Patent application number | Description | Published |
20080293157 | Apparatus and method of performing high-throughput cell-culture studies on biomaterials - In one embodiment, a kit includes a base and a specimen removably couplable to the base. A top plate defines a plurality of apertures and is removably couplable to the base such that at least two of the apertures are associated with a specimen and each aperture defines a well with that specimen. Each well is configured to receive a sample material therein in contact with the specimen. A method includes disposing a specimen within a recessed portion of a test apparatus and coupling a top plate of the test apparatus to a base of the test apparatus such that a sealing engagement is formed between the top plate and the specimen. The top plate defines a plurality of apertures, each of at least two of the apertures collectively with the specimen defines a well. A sample material can be disposed within at least one well. | 11-27-2008 |
20090259286 | Sheath With Radio-Opaque Markers For Identifying Split Propagation - A medical device delivery system includes a self-expanding medical device mounted on a balloon portion of a catheter. A sheath is provided around the medical device to hold the device in place with the device staying in a compressed state. The balloon portion is inflated to cause the sheath to rupture and release the self-expanding medical device. A number of radio-opaque markers in a pattern that will aid in determining whether or not the sheath has properly ruptured upon inflation of the balloon portion are provided on the sheath. The radio-opaque markers are positioned with respect to an expected sheath rupture propagation path along which the sheath is expected to rupture. The pattern of the markers changes as the sheath ruptures and this change is detected by an operator of the system. | 10-15-2009 |
20110091549 | Modulating Drug Release Rate By Controlling The Kinetics Of The pH Transition In Hydrogels - Methods and compositions relate to modulating the release profile of drug molecules from a hydrogel by controlling the kinetics of the pH transition of the hydrogel. The hydrogel is formed by in situ polymerization and includes a drug molecule having a pKa between the pH of the formed hydrogel and the physiologic environment in which the hydrogel is placed. | 04-21-2011 |
20110092899 | Prevention Of Premature Gelling Of Delivery Devices For pH Dependent Forming Materials - The present disclosure provides treatment of an apparatus, in embodiments a delivery device, which prevents premature gelling of any materials or precursor(s) of a pH dependent forming material, in embodiments a hydrogel, dispensed by the delivery device. The pH microenvironment near the surface of a lumen of the device, in embodiments the tip of a spray applicator through which the material to be dispensed is expelled from the device, may be controlled to prevent premature gelling. | 04-21-2011 |
20110093057 | Mitigating Thrombus Formation On Medical Devices By Influencing pH Microenvironment Near The Surface - The present disclosure provides treatments of medical devices which inhibit thrombus formation. At least a portion of a substrate of a medical device includes a surface possessing a functionality and/or surface charge adapted to modulate the pH of the surface of the medical device, as well as the pH microenvironment near the surface of a medical device. | 04-21-2011 |
20120156289 | Biodegradable Osmotic Pump Implant For Drug Delivery - The present disclosure relates to a drug delivery device including a biodegradable housing and a hydrogel within the biodegradable housing. The housing, the hydrogel, or both, may include a bioactive agent. Also disclosed is a method of drug delivery including the steps of forming the biodegradable housing, in embodiments a hydrogel, suspending a bioactive agent in the hydrogel, and introducing a second hydrogel and/or precursors of a second hydrogel into the biodegradable housing. | 06-21-2012 |
20120175810 | Drug Delivery Implants, Systems And Methods For Making - The present disclosure provides implants suitable for drug delivery. In embodiments, the present disclosure provides layered biodegradable drug delivery implants and systems and methods for making these implants. | 07-12-2012 |
20120197028 | Crosslinked Polymers with the Crosslinker as Therapeutic For Sustained Release - Crosslinked polymers, methods for their preparation and use, are described in which the crosslinked polymers are formed from at least two polymer precursors, one of which is designed, upon degradation of the crosslinked polymer, to release the second polymer precursor in its original, unmodified chemical form. | 08-02-2012 |
20130156935 | Methods for Coating Medical Devices - Processes for coating medical devices are provided herein. The processes include heating a surface of the particles used to form the coating as the particles are being applied to the medical device. The resulting coating has improved adherence to the medical device, and does not require the use of solvents and/or water, obviating the need for any steps that otherwise might be required to remove these solvents and/or water. Sufficient adherence of the particles to the medical device may also occur without the need for heating the substrate used to form the medical device. | 06-20-2013 |
20130225857 | Crosslinked Polymers with the Crosslinker as Therapeutic for Sustained Release - Crosslinked polymers, methods for their preparation and use, are described in which the crosslinked polymers are formed from at least two polymer precursors, one of which is designed, upon degradation of the crosslinked polymer, to release the second polymer precursor in its original, unmodified chemical form. | 08-29-2013 |
20130296833 | BIODEGRADABLE OSMOTIC PUMP IMPLANT FOR DRUG DELIVERY - The present disclosure relates to a drug delivery device including a biodegradable housing and a hydrogel within the biodegradable housing. The housing, the hydrogel, or both, may include a bioactive agent. Also disclosed is a method of drug delivery including the steps of forming the biodegradable housing, in embodiments a hydrogel, suspending a bioactive agent in the hydrogel, and introducing a second hydrogel and/or precursors of a second hydrogel into the biodegradable housing. | 11-07-2013 |
20130323312 | Microspheres Including Oxidized Cellulose - A process for forming microspheres is disclosed. The process includes: forming a first plurality microspheres comprising at least one bioactive agent and modified cellulose; contacting the first plurality of microspheres with a solution of a biodegradable polymer to form a discontinuous phase liquid; contacting the discontinuous phase liquid with a continuous phase liquid to form an emulsion; and extracting a second plurality of microspheres from the emulsion, the second plurality of microspheres comprising the first plurality of microspheres. | 12-05-2013 |
20130323315 | Microspheres Including Oxidized Cellulose - A process for forming microspheres is disclosed. The process includes contacting a solvent with a modified cellulose to form a solution; contacting the modified cellulose solution with at least one bioactive agent to form a discontinuous phase liquid; contacting the discontinuous phase liquid with a continuous phase liquid to form an emulsion; and contacting the emulsion with a third phase liquid to extract the solvent from the emulsion, thereby forming a plurality of modified cellulose microspheres. | 12-05-2013 |
20130324910 | ABLATION DEVICE WITH DRUG DELIVERY COMPONENT AND BIOPSY TISSUE-SAMPLING COMPONENT - An ablation device includes a handle assembly, an ablation electrode extending from the handle assembly, and one or more delivery needles extending from the handle assembly. The ablation electrode includes an ablation needle. The ablation needle includes a distal end portion including a drug delivery port defined therethrough. The ablation device also includes and a biopsy tool extending from the handle assembly. | 12-05-2013 |
20130324911 | ABLATION DEVICE WITH DRUG DELIVERY COMPONENT - An ablation system includes a source of electrosurgical energy, a source of coolant fluid, and an ablation electrode assembly operatively connected to the source of electrosurgical energy and fluidly-coupled to the source of coolant fluid. The ablation electrode assembly includes a hub defining a chamber therein and one or more electrically-conductive ablation needles extending from the hub. The ablation system also includes one or more delivery needles extending from the hub. The one or more delivery needles are selectively moveable from a first position, wherein the distal end of the delivery needle is disposed proximal to the distal end portion of the ablation needle, to at least a second position, wherein at least the distal end of the delivery needle is disposed distally beyond the distal end portion of the ablation needle. | 12-05-2013 |
20140005375 | Medical Devices Based On Oxidized Cellulose | 01-02-2014 |
20140005376 | Dissolution of Oxidized Cellulose and Particle Preparation by Solvent and Non-Solvent Precipitation | 01-02-2014 |
20140005377 | Dissolution of Oxidized Cellulose and Particle Preparation by Dispersion and Neutralization | 01-02-2014 |
20140005378 | Dissolution of Oxidized Cellulose and Particle Preparation by Cross-Linking With Multivalent Cations | 01-02-2014 |
20140079790 | MULTI-ENCAPSULATED FORMULATIONS MADE WITH OXIDIZED CELLULOSE FOR IN-SITU REACTIONS - A microsphere and methods for forming the same are disclosed. The microsphere includes modified cellulose and at least one of precursors for is-situ polymerization or endothermic/exothermic reactions. | 03-20-2014 |
20140274944 | Sprayable Hemostat Using Soluble Oxidized Cellulose With Miniaturized Electrospray System And Method - An applicator for forming a film is disclosed. The applicator includes: a first extension tube coupled to a source of a modified cellulose solution; a shaft coupled to the first extension tube at a proximal end thereof, the shaft defining a first lumen in fluid communication with the first extension tube for transmission of the modified cellulose solution through the shaft; and an atomizer disposed at a distal end of the and configured to atomize the modified cellulose solution into a plurality of particles. | 09-18-2014 |
20140274945 | Resorbable Oxidized Cellulose Embolization Microspheres - A method for forming an embolism within a blood vessel is disclosed. The method includes including: implanting a plurality of oxidized cellulose microspheres into a lumen of a blood vessel to at least partially block the lumen. | 09-18-2014 |
20150065944 | DRUG-DELIVERY DEVICE FOR USE WITH ABLATION DEVICE - A drug-delivery device includes a body configured for attachment to a handle of an ablation device, a shaft portion defining a passageway therein, and a delivery lumen to provide for drug delivery to tissue. The body includes a proximal portion, a distal portion, and a contoured portion disposed therebetween. The contoured portion is configured for engagement with a contoured portion of the handle of the ablation device. The shaft portion includes a proximal end and a distal end. The proximal end of the shaft engages with an opening defined in the distal end of the body. The passageway of the shaft portion is configured to receive the delivery lumen slideably moveably therein. The delivery lumen includes a proximal portion and a distal portion. The drug-delivery device also includes a knob member coupled to the proximal portion of the delivery lumen. | 03-05-2015 |
20150065964 | DRUG-DELIVERY CANNULA ASSEMBLY - A drug-delivery cannula assembly includes a cannula housing adapted for receiving at least one obturator shaft of an obturator assembly therethrough, one or more cannulae, and a supply line coupled to the cannula housing. The cannula housing is adapted for receiving one or more obturator shafts of an obturator assembly therethrough. The one or more cannulae define a longitudinal axis and a passageway aligned with the longitudinal axis. The one or more cannulae each include a proximal end coupled to the cannula housing. The cannula housing is configured to fluidly-couple the one or more cannulae to a source of a drug delivery supply for supplying drugs via the supply line to the one or more cannulae. | 03-05-2015 |