Patent application number | Description | Published |
20090270642 | Preparation of bile acids and intermediates thereof - Synthetic methods for preparing deoxycholic acid and intermediates thereof are provided. | 10-29-2009 |
20100145083 | PREPARATION OF BILE ACIDS AND INTERMEDIATES THEREOF - Synthetic methods for preparing deoxycholic acid and intermediates thereof are provided. | 06-10-2010 |
20100160276 | SYNTHETIC BILE ACID COMPOSITIONS AND METHODS - Bile acids and related compositions and methods of synthesis and use. More specifically, deoxycholic acid and related compositions, said compositions being free of all moieties of animal origin and free of pyrogenic moieties. | 06-24-2010 |
20110152552 | PREPARATION OF BILE ACIDS AND INTERMEDIATES THEREOF - Synthetic methods for preparing deoxycholic acid and intermediates thereof are provided. | 06-23-2011 |
20110224448 | PREPARATION OF BILE ACIDS AND INTERMEDIATES THEREOF - Synthetic methods for preparing deoxycholic acid and intermediates thereof are provided. | 09-15-2011 |
20120253037 | METHODS AND COMPOSITIONS FOR PREPARING NORIBOGAINE FROM VOACANGINE - Disclosed are methods and compositions for preparing and purifying the non-addictive alkaloid noribogaine. | 10-04-2012 |
20120258943 | FORMULATIONS OF DEOXYCHOLIC ACID AND SALTS THEREOF - The present application is directed to an aqueous pharmaceutical composition comprising from about 0.4% w/v to less than about 2% w/v of a salt of deoxycholic acid, wherein the composition is maintained at a pH from about 8.1 to about 8.5 such that the composition is stabilized against precipitation. Also disclosed herein, are methods for stabilizing an aqueous pharmaceutical composition comprising from about 0.4% w/v to less than about 2% w/v of a salt of deoxycholic acid against precipitation, said method comprising maintaining pH of the solution from about 8.1 to about 8.5. | 10-11-2012 |
20130064772 | INFECTION ACTIVATED WOUND CARING COMPOSITIONS AND DEVICES - Provided are wound caring compositions and devices containing a pH-sensitive, preferably acid degradable, components contained in a water-permeable and hydronium ion permeable material. The pH-sensitive component encloses an antibiotic which is released to the wound upon infection by a microorganism at the wound site, and/or encloses a pH indicator. The antibiotic release is triggered by the microorganism's production of CO | 03-14-2013 |
20130131046 | NORIBOGAINE COMPOSITIONS - Disclosed are noribogaine compositions comprising a very high level of the 2(R), 4(S), 5(S), 6(S) and 18(R) enantiomer and not more than 0.5 wt % of ibogaine relative to the total amount of noribogaine. | 05-23-2013 |
20130137884 | METHODS FOR THE PURIFICATION OF DEOXYCHOLIC ACID - Synthetic methods for preparing deoxycholic acid and intermediates thereof, high purity synthetic deoxycholic acid, compositions and methods of use are provided. Also, provided are processes for the synthesis of 12-keto or 12-α-hydroxy-steroids from Δ-9,11-ene, 11-keto or 11-hydroxy-β-steroids. This invention is also directed to novel compounds prepared during the synthesis. This invention is also directed to the synthesis of deoxycholic acid starting from hydrocortisone. | 05-30-2013 |
20130165414 | PHOSPHATE ESTERS OF NORIBOGAINE - Disclosed herein are phosphate esters of noribogaine and dihydronoribogaine, and esters and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising such compounds, and the methods of their use, including in the treatment of addiction and/or pain. | 06-27-2013 |
20130165425 | SULFATE ESTERS OF NORIBOGAINE - Disclosed herein are sulfate esters of noribogaine or 9,17 dihydronoribogaine, and pharmaceutically acceptable salts of each thereof, pharmaceutical compositions comprising such compounds, and methods of their use, including in treating addiction and/or pain. | 06-27-2013 |
20130165647 | STEREOSELECTIVE TOTAL SYNTHESIS OF NORIBOGAINE - This invention relates generally to methods for synthesizing the non-addictive alkaloid noribogaine. | 06-27-2013 |
20130184660 | SELF-SEALING CATHETERS - Provided are catheters useful for penetrating the vascular wall and delivering medicament as necessary to tissue proximate the vasculature. Such catheters are particularly useful in delivering site specific medicaments to the tissue which can be damaged by hemorrhagic stroke, ischemia, and the like. Methods of using such catheters are also disclosed. | 07-18-2013 |
20130190283 | SYNTHETIC BILE ACID COMPOSITIONS AND METHODS - Bile acids and related compositions and methods of synthesis and use. More specifically, deoxycholic acid and related compositions, said compositions being free of all moieties of animal origin and free of pyrogenic moieties. | 07-25-2013 |
20130190517 | PREPARATION OF BILE ACIDS AND INTERMEDIATES THEREOF - Synthetic methods for preparing deoxycholic acid and intermediates thereof are provided. | 07-25-2013 |
20130211073 | SYNTHETIC VOACANGINE - Synthetic voacangine, including in substantially enantiomerically enriched forms, and derivatives thereof are provided. | 08-15-2013 |
20130211074 | INDOLE AND BENZOFURAN FUSED ISOQUINUCLIDENE DERIVATIVES AND PROCESSES FOR PREPARING THEM - Provided herein are indole and benzofuran fused isoquinuclidene derivatives. Also provided herein are processes, preferably enantioselective processes, for preparing such derivatives including processes for preparing (−) and (+) noribogaine or a salt thereof, in substantially enantiomerically pure forms. | 08-15-2013 |
20130252931 | SYNTHETIC BILE ACID COMPOSITIONS AND METHODS - Bile acids and related compositions and methods of synthesis and use. More specifically, deoxycholic acid and related compositions, said compositions being free of all moieties of animal origin and free of pyrogenic moieties. | 09-26-2013 |
20130261317 | METHODS FOR PREPARING SYNTHETIC BILE ACIDS AND COMPOSITIONS COMPRISING THE SAME - This invention relates generally to methods for preparing certain bile acids from non-mammalian sourced starting materials as well as to synthetic bile acids and compositions comprising such acids wherein the acids are characterized by a different C | 10-03-2013 |
20130267710 | (1R,4R) 7-OXO-2-AZABICYCLO[2.2.2]OCT-5-ENE AND DERIVATIVES THEREOF - This invention provides novel (1R,4R) 7-oxo-2-azabicyclo[2.2.2]oct-5-ene and derivatives thereof, preferably in substantially enantiomerically enriched forms, intermediates thereto, and processes of their synthesis. | 10-10-2013 |
20130267721 | PREPARATION OF BILE ACIDS AND INTERMEDIATES THEREOF - Synthetic methods for preparing deoxycholic acid and intermediates thereof are provided. | 10-10-2013 |
20130303756 | METHODS AND COMPOSITIONS FOR PREPARING NORIBOGAINE FROM VOACANGINE - Disclosed are methods and compositions for preparing and purifying the non-addictive alkaloid noribogaine. | 11-14-2013 |
20140038932 | SYNTHETIC BILE ACID COMPOSITIONS AND METHODS - Bile acids and related compositions and methods of synthesis and use. More specifically, deoxycholic acid and related compositions, said compositions being free of all moieties of animal origin and free of pyrogenic moieties. | 02-06-2014 |
20140148429 | FORMULATIONS OF DEOXYCHOLIC ACID AND SALTS THEREOF - The present application is directed to an aqueous pharmaceutical composition comprising from about 0.4% w/v to less than about 2% w/v of a salt of deoxycholic acid, wherein the composition is maintained at a pH from about 8.1 to about 8.5 such that the composition is stabilized against precipitation. Also disclosed herein, are methods for stabilizing an aqueous pharmaceutical composition comprising from about 0.4% w/v to less than about 2% w/v of a salt of deoxycholic acid against precipitation, said method comprising maintaining pH of the solution from about 8.1 to about 8.5. | 05-29-2014 |
20140179684 | SUBSTITUTED NORIBOGAINE - This invention relates noribogaine derivatives, compositions and methods of use thereof. | 06-26-2014 |
20140179685 | SUBSTITUTED NORIBOGAINE - This invention relates noribogaine derivatives, compositions and methods of use thereof. | 06-26-2014 |
20150037258 | INFECTION INDICATING MEDICAL DEVICES - Provided herein is an implantable medical device capable of self-reporting microbial growth adjacent the site of the implanted device. | 02-05-2015 |