Rakestraw
Cheryl Matthews Rakestraw, Niles, IL US
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20140149163 | INTERFACING A WEBLOG TO A CENTRALIZED ISSUE MANAGEMENT SYSTEM - A method that automatically links a Device Forum (DF) and a Quality Center (QC) is presented. In particular, data representative of a support issue provided through an interactive support channel of a mobile communications network provider is received at a DF server. A DF support case is established, via a DF web service running on the DF server, based on the support issue. A portal is displayed to facilitate management of a plurality of DF support cases including the DF support case. Upon determining that the DF support case has been viewed more than the threshold number of times, a message that instructs a Quality Center (QC) server to handle the support issue included in the DF support case is automatically transmitted to the QC server. | 05-29-2014 |
David J. Rakestraw, Livermore, CA US
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20100086443 | Flow Rate Control - A liquid sample is prepared at a preparation site and then processed, e.g. in an HPLC column. The sample is prepared and conveyed to the device at a flow rate which is substantially less than the flow rate through the device. The different flow rates are preferably provided by variable rate working fluid supplies which drive the sample from the preparation site and through the device. | 04-08-2010 |
Ginger C. Rakestraw, Cambridge, MA US
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20120094909 | FIBRONECTIN BASED SCAFFOLD DOMAIN PROTEINS THAT BIND TO PCSK9 - The present invention relates to fibronectin based scaffold domain proteins that bind PCSK9. The invention also relates to the use of the innovative proteins in therapeutic applications to treat atherosclerosis, hypercholesterolemia and other cholesterol related diseases. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative protein. | 04-19-2012 |
Ginger Chao Rakestraw, Somerville, MA US
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20150072919 | FIBRONECTIN BASED SCAFFOLD DOMAIN PROTEINS THAT BIND TO MYOSTATIN - The present invention relates to fibronectin-based scaffold domain proteins that bind to myostatin. The invention also relates to the use of these proteins in therapeutic applications to treat muscular dystrophy, cachexia, sarcopenia, osteoarthritis, osteoporosis, diabetes, obesity, COPD, chronic kidney disease, heart failure, myocardial infarction, and fibrosis. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the proteins. | 03-12-2015 |
Ginger Chao Rakestraw, Cambridge, MA US
Patent application number | Description | Published |
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20140105896 | FIBRONECTIN BASED SCAFFOLD DOMAIN PROTEINS THAT BIND TO MYOSTATIN - The present invention relates to fibronectin-based scaffold domain proteins that bind to myostatin. The invention also relates to the use of these proteins in therapeutic applications to treat muscular dystrophy, cachexia, sarcopenia, osteoarthritis, osteoporosis, diabetes, obesity, COPD, chronic kidney disease, heart failure, myocardial infarction, and fibrosis. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the proteins. | 04-17-2014 |
20140107020 | FIBRONECTIN BASED SCAFFOLD DOMAIN PROTEINS THAT BIND TO MYOSTATIN - The present invention relates to fibronectin-based scaffold domain proteins that bind to myostatin. The invention also relates to the use of these proteins in therapeutic applications to treat muscular dystrophy, cachexia, sarcopenia, osteoarthritis, osteoporosis, diabetes, obesity, COPD, chronic kidney disease, heart failure, myocardial infarction, and fibrosis. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the proteins. | 04-17-2014 |
20140309163 | FIBRONECTIN BASED SCAFFOLD DOMAIN PROTEINS THAT BIND TO MYOSTATIN - The present invention relates to fibronectin-based scaffold domain proteins that bind to myostatin. The invention also relates to the use of these proteins in therapeutic applications to treat muscular dystrophy, cachexia, sarcopenia, osteoarthritis, osteoporosis, diabetes, obesity, COPD, chronic kidney disease, heart failure, myocardial infarction, and fibrosis. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the proteins. | 10-16-2014 |
James A. Rakestraw, Cambridge, MA US
Patent application number | Description | Published |
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20090005264 | CELL SURFACE DISPLAY, SCREENING AND PRODUCTION OF PROTEINS OF INTEREST - Aspects of the invention provide compositions and methods for displaying engineered polypeptides on a cell surface. According to aspects of the invention, immobilized polypeptides can be screened to identify one or more variants having one or more functional or structural properties of interest. Aspects of the invention provide composition and methods for producing engineered protein or protein variants having a functional or a structural property of interest. | 01-01-2009 |
20100267057 | Cell Surface Display, Screening and Production of Proteins of Interest - Aspects of the invention provide compositions and methods for displaying engineered polypeptides on a cell surface. According to aspects of the invention, immobilized polypeptides can be screened to identify one or more variants having one or more functional or structural properties of interest. Aspects of the invention provide composition and methods for producing engineered protein or protein variants having a functional or a structural property of interest. | 10-21-2010 |
20140357508 | Cell Surface Display, Screening and Production of Proteins of Interest - Aspects of the invention provide compositions and methods for displaying engineered polypeptides on a cell surface. According to aspects of the invention, immobilized polypeptides can be screened to identify one or more variants having one or more functional or structural properties of interest. Aspects of the invention provide composition and methods for producing engineered protein or protein variants having a functional or a structural property of interest. | 12-04-2014 |
Kenneth Evan Rakestraw, Berkeley, CA US
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20120080508 | LINEAR CELL STRINGING - Techniques for linear cell stringing are disclosed. In some embodiments, a plurality of sets of solar cells are linearly positioned, a plurality of tabbing ribbon segments are placed in contact with the plurality of sets of solar cells, and the plurality of sets of solar cells and corresponding plurality of tabbing ribbon segments are soldered together to form a plurality of solar cell strings. In some cases, the plurality of solar cell strings is substantially simultaneously formed in parallel. | 04-05-2012 |
Scott L. Rakestraw, Newark, DE US
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20080226623 | Stabilized protein crystals, formulations comprising them and methods of making them - This invention relates to methods for the stabilization, storage and delivery of biologically active macromolecules, such as proteins, peptides and nucleic acids. In particular, this invention relates to protein or nucleic acid crystals, formulations and compositions comprising them. Methods are provided for the crystallization of proteins and nucleic acids and for the preparation of stabilized protein or nucleic acid crystals for use in dry or slurry formulations. The present invention is further directed to encapsulating proteins, glycoproteins, enzymes, antibodies, hormones and peptide crystals or crystal formulations into compositions for biological delivery to humans and animals. According to this invention, protein crystals or crystal formulations are encapsulated within a matrix comprising a polymeric carrier to form a composition. The formulations and compositions enhance preservation of the native biologically active tertiary structure of the proteins and create a reservoir which can slowly release active protein where and when it is needed. Methods are provided preparing stabilized formulations using pharmaceutical ingredients or excipients and optionally encapsulating them in a polymeric carrier to produce compositions and using such protein crystal formulations and compositions for biomedical applications, including delivery of therapeutic proteins and vaccines. Additional uses for the protein crystal formulations and compositions of this invention involve protein delivery in human food, agricultural feeds, veterinary compositions, diagnostics, cosmetics and personal care compositions. | 09-18-2008 |
20100255100 | STABILIZED PROTEIN CRYSTALS, FORMULATIONS COMPRISING THEM AND METHODS OF MAKING THEM - This invention relates to methods for the stabilization, storage and delivery of biologically active macromolecules, such as proteins, peptides and nucleic acids. In particular, this invention relates to protein or nucleic acid crystals, formulations and compositions comprising them. Methods are provided for the crystallization of proteins and nucleic acids and for the preparation of stabilized protein or nucleic acid crystals for use in dry or slurry formulations. The present invention is further directed to encapsulating proteins, glycoproteins, enzymes, antibodies, hormones and peptide crystals or crystal formulations into compositions for biological delivery to humans and animals. According to this invention, protein crystals or crystal formulations are encapsulated within a matrix comprising a polymeric carrier to form a composition. The formulations and compositions enhance preservation of the native biologically active tertiary structure of the proteins and create a reservoir which can slowly release active protein where and when it is needed. Methods are provided preparing stabilized formulations using pharmaceutical ingredients or excipients and optionally encapsulating them in a polymeric carrier to produce compositions and using such protein crystal formulations and compositions for biomedical applications, including delivery of therapeutic proteins and vaccines. Additional uses for-the protein crystal formulations and compositions of this invention involve protein delivery in human food, agricultural feeds, veterinary compositions, diagnostics, cosmetics and personal care compositions. | 10-07-2010 |
20140086988 | Stabilized Protein Crystals, Formulations Containing Them and Methods of Making Them - This invention relates to methods for the stabilization, storage and delivery of biologically active macromolecules, such as proteins, peptides and nucleic acids. In particular, this invention relates to protein crystals, formulations and compositions comprising them. Provided are methods and compositions for encapsulating proteins, glycoproteins, enzymes, antibodies, hormones and peptide crystals or crystal formulations into compositions for biological delivery. | 03-27-2014 |
Simon Nicolas Rakestraw, Decatur, GA US
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20140087819 | ELECTRONIC GAMING DEVICE WITH PHYSICS-BASED GAMING FUNCTIONALITY - Examples disclosed herein relate to systems and methods, which may receive wagers on one or more paylines. The systems and methods may utilize one or more objects in a physics-based game. The systems and methods may determine one or more payouts based on the one or more objects. The systems and methods may display one or more presentations based on the one or more objects. | 03-27-2014 |
20140113698 | ELECTRONIC GAMING DEVICE WITH WHEEL FUNCTIONALITY - Examples disclosed herein relate to systems and methods, which may receive wagers on one or more paylines. The systems and methods may utilize one or more objects in a wheel-based game. The systems and methods may determine one or more payouts based on the one or more wheel positions. The systems and methods may display one or more presentations based on the one or more wheel positions. | 04-24-2014 |
Wesley Bennett Rakestraw, Mcdonald, TN US
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20110008146 | Method and Apparatus for Lifting Cumbersome Articles - Method and apparatus for gripping and lifting heavy and cumbersome objects is disclosed. A slotted safety latch lever assembly permits the pivoting action of an upper tube relative to a main tube, facilitating the gripping and releasing action of arm assemblies at either end of the main tube. The length of the main tube is adjustable, permitting the main tube to shorten or lengthen as needed for gripping the object. The upper tube has a lifting device connector selectively positioned longitudinally relative to the upper tube for achieving correct balance point for lifting. | 01-13-2011 |