Patent application number | Description | Published |
20140075666 | SUPPORT FOR SHOWER PAN OR TUB - A support for supporting a shower pan is provided. The support comprises an expanded polypropylene tray defining a cavity, an intermediate layer made of oriented strand board and disposed with the cavity, and a top layer made of expanded polystyrene foam disposed with the cavity and having a contoured top surface substantially matching the contoured underside of the shower pan. | 03-20-2014 |
20140353317 | Thermally Insulated VIP Sandwich Shipper and Method of Making Same - A thermally insulated VIP sandwich shipper for a temperature sensitive payload is provided. The shipper comprises an outer shell, an inner shell and vacuum insulated panels sandwiched therebetween. The outer shell and the inner shell may be unitary rigid structures made of an expanded foam material and comprising a bottom having a perimeter and sides extending from the bottom perimeter and terminating in a rim. The inner shell rim may be spaced from the outer shell rim to define a gap, the gap being sealed to create an enclosed space within which the vacuum insulated panels are located. Each vacuum insulated panel may be oriented substantially orthogonally to at least one adjacent vacuum insulated panel and have an edge that abuts the adjacent vacuum insulated panels. | 12-04-2014 |
20140367393 | THERMALLY INSULATED POLYURETHANE SHIPPER AND METHOD OF MAKING SAME - A thermally insulated sandwich polyurethane (PUR) shipper for a temperature sensitive payload is provided. The sandwich PUR shipper comprises an outer corrugated box, an inner corrugated box, vacuum insulated panels (such as VIP panels) and PUR foam. The inner box is nested within the outer box and has a bottom, sides and a top. The inner box defines a payload compartment. The VIP panels are adhered to the outer facing surfaces of the inner box. Preferably the VIP panels are wedged against each other so that a side edge of one VIP panel abuts an adjacent VIP panel. The PUR foam fills the space between the VIP panels and the outer box. The PUR foam may cover the top edges of the VIP panels. | 12-18-2014 |
20160023379 | Method for Molding Recycled EPS Using Powder Adhesive and Steam - A method is provided of molding recycled EPS and other suitable expanded bead materials using a powder adhesive and steam. The method allows for molding EPS parts with over 5% and up to 100% recycled content. The method involves using an adhesive to fuse the regrind EPS particles under pressure from steam. The adhesive may be in powder form and preferably comprises small particles having a high surface area per unit weight and high static so the adhesive powder sticks to the surface of the regrind EPS particles during a dry blending step. | 01-28-2016 |
20160039594 | Double Bag Vacuum Insulation Panel For Steam Chest Molding - A double bag vacuum insulation panel for use in a temperature assured shipper made in a steam chest molding machine is provided. The double bag VIP comprises a porous core, a heat sealable inner envelope and an outer bag. The inner envelope is made from a substantially gas impermeable first material having a first thickness and defines an interior having a pressure of less than or equal to about 30 millibar. The outer bag is made from a substantially gas impermeable second material having a second thickness. The outer bag encapsulates the inner envelope. The double bag vacuum insulation panel has an R value of at least about 28 hr-ft | 02-11-2016 |
20160059448 | Method of Making a Thermally Insulated Shipper - A method of making a thermally insulated shipper for a temperature sensitive payload is provided. The shipper comprises vacuum insulated panels located between inner and outer molded shells. | 03-03-2016 |
20160130066 | Thermally Insulated VIP Sandwich Shipper - A thermally insulated VIP sandwich shipper for a temperature sensitive payload is provided. The shipper comprises an outer shell, an inner shell and vacuum insulated panels sandwiched therebetween. The outer shell and the inner shell may be unitary rigid structures made of an expanded foam material and comprising a bottom having a perimeter and sides extending from the bottom perimeter and terminating in a rim. The inner shell rim may be spaced from the outer shell rim to define a gap, the gap being sealed to create an enclosed space within which the vacuum insulated panels are located. Each vacuum insulated panel may be oriented substantially orthogonally to at least one adjacent vacuum insulated panel and have an edge that abuts the adjacent vacuum insulated panels. | 05-12-2016 |
Patent application number | Description | Published |
20150217927 | Method of Making a Thermally Insulated Polyurethane Shipper - A method of making a thermally insulated sandwich polyurethane (PUR) shipper for a temperature sensitive payload is provided. The method comprises the steps of mounting an inner box upside down on a tool, adhering an insulating panel to the outer facing surfaces of the inner box, positioning an outer box around the inner box assembly, pouring liquid polyurethane into the gap between the outer box and inner box assembly, and foaming the liquid polyurethane. The PUR foam fills the space between the VIP panels and the outer box, and preferably covers the VIP panels. | 08-06-2015 |
20150232266 | Convection Based Temperature Assured Packaging System - A packaging system for a temperature sensitive payload is provided. The system comprises insulative panels, including side panels and end panels, forming a product compartment. Cooling layers within the product compartment are located below and above the products. Channel members affixed to the side panels and/or the end panels create spaces and channels for convective air movement. | 08-20-2015 |
20160075471 | Temperature Controlled Pallet Shipper - A thermally insulated pallet shipper is provided for use in any industry where temperature sensitive products are shipped, including the pharmaceutical, hospital and food industries, particularly for shipping payloads by air. The pallet shipper is made from just four individual foam molded structures: a base, a first corner structure, a second corner structure and a lid. | 03-17-2016 |
Patent application number | Description | Published |
20130151604 | User Affiliations Spanning Multiple Virtual Spaces - Affiliations between users may be facilitated across multiple virtual spaces accessible via virtual environments. Affiliations may be established within individual ones of two or more virtual spaces. A given affiliation within a given virtual space may include a discrete group of users with a relationship having a functional significance within the given virtual space. The affiliations may include a first affiliation within a first virtual space between a group of users including a first user and a second user. A recommendation may be provided for potential affiliations to users in the two or more virtual spaces such that responsive to the first user having an account in a second virtual space, and responsive to the second user creating an account in the second virtual space, the first user may be recommended to the second user for a potential affiliation in the second virtual space based on the first affiliation. | 06-13-2013 |
20130159068 | SYSTEM AND METHOD FOR DETERMINING QUALITY OF SERVICE FOR ACTIONS TO BE PERFORMED IN A VIRTUAL SPACE - A virtual space may be provided to users. In providing the virtual space to users, actions performed in the virtual space responsive to user input may be dynamically assigned a quality of service that is dependent on one or more of user value, past user action requests, past action requests cumulatively for all users, server health, and/or other criteria. This may facilitate an operator of the virtual space increasing overall user engagement and/or value, and/or provide other enhancements. | 06-20-2013 |
20130159430 | Communications Among Users Belonging To Affiliations Spanning Multiple Virtual Spaces - Communications may be facilitated among users belonging to affiliations spanning two or more virtual spaces accessible via virtual environments. In exemplary implementations, affiliations within individual virtual spaces may be managed. A given affiliation within a given virtual space may comprise a discrete group of users with a relationship having a functional significance within the given virtual space. A communications interface may be provided for presentation to individual users. The communications interface may be configured to enable a given user to observe in-coming communications and provide out-going communications. Synchronous and/or asynchronous communications may be facilitated via the communications interface between users belonging to one or more common affiliations. The communications may be facilitated among users belonging to a common overarching affiliation, which may encompass two or more affiliations from different virtual spaces that include substantially the same group of users. | 06-20-2013 |
Patent application number | Description | Published |
20090117535 | Method for identifying HIV-1 protease inhibitors with reduced metabolic affects - The invention provides a novel in vitro method for identifying HIV-1 protease inhibitors with reduced potential for inducing metabolic abnormalities. The invention further provides diagnostic methods for identifying patients who may be at risk of developing metabolic abnormalities subsequent to the administration of an HIV-1 protease inhibitor. The invention also provides novel polynucleotides associated with the incidence of HIV-1 protease inhibitor induced metabolic abnormalities. The invention also provides polynucleotide fragments corresponding to the genomic and/or coding regions of these polynucleotides which comprise at least one polymorphic locus per fragment. Allele-specific primers and probes which hybridize to these regions, and/or which comprise at least one polymorphic locus are also provided. The polynucleotides, primers, and probes of the present invention are useful in phenotype correlations, medicine, and genetic analysis. The invention further relates to diagnostic methods for using these novel polynucleotides in the diagnosis, treatment, and/or prevention of HIV-1 protease inhibitor induced metabolic abnormalities. | 05-07-2009 |
20090202994 | Human single nucleotide polymorphisms in ion channels and other proteins - The invention provides polynucleotide fragments corresponding to the genomic and/or coding regions of these genes which comprise at least one polymorphic site per fragment. Allele-specific primers and probes that hybridize to these regions, and/or that comprise at least one polymorphic site are also provided. The polynucleotides, primers, and probes of the present invention are useful in phenotype correlations, paternity testing, medicine, and genetic analysis. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders, particularly cardiovascular diseases related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention. | 08-13-2009 |
20100190172 | GENETIC POLYMORPHISMS ASSOCIATED WITH CARDIOVASCULAR DISORDERS AND DRUG RESPONSE, METHODS OF DETECTION AND USES THEREOF - The present invention is based on the discovery of genetic polymorphisms that are associated with cardiovascular disorders, particularly acute coronary events such as myocardial infarction and stroke, and genetic polymorphisms that are associated with responsiveness of an individual to treatment of cardiovascular disorders with statin. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection. | 07-29-2010 |
20110152340 | Methods for Identifying Subjects With an Increased Likelihood of Responding to DPP-IV Inhibitors - The invention provides novel in vitro diagnostic methods for identifying subjects or patients who may have an increased likelihood of responding to DPP-IV inhibitor therapy. The invention also provides novel polynucleotides associated with increased responsiveness of a patient to DPP-IV inhibition. Polynucleotide fragments which comprise at least one polymorphic locus, are also provided. Allele-specific primers and probes which hybridize to these polymorphic regions, and/or which comprise at least one polymorphic locus are also provided. The polynucleotides, primers, and probes of the invention are useful in phenotype correlations, medicine, and genetic analysis. | 06-23-2011 |
20140221484 | GENETIC POLYMORPHISMS ASSOCIATED WITH CARDIOVASCULAR DISORDERS AND DRUG RESPONSE, METHODS OF DETECTION AND USES THEREOF - The present invention is based on the discovery of genetic polymorphisms that are associated with cardiovascular disorders, particularly acute coronary events such as myocardial infarction and stroke, and genetic polymorphisms that are associated with responsiveness of an individual to treatment of cardiovascular disorders with statin. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection. | 08-07-2014 |
Patent application number | Description | Published |
20130212656 | Dynamic PSK for Hotspots - Systems and methods for providing secured network access are provided. A user device located within range of a hotspot initiates a request sent via an open communication network associated with the hotspot. The request concerns secured network access at the hotspot by the user device. A unique pre-shared key is generated for the user device based on information in the received request and transmitted over the open communication network for display on a webpage accessible to the user device. The unique pre-shared key is stored in association with information regarding the user device. The user device may then use the unique pre-shared key in subsequent requests for secured network access. | 08-15-2013 |
20130269008 | KEY ASSIGNMENT FOR A BRAND - Systems and methods for providing secured network access are provided. A user device located within range of a branded hotspot initiates a request for the secured network access. The request concerns secured network access at the hotspot by the user device and includes a unique pre-shared key. A query regarding the unique pre-shared key is sent to a database, which retrieves information regarding a corresponding pre-shared key. That information is sent to the hotspot controller, which allows the user device secured network access as governed by one or more parameters associated with the pre-shared key. | 10-10-2013 |
20140282951 | DYNAMIC PSK FOR HOTSPOTS - Systems and methods for providing secured network access are provided. A user device located within range of a hotspot initiates a request sent via an open communication network associated with the hotspot. The request concerns secured network access at the hotspot by the user device. A unique pre-shared key is generated for the user device based on information in the received request and transmitted over the open communication network for display on a webpage accessible to the user device. The unique pre-shared key is stored in association with information regarding the user device. The user device may then use the unique pre-shared key in subsequent requests for secured network access. | 09-18-2014 |
20150257009 | KEY ASSIGNMENT FOR A BRAND - Systems and methods for providing secured network access are provided. A user device located within range of a branded hotspot initiates a request for the secured network access. The request concerns secured network access at the hotspot by the user device and includes a unique pre-shared key. A query regarding the unique pre-shared key is sent to a database, which retrieves information regarding a corresponding pre-shared key. That information is sent to the hotspot controller, which allows the user device secured network access as governed by one or more parameters associated with the pre-shared key. | 09-10-2015 |
Patent application number | Description | Published |
20090177818 | DISCOVERY OF ELECTRONIC DEVICES UTILIZING A CONTROL BUS - Discovery of electronic devices utilizing a control bus. An embodiment of a method includes connecting a receiving device to a cable, where the cable includes a control bus. If the receiving device is in a disconnect state and a signal from a transmitting device is detected on the control bus, the device is transferred to a state for a first type of transmitting device. If the receiving device is in either the disconnect state or the state for the first type of transmitting device and a predetermined voltage signal is received from the transmitting device, then the receiving device is transferred to a state for a second type of transmitting device. | 07-09-2009 |
20090177820 | CONTROL BUS FOR CONNECTION OF ELECTRONIC DEVICES - A method and apparatus for a control bus for connection of electronic devices. An embodiment of a method includes coupling a transmitting device to a receiving device, including connecting a control bus between the transmitting device and the receiving device, with the control bus being a bi-directional, single-line bus. The method further includes obtaining control of the control bus for either the transmitting device or the receiving device, with the device obtaining control becoming an initiator and the other device becoming a follower. One or more control signals are converted to one or more data packets, with each of the one or more control signals representing one of multiple different types of control signals. The generated data packets are transmitted from the initiator to the follower via the control bus. | 07-09-2009 |
20100100200 | DISCOVERY OF CONNECTIONS UTILIZING A CONTROL BUS - Discovery of connections utilizing a control bus. An embodiment of a method includes detecting a transition of a control bus from a high state to a low state by a source device, the source device being configured to be coupled with a sink device via an interface, the interface including the control bus, the source device including a pullup device and the sink device including a pulldown device;pulsing the control bus to a high state at the source device; and upon detecting by the source device that the control bus remains in the high state ceasing the pulsing of the control bus to the high state, and transitioning the source device from a disconnected state to a connected state. | 04-22-2010 |
20100109795 | TRANSMISSION OF ALTERNATIVE CONTENT OVER STANDARD DEVICE CONNECTORS - Transmission of alternative content over standard device connectors. An embodiment of a method includes connecting a first device to a second device utilizing a standard connector, the connector including multiple pins, and detecting whether the second device is operating in a standard mode or an alternative mode. If the second device is operating in the alternative mode, then switching one or more pins of the standard connector for the alternative mode and transmitting or receiving signals for the alternative mode via the plurality of pins of the standard connector. | 05-06-2010 |
20120005377 | DETECTION OF CABLE CONNECTIONS FOR ELECTRONIC DEVICES - Embodiments of the invention are generally directed to detection of cable connections for electronic devices. An embodiment of an apparatus includes a port for the connection of a cable, the port being compatible with a first protocol and a second protocol, the port including multiple pins including a first pin for a first line and a second pin for a second line. The apparatus further includes a processor to determine a type of source device connected to the cable, where determination of the type of source device includes the apparatus detecting a low signal on the first line and a high signal on the second line, and, upon detecting the low signal on first line and the high signal on the second line, the apparatus initiates a discovery sequence, the discovery sequence including transmitting a signal sequence on the second line and attempting to receive the signal sequence on the second line. If the signal sequence is successfully received on the second line, the apparatus determines that a source device compatible with the first protocol is connected to the cable. | 01-05-2012 |
20150255933 | Signal Integrity of a Multimedia Link - In one embodiment, a source device and sink device communicate with one another via a multimedia link. The multimedia link includes a cable and a plug. The cable includes one or more data lines, power lines, ground lines or control bus lines. The plug includes a plurality of pins each connected to the one or more lines included in the cable. The plug also includes a ground plane and a power plane, wherein a ground pin of the plug connects the ground plane to the ground line of the cable of the multimedia link and a power pin of the plug connects the ground plane to the power line of the cable. In one example, the ground plane and power plane are placed within a threshold distance of one another, such that the power line connected to the power plane via the power pin behaves as a signal return path. | 09-10-2015 |
20150286587 | DETECTING THE ORIENTATION OF A MULTIMEDIA LINK CONNECTED TO A DEVICE - Embodiments of the present disclosure are related to identifying the orientation of a multimedia link connected between a source device and a sink device. A sink device includes a plurality of pins that are configured to interface with a plurality of pins of the multimedia link. The sink device identifies based on the values of one or more pins of the plurality of pins of the sink device whether the multimedia link is connected to the sink device. Further, the sink device determines an orientation of the multimedia link connected to the sink device. The multimedia link can be in one of two orientations, straight or flipped. The sink device may communicate the orientation of the multimedia link to the source device. The source device may perform lane mapping based on whether the multimedia link is in the straight or flipped orientation. | 10-08-2015 |
20160072601 | Enhanced Communication Link Using Synchronization Signal as Link Command - A system communicating over a full duplex control channel of a multimedia communication link by using synchronization signals that may also function as a logical link command. Synchronization indicators are exchanged between two communicating devices for maintaining synchronization of a logical link. At least two different types of synchronization signals may be sent between the two devices as synchronization indicators. A first synchronization signal is used by default to maintain synchronization of a logical link. A second synchronization signal is used in place of the first synchronization signal to maintain synchronization of the logical link. The second synchronization signal may be used to imply a virtual link command to indicate that a device is ready to receive data or has successfully received data over the virtual link. | 03-10-2016 |
Patent application number | Description | Published |
20090098176 | MEDICAL DEVICES WITH TRIGGERABLE BIOADHESIVE MATERIAL - Described herein are implantable medical devices comprising a biocompatible polymer comprising a triggerable bioadhesive property that allows the device to adhere to body tissue. The triggerable bioadhesive property of the polymer can be triggered or activated by exposure to a stimulus. Also, the present invention pertains to methods of making an implantable medical device comprising a biocompatible polymer comprising a triggerable bioadhesive property that allows the device to adhere to body tissue. | 04-16-2009 |
20100098741 | METHOD OF INCORPORATING CARBON NANOTUBES IN A MEDICAL APPLIANCE, A CARBON NANOTUBE MEDICAL APPLIANCE, AND A MEDICAL APPLIANCE COATED USING CARBON NANOTUBE TECHNOLOGY - A method of coating an article is provided. The method includes: preparing a solution including a bioactive agent and a carbon nanotube precursor; treating the solution to form carbon nanotubes; and applying the solution to the article. A method of producing a medical device is provided. The method includes: forming a core of the medical device with a pattern on a surface of the core and assembling a multi-walled carbon nanotube array on the pattern on the surface. The pattern on the surface may determine an orientation of the multi-walled carbon nanotube array. A method of manufacturing a medical appliance is provided. The method includes creating a mixture of a carbon nanotube precursor and a polymer and injecting the mixture into a mold. The mold forms the mixture into a shape of the medical appliance. A method of forming a nanotube tissue scaffold is provided. The method includes forming a nanotube precursor and treating the nanotube precursor to form the nanotube tissue scaffold. The nanotube tissue scaffold is electrically conductive. | 04-22-2010 |
20110014264 | Medical Devices Having Nanostructured Regions For Controlled Tissue Biocompatibility And Drug Delivery - According to certain aspects of the invention, implantable or insertable medical devices are provided that contain one or more nanoporous regions, which may further comprise interconnected nanopores. Other aspects of the invention are directed to implantable or insertable medical devices that contain one or more nanostructured regions, which are formed by a variety of methods. Still other aspects of the invention are directed to implantable or insertable medical devices having nanotextured surface regions, in which cell-adhesion-promoting biomolecules (e.g., glycosaminoglycans, proteoglycans, cell adhesion peptides, and adhesive proteins) are provided on, within or beneath the nanotextured surface regions. | 01-20-2011 |
20110150972 | MEDICAL DEVICES HAVING IMPROVED PERFORMANCE - According to an aspect of the present invention, medical devices are provided that contain at least one polymeric region which contains (a) at least one block copolymer that contains at least at least three polymer blocks that differ from one another and (b) at least one therapeutic agent. | 06-23-2011 |
Patent application number | Description | Published |
20130184568 | DEVICE AND METHOD FOR DILATING AN AIRWAY STENOSIS - A medical device and a system and for dilating a stenotic airway of a patient are described. The medical device comprises a proximal end, a distal end, and a shaft system having an inflation lumen and a ventilation lumen the proximal end. The shaft system has a proximal shaft section and a distal shaft section. An inflatable balloon is attached to the distal shaft section in a position that is proximal to the distal end. The ventilating tip is distal to the balloon on the distal shaft section and has one or more radially facing openings. A method for treating a stenotic airway includes inserting the medical device into a patient's airway, and dilating and ventilating the airway. | 07-18-2013 |
20140074065 | Bioabsorbable Spacers and Spacer Delivery Systems for Use in the Ear, Nose and Throat - A spacer for delivery into the natural or man-made openings to the frontal, maxillary, sphenoid, anterior or posterior ethmoid sinuses, or other cells or cavities, anatomical regions such as nostrils, nasal cavities, nasal meatus, and other passageways such as the Eustachian tubes, naso-lachrymal ducts or airway is described. The bioabsorbable polymeric spacers maintain the opening and/or are useful for delivering drugs or other substances to the natural or man-made openings. | 03-13-2014 |
20140102461 | Adhesive Earplugs Useful for Sealing the Ear Canal - Systems and methods are provided for sealing an ear canal for retaining a solution in the ear canal. Adhesive earplugs are provided through which the solution can be delivered, and which, following delivery, retain the fluid in the ear canal. The systems and methods may also be useful for delivering an anesthetizing solution to the ear canal of a human patient and for maintaining the solution therein for use with an iontophoresis system for anesthetizing the tympanic membrane. | 04-17-2014 |
20140277060 | APPARATUS FOR SENSING AND RESPONDING TO STRAIN IN AIRWAY DILATION SHAFT - An apparatus comprises a balloon catheter, an inflatable balloon, and a force sensor. The balloon catheter is operable to communicate fluid to the balloon. The balloon is disposed on the distal end of the balloon catheter. The balloon is positionable within an airway or other anatomical passageway of a patient. The force sensor is positioned along the balloon catheter or in the balloon and is able to detect a physical change within the balloon catheter or balloon. A control logic may trigger a response based on readings by the force measuring device. For instance, the control logic may trigger an alert when a force related parameter exceeds a threshold; or when a rate of change in the parameter exceeds a threshold. In addition or in the alternative, the control logic may trigger a feature that is operable to reduce fluid pressure in the balloon in response to such conditions. | 09-18-2014 |
20140277071 | FEATURES TO ENHANCE GRIP OF BALLOON WITHIN AIRWAY - A dilation assembly includes a shaft and a dilator coupled with the distal end of the shaft. The dilator includes a proximal end, a distal end, and a center portion positioned between the proximal end and the distal end. The center portion dilates from a first configuration to a second configuration. The center portion has a larger diameter than the proximal end and the distal end when the center portion is in the second configuration. At least one gripping feature is positioned on at least a portion of the exterior surface of the center portion. The gripping feature provides friction between the center portion and a bodily lumen when the center portion is in the second configuration. | 09-18-2014 |
20150328420 | Device and Method for Dilating an Airway Stenosis - A medical device and a system and for dilating a stenotic airway of a patient are described. The medical device comprises a proximal end, a distal end, and a shaft system having an inflation lumen and a ventilation lumen the proximal end. The shaft system has a proximal shaft section and a distal shaft section. An inflatable balloon is attached to the distal shaft section in a position that is proximal to the distal end. The ventilating tip is distal to the balloon on the distal shaft section and has one or more radially facing openings. A method for treating a stenotic airway includes inserting the medical device into a patient's airway, and dilating and ventilating the airway. | 11-19-2015 |
Patent application number | Description | Published |
20080255229 | Parenteral solution containing amiodarone in NNDMA (N,N,-Dimethylacetamide) - Disclosed herein are parenteral solutions containing 3-diethylaminoethoxy benzoyl-benzofurans, such as amiodarone, in a diluent NNDMA (N,N-Dimethylacetamide) useful in the treatment of cardiac arrhythmias both supraventricular, ventricular as well as, the condition of cardiac arrest. | 10-16-2008 |
20090060894 | Treatment to aid in the metabolism of alcohol - Alcohol intoxication is a serious problem. Many individuals are more sensitive to alcohol intoxication and placed at a decided disadvantage in social drinking situations. What is proposed is a way to facilitate alcohol metabolism in individuals who have consumed alcohol by the administration of enzymes to speed the alcohols metabolism. | 03-05-2009 |
20090233951 | Parenteral solutions containing metolazone - Disclosed herein are parenteral solutions containing 7-halo-1,2,3,4-tetrahydro-3-aryl-6-quinazoline sulfonamide in N,N-dimethylactamide, polyethylene glycol and D | 09-17-2009 |
20100010096 | Methadone chiral isolate as an improved pharmaceutical - Methadone is a frequently employed agent for the treatment of drug addiction and the treatment of pain. Methadone prolongs the cardiac action potential, which on the surface electrocardiogram is represented by QT prolongation. This QT prolongation is known to increase the risk for the development of cardiac arrhythmias, especially the form of ventricular tachycardia known as Torsade de Pointes. For this reason, the FDA has inserted a “black box” warning for potential life threatening arrhythmias. The invention described in this application is the surprising finding that the R-isomer of methadone causes less inhibition of the potassium channel, IKr and thus would have less of a chance of causing life threatening arrhythmias. What is claimed is a method of chirally separating methadone with one isomer having less QT prolongation and more analgesic action that would make a superior pharmacologic agent than the racemate R,S methadone. | 01-14-2010 |
20100029577 | Chiral separation, characterization and biological action of optically active isomers of digoxin - Disclosed herein is the method for separation of enantiomers or isomers of digoxin. These isomers are to be used-in the treatment of heart failure without adverse or unneeded cardiac actions in humans. Additionally what is claimed is an isolate with less or no cardiac contractile effect but with AV node slowing such that the composition would be an effective therapy for the control of the ventricular response in atrial fibrillation. Also disclosed are methods for assaying these isomeric compounds present in biological fluids to enable the separation of pharmacologic actions. | 02-04-2010 |
20100173875 | Formulation of aspirin that is stable and showing minimal hydrolysis for parenteral adminstration for the treatment of cardiovascular and other disease states - Disclosed herein are ways to solubilize aspirin for parenteral administration containing aspirin and a diluent NNDMA (N,N-Dimethylacetamide) useful in the treatment of acute coronary syndromes as well as other disease states. The solution so constituted is stable at room temperature for prolonged periods without decomposition and avoids significant hydrolysis of the aspirin and thus the loss of the anti-platelet action when stored. | 07-08-2010 |