Patent application number | Description | Published |
20090214560 | BINDING MOLECULES TO THE HUMAN OX40 RECEPTOR - The present disclosure provides isolated binding molecules that bind to the human OX40R, nucleic acid molecules encoding an amino acid sequence of the binding molecules vectors comprising the nucleic acid molecules, host cells containing the vectors, methods of making the binding molecules, pharmaceutical compositions containing the binding molecules, and methods of using the binding molecules or compositions. | 08-27-2009 |
20090215639 | Method of Producing Human IgG Antibodies with Enhanced Effector Functions - A method for generating human IgG | 08-27-2009 |
20090317402 | ANTIBODIES TO IL-6 AND THEIR USES - Antibodies and antigen-binding portions thereof that bind to human IL-6 are provided. Also provided are nucleic acids encoding such antibodies and antigen binding portions, methods of making such antibodies and antigen binding portions, compositions comprising such antibodies or antigen binding portions, and uses of such antibodies or antigen binding portions. | 12-24-2009 |
20110206681 | BINDING MOLECULES TO THE HUMAN OX40 RECEPTOR - The present disclosure provides isolated binding molecules that bind to the human OX40R, nucleic acid molecules encoding an amino acid sequence of the binding molecules, vectors comprising the nucleic acid molecules, host cells containing the vectors, methods of making the binding molecules, pharmaceutical compositions containing the binding molecules, and methods of using the binding molecules or compositions. | 08-25-2011 |
20110229489 | Antibodies with pH Dependent Antigen Binding - The present invention relates to antibodies with pH dependent binding to its antigen such that the affinity for antigen binding at physiological pH (i.e., pH 7.4) is greater than at endosomal pH (i.e., pH 6.0 or 5.5). In other words, the K | 09-22-2011 |
20110245108 | Universal Antibody Libraries - Universal antibody libraries are described which are synthetic and derived from expressed human antibody sequences selected accordingly to certain criteria, for example, that the sequences are derived from naturally-occurring antibodies expressed in response to a certain antigen class (e.g., small molecule, polysaccharide, peptide, or protein) and having CDR regions engineered for optimal diversity. Methods for making and screening such libraries for isolating therapeutics suitable for treating disease are also disclosed. | 10-06-2011 |
20110274696 | ANTIBODIES TO CCR2 - Provided are antibodies including human antibodies and antigen-binding portions thereof that specifically bind to CCR2, specifically human CCR2, and that may function to inhibit CCR2. Anti-CCR2 antibodies include those which bind to the first and/or second extracellular loops of CCR2. Also provided are human anti-CCR2 antibodies and antigen-binding portions thereof. Isolated heavy and light chain immunoglobulins derived from human anti-CCR2 antibodies and nucleic acid molecules encoding such immunoglobulins are provided. Methods of making human anti-CCR2 antibodies or antigen-binding portions, compositions comprising these antibodies or antigen-binding portions, methods of using the antibodies and antigen-binding portions, and compositions for diagnosis and treatment are provided. Also provided are gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-CCR2 antibodies or antigen binding portions thereof | 11-10-2011 |
20120107871 | METHOD OF PRODUCING HUMAN IGG ANTIBODIES WITH ENHANCED EFFECTOR FUNCTIONS - A method for generating human IgG | 05-03-2012 |
20120202285 | ANTIBODIES TO IL-6 AND THEIR USES - Antibodies and antigen-binding portions thereof that bind to human IL-6 are provided. Also provided are nucleic acids encoding such antibodies and antigen binding portions, methods of making such antibodies and antigen binding portions, compositions comprising such antibodies or antigen binding portions, and uses of such antibodies or antigen binding portions. | 08-09-2012 |
20120225086 | BINDING MOLECULES TO THE HUMAN OX40 RECEPTOR - The present disclosure provides isolated binding molecules that bind to the human OX40R, nucleic acid molecules encoding an amino acid sequence of the binding molecules, vectors comprising the nucleic acid molecules, host cells containing the vectors, methods of making the binding molecules, pharmaceutical compositions containing the binding molecules, and methods of using the binding molecules or compositions. | 09-06-2012 |
20130115208 | HETERODIMERIC PROTEINS AND METHODS FOR PRODUCING AND PURIFYING THEM - The present invention relates to engineered heteromultimeric proteins, and more specifically, to methods for producing and purifying heterodimeric proteins, such as bispecific antibodies and other heterodimeric proteins comprising immunoglobulin-like hinge sequences. Methods for producing and purifying such engineered heterodimeric proteins and their use in diagnostics and therapeutics are also provided. | 05-09-2013 |
20130122020 | ANTIBODIES SPECIFIC FOR TROP-2 AND THEIR USES - The present invention provides antibodies that specifically bind to trophoblast cell-surface antigen-2 (Trop-2). The invention further provides antibody conjugates comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and Trop-2 antibody conjugates for the treatment of a condition associated with Trop-2 expression (e.g., cancer), such as colon, esophageal, gastric, head and neck, lung, ovarian, or pancreatic cancer. | 05-16-2013 |
20130280266 | ANTIBODIES TO IL-6 AND THEIR USES - Antibodies and antigen-binding portions thereof that bind to human IL-6 are provided. Also provided are nucleic acids encoding such antibodies and antigen binding portions, methods of making such antibodies and antigen binding portions, compositions comprising such antibodies or antigen binding portions, and uses of such antibodies or antigen binding portions. | 10-24-2013 |
20140342450 | ANTIBODIES TO CCR2 - Provided are antibodies including human antibodies and antigen-binding portions thereof that specifically bind to CCR2, preferably human CCR2, and that may inhibit CCR2. The present antibodies may bind to the first and/or second extracellular loops of CCR2. Isolated heavy and light chains derived from the antibodies and nucleic acid molecules encoding the antibodies and chains are provided. Methods of making and using the anti-CCR2 antibodies or antigen-binding portions, and compositions comprising these antibodies or antigen-binding portions, including compositions for diagnosis and treatment, are provided. Also provided are gene therapy methods using nucleic acid molecules encoding the heavy and/or light chains that comprise the human anti-CCR2 antibodies or antigen-binding portions thereof. | 11-20-2014 |
20140357844 | ANTIBODIES SPECIFIC FOR TROP-2 AND THEIR USES - The present invention provides antibodies that specifically bind to trophoblast cell-surface antigen-2 (Trop-2). The invention further provides antibody conjugates comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and Trop-2 antibody conjugates for the treatment of a condition associated with Trop-2 expression (e.g., cancer), such as colon, esophageal, gastric, head and neck, lung, ovarian, or pancreatic cancer. | 12-04-2014 |
20150203574 | ANTIBODIES TO IL-6 AND THEIR USES - Antibodies and antigen-binding portions thereof that bind to human IL-6 are provided. Also provided are nucleic acids encoding such antibodies and antigen binding portions, methods of making such antibodies and antigen binding portions, compositions comprising such antibodies or antigen binding portions, and uses of such antibodies or antigen binding portions. | 07-23-2015 |
20150218279 | BINDING MOLECULES TO THE HUMAN OX40 RECEPTOR - The present disclosure provides isolated binding molecules that bind to the human OX40R, nucleic acid molecules encoding an amino acid sequence of the binding molecules, vectors comprising the nucleic acid molecules, host cells containing the vectors, methods of making the binding molecules, pharmaceutical compositions containing the binding molecules, and methods of using the binding molecules or compositions. | 08-06-2015 |
20150266974 | ANTIBODIES WITH pH DEPENDENT ANTIGEN BINDING - The present invention relates to antibodies with pH dependent binding to its antigen such that the affinity for antigen binding at physiological pH (i.e., pH 7.4) is greater than at endosomal pH (i.e., pH 6.0 or 5.5). In other words, the K | 09-24-2015 |
Patent application number | Description | Published |
20100306484 | HETEROGENEOUS STORAGE ARRAY OPTIMIZATION THROUGH EVICTION - A storage system can comprise storage devices having storage media with differing characteristics. An eviction handler can receive information regarding the state of storage media or of data stored thereon, as well as information regarding application or operating system usage, or expected usage, of data, or information regarding policy, including user-selected policy. Such information can be utilized by the eviction handler to optimize the use of the storage system by evicting data from storage media, including evicting data in order to perform maintenance on, or replace, such storage media, and evicting data to make room for other data, such as data copied to such storage media to facilitate pre-fetching or implement policy. The eviction handler can be implemented by any one or more of processes executing on a computing device, control circuitry of any one or more of the storage devices, or intermediate storage-centric devices. | 12-02-2010 |
20100313044 | STORAGE ARRAY POWER MANAGEMENT THROUGH I/O REDIRECTION - A storage system can comprise multiple storage devices with differing characteristics, including differing power-related characteristics. A storage power manager can redirect Input/Output (I/O) communications to storage devices to maximize the power efficiency of the storage system. The storage power manager can reference metadata associated with the data of an I/O request, as well as power-related data, including continuously varying data and storage device characteristics, to select one or more storage devices to which to redirect the I/O. The storage power manager can also move or copy data between storage devices to facilitate maximum utilization of power efficient storage devices with limited storage capacity and to enable the placing of one or more storage devices into a reduced power consuming state. The moving or copying of data can be performed with reference to lifecycle information to identify data that has changed since a storage device was last active. | 12-09-2010 |
20100313045 | STORAGE ARRAY POWER MANAGEMENT USING LIFECYCLE INFORMATION - A multi-device storage system can be arranged into power saving systems by placing one or more storage devices into a reduced power consuming state when the storage activity associated with the system is sufficiently reduced that an attendant decrease in throughput will not materially affect users of the storage system. Where data redundancy is provided for, a redundant storage device can be placed into the reduced power consuming state and its redundancy responsibilities can be transitioned to a partition of a larger storage device. Such transitions can be based on specific parameters, such as write cycles or latency, crossing thresholds, including upper and lower thresholds, they can also be based on pre-set times, or a combination thereof. Lifecycle information, including lifecycle information collected in real-time by storage devices on a block-by-block basis, can be utilized to obtain historical empirical data from which to select the pre-set times. | 12-09-2010 |
Patent application number | Description | Published |
20130067174 | NONVOLATILE MEDIA JOURNALING OF VERIFIED DATA SETS - The storage of data sets in a storage set (e.g., data sets written to hard disk drives comprising a RAID array) may diminish the performance of the storage set through non-sequential writes, particularly if the storage devices promptly write data sets that are followed by sequentially following data sets. Additionally, storage sets may exhibit inconsistencies due to non-atomic writes of data sets and verifiers (e.g., checksums) and an intervening failure, such as an occurrence of the RAID write hole. Instead, data sets and verifiers may first be written to a stored on the nonvolatile media of a storage device before being committed to the storage set. Such writes may be sequentially written to the journal, irrespective of the locations of the data sets in the storage set; and recovery of a failure may simply involve re-committing the consistent records in the journal to correct incomplete writes to the storage set. | 03-14-2013 |
20130067188 | STORAGE DEVICE DRIVERS AND CLUSTER PARTICIPATION - The representation of storage devices on computers (e.g., as logical volumes) may be complicated by the pooling of multiple storage devices in order to apply redundancy plans such as mirroring and checksumming. Presented herein is a storage device driver configured to operate as a storage device interface generating representations of the storage regions of the storage devices; to claim those regions as a storage controller; and to expose pooled storage regions as logical disks. Additionally, the storage device driver may support the inclusion of storage devices in a cluster, comprising nodes that may be appointed as managers of the storage pool configuration; as managers of the storage devices; as owners having exclusive read/write access to the storage pool or cluster resources; and as cluster resource writers having excusive write access to a cluster resource. The nodes of the cluster may interoperate to share the storage devices while avoiding write conflicts. | 03-14-2013 |
20140279966 | VOLUME HAVING TIERS OF DIFFERENT STORAGE TRAITS - A volume system that presents a volume having an extent of logical addresses to a file system. A volume exposure system exposes the volume to the file system in a manner that the volume has multiple tiers, each offering storage of different traits. This is performed using multiple heterogenic underlying storage systems, each having different storage system-specific traits. Each underlying storage system may be hardware, software, or a combination thereof that permits each storage system to expose storage having the particular storage system-specific traits to the file system. The volume system supports each tier by mapping logical addresses of the tier to portions of underling storage systems that are consistent with the tier traits. | 09-18-2014 |
20140280397 | HETEROGENIC VOLUME GENERATION AND USE SYSTEM - A system in which a file system may operate on a volume in which the logical address extent of the volume is divided into multiple tiers, each tier providing storage having a distinct trait set by mapping the logical addresses of the volume to appropriate underlying storage systems. A volume system exposes the volume to the file system in a manner that the file system itself has awareness of the tiers, and is aware of the trait sets of each tier. The file system may thus store file system namespaces (such as directories and files) into the tiers as appropriate for the file system namespace. A provisioning system may also be provided and be configured to provision the volume to include such tiers, and if desired, to extend the tiers. | 09-18-2014 |
20140281227 | PROVISIONING IN HETEROGENIC VOLUME OF MULTIPLE TIERS - The provisioning of a volume that has multiple tiers corresponding to different trait sets. The volume to be provisioned is identified along with multiple tiers that are to be in the volume. For each of the tiers that are to be provisioned within the volume, a corresponding trait set is identified as to be applied to each tier. This corresponding trait set may be based on underlying storage systems that are available at the time of provisioning, or which are anticipated to be available. The volume is then caused to be provisioned with the corresponding tiers having the corresponding trait sets. Also, the provisioning of a file, which is determined to have one or more storage traits. Based on these storage traits, the file is then caused to be assigned to an appropriate tier. | 09-18-2014 |
20140297987 | Managing Capacity of a Thinly Provisioned Storage System - A thinly provisioned storage system detects whether physical storage capacity is available when there is a request to allocate storage capacity, prior to data being written to the storage system. In particular, at the time when the file system allocates storage, such as when creating a file or performing an extending write (append) operation, allocating storage to an unallocated region of a sparse file, defragmenting a file, and the like, a storage system can verify that actual physical storage capacity is available. Thus, if there is insufficient actual physical capacity at the time when a storage allocation is attempted, then an error message can be sent and remedial action can be taken. | 10-02-2014 |
20140310278 | CREATING GLOBAL AGGREGATED NAMESPACES FOR STORAGE MANAGEMENT - Embodiments are directed to creating global, aggregated namespaces for storage management and to providing consistent namespaces in a distributed storage system. In one scenario, a computer system defines data storage objects for each data storage node. The data storage objects uniquely identify storage elements of the data storage nodes, where each data storage object includes various associated attributes. The computer system replicates the defined data storage objects and any associated attributes from a first data storage node to a second, different data storage node among the data storage nodes. As such, the defined data storage objects are visible from any node in the data storage nodes. The computer system also aggregates the defined data storage objects for each of the data storage nodes and creates a global, aggregated namespace that includes the aggregated data storage objects for each of the data storage nodes. | 10-16-2014 |
Patent application number | Description | Published |
20120260232 | SYSTEMS AND METHODS FOR A MOBILE APPLICATION DEVELOPMENT AND DEPLOYMENT PLATFORM - Systems and methods for developing, customizing, and deploying mobile device applications are provided through a mobile application development and deployment platform. Preferably, these systems and methods are implemented in an Internet based environment that allows non-technical users to build sophisticated, highly-customizable cross-platform mobile applications. The platform allows users to select, input, create, customize, and combine various content, design characteristics, and application components, such as modules, some of which make use of features and functionality associated with various mobile devices and mobile operating systems. In certain embodiments, the platform allows users to compile the mobile application for various mobile operating systems and generates a configuration file for the mobile application that can be distributed to end users for execution on various mobile devices. When the mobile application is installed on, or executed by the mobile device, the configuration file may enable the retrieval of various data associated with the mobile application. | 10-11-2012 |
20130205276 | SYSTEMS AND METHODS FOR A MOBILE APPLICATION DEVELOPMENT AND DEPLOYMENT PLATFORM - Systems and methods for developing, customizing, and deploying mobile device applications are provided through a mobile application development and deployment platform. Preferably, these systems and methods are implemented in an Internet based environment that allows non-technical users to build sophisticated, highly-customizable cross-platform mobile applications. The platform allows users to select, input, create, customize, and combine various content, design characteristics, and application components, such as modules, some of which utilize features and functionality associated with various mobile devices and mobile operating systems. In certain embodiments, the platform allows users to compile, and generate a configuration file for, the mobile application that can be distributed to end users for execution on various mobile devices and mobile operating systems. When the mobile application is installed on, or executed by the mobile device, the configuration file may enable the retrieval of various data associated with the mobile application. | 08-08-2013 |
20130205278 | SYSTEMS AND METHODS FOR A MOBILE APPLICATION DEVELOPMENT AND DEPLOYMENT PLATFORM - Systems and methods for developing, customizing, and deploying mobile device applications are provided through a mobile application development and deployment platform. Preferably, these systems and methods are implemented in an Internet based environment that allows non-technical users to build sophisticated, highly-customizable cross-platform mobile applications. The platform allows users to select, input, create, customize, and combine various content, design characteristics, and application components, such as modules, some of which utilize features and functionality associated with various mobile devices and mobile operating systems. In certain embodiments, the platform allows users to compile, and generate a configuration file for, the mobile application that can be distributed to end users for execution on various mobile devices and mobile operating systems. When the mobile application is installed on, or executed by the mobile device, the configuration file may enable the retrieval of various data associated with the mobile application. | 08-08-2013 |
20130219429 | SYSTEMS AND METHODS FOR A TELEVISION AND SET-TOP BOX APPLICATION DEVELOPMENT AND DEPLOYMENT PLATFORM - Systems and method are disclosed for creating or updating an application. An application development platform is adapted to assist a user with creating or updating an application. The platform includes tools that permit a user to determine application features for the application. A plurality of application modules associated with the application are determined. The application modules are associated with one or more customization interfaces that permit the user to customize the functionality, design and content of the application. A plurality of selections are received from the user via the one or more customization interfaces associated with the application modules. A user input is also received that identifies at least one content delivery device on which the application is to be executed. Compiled data is generated for the application based on the selections received from the user. | 08-22-2013 |
20130247005 | SYSTEMS AND METHODS FOR A MOBILE BUSINESS APPLICATION DEVELOPMENT AND DEPLOYMENT PLATFORM - Systems and methods for developing, customizing, and deploying mobile device business applications are provided through a mobile application development and deployment platform. Preferably, these systems and methods are implemented in an Internet based environment that allows non-technical users to build highly-customizable cross-platform mobile applications. The platform allows users to select, input, create, customize, and combine various content, design characteristics, database structure, and application components, such as modules, some of which allow an end user to store and access data in an end user database for business applications. In certain embodiments, the platform allows users to compile and generate a configuration file for the mobile application that can be distributed to end users for execution on various mobile devices and mobile operating systems. When the mobile application is installed on, or executed by the mobile device, the configuration file may enable the retrieval of data associated with the mobile application. | 09-19-2013 |
20130283305 | SYSTEMS AND METHODS FOR A TELEVISION AND SET-TOP BOX APPLICATION DEVELOPMENT AND DEPLOYMENT PLATFORM - Systems and method are disclosed for providing a viewer environment on a television device. An authentication component permits a viewer to access a profile on a television device having a network connection, wherein the profile includes personalization data for customizing a viewer environment. The personalization data is derived, at least in part, from the viewer's interaction with the viewer environment. Access to the profile is granted in response to determining that the login credentials received from the viewer are valid. One or more customization aspects to be incorporated into the viewer environment are determined based on the personalization data in the profile. Data is provided for rendering the viewer environment on the television device of the viewer in a manner that includes the customization aspects associated with the personalization data. | 10-24-2013 |
20130305218 | SYSTEMS AND METHODS FOR A SPECIALIZED APPLICATION DEVELOPMENT AND DEPLOYMENT PLATFORM - Systems and methods for developing, customizing, and deploying applications for devices are provided through a application development and deployment platform. Preferably, these systems and methods are implemented in an Internet based environment that allows non-technical users to build sophisticated, highly-customizable cross-platform applications. The platform allows users to select, input, create, customize, and combine various content, design characteristics, and application components, such as modules, some of which utilize features and functionality associated with various devices capable of running applications, operating systems, and app-enabled accessories. In certain embodiments, the platform allows users to compile and generate a configuration file for the application that can be distributed to end users for execution on various devices and operating systems. When the application is installed on, or executed by the device, the configuration file may enable the retrieval of various data associated with the application. | 11-14-2013 |
20140109046 | SYSTEMS AND METHODS FOR A VOICE- AND GESTURE-CONTROLLED MOBILE APPLICATION DEVELOPMENT AND DEPLOYMENT PLATFORM - Systems and methods for developing, customizing, and deploying mobile device applications through voice and/or gesture interactions are provided through a mobile application development and deployment platform. Preferably, these systems and methods are implemented in an Internet based environment that allows non-technical users to build sophisticated, highly-customizable cross-platform mobile applications. The platform allows users to use voice and/or gesture interactions to select, input, create, customize, and combine various content, design characteristics, and application components, such as modules, some of which utilize features and functionality associated with various mobile devices and mobile operating systems. In certain embodiments, the platform allows users to compile the mobile application for various mobile operating systems and generates a configuration file for the mobile application that can be distributed to end users for execution on various mobile devices. When the mobile application is installed on, or executed by the mobile device, the configuration file may enable the retrieval of various data associated with the mobile application. | 04-17-2014 |
20140281886 | SYSTEMS AND METHODS FOR CREATING OR UPDATING AN APPLICATION USING WEBSITE CONTENT - The disclosure herein relates to systems and methods for creating or updating applications using website content. An input may be received that identifies website content to be utilized in creating or updating an application. One or more application modules may to be derived from the website content. The website content may be analyzed in accordance with a rule set to detect website features associated with the website. The website features may be incorporated into the one or more application modules. The application modules may then be compiled into an application such as a mobile application or HTML 5 application. | 09-18-2014 |
20140282371 | SYSTEMS AND METHODS FOR CREATING OR UPDATING AN APPLICATION USING A PRE-EXISTING APPLICATION - The disclosure herein relates to systems and methods for creating or updating applications using content from a pre-existing application, and in particular, utilizing content of a pre-existing application to create or update mobile applications and web applications including HTML 5 applications. An input may be received that identifies a pre-existing application to be utilized in creating or updating an application. One or more application modules may be derived from the content of the pre-existing application. The application content may be analyzed in accordance with a rule set to detect application features associated with the pre-existing application. The application features may be incorporated into the one or more application modules. The application modules may then be compiled into an application such as a mobile application or HTML 5 application. | 09-18-2014 |
20150089339 | SYSTEMS AND METHODS FOR CREATING OR UPDATING AN APPLICATION USING WEBSITE CONTENT - The disclosure herein relates to systems and methods for creating or updating applications using website content. An input may be received that identifies website content to be utilized in creating or updating an application. One or more application modules may be derived from the website content. The website content may be analyzed in accordance with a rule set to detect website features associated with the website. The website features may be incorporated into the one or more application modules. The application modules may then be compiled into an application such as a mobile application or HTML 5 application. | 03-26-2015 |