Patent application number | Description | Published |
20080268534 | COMPOSITIONS AND METHODS USEFUL FOR CULTURING DIFFERENTIABLE CELLS - The present invention relates to cell culture methods and compositions that are essentially serum-free and comprise a basal salt nutrient solution and an ErbB3 ligand. | 10-30-2008 |
20090104696 | Methods and Compositions for Feeder-Free Pluripotent Stem Cell Media Containing Human Serum - The present invention provides compositions and methods for the culture and maintenance of pluripotent stem cells. More particularly, the present invention provides for compositions and methods for culturing, maintaining, growing and stabilizing primate pluripotent stem cells in a feeder-free defined media further comprising human serum, or a soluble attachment component of the human serum, for promoting cell attachment. | 04-23-2009 |
20100112691 | Stem Cell Aggregate Suspension Compositions and Methods of Differentiation Thereof - The present invention relates to methods for production of undifferentiated or differentiated embryonic stem cell aggregate suspension cultures from undifferentiated or differentiated embryonic stem cell single cell suspensions and methods of differentiation thereof. | 05-06-2010 |
20100279399 | Human Cancer Stem Cell Culture Compositions Comprising ErbB2 Variants and Methods of Use - The present invention provides compositions and methods for the culture and maintenance of cancer stem cells. More particularly, the present invention provides the identification of cancer stem cell specific markers and methods of recognizing the same for the detection of tumors, for facilitating the prognosis of a patient with a tumor, and for the treatment of various cancers. The invention also provides antibodies that specifically recognize the disulfide linked Erbb2Δ16 homodimer, an Erbb2Δ16/Erbb3 heterodimer, or post-translational modifications of Erbb2 that are specific to Erbb2 of variant hESCs, in addition, the invention provides a modified defined media useful in the absence of a feeder layer and in the absence of serum or serum replacement, that comprises a basal salt nutrient solution, bFGF, IGF-I, and Activin A, and wherein the composition does not comprise heregulin. The invention further relates to the use of an Erbb2 variant isoform to generate robust cell cultures that are independent of heregulin. | 11-04-2010 |
20100311164 | METHODS AND COMPOSITIONS FOR FEEDER-FREE PLURIPOTENT STEM CELL MEDIA CONTAINING HUMAN SERUM - The present invention provides compositions and methods for the culture and maintenance of pluripotent stem cells. More particularly, the present invention provides for compositions and methods for culturing, maintaining, growing and stabilizing primate pluripotent stem cells in a feeder-free defined media further comprising human serum, or a soluble attachment component of the human serum, for promoting cell attachment. | 12-09-2010 |
20120021513 | SMALL MOLECULES SUPPORTING PLURIPOTENT CELL GROWTH AND METHODS THEREOF - The present invention relates to compositions and methods for maintaining undifferentiated pluripotent stem cell cultures. | 01-26-2012 |
20120045830 | STEM CELL AGGREGATE SUSPENSION COMPOSITIONS AND METHODS OF DIFFERENTIATION THEREOF - The present invention relates to methods for production of undifferentiated or differentiated embryonic stem cell aggregate suspension cultures from undifferentiated or differentiated embryonic stem cell single cell suspensions and methods of differentiation thereof. | 02-23-2012 |
20120214237 | COMPOSITIONS AND METHODS USEFUL FOR CULTURING DIFFERENTIABLE CELLS - The present invention relates to cell culture methods and compositions that are essentially serum-free and comprise a basal salt nutrient solution and an ErbB3 ligand. | 08-23-2012 |
20130309708 | Compositions and Methods Useful for Culturing Differentiable Cells - The present invention relates to cell culture methods and compositions that are essentially serum-free and comprise a basal salt nutrient solution and an ErbB3 ligand. | 11-21-2013 |
20140099713 | METHODS AND COMPOSITIONS FOR FEEDER-FREE PLURIPOTENT STEM CELL MEDIA CONTAINING HUMAN SERUM - The present invention provides compositions and methods for the culture and maintenance of pluripotent stem cells. More particularly, the present invention provides for compositions and methods for culturing, maintaining, growing and stabilizing primate pluripotent stem cells in a feeder-free defined media further comprising human serum, or a soluble attachment component of the human serum, for promoting cell attachment. | 04-10-2014 |
20140154802 | Compositions and Methods Useful for Culturing Differentiable Cells - The present invention relates to cell culture methods and compositions that are essentially serum-free and comprise a basal salt nutrient solution and an ErbB3 ligand. | 06-05-2014 |
20140186948 | SMALL MOLECULES SUPPORTING PLURIPOTENT CELL GROWTH AND METHODS THEREOF - The present invention relates to compositions and methods for maintaining undifferentiated pluripotent stem cell cultures. | 07-03-2014 |
Patent application number | Description | Published |
20090125518 | Collaborative Authoring - A collaborative authoring application provides an authoring environment in which two or more users can edit a document concurrently. Each user edits a copy of the document, sends updates to a master copy of the document, and receives updates from the master copy of the document. The authoring environment generally inhibits the users from providing conflicting editing instructions to the master copy of the document. For example, each user can generate a content lock about one or more data units within the document. The authoring environment may synchronize content locks automatically and content only at the request of the user. | 05-14-2009 |
20110184906 | Client Side Locking - A collaborative authoring application provides an authoring environment in which two or more users can edit a document concurrently. Each user edits a copy of the document, sends updates to a master copy of the document, and receives updates from the master copy of the document. The authoring environment generally inhibits the users from providing conflicting editing instructions to the master copy of the document. For example, each user can generate a content lock about one or more data units within the document. The authoring environment may synchronize content locks automatically and content only at the request of the user. | 07-28-2011 |
20120278276 | Collaborative Authoring - A collaborative authoring application provides an authoring environment in which two or more users can edit a document concurrently. Each user edits a copy of the document, sends updates to a master copy of the document, and receives updates from the master copy of the document. The authoring environment generally inhibits the users from providing conflicting editing instructions to the master copy of the document. For example, each user can generate a content lock about one or more data units within the document. The authoring environment may synchronize content locks automatically and content only at the request of the user. | 11-01-2012 |
20150067467 | COLLABORATIVE AUTHORING - A collaborative authoring application provides an authoring environment in which two or more users can edit a document concurrently. Each user edits a copy of the document, sends updates to a master copy of the document, and receives updates from the master copy of the document. The authoring environment generally inhibits the users from providing conflicting editing instructions to the master copy of the document. For example, each user can generate a content lock about one or more data units within the document. The authoring environment may synchronize content locks automatically and content only at the request of the user. | 03-05-2015 |
Patent application number | Description | Published |
20090322510 | SECURING, MONITORING AND TRACKING SHIPPING CONTAINERS - A method of securing a container includes inserting, into a seal device at a container, an electronic bolt; reading, by the seal device, a serial number stored in the electronic bolt; communicating, from the seal device, to a user application, insertion of the bolt; scanning, by the user via a handheld device, a barcode on the seal device representative of an identification of the seal device; communicating, from the handheld device to the user application, the identification of the seal device; inputting, by a user at the container via the handheld device, information associated with the container; communicating, from the handheld device to the user application, the information associated with the container; associating, in a database by the user application, the information associated with the container with the bolt serial number and the identification of the seal device; communicating, by the user application, a confirmation to the seal device. | 12-31-2009 |
20100150026 | UPDATING NODE PRESENCE BASED ON COMMUNICATION PATHWAY - A data communications network, for which presence information is maintained for wireless data communication devices forming nodes of the network, includes: a presence server; and a plurality of nodes formed by the wireless data communication devices, each of the devices configured to send periodic check-in messages to the presence server. The presence server is configured to send an acknowledgment in response to a check-in message. Each of the wireless data communication devices is configured to reset a timer associated with the sending of the check-in messages by it upon (i) communicating, as an intermediate node, a check-in message originating at another node, and (ii) communicating, as an intermediate node, a corresponding acknowledgment originating at the presence server. The presence server is configured to update presence information of wireless data communication device from which a check-in message originates and each intermediate node. | 06-17-2010 |
20100150122 | MANAGING AND MONITORING EMERGENCY SERVICES SECTOR RESOURCES - A system includes one or more wireless islands, one or more incident management applications, and one or more message management and routing (MMR) systems. Each MMR systems is configured to act as an intermediary for communication between one of the wireless islands and one or more of the incident management applications. One of the wireless islands includes a radio network. The radio network includes a plurality of remote sensor nodes (RSNs), and a gateway controller. An RSN of the plurality of RSNs is worn by ESS personnel, the gateway controller is mounted to an ESS vehicle, and the RSN is configured to wirelessly communicate with the gateway controller. | 06-17-2010 |
20100265042 | CONJOINED CLASS-BASED NETWORKING - A data communication network includes two logically distinct class-based networks conjoined by at least one common node that has membership in each of the respective classes of the two logically distinct class-based networks. Optionally, three or more class-based networks may be conjoined to form a data communications network. | 10-21-2010 |
20130012122 | CONJOINED CLASS-BASED NETWORKING - A data communication network includes two logically distinct class-based networks conjoined by at least one common node that has membership in each of the respective classes of the two logically distinct class-based networks. Optionally, three or more class-based networks may be conjoined to form a data communications network. | 01-10-2013 |
20130016636 | SECURING, MONITORING AND TRACKING SHIPPING CONTAINERS - A method of securing a container includes inserting, into a seal device at a container, an electronic bolt; reading, by the seal device, a serial number stored in the electronic bolt; communicating, from the seal device, to a user application, insertion of the bolt; scanning, by the user via a handheld device, a barcode on the seal device representative of an identification of the seal device; communicating, from the handheld device to the user application, the identification of the seal device; inputting, by a user at the container via the handheld device, information associated with the container; communicating, from the handheld device to the user application, the information associated with the container; associating, in a database by the user application, the information associated with the container with the bolt serial number and the identification of the seal device; communicating, by the user application, a confirmation to the seal device. | 01-17-2013 |
20130044637 | UPDATING NODE PRESENCE BASED ON COMMUNICATION PATHWAY - A data communications network, for which presence information is maintained for wireless data communication devices forming nodes of the network, includes: a presence server; and a plurality of nodes formed by the wireless data communication devices, each of the devices configured to send periodic check-in messages to the presence server. The presence server is configured to send an acknowledgment in response to a check-in message. Each of the wireless data communication devices is configured to reset a timer associated with the sending of the check-in messages by it upon (i) communicating, as an intermediate node, a check-in message originating at another node, and (ii) communicating, as an intermediate node, a corresponding acknowledgment originating at the presence server. The presence server is configured to update presence information of wireless data communication device from which a check-in message originates and each intermediate node. | 02-21-2013 |
20130072144 | MANAGING AND MONITORING EMERGENCY SERVICES SECTOR RESOURCES - A system includes one or more wireless islands, one or more incident management applications, and one or more message management and routing (MMR) systems. Each MMR systems is configured to act as an intermediary for communication between one of the wireless islands and one or more of the incident management applications. One of the wireless islands includes a radio network. The radio network includes a plurality of remote sensor nodes (RSNs), and a gateway controller. An RSN of the plurality of RSNs is worn by ESS personnel, the gateway controller is mounted to an ESS vehicle, and the RSN is configured to wirelessly communicate with the gateway controller. | 03-21-2013 |
Patent application number | Description | Published |
20120244778 | SLOTTED COIN TOY - A toy for playing various coin-based games includes a polyhedral block having a slot for inserting a card and a channel for rolling a coin. | 09-27-2012 |
20120302130 | WINDUP TOY VEHICLE - A windup toy vehicle is provided. In some embodiments, the vehicle may include a body and a wheel assembly that is connected to the body and that defines an axis about which the wheel assembly spins. The vehicle also may include a spring extending at least generally along the axis and having a first end and a second end that are respectively fixed and pivotable with respect to the wheel assembly. An arm may be coupled to the spring at the second end such that the arm and the second end pivot as a unit. The vehicle further may include a stop supported by the body and configured to block the arm from spinning with respect to the body. | 11-29-2012 |
20140047618 | MOTOCROSS PANTS - A pair of motocross pants is described, including a waist portion, a seat portion, a crotch and inner thigh portion, and two leg portions, the pants being formed by plurality of panels of material numbering less than 20. A majority of the surface area of the pants may include elastic material, and a nearly straight knee angle may be formed. | 02-20-2014 |
20140123804 | HANDLEBAR SYSTEM - A handlebar is described, including a handlebar tube having two grip portions at opposite ends of the handlebar. Each grip portion may include an internal compartment containing a filler material. The filler material may include a plurality of non-elastomeric particles. The non-elastomeric particles may include small, substantially spherical glass beads. | 05-08-2014 |
20140123805 | HANDLEBAR VIBRATION DAMPING - A handlebar is described, including a handlebar tube having a middle portion and two rising portions disposed on opposite sides of the middle portion. A damping device may be spaced from the middle portion and may span from one rising portion to the other rising portion, the damping device including a first member operatively connected to a second member by an articulation device. The articulation device may be configured to dampen axial movement of the first member relative to the second member. | 05-08-2014 |
Patent application number | Description | Published |
20090320545 | Gutter guard forming machine - The gutter guard forming machine accepts relatively narrow, elongate sheets of imperforate materials and foraminous screen materials from a series of supply rollers and passes those sheets of material through a series of forming rollers and dies to crimp the sheets mechanically together along their common elongate edges to form the desired cross-sectional shape for the finished gutter guard. The raw sheet materials are fed into the machine in two overlying and two underlying streams, which are joined together and shaped by the forming rollers and dies. The process is continuous, with an automated cutoff saw cutting the completed gutter guard to practical lengths after formation. The mechanism is primarily electrically-powered, with a pneumatic-hydraulic cylinder being used for one of the operations. Various components are adjustable to allow the configuration of the completed gutter guard to be adjusted as desired. | 12-31-2009 |
20110265391 | GUTTER GUARD - A gutter guard for mounting on a gutter. The gutter guard comprises an elongated panel extending laterally from an inner portion to an outer portion of an underlying gutter. The panel is of undulating construction and comprises a plurality of longitudinally extending, laterally spaced, elongated raised areas for retarding the flow of rain water across the panel. The raised areas are separated by longitudinally extending recess channels. The raised areas and recessed channels have a plurality of longitudinally extending, laterally spaced rows of longitudinally spaced first holes extending through the panel to enable rain water flowing outwardly across the panel to flow through the first holes into an underlying gutter. The first holes have a narrow end portion facing the inner side of the panel and expanding outwardly toward the outer side of the panel to facilitate spreading of rain water as it travels across the panel toward the outer side thereof. | 11-03-2011 |
20120110923 | Gutter guard - A gutter guard constructed to be mounted on a gutter and to extend from the front to the rear thereof. The gutter guard comprises a central screen portion, a front mounting portion and a rear mounting portion. The central screen portion comprises a fine mesh top layer and a bottom support layer of expanded construction with openings of a desired size. The front mounting portion comprises a first metal sheet folded over and crimped to an adjacent front end of the screen portion. The rear mounting portion comprises a second metal sheet folded over and crimped to an adjacent rear end of the screen portion. The mesh top layer is hemmed to the bottom support layer and they are thereafter roll formed in a new and improved manner to prevent damage to the mesh top layer, to control its tension, and to provide close contact of the mesh top layer to the bottom support layer. | 05-10-2012 |
20130091780 | Clip for Securing Gutter Guard to Gutter - A clip for removably securing the front lip of a gutter guard having holes therethrough to the underlying front lip of a gutter having a downwardly and forwardly extending end portion. The clip comprises an elongated body with a forwardly and upwardly extending first tab at a front end thereof and a rearwardly extending second tab at a rear end thereof. The first tab can be inserted through a first hole at the front of the gutter guard with the body in an upwardly extending first position so that the first tab is located adjacent to and beneath the end portion of the gutter. The body can then be rotated downwardly toward the gutter guard to a second position wherein the first tab is moved upwardly to engage the end portion of the gutter and the second tab is received within a second hole in the gutter guard. | 04-18-2013 |
20150075084 | GUTTER SCREEN ASSEMBLIES - A screen assembly for receiving high volumes of water flowing from a roof to a gutter. The screen assembly has a first support frame having an upstanding rim extending around a periphery thereof and being construed to be mounted on the gutter and secured to an adjacent portion of a roof fascia. The first support frame has an opening in a bottom surface thereof that is constructed to be disposed over a gutter opening when the first support frame is mounted on the gutter. The screen assembly has a second support frame having a screen secured thereto and extending over the second support frame. The second support frame has a shape corresponding to that of the first support frame and is mounted thereon in close relationship to and within the upstanding rim of the first support frame, the second support frame being connected to the upstanding rim. | 03-19-2015 |
20150079330 | RADIANT AND INSULATING BARRIER - A radiant and insulating barrier having two sheets bonded together along spaced flat channels to define a plurality of hermetically sealed and spaced pockets between the channels. The pockets are filled with insulation. The sheets have an outer surface formed of a radiant heat reflecting material. | 03-19-2015 |
Patent application number | Description | Published |
20090156535 | MicroRNAs for Modulating Herpes Virus Gene Expression - An algorithm for identification of microRNA (miRNA) targets within viral and cellular RNA is disclosed. Also disclosed are essential herpes virus genes whose transcripts contain one or more targets of miRNAs encoded by herpes viruses or by host cells as predicted by the algorithm, and the use of such targets, miRNAs and their derivatives for modulating viral replication and latency. | 06-18-2009 |
20100203081 | VIRAL INHIBITORY NUCLEOTIDE SEQUENCES AND VACCINES - The invention relates to inhibitory nucleotide signal sequences or “INS” sequences in the genomes of lentiviruses. In particular the invention relates to the AGG motif present in all viral genomes. The AGG motif may have an inhibitory effect on a virus, for example by reducing the levels of, or maintaining low steady-state levels of, viral RNAs in host cells, and inducing and/or maintaining in viral latency. In one aspect, the invention provides vaccines that contain, or are produced from, viral nucleic acids in which the AGG sequences have been mutated. In another aspect, the invention provides methods and compositions for affecting the function of the AGG motif, and methods for identifying other INS sequences in viral genomes. | 08-12-2010 |
20140370544 | METHODS FOR IDENTIFYING SEQUENCE MOTIFS, AND APPLICATIONS THEREOF - The present invention relates to methods and algorithms that can be used to identify sequence motifs that are either under- or over-represented in a given nucleotide sequence as compared to the frequency of those sequences that would be expected to occur by chance, or that are either under- or over-represented as compared to the frequency of those sequences that occur in other nucleotide sequences, and to methods of scoring sequences based on the occurrence of these sequence motifs. Such sequence motifs may be biologically significant, for example they may constitute transcription factor binding sites, mRNA stability/instability signals, epigenetic signals, and the like. The methods of the invention can also be used, inter alia, to classify sequences or organisms in terms of their phylogenetic relationships, or to identify the likely host of a pathogenic organism. The methods of the present invention can also be used to optimize expression of proteins. | 12-18-2014 |
20150218656 | METHODS FOR DETECTION AND DIAGNOSIS OF A LYMPHOID MALIGNANCY USING HIGH THROUGHPUT SEQUENCING - Methods and compositions are provided for detection and diagnosis of a lymphoid malignancy using high throughput sequencing of rearranged T cell receptor DNA sequences. | 08-06-2015 |
Patent application number | Description | Published |
20100330571 | METHOD OF MEASURING ADAPTIVE IMMUNITY - A method of measuring immunocompetence is described. This method provides a means for assessing the effects of diseases or conditions that compromise the immune system and of therapies aimed to reconstitute it. This method is based on quantifying T-cell diversity by calculating the number of diverse T-cell receptor (TCR) beta chain variable regions from blood cells. | 12-30-2010 |
20120058902 | METHOD OF MEASURING ADAPTIVE IMMUNITY - Compositions and methods for measuring adaptive immune receptor (T cell receptor and immunoglobulin) diversity are described, and find uses for assessing immunocompetence and other purposes. Means are provided for assessing the effects of diseases or conditions that compromise the immune system and of therapies aimed to reconstitute it. Lymphoid (B- and T-cell) adaptive immune receptor diversity is quantified by calculating the number of uniquely rearranged, CDR3-containing immunoglobulin (Ig) or T-cell receptor (TCR) variable region-encoding genes from sample cells such as blood cells. | 03-08-2012 |
20130253842 | DIAGNOSIS OF LYMPHOID MALIGNANCIES AND MINIMAL RESIDUAL DISEASE DETECTION - Methods are described for diagnosis of a lymphoid hematological malignancy in a subject prior to treatment, and for detecting minimal residual disease (MRD) in the subject after treatment for the malignancy, by high throughput quantitative sequencing (HTS) of multiple unique adaptive immune receptor (TCR or Ig) encoding DNA molecules that have been amplified from DNA isolated from blood samples or other lymphoid cell-containing samples. Amplification employs oligonucleotide primer sets designed to amplify CDR3-encoding sequences within substantially all possible human VDJ or VJ combinations. Disease-characteristic adaptive immune receptor clonotypes occur, prior to treatment, at a relative frequency of at least 15-30% of rearranged receptor CDR3-encoding gene regions. Following treatment, persistence of at least one such clonotype at a detectable frequency of at least 10 | 09-26-2013 |
20130288237 | QUANTIFICATION OF ADAPTIVE IMMUNE CELL GENOMES IN A COMPLEX MIXTURE OF CELLS - Compositions and methods are described for highly sensitive quantification of the relative representation of DNA from adaptive immune cells (e.g., T and/or B lymphocytes) in DNA extracted from complex mixtures of cells that include cells which are not adaptive immune cells. Included are methods for determining the relative presence in a tumor of tumor infiltrating lymphocytes (TIL), the relative presence of lymphocytes infiltrating a somatic tissue that is the target of an autoimmune disease, and the relative presence of lymphocytes infiltrating a transplanted organ. | 10-31-2013 |
20140186848 | Quantification of Adaptive Immune Cell Genomes in a Complex Mixture of Cells - Compositions and methods are described for highly sensitive quantification of the relative representation of DNA from adaptive immune cells (e.g., T and/or B lymphocytes) in DNA extracted from complex mixtures of cells that include cells which are not adaptive immune cells. Included are methods for determining the relative presence in a tumor of tumor infiltrating lymphocytes (TIL), the relative presence of lymphocytes infiltrating a somatic tissue that is the target of an autoimmune disease, and the relative presence of lymphocytes infiltrating a transplanted organ. | 07-03-2014 |
20140194295 | Method of Measuring Adaptive Immunity - A method of measuring immunocompetence is described. This method provides a means for assessing the effects of diseases or conditions that compromise the immune system and of therapies aimed to reconstitute it. This method is based on quantifying T-cell diversity by calculating the number of diverse T-cell receptor (TCR) beta chain variable regions from blood cells. | 07-10-2014 |
20140213463 | Method of Measuring Adaptive Immunity - A method of measuring immunocompetence is described. This method provides a means for assessing the effects of diseases or conditions that compromise the immune system and of therapies aimed to reconstitute it. This method is based on quantifying T-cell diversity by calculating the number of diverse T-cell receptor (TCR) beta chain variable regions from blood cells. | 07-31-2014 |
20140256567 | Method of Measuring Adaptive Immunity - A method of measuring immunocompetence is described. This method provides a means for assessing the effects of diseases or conditions that compromise the immune system and of therapies aimed to reconstitute it. This method is based on quantifying T-cell diversity by calculating the number of diverse T-cell receptor (TCR) beta chain variable regions from blood cells. | 09-11-2014 |
20140322716 | Uniquely Tagged Rearranged Adaptive Immune Receptor Genes in a Complex Gene Set - Compositions and methods are disclosed for uniquely tagging each rearranged gene segment that encodes a T cell receptor (TCR) and/or an immunoglobulin (Ig), in a DNA (or mRNA or cDNA reverse transcribed therefrom) sample from lymphoid cells. These and related embodiments permit accurate, high throughput quantification of distinct TCR and/or Ig encoding sequences. Also provided are compositions and methods for quantitatively sequencing the genes that encode both chains of a TCR or Ig heterodimer in a single cell, for example, to characterize the degree of T or B cell clonality in a sample. | 10-30-2014 |
20150051089 | Quantification of Adaptive Immune Cell Genomes in a Complex Mixture of Cells - Compositions and methods are described for highly sensitive quantification of the relative representation of DNA from adaptive immune cells (e.g., T and/or B lymphocytes) in DNA extracted from complex mixtures of cells that include cells which are not adaptive immune cells. Included are methods for determining the relative presence in a tumor of tumor infiltrating lymphocytes (TIL), the relative presence of lymphocytes infiltrating a somatic tissue that is the target of an autoimmune disease, and the relative presence of lymphocytes infiltrating a transplanted organ. | 02-19-2015 |
20150299785 | METHOD OF MEASURING ADAPTIVE IMMUNITY - Compositions and methods for measuring adaptive immune receptor (T cell receptor and immunoglobulin) diversity are described, and find uses for assessing immunocompetence and other purposes. Means are provided for assessing the effects of diseases or conditions that compromise the immune system and of therapies aimed to reconstitute it. Lymphoid (B- and T-cell) adaptive immune receptor diversity is quantified by calculating the number of uniquely rearranged. CDR3-containing immunoglobulin (Ig) or T-cell receptor (TCR) variable region-encoding genes from sample cells such as blood cells. | 10-22-2015 |
20150299786 | UNIQUELY TAGGED REARRANGED ADAPTIVE IMMUNE RECEPTOR GENES IN A COMPLEX GENE SET - Compositions and methods are disclosed for uniquely tagging each rearranged gene segment that encodes a T cell receptor (TCR) and/or an immunoglobulin (Ig), in a DNA (or mRNA or cDNA reverse transcribed therefrom) sample from lymphoid cells. These and related embodiments permit accurate, high throughput quantification of distinct TCR and/or Ig encoding sequences. Also provided are compositions and methods for quantitatively sequencing the genes that encode both chains of a TCR or Ig heterodimer in a single cell, for example, to characterize the degree of T or B cell clonality in a sample. | 10-22-2015 |
Patent application number | Description | Published |
20140206548 | METHOD OF MEASURING ADAPTIVE IMMUNITY - A method of measuring immunocompetence is described. This method provides a means for assessing the effects of diseases or conditions that compromise the immune system and of therapies aimed to reconstitute it. This method is based on quantifying T-cell diversity by calculating the number of diverse T-cell receptor (TCR) beta chain variable regions from blood cells. | 07-24-2014 |
20140206549 | METHOD OF MEASURING ADAPTIVE IMMUNITY - A method of measuring immunocompetence is described. This method provides a means for assessing the effects of diseases or conditions that compromise the immune system and of therapies aimed to reconstitute it. This method is based on quantifying T-cell diversity by calculating the number of diverse T-cell receptor (TCR) beta chain variable regions from blood cells. | 07-24-2014 |
20140221220 | METHOD OF MEASURING ADAPTIVE IMMUNITY - A method of measuring immunocompetence is described. This method provides a means for assessing the effects of diseases or conditions that compromise the immune system and of therapies aimed to reconstitute it. This method is based on quantifying T-cell diversity by calculating the number of diverse T-cell receptor (TCR) beta chain variable regions from blood cells. | 08-07-2014 |
20150017652 | Compositions and Method for Measuring and Calibrating Amplification Bias in Multiplexed PCR Reactions - Compositions and methods are described for standardizing the DNA amplification efficiencies of a highly heterogeneous set of oligonucleotide primers as may typically be used to amplify a heterogeneous set of DNA templates that contains rearranged lymphoid cell DNA encoding T cell receptors (TCR) or immunoglobulins (IG). The presently disclosed embodiments are useful to overcome undesirable bias in the utilization of a subset of amplification primers, which leads to imprecision in multiplexed high throughput sequencing of amplification products to quantify unique TCR or Ig encoding genomes in a sample. Provided is a composition comprising a diverse plurality of template oligonucleotides in substantially equimolar amounts, for use as a calibration standard for amplification primer sets. Also provided are methods for identifying and correcting biased primer efficiency during amplification. | 01-15-2015 |
20150203897 | COMPOSITIONS AND METHOD FOR MEASURING AND CALIBRATING AMPLIFICATION BIAS IN MULTIPLEXED PCR REACTIONS - Compositions and methods are described for standardizing the DNA amplification efficiencies of a highly heterogeneous set of oligonucleotide primers as may typically be used to amplify a heterogeneous set of DNA templates that contains rearranged lymphoid cell DNA encoding T cell receptors (TCR) or immunoglobulins (IG). The presently disclosed embodiments are useful to overcome undesirable bias in the utilization of a subset of amplification primers, which leads to imprecision in multiplexed N high throughput sequencing of amplification products to quantify unique TCR or Ig encoding genomes in a sample. Provided is a composition comprising a diverse plurality of template oligonucleotides in substantially equimolar amounts, for use as a calibration standard for amplification primer sets. Also provided are methods for identifying and correcting biased primer efficiency during amplification. | 07-23-2015 |
Patent application number | Description | Published |
20120219833 | LOW TEMPERATURE MOLTEN SODIUM SECONDARY CELL WITH SODIUM ION CONDUCTIVE ELECTROLYTE MEMBRANE - The present invention provides a molten sodium secondary cell. In some cases, the secondary cell includes a sodium metal negative electrode, a positive electrode compartment that includes a positive electrode disposed in a liquid positive electrode solution, and a sodium ion conductive electrolyte membrane that separates the negative electrode from the positive electrode solution. In such cases, the electrolyte membrane can comprise any suitable material, including, without limitation, a NaSICON-type membrane. Furthermore, in such cases, the liquid positive electrode solution can comprise any suitable positive electrode solution, including, but not limited to, an aqueous sodium hydroxide solution. Generally, when the cell functions, the sodium negative electrode is molten and in contact with the electrolyte membrane. Additionally, the cell is functional at an operating temperature between about 100° C. and about 170° C. Indeed, in some instances, the molten sodium secondary cell is functional between about 110° C. and about 130° C. | 08-30-2012 |
20140030571 | BATTERY CHARGE TRANSFER MECHANISMS - The present invention provides a secondary cell having a negative electrode compartment and a positive electrode compartment, which are separated by an alkali ion conductive electrolyte membrane. An alkali metal negative electrode disposed in the negative electrode compartment oxidizes to release alkali ions as the cell discharges and reduces the alkali ions to alkali metal during recharge. The positive electrode compartment includes a positive electrode contacting a positive electrode solution that includes an alkali metal compound and a metal halide. The alkali metal compound can be selected from an alkali halide and an alkali pseudo-halide. During discharge, the metal ion reduces to form metal plating on the positive electrode. As the cell charges, the metal plating oxidizes to strip the metal plating to form metal halide or pseudo halide or corresponding metal complex. | 01-30-2014 |
20140170443 | Degradation Protection of Solid Alkali Ion Conductive Electrolyte Membrane - The present invention provides an electrochemical cell having an negative electrode compartment and a positive electrode compartment. A solid alkali ion conductive electrolyte membrane is positioned between the negative electrode compartment and the positive electrode compartment. A catholyte solution in the positive electrode compartment includes a halide ion or pseudohalide ion concentration greater than 3M, which provides degradation protection to the alkali ion conductive electrolyte membrane. The halide ion or pseudohalide ion is selected from chloride, bromide, iodide, azide, thiocyanate, and cyanide. In some embodiments, the electrochemical cell is a molten sodium rechargeable cell which functions at an operating temperature between about 100° C. and about 150° C. | 06-19-2014 |
20140210422 | LOW TEMPERATURE BATTERY WITH MOLTEN SODIUM-FSA ELECTROLYTE - The present invention provides a molten sodium secondary cell. In some cases, the secondary cell includes a sodium metal negative electrode, a positive electrode compartment that includes a positive electrode disposed in a molten positive electrolyte comprising Na-FSA (sodium-bis(fluorosulonyl)amide), and a sodium ion conductive electrolyte membrane that separates the negative electrode from the positive electrolyte. One disclosed example of electrolyte membrane material includes, without limitation, a NaSICON-type membrane. Non-limiting examples of the positive electrode include Ni, Zn, Cu, or Fe. The cell is functional at an operating temperature between about 100° C. and about 150° C., and preferably between about 110° C. and about 130° C. | 07-31-2014 |
20140212707 | LOW TEMPERATURE SECONDARY CELL WITH SODIUM INTERCALATION ELECTRODE - The present invention provides a molten sodium secondary cell. In some cases, the secondary cell includes a sodium metal negative electrode, a positive electrode compartment that includes a positive electrode disposed in a molten positive electrolyte comprising Na—FSA (sodium-bis(fluorosulonyl)amide), and a sodium ion conductive electrolyte membrane that separates the negative electrode from the positive electrolyte. One disclosed example of electrolyte membrane material includes, without limitation, a NaSICON-type membrane. The positive electrode includes a sodium intercalation electrode. Non-limiting examples of the sodium intercalation electrode include Na | 07-31-2014 |
20140363717 | LOW VISCOSITY/HIGH CONDUCTIVITY SODIUM HALOALUMINATE ELECTROLYTE - An additive that is added to the NaAlX | 12-11-2014 |
20150030896 | SODIUM-HALOGEN SECONDARY CELL - A sodium-halogen secondary cell that includes a negative electrode compartment housing a negative, sodium-based electrode and a positive electrode compartment housing a current collector disposed in a liquid positive electrode solution. The liquid positive electrode solution includes a halogen and/or a halide. The cell includes a sodium ion conductive electrolyte membrane that separates the negative electrode from the liquid positive electrode solution. Although in some cases, the negative sodium-based electrode is molten during cell operation, in other cases, the negative electrode includes a sodium electrode or a sodium intercalation carbon electrode that is solid during operation. | 01-29-2015 |
20150086826 | Intermediate Temperature Sodium-Metal Halide Battery - An intermediate temperature molten sodium-metal halide rechargeable battery utilizes a molten eutectic mixture of sodium haloaluminate salts having a relatively low melting point that enables the battery to operate at substantially lower temperature compared to the traditional ZEBRA battery system and utilize a highly conductive NaSICON solid electrolyte membrane. The positive electrode comprises a mixture of NaX and MX, where X is a halogen selected from Cl, Br and I and M is a metal selected Ni, Fe, and Zn. The positive electrode is disposed in a mixed molten salt positive electrolyte comprising at least two salts that can be represented by the formula NaAlX′ | 03-26-2015 |
Patent application number | Description | Published |
20120223369 | Gated Bipolar Junction Transistors, Memory Arrays, and Methods of Forming Gated Bipolar Junction Transistors - Some embodiments include gated bipolar junction transistors. The transistors may include a base region between a collector region and an emitter region; with a B-C junction being at an interface of the base region and the collector region, and with a B-E junction being at an interface of the base region and the emitter region. The transistors may include material having a bandgap of at least 1.2 eV within one or more of the base, emitter and collector regions. The gated transistors may include a gate along the base region and spaced from the base region by dielectric material, with the gate not overlapping either the B-C junction or the B-E junction. Some embodiments include memory arrays containing gated bipolar junction transistors. Some embodiments include methods of forming gated bipolar junction transistors. | 09-06-2012 |
20120228629 | Thyristors, Methods of Programming Thyristors, and Methods of Forming Thyristors - Some embodiments include thyristors having first and second electrode regions, first and second base regions, and material having a bandgap of at least 1.2 eV in at least one of the regions. The first base region is between the first electrode region and the second base region, and the second base region is between the second electrode region and the first base region. The first base region interfaces with the first electrode region at a first junction, and interfaces with the second base region at a second junction. The second base region interfaces with the second electrode region at a third junction. A gate is along the first base region, and in some embodiments does not overlap either of the first and second junctions. Some embodiments include methods of programming thyristors, and some embodiments include methods of forming thyristors. | 09-13-2012 |
20130314986 | Thyristors - Some embodiments include thyristors having first and second electrode regions, first and second base regions, and material having a bandgap of at least 1.2 eV in at least one of the regions. The first base region is between the first electrode region and the second base region, and the second base region is between the second electrode region and the first base region. The first base region interfaces with the first electrode region at a first junction, and interfaces with the second base region at a second junction. The second base region interfaces with the second electrode region at a third junction. A gate is along the first base region, and in some embodiments does not overlap either of the first and second junctions. Some embodiments include methods of programming thyristors, and some embodiments include methods of forming thyristors. | 11-28-2013 |
20150155283 | Gated Bipolar Junction Transistors, Memory Arrays, and Methods of Forming Gated Bipolar Junction Transistors - Some embodiments include gated bipolar junction transistors. The transistors may include a base region between a collector region and an emitter region; with a B-C junction being at an interface of the base region and the collector region, and with a B-E junction being at an interface of the base region and the emitter region. The transistors may include material having a bandgap of at least 1.2 eV within one or more of the base, emitter and collector regions. The gated transistors may include a gate along the base region and spaced from the base region by dielectric material, with the gate not overlapping either the B-C junction or the B-E junction. Some embodiments include memory arrays containing gated bipolar junction transistors. Some embodiments include methods of forming gated bipolar junction transistors. | 06-04-2015 |