Roberts, MD
Anthony J. Roberts, Chesapeake City, MD US
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20140026776 | HIGH-DENSITY THERMODYNAMICALLY STABLE NANOSTRUCTURED COPPER-BASED BULK METALLIC SYSTEMS, AND METHODS OF MAKING THE SAME - High-density thermodynamically stable nanostructured copper-based metallic systems, and methods of making, are presented herein. A ternary high-density thermodynamically stable nanostructured copper-based metallic system includes: a solvent of copper (Cu) metal; that comprises 50 to 95 atomic percent (at. %) of the metallic system; a first solute metal dispersed in the solvent that comprises 0.01 to 50 at. % of the metallic system; and a second solute metal dispersed in the solvent that comprises 0.01 to 50 at. % of the metallic system. The internal grain size of the solvent is suppressed to no more than 250 nm at 98% of the melting point temperature of the solvent and the solute metals remain uniformly dispersed in the solvent at that temperature. Processes for forming these metallic systems include: subjecting powder metals to a high-energy milling process, and consolidating the resultant powder metal subjected to the milling to form a bulk material. | 01-30-2014 |
20140196813 | Apparatus and Method for Safely Depressurizing Milling Vials - The invention is an apparatus and method for safely depressurizing milling vials. The invention utilizes a machinist vise in communication with a pneumatic air cylinder mounted in a jig inside glove box enclosure. The invention utilizes a method for safely depressurizing milling vials. The milling vials are placed into the machinist vise inside the enclosure. The ram of the pneumatic air cylinder is placed on top of the milling vial and the pneumatic air cylinder is pressed firmly against the cap of the milling vial. Next, the air inside the enclosure is evacuated of atmosphere after which the pressure is slowly released from the pneumatic air cylinder. During this stage of the method the operator is a safe distance from the enclosure. As pressure is removed from the pneumatic air cylinder the ram is retracted and the cap of milling vial is removed. | 07-17-2014 |
Beverly T. Roberts, Baltimore, MD US
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20110220379 | HOUSING AND GEARBOX FOR DRILL OR DRIVER - A power tool with a handle housing, a motor, an output member and a cassette. The handle housing that defines a handle. The motor is received in the handle housing. The cassette is received in the handle housing and includes a transmission housing, a multi-stage transmission received in the transmission housing, and a rear thrust washer. The transmission housing has a first end with first and second circumferentially extending channels formed therein. The rear thrust washer has a body and first and second lock members that extend radially from the body. Each of the first and second lock members is received in an associated one of the first and second circumferentially extending channels. | 09-15-2011 |
20120222878 | POWER TOOL WITH TRANSMISSION CASSETTE RECEIVED IN CLAM SHELL HOUSING - A power tool that includes a housing and a transmission assembly. The housing has a pair of mating housing shells that cooperate to define a handle and a pair of first mounts. Each of the first mounts includes a pair of circumferentially spaced-apart ribs. At least one of the circumferentially-spaced apart ribs is contoured to define a notch. The transmission assembly has a transmission sleeve into which a multi-speed reduction gearset is received. The transmission sleeve has a pair of second mounts. Each of the second mounts includes a boss that is configured to be received in an associated one of the notches between a corresponding pair of the circumferentially-spaced apart ribs to thereby inhibit axial and rotational movement of the transmission sleeve relative to the housing. | 09-06-2012 |
20120222879 | MULTI-SPEED POWER TOOL - A power tool that includes a transmission assembly with a transmission sleeve, a multi-speed reduction gearset, and a speed selector mechanism. The transmission sleeve includes a tubular body into which the multi-speed reduction gearset is received. The multi-speed reduction gearset has a first movable member that is movable in an axial direction to at least partly coordinate operation of the multi-speed reduction gearset in a plurality of different speed ratios. The speed selector mechanism includes a first actuator and a rotary selector cam. The first actuator extends through the transmission sleeve and engages the first movable member. The rotary selector cam is rotatably mounted on the tubular body and defines a pair of first cam slots into which the first actuator is received. The first cam slots are closed and are configured to coordinate movement of the first actuator to correspondingly coordinate movement of the first movable member. | 09-06-2012 |
Dale Charles Roberts, Halethorpe, MD US
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20100045932 | Wireless scleral search coil including systems for measuring eye movement and methods related thereto - Featured is a wireless scleral search coil that includes one or more passive, resonant coils and in a particular embodiment two orthogonal, passive, resonant coils, where each coil resonates at a different frequency. Each resonant coil includes a coil-capacitor circuit, each circuit being configured to resonant at a different frequency. Such a wireless scleral search coil is disposed within a biocompatible material that is shaped to conform and rest upon the eye of a subject. Also featured are system including such a wireless scleral search coil, one or more transmitter coils, an assembly of one or more receiver coils and a calculating sub-system for processing signal data to obtain eye measurement information. | 02-25-2010 |
David D. Roberts, Bethesda, MD US
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20080249026 | PEPTIDES AND THEIR UTILITY IN MODULATION OF BEHAVIOR OF CELLS EXPRESSING alpha3beta1 INTEGRINS - The present invention relates to a peptide comprising the sequence R | 10-09-2008 |
20090203762 | METHODS FOR THE PRODUCTION OF BILIVERDIN - The present invention relates to compositions and methods for the production of biliverdin. In particular, the invention concerns methods for producing biliverdin in yeast, especially | 08-13-2009 |
20100092467 | PREVENTION OF TISSUE ISCHEMIA, RELATED METHODS AND COMPOSITIONS - Provided herein are compositions and methods for preventing, ameliorating, and/or reducing tissue ischemia and/or tissue damage due to ischemia, increasing blood vessel diameter, blood flow and tissue perfusion in the presence of vascular disease including peripheral vascular disease, atherosclerotic vascular disease, coronary artery disease, stroke and influencing other conditions, by suppressing CD47 and/or blocking TSP1 and/or CD47 activity or interaction. Influencing the interaction of CD47-TSP1 in blood vessels allows for control of blood vessel diameter and blood flow, and permits modification of blood pressure and cardiac function. Under conditions of decreased blood flow, for instance through injury or atherosclerosis, blocking TSP1-CD47 interaction allows blood vessels to dilate and increases blood flow, tissue perfusion and tissue survival. This in turn reduces or prevents tissue necrosis and death. The therapeutics identified herein allow for precise regulation of blood flow to tissues and organs which need it, while substantially avoiding systemic complications. Methods and compositions described herein can be used to increase tissue survival under conditions of trauma and surgery, as well as conditions of chronic vascular disease. Also disclosed are methods for the treatment of elderly subjects using agents that affect TSP1 and CD47 and thereby affect tissue perfusion. Additionally, provided herein are compositions and methods for influencing blood coagulation, allowing for controlled increased or decreased blood clotting. Additionally, provided herein are compositions and methods for decreasing blood flow, as in the case of cancer through mimicking the effects of TSP1 and CD47 on blood vessel diameter and blood flow. | 04-15-2010 |
20100112626 | Use of Semenogelin in the Diagnosis, Prognosis and Treatment of Cancer - Method of diagnosing cancer in a mammal comprising assaying a test sample from the mammal for an increased level of semenogelin, wherein the increased level of semenogelin in the test sample is diagnostic for the cancer; methods of prognosticating and assessing the effectiveness of treatment of a cancer in a mammal based on the level of semenogelin in a test sample; a composition comprising (a) an immune-response inducing effective amount of (i) semenogelin or polypeptide fragment thereof or (ii) antibody thereto or (b) a recombinant vector encoding and expressing an immune-response inducing effective amount of (i) or (ii); a method of inducing an immune response to a cancer in a mammal comprising administering to the mammal the foregoing composition. | 05-06-2010 |
20110009311 | PEPTIDES AND THEIR UTILITY IN MODULATION OF BEHAVIOR OF CELLS EXPRESSING ALPHA3 BETA1 INTEGRINS - The present invention relates to a peptide comprising the sequence R | 01-13-2011 |
20110135641 | RADIOPROTECTANTS TARGETING THROMBOSPONDIN-1 AND CD47 - Described herein is the discovery that cell and tissue survival can be dramatically increased following radiation exposure through inhibition of the interaction between TSP-1 and CD47. This effect is shown using antisense molecules, peptides, and antibodies, which can now be used as radioprotectant agents. These agents find application in minimizing, reducing and/or preventing tissue damage following intentional and accidental radiation exposure, as well as increasing the therapeutic efficacy of radiation therapies by protecting non-target tissue from incidental radiation damage and by increasing tumor ablation following radiation treatment. | 06-09-2011 |
20120142751 | METHODS FOR THE PRODUCTION OF BILIVERDIN - The present invention relates to compositions and methods for the production of biliverdin and methods of treatment and prevention. In particular, the invention concerns methods for producing biliverdin in yeast, especially | 06-07-2012 |
20120295956 | PREVENTION OF TISSUE ISCHEMIA AND RELATED METHODS - Provided herein are methods for preventing, ameliorating, and/or reducing tissue ischemia and/or tissue damage due to ischemia, increasing blood vessel diameter, blood flow and tissue perfusion in the presence of vascular disease including peripheral vascular disease, atherosclerotic vascular disease, coronary artery disease, stroke and influencing other conditions, by suppressing CD47 and/or blocking TSP1 and/or CD47 activity or interaction. Influencing the interaction of CD47-TSP1 in blood vessels allows for control of blood vessel diameter and blood flow, and permits modification of blood pressure and cardiac function. Under conditions of decreased blood flow, for instance through injury or atherosclerosis, blocking TSP1-CD47 interaction allows blood vessels to dilate and increases blood flow, tissue perfusion and tissue survival. | 11-22-2012 |
20120295957 | PREVENTION OF TISSUE ISCHEMIA AND RELATED COMPOSITIONS - Provided herein are compositions for preventing, ameliorating, and/or reducing tissue ischemia and/or tissue damage due to ischemia, increasing blood vessel diameter, blood flow and tissue perfusion in the presence of vascular disease including peripheral vascular disease, atherosclerotic vascular disease, coronary artery disease, stroke and influencing other conditions, by suppressing CD47 and/or blocking TSP1 and/or CD47 activity or interaction. Influencing the interaction of CD47-TSP1 in blood vessels allows for control of blood vessel diameter and blood flow, and permits modification of blood pressure and cardiac function. Under conditions of decreased blood flow, for instance through injury or atherosclerosis, blocking TSP1-CD47 interaction allows blood vessels to dilate and increases blood flow, tissue perfusion and tissue survival. | 11-22-2012 |
20150111768 | METHODS FOR GENERATION OF PLURIPOTENT AND MULTIPOTENT CELLS - This disclosure relates to methods of producing induced pluripotent (iPS), multipotent, and/or lineage-committed stem cells from differentiated cells, maintaining iPS, multipotent, and/or lineage-committed cells in culture, and re-differentiating the iPS and multipotent stem cells into any desired lineage-committed cell type. | 04-23-2015 |
Delores M. Roberts, Capital Heights, MD US
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20110076652 | READING GAME - An apparatus and method to improve reading, particularly the reading of young children. The game objective is to score points by answering questions posed by sets of cards. The card set is determined by a spinner. This game is designed to help children to read fluently. | 03-31-2011 |
Delores Moment Roberts, Capitol Hgts., MD US
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20080199836 | I-Read board game - I-READ is a board game designed to help children to read fluently, and to improve in critical thinking, problem solving, spelling, social skills and self esteem. The I-READ game can be used by all young children, ages 6-12, as a learning tool at home, in schools, early learning centers, after school and tutoring programs and libraries. Used frequently to help increase test scores. | 08-21-2008 |
Gary D. Roberts, Huntington, MD US
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20090237247 | REMOTE AREA MONITORING SYSTEM - A Remote Area Monitoring System (RAMS) for detecting movement in a disallowed direction through a passageway (P). The RAMS monitors two volumetric spaces that are established by the system, both of which spaces are defined with respect to depth, width, and height. Both a warning zone and an alarm zone are defined for each space. The warning zone protects against inadvertent incursion into the protected spaces; while the alarm zone protects against intentional intrusions thereinto by movement in the disallowed direction. The RAMS automatically monitors both zones and does not require human vigilance to detect and warn of an incursion or intrusion. Human traffic, in both directions through the zones, is monitored; as well as the movement of objects. Movement of humans is detected using a sensor ( | 09-24-2009 |
Guy Roberts, Potomac, MD US
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20100127870 | Detecting Loading and Unloading of Material - An apparatus and techniques for detecting the loading and unloading of materials on a mobile structure are disclosed. The techniques can be used to detect when material is on a support structure of the mobile structure and to detect when the material is off the support structure of the mobile structure. | 05-27-2010 |
Guy P. Roberts, Potomac, MD US
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20120169569 | INTEGRATED ANTENNA ACTIVITY MONITOR SYSTEM AND METHOD - The present disclosure provides an integrated antenna activity monitor system and method that provides an integrated activity indicator for the antenna by tapping a portion of the radio frequency (RF) energy from the antenna and utilizing the RF energy to drive the integrated activity indicator. In an exemplary embodiment, the integrated activity indicator circuit comprises an impedance matching network, a high-frequency rectifier circuit, and a light emitting diode. The impedance matching network is coupled to an antenna feed of the antenna, and configured to tap a portion of radio frequency energy from the antenna feed. The high-frequency rectifier circuit is coupled to the impedance matching network, and the light emitting diode coupled to an output of the high-frequency rectifier circuit. | 07-05-2012 |
Jack C. Roberts, Columbia, MD US
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20090029150 | Impact Resistant Flexible Body Device - An impact resistant device is provided comprising a support matrix and a plurality of energy absorbing elements operatively connected to the support matrix, each element comprising at least one ceramic material and at least one strain rate sensitive material. The impact resistant device can be worn as body armor to protect the wearer from high velocity projectiles. | 01-29-2009 |
20120330599 | Methods and Systems to Implement a Surrogate Head Model and Directly Measure Brain/Skull Relative Displacement - A human surrogate head model (HSHM) to measure brain/skull displacement due to a physical force, such as due to an explosive, ballistic, or automotive crash type of event. A HSHM may include a plurality of magnetic field generators positioned stationary relative to a HSHM skull, each to generate a magnetic field oriented with respect to a corresponding one of multiple directions. The HSHM may include one or more electromagnetic force (EMF)-based displacement sensors, each of which may include three inductive coils oriented orthogonally with respect to one another and co-aligned about a central point. A signal processor may be implemented to separate signals generated by each coil of each EMF-based displacement sensor into a plurality of component magnitudes, each attributable to a corresponding one of the magnetic fields. A computer-implemented model may be implemented to correlate between the component magnitudes and a corresponding position and orientation of the displacement sensor. | 12-27-2012 |
20140220530 | Human Surrogate Neck Model - A human surrogate neck model includes a spinal neck region containing cervical vertebrae. A biosimulant intervertebral material is inserted between the cervical vertebrae. The spinal neck region is surrounded by a first silicone material mixed with a polymeric cross-linking inhibitor. One or more elastic tension bands are anchored to a top interface and a bottom interface of the neck model. A second silicone material mixed with a polymeric cross-linking inhibitor is applied to surround the spinal neck region and the first silicone material and to embed the tension bands. One or more of the elastic tension bands and/or a concentration ratio of the first silicone material or second silicone material to the polymeric cross-linking inhibitor can be adjusted for variable test conditions to closely simulate or mimic the static and dynamic characteristics of a human neck in various scenarios. | 08-07-2014 |
20140302306 | Cranial Bone Surrogate and Methods of Manufacture Thereof - A surrogate multilayered material includes a first fiber reinforced layer; the first reinforced layer including a crosslinked polymer and fibers; a second fiber reinforced layer; the second reinforced layer including the crosslinked polymer and the fibers; a foam layer; the foam layer disposed between the first fiber reinforced layer and the second fiber reinforced layer; where opposite faces of the foam layer are in direct contact with the first fiber reinforced layer and the second fiber reinforced layer; the foam layer having a compressive strength of about 3.5 to about 4.5 MPa, when measured as per ASTM-D-1621-73, and a shear strength of 1.50 to about 2.15 MPa, when measured as per ASTM-C-273. | 10-09-2014 |
Jay B. Roberts, Silver Spring, MD US
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20100011431 | METHODS AND APPARATUS FOR AUTHORIZING ACCESS TO DATA - In one embodiment, a method comprises receiving a request from a first party for access to controlled data, and providing access to the controlled data to a second party. The first party requests access to the controlled data and a token is provided to the first party. The token includes data associated with authorized access to the controlled data. A request for access to the controlled data including the token is later received from the second party, and access to the controlled data is provided to the second party. | 01-14-2010 |
20100100950 | CONTEXT-BASED ADAPTIVE AUTHENTICATION FOR DATA AND SERVICES ACCESS IN A NETWORK - A method includes sending a command set to a client module via a network, receiving via the network a context identifier and a data set associated with the command set, verifying the command set, and authenticating the client module. The command set is verified based on the data set. The client module is authenticated based on the context identifier. A service is made accessible to the client module after the authenticating, The service is inaccessible to the client module before the authenticating. | 04-22-2010 |
Jay Benson Roberts, Silver Spring, MD US
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20140090036 | ONLINE CREDENTIAL PLATFORM - An online credential platform enables organizations and people to create, manage, exchange and verify professional and personal credentials to support trust, reputation and transactions. The platform can allow credential issuers to create credential types and then assign them to proxies that represent real world persons or entities. Following this, it can allow other sites and applications to verify a person's or entity's credentials within the scope of their site or application reliably and with maximum privacy/anonymity. | 03-27-2014 |
Jeff Roberts, Rockville, MD US
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20100135902 | PAPILLOMAVIRUS PSEUDOVIRUSES FOR DETECTION AND THERAPY OF TUMORS - Disclosed herein are methods of detecting tumors, monitoring cancer therapy, and selectively inhibiting the proliferation and/or killing of cancer cells utilizing a papilloma pseudovirus or a papilloma virus-like particle (VLP) | 06-03-2010 |
20130230456 | PAPILLOMAVIRUS PSEUDOVIRUSES FOR DETECTION AND THERAPY OF TUMORS - Disclosed herein are methods of detecting tumors, monitoring cancer therapy, and selectively inhibiting the proliferation and/or killing of cancer cells utilizing a papilloma pseudovirus or a papilloma virus-like particle (VLP) | 09-05-2013 |
Jeffrey Roberts, Rockville, MD US
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20150157738 | Papillomavirus Pseudoviruses for Detection and Therapy of Tumors - Disclosed herein are methods of detecting tumors, monitoring cancer therapy, and selectively inhibiting the proliferation and/or killing of cancer cells utilizing a papilloma pseudovirus or a papilloma virus-like particle (VLP) | 06-11-2015 |
Jeffrey N. Roberts, Rockville, MD US
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20110091496 | METHODS AND COMPOSITIONS FOR THE DELIVERY OF VACCINES TO DISRUPTED EPITHELIUM - The invention features immunogenic compositions and methods useful for eliciting an immune response. In preferred embodiments, papillomavirus or adenovirus vectors are used to elicit exceptionally potent antibody and T cells responses in disrupted epithelium. The methods are useful in preventing or treating a subject having a disease or an infection. In particular examples, the methods are useful for preventing or treating a viral infection. | 04-21-2011 |
John K. Roberts, Ellicott City, MD US
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20140361712 | SYSTEMS AND METHODS FOR PROVIDING COLOR MANAGEMENT CONTROL IN A LIGHTING PANEL - Provided are systems and methods for providing a stabilized color management system in a solid state lighting panel. Methods according to some embodiments include receiving, in the microcontroller, a color management reference value corresponding to a color characteristic of the solid state lighting panel and adjusting a control mode of the microcontroller responsive to the color management reference value. | 12-11-2014 |
Michael S. Roberts, Myersville, MD US
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20110117060 | CANCER TREATMENT USING VIRUSES, FLUOROPYRIMIDINES AND CAMPTOTHECINS - Mammalian subjects having a neoplasm are treated with a virus, a fluoropyrimidine, for example 5-fluorouracil, and a camptothecin compound. The virus is selected from the group consisting of a Newcastle disease virus, a measles virus, a vesicular stomatitis virus, an influenza virus, a Sindbis virus, a picornavirus, and a myxoma virus. | 05-19-2011 |
20130323779 | Lighting Systems and Methods of Using Lighting Systems for In Vitro Potency Assay for Photofrin - Presently disclosed is a lighting system and methods of using the lighting system for in vitro potency assay for photofrin. The lighting system includes a lamp housing, a first lens, an infrared absorbing filter, an optical filter, and a second lens. The lamp housing includes a lamp and a light-port. In operation, broad spectrum light from the lamp exits the lamp housing by passing through the light-port. The first lens then collimates the broad spectrum light that exits the lamp housing through the light-port. The infrared absorbing filter then passes a first portion of the collimated broad spectrum light to the optical filter and absorbs infrared light of the broad spectrum light. The optical filter then passes a second portion of the collimated broad spectrum light to the second lens. The second lens then disperses the second portion of the collimated light to provide uniform irradiation of a cell culture plate. A method of using the lighting system for studying a photosensitizer is also disclosed. | 12-05-2013 |
Michael S. Roberts, Walkersville, MD US
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20090081161 | Treatment of neoplasms with viruses - The subject invention relates to viruses that are able to replicate and thereby kill neoplastic cells with a deficiency in the IFN-mediated antiviral response, and their use in treating neoplastic disease including cancer and large tumors. RNA and DNA viruses are useful in this regard. The invention also relates to methods for the selection, design, purification and use of such viruses for cancer therapy. | 03-26-2009 |
Michael Scot Roberts, Myersville, MD US
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20140065140 | CANCER TREATMENT USING VIRUSES AND CAMPTOTHECINS - Mammalian subjects having a neoplasm are treated with a virus and a camptothecin compound, for example irinotecan or topotecan. The virus is selected from the group consisting of a Newcastle disease virus, a measles virus, a vesicular stomatitis virus, an influenza virus, a Sindbis virus, a picornavirus, and a myxoma virus. The treatment can also include administration of a monoclonal antibody against epidermal growth factor receptor, for example cetuximab. | 03-06-2014 |
Raymond G. Roberts, Montgomery Village, MD US
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20090184889 | Method and apparatus for displaying - Aspects of the disclosure provide a display system. The display system can include a display module having a configurable optical characteristic that varies from substantially transmissive to substantially reflective, at least one data capturing device configured to capture data to form a display image, and at least a first projector configured to project the display image to the display module. Therefore, the display image can be overlaid with a real image according to an optical configuration of the display module. | 07-23-2009 |
Steve Roberts, Potomac, MD US
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20090155289 | FURIN-CLEAVABLE PEPTIDE LINKERS FOR DRUG-LIGAND CONJUGATES - Disclosed are certain peptide linkers for conjugating drugs to ligands, and the resulting drug-linker-ligand molecules and compositions thereof. The conjugated molecules useful for the targeted delivery of drugs to the desired cells, and allow for the intracellular release of the drug in cases where the targeted antigen is internalized via the trans Golgi network and not the lysosomal pathway. | 06-18-2009 |
Steven F. Roberts, Bethesda, MD US
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20110027321 | Chlamydia Vaccine Comprising HtrA Polypeptides - The present invention provides vaccine compositions useful in prevention and treatment of | 02-03-2011 |
William J. Roberts, Rockville, MD US
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20140041032 | System and Method for Detecting Network Intrusions Using Statistical Models and a Generalized Likelihood Ratio Test - A system and method for detecting network intrusions using one or more statistical models and a generalized likelihood ratio test (GLRT) is provided. The system includes a computer system and a network intrusion detection engine executed by the computer system. To detect network intrusions, the system receives network traffic data, computes a likelihood using one or more statistical models, such as an Markov-modulated Poisson process, and processes the traffic data using a GLRT. The statistical models are used to assess the likelihood of seeing a particular pattern of network traffic. The GLRT is used to classify a particular pattern as either indicative of an attack or not indicative of an attack. The system could apply one or more types of statistical models, such as in a flexible multi-tiered approach. | 02-06-2014 |
William J.j. Roberts, Rockville, MD US
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20140058882 | Method and Apparatus for Ordering Recommendations According to a Mean/Variance Tradeoff - Aspects of the present disclosure are directed to systems and methods that facilitate the recommendation of an item to a user. One particular aspect includes a method including the steps of: a) receiving a user request for a new recommendation including rating information for previously-selected items, b) retrieving a mean vector and a covariance matrix representing estimates of prior ratings for a plurality of items by other users, c) calculating a selection likelihood statistics as a function of the estimated mean vector, the estimated covariance matrix and the rating information provided by the, d) calculating ranking statistics as a function of the selection likelihood statistics, and e) transmitting a response to the user recommending at least one of the items not previously selected as a function of the ranking statistics. The recommended item may, for example, be a movie. | 02-27-2014 |
20140059055 | System and Method for Combining Multiple Recommender Systems - A system and method for recommending items to a user is provided. The system could combine recommendations provided by multiple recommenders by: a) calculating for each recommender j a maximum score P | 02-27-2014 |