion of instructions in the test script. An output is received including information displayed using the user interface in response to the user interaction. Verification processing is performed for the output. The verification processing includes executing a second portion of instructions in the test script. A first instruction in the test script references a user interface data element without specifying a complete path for the user interface data element. | 09-05-2013 |
Mark Macdonough Robinson, Kingston, MA US
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20120258410 | OXY-HYDROGEN FUEL INTEGRATION AND CONTROL SYSTEM - An oxy-hydrogen generator control system may include an oxy-hydrogen generator for fuel production on demand. A controller may determine if ignition is present in a burner assembly prior to generating the oxy-hydrogen fuel and providing it to the burner assembly. The controller may also purge system lines of any residual oxy-hydrogen fuel when heating is no longer needed. | 10-11-2012 |
Martin Robinson, Auburn, MA US
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20080265609 | Quick-attach/detach cab for vehicle - Removable cab components and a removable cab assembly for a vehicle. A durable cab assembly is provided, which generally includes a roof, a windshield and a rear panel that is removably attachable to the vehicle. In certain embodiments, the roof, windshield and rear panel are separate components, each separately removably attachable to the vehicle. In certain embodiments, each component of the cab assembly is removably attachable to the roll cage of the vehicle without comprising the integrity of the roll cage. The attachment and detachment of the cab assembly can be carried out manually, by a single person, in a short period of time, without requiring separate tools. The invention is also directed to the windshield, roof and rear panel as individual components adapted for quick attachment/detachment to a vehicle, and a method of attaching or detaching cab components or a cab assembly. | 10-30-2008 |
Murray Robinson, Boston, MA US
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20080234304 | N3-Pyridyl-Thiamine And Its Use In Cancer Treatments - The invention provides methods using N3-pyridyl-thiamine compounds and pharmaceutical compositions comprising N3-pyridyl-thiamine, which are especially useful for preventing or reducing tumor growth in vivo. The invention is also directed to the benefits of reducing thiamine concentrations, e.g., by means of a thiamine reduced diet, as an effective step in a therapeutic regime for patients treated with N3-pyridyl-thiamine. | 09-25-2008 |
20090165150 | DIRECTED COMPLEMENTATION WITH REMOVABLE GENE OF INTEREST - The invention provides an improved directed complementation method for generating a conditionally tumorigenic mouse cell. In a directed complementation method, the tumorigenicity of a conditionally tumorigenic mouse cell depends on either the expression of an inducible recombinant oncogene or the expression of a recombinant gene of interest that functionally complements an uninduced recombinant oncogene. The invention provides a method of producing a tumorigenic mouse cell containing an uninduced oncogene, a recombinant gene of interest that functionally complements the uninduced oncogene, and a Cre-ER system capable of excising the recombinant gene of interest. When the Cre-ER system is activated, the recombinant gene of interest is excised. From the effect on the mouse cell it is possible to determine whether the recombinant gene of interest is a tumor maintenance gene. | 06-25-2009 |
20120231478 | TIVOZANIB RESPONSE PREDICTION - A diagnostic method for predicting whether a human tumor will be sensitive or resistant to treatment with tivozanib (AV-951) is disclosed. The method is based on measurement of macrophage content in a tissue sample from a tumor. Measurement of macrophage content can be based on analysis of macrophage marker gene expression, e.g., by RNA analysis or immunohistochemistry. | 09-13-2012 |
20120302572 | USE OF EMT GENE SIGNATURES IN CANCER DRUG DISCOVERY, DIAGNOSTICS, AND TREATMENT - The present invention provides diagnostic methods for assessing the EMT status of tumor cells, and for predicting the effectiveness of treatment of a cancer patient with an EGFR or IGF-1R kinase inhibitor, utilizing an EMT gene signature index score. The present invention further provides methods for treating patients with cancer that incorporate these methods. | 11-29-2012 |
20130165337 | IDENTIFICATION OF MULTIGENE BIOMARKERS - Methods for identifying multigene biomarkers for predicting sensitivity or resistance to an anti-cancer drug of interest, or multigene cancer prognostic biomarkers are disclosed. The disclosed methods are based on the classification of the mammalian genome into 51 transcription clusters, i.e., non-overlapping, functionally relevant groups of genes whose intra-group transcript levels are highly correlated. Also disclosed are specific multigene biomarkers for predicting sensitivity or resistance to tivozanib, or rapamycin, and a specific multigene biomarker for determining breast cancer prognosis, all of which were identified using the methods disclosed herein. | 06-27-2013 |
20130165343 | IDENTIFICATION OF MULTIGENE BIOMARKERS - Methods for identifying multigene biomarkers for predicting sensitivity or resistance to an anti-cancer drug of interest, or multigene cancer prognostic biomarkers are disclosed. The disclosed methods are based on the classification of the mammalian genome into 51 transcription clusters, i.e., non-overlapping, functionally relevant groups of genes whose intra-group transcript levels are highly correlated. Also disclosed are specific multigene biomarkers for predicting sensitivity or resistance to tivozanib, or rapamycin, and a specific multigene biomarker for determining breast cancer prognosis, all of which were identified using the methods disclosed herein. | 06-27-2013 |
20140045715 | TIVOZANIB RESPONSE PREDICTION - A diagnostic method for predicting whether a human tumor will be sensitive or resistant to treatment with tivozanib (AV-951) is disclosed. The method is based on measurement of macrophage content in a tissue sample from a tumor. Measurement of macrophage content can be based on analysis of macrophage marker gene expression, e.g., by RNA analysis or immunohistochemistry. | 02-13-2014 |
Niall D. Robinson, Newburyport, MA US
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20130295219 | Injection Mold Having a Simplified Evaporative Cooling System or a Simplified Cooling System with Exotic Cooling Fluids - An injection mold assembly for a high output consumer product injection molding machine, the injection mold assembly having a simplified cooling system that is an evaporative cooling system or a cooling system including a hazardous, dangerous, or expensive cooling fluid. The simplified cooling system has a cooling fluid channel that is confined to a mold support plate. | 11-07-2013 |
20130295220 | Injection Mold Having a Simplified Evaporative Cooling System - An injection mold assembly for a high output consumer product injection molding machine, the injection mold assembly having a simplified cooling system that is an evaporative cooling system or a cooling system including a hazardous, dangerous, or expensive cooling fluid. The simplified cooling system has a cooling fluid channel that is confined to a mold support plate. | 11-07-2013 |
20150064303 | Injection Mold Having a Simplified Evaporative Cooling System or a Simplified Cooling System with Exotic Cooling Fluids - An injection mold assembly for a high output consumer product injection molding machine, the injection mold assembly having a simplified cooling system that is an evaporative cooling system or a cooling system including a hazardous, dangerous, or expensive cooling fluid. The simplified cooling system has a cooling fluid channel that is confined to a mold support plate. | 03-05-2015 |
Peter Robinson, Boston, MA US
Patent application number | Description | Published |
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20130024273 | Sales & marketing recommendation system - A Sales and Marketing Recommendation System comprises one or more software packages designed to run on various hardware platforms (Windows PC, Apple, iPad, Android, BlackBerry, iPhone) and access a secure website, where a corporation's users may configure, initiate, and track marketing and sales activities. Behind the website is a database to track activity occurring within the system, as well as data on activity and customers received from other integrated systems. Additionally, a recommendation engine analyzes the data to constantly provide updated suggestions to the users regarding which customers to target and what messages to use. | 01-24-2013 |
Philip T. Robinson, Harvard, MA US
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20110006603 | PORTABLE POWER MANAGER OPERATING METHODS - Various aspects of invention provide portable power manager operating methods. One aspect of the invention provides a method for operating a power manager having a plurality of device ports for connecting with external power devices and a power bus for connecting with each device port. The method includes: disconnecting each device port from the power bus when no external power device is connected to the device port; accessing information from newly connected external power devices; determining if the newly connected external power devices can be connected to the power bus without power conversion; if not, determining if the newly connected external power devices can be connected to the power bus over an available power converter; and if so, configuring the available power converter for suitable power conversion. | 01-13-2011 |
20110007491 | PORTABLE POWER MANAGER ENCLOSURE - Various aspects of the invention provide power manager enclosures. One aspect of the invention provides a power manager enclosure including: a sealed housing comprising opposing substantially rectangular top and bottom faces, opposing substantially rectangular longitudinal front and back faces and opposing substantially rectangular transverse left and right side faces; and a plurality of device ports for operably connecting external power devices to the power manger disposed on one or more of the left and right side faces and on only one of the front and back faces. | 01-13-2011 |
20120151240 | PORTABLE POWER MANAGER - A portable DC power manager ( | 06-14-2012 |
20130342011 | POWER MANAGERS AND METHODS FOR OPERATING POWER MANAGERS - Various aspects of invention provide portable power manager operating methods. One aspect of the invention provides a method for operating a power manager having a plurality of device ports for connecting with external power devices and a power bus for connecting with each device port. The method includes: disconnecting each device port from the power bus when no external power device is connected to the device port; accessing information from newly connected external power devices; determining if the newly connected external power devices can be connected to the power bus without power conversion; if not, determining if the newly connected external power devices can be connected to the power bus over an available power converter; and if so, configuring the available power converter for suitable power conversion. | 12-26-2013 |
20140103720 | POWER MANAGERS AND METHODS FOR OPERATING POWER MANAGERS - Various aspects of invention provide portable power manager operating methods. One aspect of the invention provides a method for operating a power manager having a plurality of device ports for connecting with external power devices and a power bus for connecting with each device port. The method includes: disconnecting each device port from the power bus when no external power device is connected to the device port; accessing information from newly connected external power devices; determining if the newly connected external power devices can be connected to the power bus without power conversion; if not, determining if the newly connected external power devices can be connected to the power bus over an available power converter; and if so, configuring the available power converter for suitable power conversion. | 04-17-2014 |
Simon P. Robinson, Stow, MA US
Patent application number | Description | Published |
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20090252676 | N-ALKOXYAMIDE CONJUGATES AS IMAGING AGENTS - The present disclosure is directed to compounds, diagnostic agents, and related methods. In some cases, methods for treating patients are provided. More specifically, the disclosure provides compounds, diagnostic agents, and kits for detecting and/or imaging and/or monitoring elastin rich tissues. In addition, the disclosure provides methods of detecting and/or imaging and/or monitoring the presence of coronary plaque, carotid plaque, iliac/femoral plaque, aortic plaque, renal artery plaque, plaque of any arterial vessel, aneurism, vasculitis, other diseases of the arterial wall, and/or damage or structural changes in ligaments, uterus, lungs or skin, as indicated by changes in total vessel wall area, internal lumen size, and exterior arterial perimeter. | 10-08-2009 |
20100221182 | LIGANDS FOR IMAGING CARDIAC INNERVATION - Novel compounds that find use as imaging agents within nuclear medicine applications (PET imaging) for imaging of cardiac innervation are disclosed. These PET based radiotracers may exhibit increased stability, decreased NE release (thereby reducing side effects), improved quantitative data, and/or high affinity for VMAT over prior radiotracers. Methods of using the compounds to image cardiac innervation are also provided. In some instances the compounds are developed by derivatizing certain compounds with | 09-02-2010 |
20110091374 | CONTRAST AGENTS FOR APPLICATIONS INCLUDING PERFUSION IMAGING - The present invention is directed, in part, to compounds and methods for imaging the central nervous system or cancer, comprising administering to a subject a contrast agent which comprises a compound that binds MC-I, and an imaging moiety, and scanning the subject using diagnostic imaging. | 04-21-2011 |
20120276006 | CONTRAST AGENTS FOR MYOCARDIAL PERFUSION IMAGING - The present disclosure is directed, in part, to compounds and methods for imaging myocardial perfusion, comprising administering to a patient a contrast agent which comprises a compound that binds MC-1, and an imaging moiety, and scanning the patient using diagnostic imaging. | 11-01-2012 |
20120328514 | N-ALKOXYAMIDE CONJUGATES AS IMAGING AGENTS - The present disclosure is directed to compounds, diagnostic agents, and related methods. In some cases, methods for treating patients are provided. More specifically, the disclosure provides compounds, diagnostic agents, and kits for detecting and/or imaging and/or monitoring elastin rich tissues. In addition, the disclosure provides methods of detecting and/or imaging and/or monitoring the presence of coronary plaque, carotid plaque, iliac/femoral plaque, aortic plaque, renal artery plaque, plaque of any arterial vessel, aneurism, vasculitis, other diseases of the arterial wall, and/or damage or structural changes in ligaments, uterus, lungs or skin, as indicated by changes in total vessel wall area, internal lumen size, and exterior arterial perimeter. | 12-27-2012 |
20130315822 | N-ALKOXYAMIDE CONJUGATES AS IMAGING AGENTS - The present disclosure is directed to compounds, diagnostic agents, and related methods. In some cases, methods for treating patients are provided. More specifically, the disclosure provides compounds, diagnostic agents, and kits for detecting and/or imaging and/or monitoring elastin rich tissues. In addition, the disclosure provides methods of detecting and/or imaging and/or monitoring the presence of coronary plaque, carotid plaque, iliac/femoral plaque, aortic plaque, renal artery plaque, plaque of any arterial vessel, aneurism, vasculitis, other diseases of the arterial wall, and/or damage or structural changes in ligaments, uterus, lungs or skin, as indicated by changes in total vessel wall area, internal lumen size, and exterior arterial perimeter. | 11-28-2013 |
20140030189 | LIGANDS FOR IMAGING CARDIAC INNERVATION - Novel compounds that find use as imaging agents within nuclear medicine applications (PET imaging) for imaging of cardiac innervation are disclosed. These PET based radiotracers may exhibit increased stability, decreased NE release (thereby reducing side effects), improved quantitative data, and/or high affinity for VMAT over prior radiotracers. Methods of using the compounds to image cardiac innervation are also provided. In some instances the compounds are developed by derivatizing certain compounds with 18F in a variety of positions: aryl, alkyl, a keto, benzylic, beta-alkylethers, gamma-propylalkylethers and beta-proplylalkylethers. Alternatively or additionally, a methyl group a is added to the amine, and/or the catechol functionality is either eliminated or masked as a way of making these compounds more stable. | 01-30-2014 |
20150078997 | N-ALKOXYAMIDE CONJUGATES AS IMAGING AGENTS - The present disclosure is directed to compounds, diagnostic agents, and related methods. In some cases, methods for treating patients are provided. More specifically, the disclosure provides compounds, diagnostic agents, and kits for detecting and/or imaging and/or monitoring elastin rich tissues. In addition, the disclosure provides methods of detecting and/or imaging and/or monitoring the presence of coronary plaque, carotid plaque, iliac/femoral plaque, aortic plaque, renal artery plaque, plaque of any arterial vessel, aneurism, vasculitis, other diseases of the arterial wall, and/or damage or structural changes in ligaments, uterus, lungs or skin, as indicated by changes in total vessel wall area, internal lumen size, and exterior arterial perimeter. | 03-19-2015 |
20150094465 | N-ALKOXYAMIDE CONJUGATES AS IMAGING AGENTS - The present disclosure is directed to compounds, diagnostic agents, and related methods. In some cases, methods for treating patients are provided. More specifically, the disclosure provides compounds, diagnostic agents, and kits for detecting and/or imaging and/or monitoring elastin rich tissues. In addition, the disclosure provides methods of detecting and/or imaging and/or monitoring the presence of coronary plaque, carotid plaque, iliac/femoral plaque, aortic plaque, renal artery plaque, plaque of any arterial vessel, aneurism, vasculitis, other diseases of the arterial wall, and/or damage or structural changes in ligaments, uterus, lungs or skin, as indicated by changes in total vessel wall area, internal lumen size, and exterior arterial perimeter. | 04-02-2015 |
20150196672 | COMPOSITIONS, METHODS, AND SYSTEMS FOR THE SYNTHESIS AND USE OF IMAGING AGENTS - The present invention provides compounds with imaging moieties for imaging a subject. The present invention also relates to systems, compositions, and methods for the synthesis and use of imaging agents, or precursors thereof. An imaging agent precursor may be converted to an imaging agent using the methods described herein. In some cases, a composition or plurality of imaging agents is enriched in 18 F. In some cases, an imaging agent may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs. | 07-16-2015 |
Simon P. Robinson, Stwo, MA US
Patent application number | Description | Published |
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20140328756 | COMPOSITIONS, METHODS, AND SYSTEMS FOR THE SYNTHESIS AND USE OF IMAGING AGENTS - The present invention relates to systems, compositions, and methods for the synthesis and use of imaging agents, or precursors thereof. An imaging agent precursor may be converted to an imaging agent using the methods described herein. In some cases, the imaging agent is enriched in | 11-06-2014 |
Stacey Robinson, Worcester, MA US
Patent application number | Description | Published |
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20140318467 | ANIMAL CLAW TRIMMING CHAMBER ASSEMBLY - A chamber assembly is disclosed for holding an animal securely with minimal stress during claw trimming while providing the user access to the portion of the claw that is to be trimmed. In preferred embodiments, the chamber is adjustable to accommodate different sized animals. In certain embodiments, the chamber can be collapsed for storage or transport. | 10-30-2014 |
Thomas E. Robinson, Walpole, MA US
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20150128856 | DISPENSING APPARATUS HAVING TRANSPORT SYSTEM AND METHOD FOR TRANSPORTING A SUBSTRATE WITHIN THE DISPENSING APPARATUS - A dispenser, which is configured to dispense viscous material on a substrate, includes a frame, a gantry system coupled to the frame, and a dispensing unit coupled to the gantry system. The gantry system is configured to move the dispensing unit in x-axis, y-axis, and z-axis directions. The dispenser further includes a substrate support assembly coupled to the frame and configured to support the substrate to dispense material on the substrate in a dispense position, and a transport system configured to transport the substrate to the dispense position and to remove the substrate from the dispense position. The transport system includes a first pusher assembly configured to move the substrate within the dispenser. A transport system and methods of dispensing material on a substrate are further disclosed. | 05-14-2015 |
20150132482 | DISPENSING APPARATUS HAVING SUBSTRATE INVERTER SYSTEM AND CLAMPING SYSTEM, AND METHOD FOR DISPENSING A VISCOUS MATERIAL ON A SUBSTRATE - A dispenser, which is capable of dispensing viscous material on a substrate having a top surface and a bottom surface, includes a frame, a gantry system, and a dispensing unit. The gantry system is configured to move the dispensing unit in x-axis, y-axis, and z-axis directions. The dispenser further includes a substrate support assembly configured to support the substrate in a dispense position to dispense material on the top surface of the substrate and on the bottom surface of the substrate. The substrate support assembly includes a clamping system and an inverter system. The inverter system is configured to rotate the clamping system about an axis that is parallel to the y-axis direction between a first position in which the top surface of the substrate is in the dispense position and a second position in which the bottom surface of the substrate is in the dispense position. | 05-14-2015 |
20160038957 | REMOTE BULK FEED SYSTEM FOR A DISPENSING SYSTEM AND METHOD OF SUPPLYING VISCOUS MATERIAL TO A DISPENSING SYSTEM - A dispenser includes a frame, a substrate support assembly, and a gantry system to move a dispensing pump in x-axis, y-axis, and z-axis directions. The dispensing pump includes a local supply reservoir, a dispensing nozzle, a first line to provide fluid communication between the local supply reservoir and the dispensing nozzle. The dispenser further includes a remote bulk feed system coupled to the local supply reservoir of the dispensing pump. The bulk feed system includes a first remote supply container configured to contain viscous material, a second line to provide fluid communication between the remote bulk feed system and the local supply reservoir, and a first valve disposed in the second line and operable to deliver viscous material to and to cut off viscous material from the remote supply container. | 02-11-2016 |
Timothy K. Robinson, Arlington, MA US
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20150351493 | FOOTWEAR WITH TRACTION ELEMENTS - The invention relates to articles of footwear having traction elements, and systems and methods for manufacturing same. An example shoe includes an upper and a sole plate, the sole plate including a lower surface adapted for ground contact having a first sole portion including first traction elements, the first traction elements having a distal end and a side wall with extensions extending from a central core, and a second sole portion including second traction elements, the second traction elements having at least one geometrical feature differing in one or more aspects from a corresponding geometrical feature of the first traction elements. | 12-10-2015 |
Zachary Robinson, Arlington, MA US
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20150017192 | SITE-SPECIFIC CHEMOENZYMATIC PROTEIN MODIFICATIONS - The present invention relates to methods and reagents for use in site-selective modification of proteins having lysine residues with functionalized peptides using a chemoenzymatic microbial transglutaminase-mediated reaction. The functionalized proteins may be used for study or therapeutic uses. | 01-15-2015 |