Qingyun
Qingyun Huang, Hefei CN
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20140046095 | Method of Preparing (S)-2-amino-5-Methoxytetralin Hydrochloride - A method of preparing (S)-2-amino-5-methoxytetralin hydrochloride[(S)-2-amino-5-methoxyl-1,2,3,4-tetrahydronaphthalene hydrochloride], comprising the steps of: (1) producing a compound (I) by addition-elimination reaction of 5-methoxy-2-tetralone and R-(+)-a-phenylethylamine; (2) producing a compound (II) by reduction reaction of the compound (I) with a reducing agent; and (3) producing a compound (II) hydrochloride by reacting the compound (II) with a salt-forming agent, then carrying out reduction reaction with a palladium-carbon catalyst to produce (S)-2-amino-5-methoxytetralin hydrochloride. The method can significantly increase the yield of (S)-2-amino-5-methoxytetralin hydrochloride with short synthetic path, low preparation cost and less pollution, which is environmentally friendly and is suitable for medical industrialized production. The structural formulae of the compound (I) and the compound (II) are: | 02-13-2014 |
20140296517 | L-Setastine Hydrochloride and Preparation Method Thereof - The present invention relates to the field of medicine, and disclosed are an L-setastine hydrochloride and a preparation method therefor. The compound of the present invention has the advantages of stronger histamine Hi receptor antagonism and small side effect; the yield of the preparation method is more than 80%, and the product purity is high. The present invention also provides an application of the compound as an H1 histamine receptor antagonist. | 10-02-2014 |
Qingyun Lin, The Woodlands, TX US
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20130143227 | REGULATION OF WNT/BETA-CATENIN SIGNALING - A composition and method for detecting the ability of a compound to modulate the activity of LGR4, LGR5, or LGR6 receptors in a cell. LGR4, LGR5, and LGR6 are capable of activating the Wnt/β-catenin signaling system which plays essential roles in embryonic development and in the self-renewal and maintenance of adult stem cells. | 06-06-2013 |
Qingyun Ren, Dongguan CN
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20140147412 | SPIRO COMPOUNDS AS HEPATITIS C VIRUS INHIBITORS - Disclosed are spiro compounds of formula (I), or stereomers, geometric isomers, tautomers, nitrogen oxides, hydrates, solvates, metabolites, pharmaceutically acceptable salts or prodrugs thereof. The compounds can be used to treat hepatitis C virus (HCV) infection or hepatitis C disease. Furthermore disclosed are pharmaceutical compositions containing the compounds and the method of using the compounds or pharmaceutical compositions in the treatment of HCV infection or hepatitis C disease. | 05-29-2014 |
20150079028 | Bridged Ring compounds As Hepatitis C Virus (HCV) Inhibitors And Pharmaceutical Applications Thereof - Provided herein is a compound having Formula (I), or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, which can be used for treating HCV infection or a HCV disorder. Also provided herein are pharmaceutical compositions comprising the compounds disclosed herein, which can be used for treating HCV infection or a HCV disorder. | 03-19-2015 |
20150152096 | DIHYDROPYRIMIDINE COMPOUNDS AND THEIR APPLICATION IN PHARMACEUTICALS - Provided herein are dihydropyrimidine compounds and their pharmaceutical applications, especially for use in treating and preventing HBV diseases. Specifically, provided herein are compounds having Formula (I) or (Ia), or an enantiomer, a diastereoisomer, a tautomer, a hydrate, a solvate, or a pharmaceutically acceptable salt thereof, wherein the variables of the formulas are as defined in the specification. Also provided herein is the use of the compounds having Formula (I) or (Ia), or an enantiomer, a diastereoisomer, a tautomer, a hydrate, a solvate, or a pharmaceutically acceptable salt thereof for treating and preventing HBV diseases. | 06-04-2015 |
20150232509 | SPIRO RING COMPOUNDS AS HEPATITIS C VIRUS (HCV) INHIBITORS - A compound of formula (I) or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof is provided, which can be used for treating HCV infection or a HCV disorder. Also a pharmaceutical composition comprising the compound and the use of the compound and the pharmaceutical composition thereof are provided, which can also be used for treating HCV infection or a HCV disorder. | 08-20-2015 |
20150239877 | CRYSTALLINE FORMS OF DIHYDROPYRIMIDINE DERIVATIVES - The present invention relates to crystalline forms of dihydropyrimidine derivatives, and pharmaceutical compositions comprising the crystalline forms disclosed herein, which may be used for preventing, managing, treating or lessening the severity of a viral disease in a patient, especially hepatitis B infection or a disease caused by hepatitis B infection. | 08-27-2015 |
20150299215 | SPIRO RING COMPOUND AS HEPATITIS C VIRUS (HCV) INHIBITOR AND USES THEREOF - A compound of formula (I) or a stereoisomer, a geometric isomer. a tautomer, an N-oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof is provided, which can be used for treating HCV infection or a HCV disorder. Also a pharmaceutical composition comprising the compound and the use of the compound and the pharmaceutical composition thereof are provided, which can also be used for treating HCV infection or a HCV disorder. | 10-22-2015 |
20150307509 | FUSED RING COMPOUNDS AS HEPATITIS C VIRUS INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF - Provided are fused tricyclic compounds effective to inhibit the function of the NS5A protein of formula (I), wherein X, X′, Y, Y′, A, A′, Q | 10-29-2015 |
Qingyun Xie, Bedford, NH US
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20140250060 | IMPLEMENTING A MULTI-COLUMN/MULTI-ROW CONSTRAINT IN A RELATIONAL DATABASE TABLE - A method, system, and computer program product for implementing a multi-column/multi-row constraint. Lock techniques prevent access collisions even when two or more concurrently running software applications are attempting to insert rows into the same relational database table (subject to the same multi-column/multi-row constraints). The method commences by receiving (e.g., from a first process) a first row to be inserted into a relational database table where the row comprises at least two constrained columns corresponding to the multi-column/multi-row constraint, then receiving (e.g., from a second process) a second row to be inserted into the same table. Using column locks, the method recognizes the potential for conflicting row insertions, and manages locks to prevent conflicting access grants to the two constrained columns of the existing database table. The evaluation of the multi-column/multi-row constraint is performed over the first row to be inserted and a row or rows of the relational database table. | 09-04-2014 |
20140270478 | IMAGE MOSAICKING USING A VIRTUAL GRID - Systems, methods, and other embodiments associated with generating a mosaic image using a virtual grid are described. In one embodiment, a method includes analyzing, by a processor of an apparatus, a boundary of a requested image to determine source images that collectively form an area that includes the requested image. The method also includes generating, by the processor, a virtual grid from coordinates of the source images by identifying edges of the source images from the coordinates to define rows and columns of the virtual grid within the boundary. The rows and columns of the virtual grid define virtual tiles in the virtual grid. | 09-18-2014 |
Qingyun Yan, Benxi CN
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20150122147 | COLORING SOLUTION FOR DENTAL ZIRCONIA CERAMICS AND METHOD FOR USING THE SAME - A coloring solution for dental zirconia ceramics and a method for using the same are provided. The coloring solution consists of coloring agents, a solvent, and an additive. The coloring agents are a combination of two or more rare earth metal compounds, wherein the rare earth metal compounds having rare earth metal ions selected from the group consisting of praseodymium (Pr) ions, erbium (Er) ions, cerium (Ce) ions, and neodymium (Nd) ions. The concentration of the rare earth metal ions in the solution is 0.05˜3 mol/liter solvent. The molar ratio of Pr ions:Er ions:Ce ions:Nd ions in the solution is 1:(10˜50):(0˜20):(0˜30). | 05-07-2015 |
Qingyun Yan, Benxi City CN
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20130115365 | METHOD OF CHANGING TRANSLUCENT PROPERTIES OF ZIRCONIA DENTAL MATERIALS - The present invention relates to a method for changing translucency of zirconia dental materials through applying an yttrium or ytterbium salt solution onto a pre-sintered zirconia material by dipping or brush-coating. Accordingly, the need of young patient in relation to the translucent requirement for incisal portion of anterior teeth is met in which the translucent level from the crown neck to the incisal portion is gradually changed in a natural manner, similar to natural teeth. A color gradient effect of the crown is produced through dipping in or brush-coating with yttrium or ytterbium salt solution. Moreover, the present invention involves simple operating steps and low cost while providing high consistency in quality. | 05-09-2013 |
Qingyun Yuan, Weihai CN
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20150323746 | A MULTI-FUNCTION CUTTING FIXTURE - The utility model relates to the technical field of optical fiber cutting device, and particularly relates to a kind of multi-function cutting fixture which is used to fix the optical fiber in cutting process. The utility model of multi-function cutting fixture for the optical fiber cutting device includes the clamp body and the clamp cover. One side of the said clamp body is pivoted to the said clamp cover, and the other side of the said clamp body is clamping connected to the said clamp cover. The said clamp body is equipped at least with No.1 fiber placing groove, No.2 fiber placing groove and No.3 fiber placing groove. The said clamp cover is equipped with the elastomer that contacts with the said No.1 fiber placing groove, and No.1 contact structure that contacts with the said No.2 fiber placing groove. The said No.1 contact structure is equipped with a convex body that contacts with the said No.3 fiber placing groove. Compared with the prior art, the utility model of multi-function cutting fixture can hold a variety of types of optical fiber. When holding different types of optical fiber, we do not need to change the fixture. The work efficiency is improved greatly. | 11-12-2015 |
Qingyun Zhang, Beijing CN
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20120148589 | HUMAN CANCER-RELATED GENE, ITS ENCODED PRODUCTS AND APPLICATIONS - The invention discloses a human cancer-related gene, LAPTM4B, its encoded products and their applications thereof. This human cancer-related gene provided by this invention comprises one of the following nucleotide sequences: (1) SEQ ID No: 1, SEQ ID No: 2, SEQ ID No: 3, SEQ ID No: 6, or SEQ ID No: 8 in the sequence listings; (2) SEQ ID No: 4, SEQ ID No: 5, or SEQ ID No: 7 in the sequence listings which are proteins encoded by the polynucleotides in sequences of SEQ ID No: 1, SEQ ID No: 2, SEQ ID No: 3 and SEQ ID No: 6. (3) Applications of the polynucleotides and polypeptides in the listings in diagnosis and treatments of cancer. This invention enables the developments of new cancer diagnostic markers and new anti-cancer medicines. It would create a significant impact on human society. | 06-14-2012 |