Ray, GB
Andrew Robert Ray, Tring Hertfordshire GB
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20160030133 | REGISTRATION OBJECT, CORRECTION METHOD AND APPARATUS FOR COMPUTED RADIOGRAPHIC TOMOGRAPHY - Disclosed is a registration object for computed radiographic tomography. The object has a body portion defining a void for including at least part of a target object. The registration object comprises one or more relatively radiopaque or relatively radiolucent features. Said feature or features provide, in a suitable proportion of radiographic projections of the registration object with respect to angle about a predetermined axis, a pair of identifiable registration points which are spaced apart in a direction parallel to the predetermined axis by a first distance, and whose positions in that direction are each either a constant or a function only of the angle of the projection about the predetermined axis. Said feature or features define, in the suitable proportion of radiographic projections of the object with respect to angle about a predetermined axis, a pair of identifiable registration points which are spaced apart in a direction perpendicular to the predetermined axis by a second distance whose positions in that direction are each either a constant or a continuous function only of the angle of the projection about the predetermined axis. The suitable proportion can be substantially all or all radiographic projections. Also disclosed are a method, an apparatus, a storage medium and a signal for correcting computerised radiographic tomography data, optionally using such an object. | 02-04-2016 |
David J.m. Ray, Milton Keynes GB
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20100144544 | FLUORESCENCE LABELLING - Fluorescence Labelling This invention generally relates to techniques for fluorescence labelling, and to methods, apparatus and computer program code for processing fluorescence signal data. A method of determining respective first and second degree-of-labelling signals for different respective first and second fluorophores associated with a common entity, the method comprising: determining a first fluorescence signal from said first and second fluorophores under first conditions; determining a second fluorescence signal from said first and second fluorophores under second conditions different to said first conditions; and determining said first and second degree-of-labelling signals for said first and second fluorophores from said first and second fluorescence signals; and wherein said determining of said first and second degree-of-labelling signals is responsive to at least one coupling value (c | 06-10-2010 |
Debajyoti Ray, London GB
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20090099986 | LEARNING TRADEOFFS BETWEEN DISCRIMINATIVE POWER AND INVARIANCE OF CLASSIFIERS - Systems and methods are described for learning the discriminative power-invariance tradeoffs for classification of input data (“tradeoff learning system”). In various embodiments, the tradeoff learning system receives multiple classifiers (“base classifiers”) and employs a learning technique to produce a combined classifier. Each received base classifier achieves a different level of tradeoff. The learning technique then decreases a function of kernel weights associated with each of the received classifiers to produce the combined classifier. By decreasing the function of kernel weights, the tradeoff learning system computes a combined classifier that classifies input data more accurately than the received multiple classifiers. | 04-16-2009 |
Keith Ray, Prestwood GB
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20120244120 | INHIBITORS OF HEMOPOIETIC CELL KINASE (P59-HCK) AND THEIR USE IN THE TREATMENT OF INFLUENZA INFECTION - The present invention relates inter alia to the treatment or prevention of influenza virus infection (including subtypes influenza A virus, influenza B virus, avian strain H5N1, A/H1N1, H3N2 and/or pandemic influenza) using compounds which inhibit the activity of p59-HCK and to a method of screening for a candidate drug substance intended to prevent or treat influenza virus infection in a subject, said method comprising identifying a test substance capable of inhibiting p59-HCK activity. | 09-27-2012 |
Keith Paul Ray, Great Missenden GB
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20120004160 | METHODS FOR IDENTIFYING AND COMPOUNDS USEFUL FOR THE DIAGNOSIS AND TREATMENT OF DISEASES INVOLVING INFLAMMATION - The present invention relates to agents, and methods for identifying compounds, which agents and compounds result in the inhibition of the activation of macrophages. In addition, the invention relates to compositions and methods for the use thereof in treating conditions that are characterized by activation of macrophages including infections, allograft reactions, inflammation, allergic and autoimmune diseases, metabolic disease, cardiovascular disease, tissue injury, and cancer. | 01-05-2012 |
Michael Jason Ray, London GB
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20110053239 | METHODS - A method of pre-treating lignocellulosic and cellulosic biomass for utilization of carbohydrate or lignin from the biomass, the method comprising the steps of inoculating the lignocellulosic biomass with lignocellulose degrading brown rot fungus and incubating the inoculated biomass under conditions in which growth of the lignocellulose degrading brown rot is promoted. The incubation may be under conditions in which growth of the lignocellulose degrading brown rot is promoted is terminated after less than 50 days or before substantial depletion of glucose in the biomass occurs. | 03-03-2011 |
Nicholas Ray, Harlow GB
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20150065532 | PYRIMIDINE CYCLOHEXYL GLUCOCORTICOID RECEPTOR MODULATORS - The present invention provides a class of pyrimidinedione cyclohexyl compounds and methods of using these compounds as glucocorticoid receptor modulators. | 03-05-2015 |
Nicholas Ray, Essex GB
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20140038926 | Heteroaryl-Ketone Fused Azadecalin Glucocorticoid Receptor Modulators - The present invention provides heteroaryl ketone fused azadecalin compounds and methods of using the compounds as glucocorticoid receptor modulators. | 02-06-2014 |
20150080389 | HETEROARYL-KETONE FUSED AZADECALIN GLUCOCORTICOID RECEPTOR MODULATORS - The present invention provides heteroaryl ketone fused azadecalin compounds and methods of using the compounds as glucocorticoid receptor modulators. | 03-19-2015 |
Nicholas Ray, Flex Meadow GB
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20130072486 | PYRIMIDINE CYCLOHEXYL GLUCOCORTICOID RECEPTOR MODULATORS - The present invention provides a class of pyrimidinedione cyclohexyl compounds and methods of using these compounds as glucocorticoid receptor modulators. | 03-21-2013 |
20140162361 | PYRIMIDINE CYCLOHEXYL GLUCOCORTICOID RECEPTOR MODULATORS - The present invention provides a class of pyrimidinedione cyclohexyl compounds and methods of using these compounds as glucocorticoid receptor modulators. | 06-12-2014 |
Nicholas C. Ray, Harlow GB
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20100120759 | AZADECALIN GLUCOCORTICOID RECEPTOR MODULATORS - The present invention provides a novel class of azadecalin compounds and methods of using the compounds as glucocorticoid receptor modulators. | 05-13-2010 |
20110166110 | Fused Ring Azadecalin Glucocorticoid Receptor Modulators - The present invention provides a novel class of fused ring azadecalin compounds and methods of using the compounds as glucocorticoid receptor modulators. | 07-07-2011 |
20120225856 | FUSED RING AZADECALIN GLUCOCORTICOID RECEPTOR MODULATORS - The present invention provides a novel class of fused ring azadecalin compounds and methods of using the compounds as glucocorticoid receptor modulators. | 09-06-2012 |
20130225633 | PHENYL HETEROCYCLOALKYL GLUCOCORTICOID RECEPTOR MODULATORS - The present invention provides phenyl-heterocycloalkyl fused azadecalin compounds and methods of using the compounds as glucocorticoid receptor modulators. | 08-29-2013 |
20140179671 | FUSED RING AZADECALIN GLUCOCORTICOID RECEPTOR MODULATORS - The present invention provides a novel class of fused ring azadecalin compounds and methods of using the compounds as glucocorticoid receptor modulators. | 06-26-2014 |
Nicholas Charles Ray, Harlow Essex GB
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20150336962 | 5-CHLORO-2-DIFLUOROMETHOXYPHENYL PYRAZOLOPYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF - Compounds of Formula (00A) and methods of use as Janus kinase inhibitors are described herein. | 11-26-2015 |
Nicholas Charles Ray, Harlow GB
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20110319446 | BICYCLO[2.2.1]HEPT-7-YLAMINE DERIVATIVES AND THEIR USES - Compounds of formula (I) have muscarinic M3 receptor modulating activity; | 12-29-2011 |
20130150343 | KINASE INHIBITORS - Compounds of formula (I) and pharmaceutically acceptable salts thereof: | 06-13-2013 |
20130150361 | KINASE INHIBITORS - Compounds of formula (I): | 06-13-2013 |
20140018345 | INHIBITION OF ENZYMES - Compounds of formula (I): | 01-16-2014 |
20140323470 | KINASE INHIBITORS - Compounds of formula (I) and pharmaceutically acceptable salts thereof: | 10-30-2014 |
20140343055 | KINASE INHIBITORS - Compounds of formula (I): | 11-20-2014 |
20150080375 | KINASE INHIBITORS - Compounds of formula (I) and pharmaceutically acceptable salts thereof: | 03-19-2015 |
20150344475 | KINASE INHIBITORS - Compounds of formula (I) and pharmaceutically acceptable salts thereof: | 12-03-2015 |
Nicolas C. Ray, Flex Meadow GB
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20090275600 | MODIFIED PYRIMIDINE GLUCOCORTICOID RECEPTOR MODULATORS - The present invention provides a novel class of modified pyrimidine compounds and compositions and methods of using the compounds as glucocorticoid receptor modulators. | 11-05-2009 |
Peter Christopher Ray, Newhouse GB
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20100210680 | TRICYCLIC HETEROCYCLIC DERIVATIVES - The present invention relates to a tricyclic heterocyclic derivative of Formula (I) wherein the variables are as defined in the specification. The present invention further relates to pharmaceutical compositions comprising these compounds and to their use in therapy, in particular for the treatment of serotonin-mediated disorders such as obesity, schizophrenia and cognitive dysfunction. | 08-19-2010 |
20120232122 | TRICYCLIC HETEROCYCLIC DERIVATIVES - The present invention relates to a tricyclic heterocyclic derivative according to Formula (I), wherein the variables are defined as in the specification, or to a pharmaceutically acceptable salt or solvate thereof. The present invention also relates to pharmaceutical compositions comprising said tricyclic heterocyclic derivatives and to their use in therapy, for instance in the treatment or prevention of serotonin mediated disorders, such as obesity. | 09-13-2012 |
Stephen Ray, Bath GB
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20090022699 | Method Of Genotypically Modifying Cells By Administration Of RNA - A method of inducing genotypic modification in a cell, which comprises providing isolated RNA comprising RNA extractable from source tissue to the cell under conditions whereby the desired induction of genotypic modification is achieved, wherein the RNA is isolated polyA positive RNA in substantially pure form. | 01-22-2009 |
20110014251 | Microvesicles - A method of producing a population of differentiated cells comprising: a) inducing differentiation in a first population of cells by applying an inducer to said cells, b) harvesting microvesicles produced from first population of cells, and c) inducing differentiation in a second population of cells by applying said microvesicles or a derivative thereof to said second population of cells wherein, said first population of cells is autologous to said second population of cells and wherein the inducer applied to said first population of cells is not present in said second population of cells or is only present in trace amounts. Also related methods of producing microvesicles, methods of medical and/or cosmetic treatment and related products and uses. | 01-20-2011 |
20160032322 | Microvesicles - A method of producing a population of differentiated cells comprising: a) inducing differentiation in a first population of cells by applying an inducer to said cells, b) harvesting microvesicles produced from first population of cells, and c) inducing differentiation in a second population of cells by applying said microvesicles or a derivative thereof to said second population of cells wherein, said first population of cells is autologous to said second population of cells and wherein the inducer applied to said first population of cells is not present in said second population of cells or is only present in trace amounts. Also related methods of producing microvesicles, methods of medical and/or cosmetic treatment and related products and uses. | 02-04-2016 |
Stephen Ray, Oxfordshire GB
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20080233090 | Method of Treatment by Administration of Rna - A method of effecting a treatment response in a target tissue of a subject, comprising: administering to the subject isolated RNA comprising an RNA sequence extractable or extracted from a source tissue such that said treatment response is effected; wherein the RNA is isolated polyA positive RNA in substantially pure form. | 09-25-2008 |
Stuart Ray, West Sussex GB
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20140092702 | Blender - A blending device ( | 04-03-2014 |
William F. Ray, Attenborough GB
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20140306690 | APPARATUS FOR CURRENT MEASUREMENT - A voltage to current converter is provided for use with a current measuring device, said current measuring device being operable to provide an output voltage which is an analogue of a current to be measured. The converter is arranged to provide an output current which is an analogue of the current to be measured. The converter comprises an electronic controller, a switching amplifier and means for measuring the output current as an analogue voltage and providing a measure of said analogue voltage to the electronic controller. | 10-16-2014 |
William Frederick Ray, Long Eaton GB
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20150015244 | TEMPERATURE COMPENSATED CURRENT MEASUREMENT - A temperature compensated current measurement device comprises a Rogowski coil having a terminating impedance arranged to adjust the attenuation of the coil to balance changes in coil sensitivity so that the output voltage indicative of measured current remains substantially unchanged, the terminating impedance having different values above and below a threshold frequency. | 01-15-2015 |