Patent application number | Description | Published |
20080265152 | Mass Spectrometer - A mass spectrometer is disclosed comprising a High Pressure Liquid Chromatography system ( | 10-30-2008 |
20090014639 | Mass Spectrometer - A method is disclosed of identifying parent ions by matching daughter ions found to be produced at substantially the same time that the parent ions elute from a mixture. Ions emitted from an ion source ( | 01-15-2009 |
20090014641 | Mass Spectrometer - A closed-loop ion guide ( | 01-15-2009 |
20090065689 | MASS ANALYSIS USING ALTERNATING FRAGMENTATION MODES - A method for the analysis of mixtures of components includes separating or partially separating different components of a mixture of a sample by means that causes the components to elute sequentially over a period of time, forming precursor ions from the components in the eluent, repeatedly switching, altering or varying an Electron Transfer Dissociation fragmentation device back and forth between a hi-fragmentation mode and a low-fragmentation mode to alternately produce product ions from the precursor ions in the hi-fragmentation mode and to produce substantially fewer product ions in the low-fragmentation mode, and obtaining mass spectra during the period of time from the precursor and product ions received from the Electron Transfer Dissociation fragmentation device. | 03-12-2009 |
20090065690 | MASS ANALYSIS WITH ALTERNATING BYPASS OF A FRAGMENTATION DEVICE - A method for analyzing a mixture of components includes forming precursor ions from the components, alternately causing the precursor ions to pass to and to by-pass a fragmentation device, to form product ions from the precursor ions that pass to the device and to form substantially fewer product ions from precursor ions that by-pass the device, and obtaining mass spectra from product ions received from the device and from precursor ions that by-passed the device. An apparatus for analyzing a sample includes an ion source for forming precursor ions from the components of the sample, a fragmentation device for forming product ions from the precursor ions, a by-pass device disposed upstream of the fragmentation device for switchable by-pass of the fragmentation device, and a mass analyzer. | 03-12-2009 |
20090114808 | Mass spectrometer - A method of mass spectrometry is disclosed wherein voltage signals from an ion detector are analysed. A second differential of each voltage signal is obtained and the start and end times of observed voltage peaks are determined. The intensity and average time of each voltage peak is then determined and the intensity and time values are stored. An intermediate composite mass spectrum is then formed by combining the intensity and time values which relate to each voltage peak observed from multiple experimental runs. The various pairs of time and intensity data are then integrated to produce a smooth continuum mass spectrum. The continuum mass spectrum may then be further processed by determining the second differential of the continuum mass spectrum. The start and end times of mass peaks observed in the continuum mass spectrum may be determined. The intensity and mass to charge ratio of each mass peak observed in the continuum mass spectrum may then determined. A final discrete mass spectrum comprising just of an intensity value and mass to charge ratio per species of ion may then be displayed or output. | 05-07-2009 |
20090173877 | Mass Spectrometer - A mass spectrometer is disclosed comprising a first ion trap or ion guide ( | 07-09-2009 |
20090173880 | Mass Spectrometer - An ion guide ( | 07-09-2009 |
20090194688 | Mass Spectrometer - A mass spectrometer is disclosed comprising a quadrupole rod set ion guide or mass filter device ( | 08-06-2009 |
20090321628 | MASS SPECTROMETER - A mass spectrometer is disclosed comprising a Time of Flight mass analyser comprising an ion detector comprising an Analogue to Digital Converter. Signals from the Analogue to Digital Converter are digitised and the arrival time and intensity of ions are determined. The arrival time T | 12-31-2009 |
20100001180 | MASS SPECTROMETER - A Time of Flight mass analyser is disclosed comprising an ion detector comprising an Analogue to Digital Converter. Output signals from the ion detector are digitised and the arrival times and intensity values relating to ion arrival events are determined. If the determined arrival times from two signals fall within the same time window then the arrival times are added together in a weighted manner and the intensity values are combined. | 01-07-2010 |
20100065733 | MASS SPECTROMETER - A mass spectrometer is disclosed comprising an ion mobility spectrometer or separator ( | 03-18-2010 |
20100108878 | Mass Spectrometer - A mass spectrometer is disclosed comprising a first quadrupole rod set mass filter ( | 05-06-2010 |
20100294923 | MASS SPECTROMETER - A collision or fragmentation cell ( | 11-25-2010 |
20110042565 | Mass Spectrometer - A mass spectrometer is disclosed comprising an ion mobility spectrometer or separator | 02-24-2011 |
20110057097 | Mass Spectrometer - A mass spectrometer is disclosed comprising a 2D or 3D ion trap. The 2D ion trap comprises a quadrupole rod set ion trap wherein a slot is provided in each of the rods | 03-10-2011 |
20110062324 | MASS SPECTROMETER WITH BYPASS OF A FRAGMENTATION DEVICE - A method for analyzing a mixture of components includes forming precursor ions from the components, alternately causing the precursor ions to pass to and to by-pass a fragmentation device, to form product ions from the precursor ions that pass to the device and to form substantially fewer product ions from precursor ions that by-pass the device, and obtaining mass spectra from product ions received from the device and from precursor ions that by-passed the device. An apparatus for analyzing a sample includes an ion source for forming precursor ions from the components of the sample, a fragmentation device for forming product ions from the precursor ions, a by-pass device disposed upstream of the fragmentation device for switchable by-pass of the fragmentation device, and a mass analyzer. | 03-17-2011 |
20110210242 | Ion Source with Device for Oxidising a Sample - An ion source is disclosed wherein a sample is introduced into the sample chamber ( | 09-01-2011 |
20110215237 | Mass Analysis Using Alternating Fragmentation Modes - A method for the analysis of mixtures of components includes separating or partially separating different components of a mixture of a sample by means that causes the components to elute sequentially over a period of time, forming precursor ions from the components in the eluent, repeatedly switching, altering or varying an Electron Capture Dissociation fragmentation device back and forth between a hi-fragmentation mode and a low-fragmentation mode to alternately produce product ions from the precursor ions in the hi-fragmentation mode and to produce substantially fewer product ions in the low-fragmentation mode, and obtaining mass spectra during the period of time from the precursor and product ions received from the Electron Capture Dissociation fragmentation device. | 09-08-2011 |
20130056629 | Mass Spectrometer - A mass spectrometer is disclosed comprising an ion mobility spectrometer or separator and an ion guide arranged downstream of the ion mobility spectrometer or separator. A plurality of axial potential wells are created in the ion guide so that ions received from the ion mobility spectrometer or separator become confined in separate axial potential wells. The potential wells maintain the fidelity and/or composition of ions received from the ion mobility spectrometer or separator. The potential wells are translated along the length of the ion guide. | 03-07-2013 |
20140131566 | Mass Spectrometer - A collision or fragmentation cell is disclosed comprising a plurality of electrodes wherein a first RF voltage is applied to an upstream group of electrodes and a second different RF voltage is applied to a downstream group of electrodes. The radial confinement of parent ions entering the collision or fragmentation cell is optimised by the first RF voltage applied to the upstream group of electrodes and the radial confinement of daughter or fragment ions produced within the collision or fragmentation cell is optimised by the second different RF voltage applied to the downstream group of electrodes. | 05-15-2014 |
20140246580 | Mass Analysis Using Alternating Fragmentation Modes - A method of mass spectrometry is disclosed wherein a Surface Induced Dissociation fragmentation device is repeatedly switched between a high fragmentation mode and a low fragmentation mode. Parent ions from a first sample are passed through the device and parent ion mass spectra and fragmentation ion mass spectra are obtained. Parent ions from a second sample are then passed through the device and a second set of parent ion mass spectra and fragmentation ion mass spectra are obtained. The mass spectra are then compared and if either certain parent ions or certain fragmentation ions in the two samples are expressed differently then further analysis is performed to seek to identify the ions which are expressed differently in the two different samples. | 09-04-2014 |