Patent application number | Description | Published |
20080279824 | ARTICLES FOR TISSUE REGENERATION WITH BIODEGRADABLE POLYMER - The invention is to articles made from extracellular matrix sheets that encase biodegradable polymeric material. Methods of healing wounds or regenerating tissue at sites of defect by placing said articles in mammals are claimed. The biodegradable polymer can change quality upon contact with a physiological parameter such as temperature or pH that causes, for example, a liquid polymer to gel or harden. The degradation of the polymer can be controlled to suit a tissue regeneration or wound healing time course. Additional components such as proteins, cells and drugs can be added to the biopolymer composition. | 11-13-2008 |
20080279833 | LAMINATE SHEET ARTICLES FOR TISSUE REGENERATION - The invention is to articles of extracellular matrix. The articles comprise one or more sheets of mammalian extracellular matrix laminated together. A single sheet can be folded over and laminated on 3 sides. Two or more sheets can be laminated to each other at their edges. The sheets can further encase a composition comprising a cell or cells, such as for example, a stem cell. A single sheet can be folded over to encase a composition, or rolled to encase a composition with lamination at either end of the roll, for example. The invention also includes methods of using these articles to regenerate tissue at tissue defects, or heal wounds in damaged tissue. | 11-13-2008 |
20080281419 | BREAST IMPLANTS AND COMPOSITIONS OF EXTRACELLULAR MATRIX - The invention is articles and compositions of extracellular matrix for forming breast implants and otherwise augmenting or reconstructing breast tissue and other cosmetically desired tissue in humans, such as lips and cheeks. The invention is also to methods of using these in implant articles to augment or reconstruct a human breast or other tissue. | 11-13-2008 |
20090157170 | Trileaflet Semi-Lunar Prosthetic Tissue Valve - The invention provides a trileaflet semi-lunar prosthetic tissue valve for aortic, pulmonary, mitral or tricuspid valve replacement. The valve is planar before attachment at an annulus of a valvular lumen, and non-planar upon attachment at the annulus of the defective valve. A sewing ring having a circumference greater than the annular circumference of annulus of the valve being replaced is also described and the sewing ring is placed at the approximate position of the annulus of the defective valve in a non-planar configuration. | 06-18-2009 |
20090157177 | Sewing Ring for a Prosthetic Tissue Valve - The invention provides a trileaflet semi-lunar prosthetic tissue valve for aortic, pulmonary, mitral, or tricuspid valve replacement. The valve is planar before attachment at an annulus of a valvular lumen, and non-planar upon attachment at the annulus of the defective valve. A sewing ring having a circumference greater than the annular circumference of annulus of the valve being replaced is also described and the sewing ring is placed at the approximate position of the annulus of the defective valve in a non-planar configuration. | 06-18-2009 |
20090238855 | LAMINATE SHEET ARTICLES FOR TISSUE REGENERATION - The invention is to articles of extracellular matrix. The articles comprise one or more sheets of mammalian extracellular matrix laminated together. A single sheet can be folded over and laminated on 3 sides. Two or more sheets can be laminated to each other at their edges. The sheets can further encase a composition comprising a cell or cells, such as for example, a stem cell. A single sheet can be folded over to encase a composition, or rolled to encase a composition with lamination at either end of the roll, for example. The invention also includes methods of using these articles to regenerate tissue at tissue defects, or heal wounds in damaged tissue. | 09-24-2009 |
20100010627 | Breast Implants and Compositions of Extracellular Matrix - The invention is articles and compositions of extracellular matrix for forming breast implants and otherwise augmenting or reconstructing breast tissue and other cosmetically desired tissue in humans, such as lips and cheeks. The invention is also to methods of using these in implant articles to augment or reconstruct a human breast or other tissue. | 01-14-2010 |
20100233235 | COMPOSITIONS AND METHODS FOR PREVENTING CARDIAC ARRHYTHMIA - Disclosed herein are compositions and methods for treating or preventing cardiac arrhythmia in a subject. | 09-16-2010 |
20110066237 | PROSTHETIC TISSUE VALVE - A prosthetic tissue valve for aortic, pulmonary, mitral or tricuspid valve replacement is described herein. A sewing ring for use with the prosthetic tissue valve is also described. The valve can have a circumference that is a predetermined distance larger than the circumference of an annulus in a defective valve. The valve can be substantially planar in an unstressed position before attachment at the annulus and substantially non-planar upon attachment in a biased position at the annulus. Methods are provided for placing the valve as described herein in the biased position within the annulus of the defective valve. | 03-17-2011 |
20120016491 | LAMINATE SHEET ARTICLES FOR TISSUE REGENERATION - The invention is to articles of extracellular matrix. The articles comprise one or more sheets of mammalian extracellular matrix laminated together. A single sheet can be folded over and laminated on 3 sides. Two or more sheets can be laminated to each other at their edges. The sheets can further encase a composition comprising a cell or cells, such as for example, a stem cell. A single sheet can be folded over to encase a composition, or rolled to encase a composition with lamination at either end of the roll, for example. The invention also includes methods of using these articles to regenerate tissue at tissue defects, or heal wounds in damaged tissue. | 01-19-2012 |
20120034191 | EXTRACELLULAR MATRIX COMPOSITIONS FOR TISSUE REGENERATION - The invention is compositions of extracellular matrix that comprise mammalian extracellular matrix from two or more tissue sources in a mammal. The invention also includes methods of using these compositions to regenerate tissue or generate new tissue at sites of defects or wounds in mammals. | 02-09-2012 |
20120251507 | COMPOSITIONS FOR PREVENTING CARDIAC ARRHYTHMIA - Disclosed herein are compositions and methods for treating or preventing a cardiac arrhythmia in a subject. | 10-04-2012 |
20120290080 | PROSTHETIC TISSUE VALVE - A prosthetic tissue valve for aortic, pulmonary, mitral or tricuspid valve replacement is described herein. A sewing ring for use with the prosthetic tissue valve is also described. The valve can have a circumference that is a predetermined distance larger than the circumference of an annulus in a defective valve. The valve can be substantially planar in an unstressed position before attachment at the annulus and substantially non-planar upon attachment in a biased position at the annulus. Methods are provided for placing the valve as described herein in the biased position within the annulus of the defective valve. | 11-15-2012 |
20120290081 | PROSTHETIC TISSUE VALVE - A prosthetic tissue valve for aortic, pulmonary, mitral or tricuspid valve replacement is described herein. A sewing ring for use with the prosthetic tissue valve is also described. The valve can have a circumference that is a predetermined distance larger than the circumference of an annulus in a defective valve. The valve can be substantially planar in an unstressed position before attachment at the annulus and substantially non-planar upon attachment in a biased position at the annulus. Methods are provided for placing the valve as described herein in the biased position within the annulus of the defective valve. | 11-15-2012 |
20120302499 | STERILIZED, ACELLULAR EXTRACELLULAR MATRIX COMPOSITIONS AND METHODS OF MAKING THEREOF - Methods for sterilizing and decellularizing extracellular matrix materials are disclosed. Extracellular matrix compositions produced using the disclosed methods are also disclosed. | 11-29-2012 |
20120303117 | EXTRACELLULAR MATRIX MATERIAL CONDUITS AND METHODS OF MAKING AND USING SAME - Extracellular matrix (ECM) material conduits are disclosed. Methods for regenerating atrioventricular valves to replace defective atrioventricular valves within a heart of a subject using the ECM material conduits are also disclosed. Methods of sterilizing and decellularizing an ECM material are also disclosed. | 11-29-2012 |
20120310335 | EXTRACELLULAR MATRIX MATERIAL VALVE CONDUIT AND METHODS OF MAKING THEREOF - Methods for forming extracellular matrix valve conduits are disclosed. Extracellular matrix valve conduits produced using the disclosed methods are also disclosed. Methods of sterilizing and decellularizing extracellular matrix materials are also disclosed. | 12-06-2012 |
20130023721 | Extracellular matrix encasement structures and methods - A remodelable encasement structure comprising a pouch formed from at least one sheet of bioremodelable material, the pouch having an internal region configured to receive a device therein, the bioremodelable material comprising an extracellular matrix (ECM) composition that includes an ECM scaffold component derived from a mammalian source and at least a bioactive component selected from the group consisting of a statin and a chitin derivative | 01-24-2013 |
20130058904 | Method and system for treatment of biological tissue - A composition for reconstruction, replacement or repair of damaged or diseased biological tissue comprising an extracellular matrix (ECM) composition that includes an ECM scaffold component derived from a mammalian source and at least one additional bioactive component selected from the group consisting of a statin and a chitin derivative. | 03-07-2013 |
20130066418 | PROSTHETIC TISSUE VALVE - A prosthetic tissue valve for aortic, pulmonary, mitral or tricuspid valve replacement is described herein. A sewing ring for use with the prosthetic tissue valve is also described. The valve can have a circumference that is a predetermined distance larger than the circumference of an annulus in a defective valve. The valve can be substantially planar in an unstressed position before attachment at the annulus and substantially non-planar upon attachment in a biased position at the annulus. The valve can have a multi-lobal shape in the unstressed position. Methods are provided for placing the valve as described herein in the biased position within the annulus of the defective valve. | 03-14-2013 |
20130101563 | Compositions for Regenerating Defective or Absent Myocardium - Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function. | 04-25-2013 |
20130116198 | Compositions for Regenerating Defective or Absent Myocardium - Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function. | 05-09-2013 |
20130122108 | Compositions for Regenerating Defective or Absent Myocardium - Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function. | 05-16-2013 |
20130123176 | Compositions for Regenerating Defective or Absent Myocardium - Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function. | 05-16-2013 |
20130123348 | Compositions for Regenerating Defective or Absent Myocardium - Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function. | 05-16-2013 |
20130129690 | Compositions for Regenerating Defective or Absent Myocardium - Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function. | 05-23-2013 |
20130129831 | Compositions for Regenerating Defective or Absent Myocardium - Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function. | 05-23-2013 |
20130129833 | Compositions for Regenerating Defective or Absent Myocardium - Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function. | 05-23-2013 |
20130129834 | Compositions for Regenerating Defective or Absent Myocardium - Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function. | 05-23-2013 |
20130266546 | Compositions for Regenerating Defective or Absent Myocardium - Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function. | 10-10-2013 |
20130266547 | Compositions for Regenerating Defective or Absent Myocardium - Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function. | 10-10-2013 |
20130266548 | Compositions for Regenerating Defective or Absent Myocardium - Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function. | 10-10-2013 |
20130316013 | Compositions for Preventing Cardiac Arrhythmia - Disclosed herein are compositions and methods for treating or preventing a cardiac arrhythmia in a subject. | 11-28-2013 |
20140067046 | Vascular prosthesis - A vascular prosthesis comprising a tubular shaped expandable ECM member and at least one anchoring mechanism. In one embodiment, the anchoring mechanism comprises proximal and distal single or dual-ring anchors. In one embodiment, the anchoring mechanism comprises a multiple-ring anchor. The anchors preferably comprise a biodegradable metal, such as magnesium. The anchors can also comprise a shape memory alloy, such as nitinol, and a cross-linked ECM material. In some embodiments, the ECM member includes a pharmacological agent. | 03-06-2014 |
20140086867 | Systems, Compositions and Methods for the Treatment of Alopecia - A method of inducing or promoting hair growth on the scalp of a subject, comprising the steps of (i) providing an ECM composition including at least one ECM material, (ii) administering inciting event means to a target location on the scalp of the subject to induce an inciting event at the target scalp location, and (iii) administering a therapeutically effective amount of said ECM composition to the target scalp location. In some embodiments, the ECM composition includes at least one additional biologically active agent. | 03-27-2014 |
20140087000 | Method and System for Treatment of Biological Tissue - A composition for reconstruction, replacement or repair of damaged or diseased biological tissue comprising an extracellular matrix (ECM) composition that includes an ECM scaffold component derived from a mammalian source and at least one additional bioactive component selected from the group consisting of a statin and a chitin derivative. | 03-27-2014 |
20140088502 | Multi-Needle Injection Apparatus and System for Delivering Pharmacological Agents to Biological Tissue - An injector system for delivery of a pharmacological agent to biological tissue having a plurality of needles arranged in an array, a plurality of reservoirs configured to receive a pharmacological composition therein, the reservoirs being in fluid communication with a respective one of the plurality of needles, a pneumatic pressure source, a pneumatic drive system that is configured to induce a first discharge of the pharmacological composition out of the reservoirs and needles in a plurality of delivery modes, agent delivery volume control means for controlling volume of the pharmacological composition discharged from the needles, and a control system having actuation control means for controlling said pneumatic drive system. The control system is programmed to control the delivery modes. | 03-27-2014 |
20140099330 | Method and System for Treating Biological Tissue - A tissue prosthesis comprising a support structure having at least one surface, the support structure comprising a base material, the support structure further including an extracellular matrix (ECM) composition having at least one ECM material from a mammalian tissue source. The tissue prosthesis induces modulated healing of damaged biological tissue when deployed proximate thereto. | 04-10-2014 |
20140099352 | Compositions, Structures and Methods for Neural Regeneration - A nerve regeneration device comprising a support structure having an outer surface and a plurality of conduits extending therethrough, the support structure comprising a first extracellular matrix (ECM) material from a mammalian tissue source, the support structure outer layer including at least a first layer comprising a first ECM composition having at least a second ECM material from a mammalian tissue source. When the nerve regeneration device is deployed proximate damaged neural tissue, the device induces modulated healing of the damaged tissue. | 04-10-2014 |
20140100648 | Multi-Layer Vascular Prosthesis - A vascular prosthesis comprising a tubular support structure having an outer surface and an internal lumen therethrough, the support structure comprising a base material, which can comprise natural or synthetic materials, the internal lumen surface including an extracellular matrix (ECM) layer that includes at least one ECM material, wherein, when said vascular prosthesis is deployed proximate damaged cardiovascular tissue, the prosthesis induces modulated healing of the damaged tissue. In some embodiments, the support member outer surface also includes an ECM layer. | 04-10-2014 |
20140148897 | ECM Constructs for Tissue Regeneration - An extracellular matrix (ECM) construct comprising a biodegradable support scaffold that includes a plurality of biodegradable microneedles that are capable of piercing tissue and anchoring therein, and at least a first layer of ECM material disposed on the top surface of the support scaffold. In some embodiments, the microneedles are capable of administering a pharmacological composition to the engaged tissue. | 05-29-2014 |
20140161900 | Compositions for Regenerating Defective or Absent Myocardium - Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function. | 06-12-2014 |
20140171908 | Intra-Myocardial Agent Delivery Device, System and Method - An intra-myocardial agent delivery device comprising a myocardial tissue access line that is configured to receive a pharmacological agent therein and at least a first agent delivery line having a central lumen therethrough, the first agent delivery line being in fluid communication with the tissue access line and including a plurality of dispersal lumens extending through the delivery line wall, wherein, when the first agent delivery line is disposed in myocardial tissue and the pharmacological agent is introduced into the tissue access line, the plurality of dispersal lumens allow the pharmacological agent to be transferred from the central lumen to the myocardial tissue. | 06-19-2014 |
20140179603 | Compositions for Regenerating Defective or Absent Myocardium - Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function. | 06-26-2014 |
20140186304 | Compositions for Regenerating Defective or Absent Myocardium - Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function. | 07-03-2014 |
20140188218 | Extracellular Matrix Material Conduits and Methods of Making and Using Same - Extracellular matrix (ECM) valve conduits are disclosed. Methods for regenerating atrioventricular valves to replace defective atrioventricular valves within a heart of a subject using the ECM valve conduits are also disclosed. Methods of sterilizing and decellularizing an ECM material are also disclosed. | 07-03-2014 |
20140205565 | Compositions and Methods for Treating Organ Dysfunction - A method of retarding cellular senescence comprising (i) providing an extracellular matrix (ECM) composition comprising ECM from an adolescent tissue source, the ECM comprising an exogenously added cytokine, and (ii) administering ECM composition to an organ with cells exhibiting cellular senescence, wherein, the cytokine interacts with at least one molecule in the ECM composition and modulates ROS production of the cells, whereby, the cellular senescence is abated. | 07-24-2014 |
20140242065 | Compositions for Regenerating Defective or Absent Myocardium - Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function. | 08-28-2014 |
20140330369 | Prosthetic Tissue Valves and Methods for Anchoring Same to Cardiovascular Structures - A prosthetic atrioventricular tissue valve comprising a continuous tubular member formed from a first biocompatible material, the tubular member having proximal and distal ends, and at least one valve leaflet formed therein, the distal end of the tubular member including cardiovascular structure engagement means for connecting the tubular member to a cardiovascular structure, the cardiovascular structure engagement means comprising a plurality of elongated members that extend distally from the distal end of the tubular member. | 11-06-2014 |
20140330370 | Prosthetic Valve Delivery and Mounting Apparatus and System - A valve mounting apparatus having an elongated tubular mesh structure with proximal and distal ends, a cardiovascular structure engagement region disposed between the proximal and distal ends, and a lumen therethrough, the distal end of the structure including a valve engagement region that is configured to engage a first end of a prosthetic valve, the mesh structure being configured to transition from a pre-deployment configuration, wherein the structure is capable of being disposed at a cardiovascular valve region, such as a valve annulus region, to a post-deployment expanded configuration, wherein the cardiovascular structure engagement region is anchored to the cardiovascular valve region. | 11-06-2014 |
20140330373 | Reinforced Prosthetic Tissue Valves - A prosthetic atrioventricular valve that includes a continuous tubular member having proximal and distal ends, the tubular member comprising an extracellular matrix (ECM) material, and a reinforcement member disposed in the tubular member lumen and attached to the distal end of the tubular member, the reinforcement member comprising at least two elongated linear members that are configured to connect the joined tubular and reinforcement members to a cardiovascular structure. | 11-06-2014 |
20140335046 | Compositions, Methods and Systems for Regenerative Cosmetics - A method of inducing or promoting hair growth on the scalp of a subject, comprising the steps of (i) providing an ECM composition including at least one ECM material, (ii) administering inciting event means to a target skin location on the subject to induce an inciting event, and (iii) administering a therapeutically effective amount of said ECM composition to the target skin location. In some embodiments, the ECM composition includes at least one additional biologically active agent. | 11-13-2014 |
20140336124 | Compositions for Regenerating Defective or Absent Myocardium - Injectable collagen based graft compositions and grafts formed from the compositions for tissue regeneration. The compositions and grafts further include a glycosaminoglycan (GAG) to control matrix formation and remodeling. | 11-13-2014 |
20140336780 | Extracellular Matrix (ECM) Structures for Tissue Regeneration - An extracellular matrix (ECM) structure for tissue regeneration, the ECM structure having a a sheet member comprising small intestine submucosa (SIS), the SIS sheet member being folded and laminated proximate the sheet member edge, wherein a folded laminated ECM structure having a cavity therein is formed, the ECM structure further including an ECM composition that is disposed in the ECM structure cavity, the ECM composition including liver basement membrane, urinary bladder submucosa, a mesenchymal stem cell and a growth factor. | 11-13-2014 |
20140342984 | Compositions for Regenerating Defective or Absent Myocardium - Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition can also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function. | 11-20-2014 |
20140343673 | Extracellular Matrix Encasement Structures and Methods - A remodelable encasement structure comprising a pouch formed from at least one sheet of bioremodelable material, the pouch including an internal region and at least one lead conduit, the internal region being configured to receive a device therein, the lead conduit being configures to receive at least one device lead therein, the bioremodelable material comprising an extracellular matrix (ECM) composition that includes an ECM component derived from a mammalian source. | 11-20-2014 |
20140370116 | Method and System for Treatment of Biological Tissue - A composition for reconstruction, replacement or repair of damaged or diseased biological tissue comprising an extracellular matrix (ECM) composition that includes an ECM scaffold component and a bioactive agent component. In a preferred embodiment, the ECM scaffold component comprises mesothelial tissue and the bioactive agent comprises a statin. | 12-18-2014 |
20140377217 | Compositions for Preventing Cardiac Arrhythmia - Disclosed herein are compositions and methods for treating or preventing a cardiac arrhythmia in a subject. | 12-25-2014 |
20150017254 | Method for Treatment of Cardiovascular Disorders - Methods for treating a cardiovascular disorder comprising concomitant administration of one or more extracellular matrix (ECM) based compositions directly to damaged or diseased cardiovascular tissue associated with the cardiovascular disorder, and provision of ventricular assistance. In a preferred embodiment, the ECM based compositions include an ECM material derived from a mammalian source. | 01-15-2015 |
20150032205 | Seamless Tubular Extracellular Matrix Prosthetic Valve and Method for Forming Same - A seamless prosthetic valve having an outer abluminal surface, a triple walled intermediate portion, and at least one valve leaflet that is configured to selectively restrict fluid flow through the valve, the valve leaflet being formed by suturing the triple walled intermediate portion at a first commissure connection point. | 01-29-2015 |
20150073548 | Systems, Apparatus and Methods for Sealing Perivalvular Leaks - An expandable member that is configured to engage an interior region of a prosthetic valve and capable of transitioning from a pre-deployment configuration at a pre-deployment temperature, where the expandable member is capable of being positioned in the valve at an interior valve region when the valve is disposed in a cardiovascular structure, to a post-deployment configuration when the expandable member is subjected to cardiovascular tissue temperature, where an outer surface region of the valve proximate the interior valve region is placed in intimate contact with host cardiovascular tissue of the cardiovascular structure at a first position and seals perivalvular leaks present at the first cardiovascular structure position. | 03-12-2015 |
20150081010 | Reinforced Vascular Prostheses - Vascular grafts for treating, reconstructing and replacing damaged or diseased cardiovascular vessels that are formed from decellularized extracellular matrix (ECM). The vascular grafts include structural reinforcement means, such as a strand of wound biodegradable polymeric material disposed proximate the outer surface of the graft. | 03-19-2015 |