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| 20100294776 | HIGH PRESSURE STORAGE DEVICE AND METHOD - A composite pressure vessel, comprising: a liner assembly, further comprising: a liner; at least one of a polar boss and a blind boss; and a shell, further comprising: at least one layer of a filament wrap continuously disposed around at least a substantial portion of the liner assembly, wherein the liner assembly and the filament wrap combined have a non-homogenous support profile; and at least one fiber segment locally disposed on an area of the liner assembly and the at least one layer of a filament wrap that may be more susceptible to rupture than other areas of the liner assembly, according to the non-homogenous support profile. Complementary pairs of fiber segments and/or hoops may be configured to address a non-homogenous stress distribution profile of the composite pressure vessel. | 11-25-2010 |
| 20110087814 | Enhanced I/O Performance in a Multi-Processor System Via Interrupt Affinity Schemes - Disclosed herein is a method for improving Input/Output (I/O) performance in a host system having multiple CPUs. Under this method, various interrupt affinity schemes are provided, which associate multiple processors, interrupts, and I/O channels for sending the interrupts, thereby allowing the interrupts to be almost evenly loaded among the multiple I/O channels and processors. Also, data locality (“warm cache”) can be achieved through the interrupt affinity schemes that associate each interrupt to its source processor, namely, the processor originating the I/O request that results in the interrupt. | 04-14-2011 |
| 20140082244 | Enhanced I/O Performance in a Multi-Processor System Via Interrupt Affinity Schemes - Disclosed herein is a method for improving Input/Output (I/O) performance in a host system having multiple CPUs. Under this method, various interrupt affinity schemes are provided, which associate multiple processors, interrupts, and I/O channels for sending the interrupts, thereby allowing the interrupts to be almost evenly loaded among the multiple I/O channels and processors. Also, data locality (“warm cache”) can be achieved through the interrupt affinity schemes that associate each interrupt to its source processor, namely, the processor originating the I/O request that results in the interrupt. | 03-20-2014 |
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| 20100143721 | POROUS METAL OXIDE PARTICLES AND THEIR METHODS OF SYNTHESIS - Methods are generally disclosed for synthesis of porous particles from a solution formed from a leaving agent, a surfactant, and a soluble metal salt in a solvent. The surfactant congregates to form a nanoparticle core such that the metal salt forms about the nanoparticle core to form a plurality of nanoparticles. The solution is heated such that the leaving agent forms gas bubbles in the solution, and the plurality of nanoparticles congregate about the gas bubbles to form a porous particle. The porous particles are also generally disclosed and can include a particle shell formed about a core to define an average diameter from about 0.5 μm to about 50 μm. The particle shell can be formed from a plurality of nanoparticles having an average diameter of from about 1 nm to about 50 nm and defined by a metal salt formed about a surfactant core. | 06-10-2010 |
| 20110081596 | Novel Electrode Design for Low Temperature Direct-Hydrocarbon Solid Oxide Fuel Cells - In certain embodiments of the present disclosure, a solid oxide fuel cell is described. The solid oxide fuel cell includes a hierarchically porous cathode support having an impregnated cobaltite cathode deposited thereon, an electrolyte, and an anode support. The anode support includes hydrocarbon oxidation catalyst deposited thereon, wherein the cathode support, electrolyte, and anode support are joined together and wherein the solid oxide fuel cell operates a temperature of 600° C. or less. | 04-07-2011 |
| 20110189582 | Mixed Ionic and Electronic Conductor Based on Sr2Fe2-x MoXO6 Perovskite - In accordance with the present disclosure, a method for fabricating a symmetrical solid oxide fuel cell is described. The method includes synthesizing a composition comprising perovskite and applying the composition on an electrolyte support to form both an anode and a cathode. | 08-04-2011 |
| 20130164536 | Porous Metal Oxide Particles and Their Methods of Synthesis - Methods are generally disclosed for synthesis of porous particles from a solution formed from a leaving agent, a surfactant, and a soluble metal salt in a solvent. The surfactant congregates to form a nanoparticle core such that the metal salt forms about the nanoparticle core to form a plurality of nanoparticles. The solution is heated such that the leaving agent forms gas bubbles in the solution, and the plurality of nanoparticles congregate about the gas bubbles to form a porous particle. The porous particles are also generally disclosed and can include a particle shell formed about a core to define an average diameter from about 0.5 μm to about 50 μm. The particle shell can be formed from a plurality of nanoparticles having an average diameter of from about 1 nm to about 50 nm and defined by a metal salt formed about a surfactant core. | 06-27-2013 |
| 20140287345 | Mixed Ionic and Electronic Conductor Based on Sr2Fe2-xMoxO6 Perovskite - In accordance with the present disclosure, a method for fabricating a symmetrical solid oxide fuel cell is described. The method includes synthesizing a composition comprising perovskite and applying the composition on an electrolyte support to form both an anode and a cathode. | 09-25-2014 |
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| 20080242847 | Position dependent recognition of GNN nucleotide triplets by zinc fingers - The specificity of binding of a zinc finger to a triplet or quadruplet nucleotide target subsite depends upon the location of the zinc finger in a multifinger protein and, hence, upon the location of its target subsite within a larger target sequence. The present disclosure provides zinc finger amino acid sequences for recognition of triplet target subsites having the nucleotide G in the 5′-most position of the subsite, that have been optimized with respect to the location of the subsite within the target site. Accordingly, the disclosure provides finger position-specific amino acid sequences for the recognition of GNN target subsites. This allows the construction of multi-finger zinc finger proteins with improved affinity and specificity for their target sequences, as well as enhanced biological activity. | 10-02-2008 |
| 20080281076 | IL-6 binding proteins - Polypeptides comprising monomer domains that bind to IL-6, or portions thereof, are provided. | 11-13-2008 |
| 20090305962 | IL-6 binding proteins - Polypeptides comprising monomer domains that bind to IL-6, or portions thereof, are provided. | 12-10-2009 |
| 20100093838 | REGULATION OF ANGIOGENESIS WITH ZINC FINGER PROTEINS - Provided herein are a variety of methods and compositions for regulating angiogenesis, such methods and compositions being useful in a variety of applications where modulation of vascular formation is useful, including, but not limited to, treatments for ischemia and wound healing. Certain of the methods and compositions accomplish this by using various zinc finger proteins that bind to particular target sites in one or more VEGF genes. Nucleic acids encoding the zinc finger proteins are also disclosed. Methods for modulating the expression of one or more VEGF genes with the zinc finger proteins and nucleic acids are also disclosed. Such methods can also be utilized in a variety of therapeutic applications that involve the regulation of endothelial cell growth. Pharmaceutical compositions including the zinc finger proteins or nucleic acids encoding them are also provided. | 04-15-2010 |
| 20100292167 | C-MET KINASE BINDING PROTEINS - Polypeptides comprising monomer domains that bind to c-MET, or portions thereof, are provided. | 11-18-2010 |
| 20130123484 | POSITION DEPENDENT RECOGNITION OF GNN NUCLEOTIDE TRIPLETS BY ZINC FINGERS - The specificity of binding of a zinc finger to a triplet or quadruplet nucleotide target subsite depends upon the location of the zinc finger in a multifinger protein and, hence, upon the location of its target subsite within a larger target sequence. The present disclosure provides zinc finger amino acid sequences for recognition of triplet target subsites having the nucleotide G in the 5′-most position of the subsite, that have been optimized with respect to the location of the subsite within the target site. Accordingly, the disclosure provides finger position-specific amino acid sequences for the recognition of GNN target subsites. This allows the construction of multi-finger zinc finger proteins with improved affinity and specificity for their target sequences, as well as enhanced biological activity. | 05-16-2013 |
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| 20090193319 | DATA BUS SYSTEM, ITS ENCODER/DECODER AND ENCODING/DECODING METHOD - The present application relates to a data bus system, its encoder/decoder and encoding/decoding method. The data bus encoder comprises: a bus-invert encoder for generating encoded data and invert-indication information by performing bus-invert encoding on data according to a predetermined bus-invert encoding scheme; a virtual bit-group generator for converting the invert-indication information into a virtual bit-group according to a predetermined code mapping; and an error-checking-and-correction encoder for generating an error-checking-and-correction code for a virtual word according to a predetermined error-checking-and-correction encoding scheme, wherein the number of error-checking bits is more than the number of error-correction bits at least by one in the predetermined error-checking-and-correction encoding scheme, the mapping is such that the Hamming distance between any possible value of the virtual bit-group and a reference virtual bit-group which cannot be converted into under the mapping is a fixed value, and not greater than the number of error-correction bits of the error-checking-and-correction encoding scheme, and the virtual word includes the data to be output, the virtual bit-group corresponding to the data, and at least one padding bit of a fixed value, which is configured as required by the error-checking-and-correction encoding scheme. | 07-30-2009 |
| 20090281363 | PROCESS FOR PRODUCING ETHYLENE FROM ETHANOL COMBINING THE CATALYTIC CONVERSION OF HYDROCARBONS - A process for producing ethylene from ethanol combining the catalytic conversion of hydrocarbons: an ethanol feedstock is contacted with a Y-zeolite containing catalyst to give a product stream, and a coked catalyst and an target product of ethylene are obtained after separating the reaction stream; a hydrocarbon feedstock is contacted with a Y-zeolite containing catalyst to give a product stream, a spent catalyst and an oil vapor are obtained after separating the reaction stream, and the oil vapor is further separated to give the products such as gas, gasoline and the like; a part or all of the coked catalyst and a part or all of the spent catalyst enter the regenerator for the coke-burning regeneration, and the regenerated catalyst is divided into two portions, wherein one portion returns to be contacted with the hydrocarbon feedstock, and the other portion, after cooling, returns to be contacted with ethanol feedstock. This process not only reasonably utilizes the excessive thermal energy of the hydrocarbon conversion, but also solves the problem of heat supply for the conversion of ethanol, thus ensuring the continuous catalytic conversion of ethanol and generating enormous economic benefits. For the catalytic conversion of the ethanol, the content of ethylene is 95 vol % or more in the gas product; and the conversion of ethylene is not less than 99%. For the catalytic conversion of the hydrocarbons, the yield for the light olefins increases slightly by at least 2 mol %. | 11-12-2009 |
| 20090300330 | DATA PROCESSING METHOD AND SYSTEM BASED ON PIPELINE - A data processing system and method are disclosed. The system comprises an instruction-fetch stage where an instruction is fetched and a specific instruction is input into decode stage; a decode stage where said specific instruction indicates that contents of a register in a register file are used as an index, and then, the register file pointed to by said index is accessed based on said index; an execution stage where an access result of said decode stage is received, and computations are implemented according to the access result of the decode stage. | 12-03-2009 |
| 20090318742 | PROCESS FOR COMBINING THE CATALYTIC CONVERSION OF ORGANIC OXYGENATES AND THE CATALYTIC CONVERSION OF HYDROCARBONS - A process for combining the catalytic conversion of organic oxygenates and the catalytic conversion of hydrocarbons: an organic oxygenate feedstock is contacted with a Y-zeolite containing catalyst to produce a reaction stream, and a coked catalyst and a product stream are obtained after separating the reaction stream; a hydrocarbon feedstock is contacted with a Y-zeolite containing catalyst to produce a reaction stream, a spent catalyst and a reaction oil vapor are obtained after separating the reaction stream, and the reaction oil vapor is further separated to give the products such as gas, gasoline and the like; a part or all of the coked catalyst and a part or all of the spent catalyst enter the regenerator for the coke-burning regeneration, and the regenerated catalyst is divided into two portions, wherein one portion returns to be contacted with the hydrocarbon feedstock, and the other portion, after cooling, returns to be contacted with the organic oxygenate feedstock. This process not only reasonably utilizes the excessive thermal energy of the hydrocarbon conversion, but also solves the problem of heat supply for the conversion of the organic oxygenate, thus ensuring the continuous catalytic conversion of the organic oxygenate. | 12-24-2009 |
| 20090323279 | LATCHING MECHANISMS FOR PORTABLE ELECTRONIC DEVICES - A latching mechanism ( | 12-31-2009 |
| 20100191508 | Detecting and Recording Performance Events in a Data Processing System - A method and apparatus in a data processing system. The apparatus includes a performance event record generation component for generating a performance event record according to the system clock for a performance event monitored in the data processing system and a performance event record storage component for storing the performance event record generated by the performance event record generation component. The method in a data processing system according to the present invention includes the steps of: generating a performance event record based on the system clock for a performance event monitored in the data processing system; storing the generated performance event record; and arbitrating the storage conflict when multiple performance event records are generated at the same time in the step of generating a performance event record, in order to determine the storage order of the performance event records. | 07-29-2010 |
| 20120144163 | DATA PROCESSING METHOD AND SYSTEM BASED ON PIPELINE - A data processing system and method are disclosed. The system comprises an instruction-fetch stage where an instruction is fetched and a specific instruction is input into decode stage; a decode stage where said specific instruction indicates that contents of a register in a register file are used as an index, and then, the register file pointed to by said index is accessed based on said index; an execution stage where an access result of said decode stage is received, and computations are implemented according to the access result of the decode stage. | 06-07-2012 |
| 20120204082 | DATA BUS SYSTEM, ITS ENCODER/DECODER AND ENCODING/DECODING METHOD - The present application relates to a data bus system, its encoder/decoder and encoding/decoding method. The data bus encoder comprises: a bus-invert encoder for generating encoded data and invert-indication information by performing bus-invert encoding on data according to a predetermined bus-invert encoding scheme; a virtual bit-group generator for converting the invert-indication information into a virtual bit-group according to a predetermined code mapping; and an error-checking-and-correction encoder for generating an error-checking-and-correction code for a virtual word according to a predetermined error-checking-and-correction encoding scheme, wherein the number of error-checking bits is more than the number of error-correction bits at least by one in the predetermined error-checking-and-correction encoding scheme, and the virtual word includes the data to be output, the virtual bit-group corresponding to the data, and at least one padding bit of a fixed value, which is configured as required by the error-checking-and-correction encoding scheme. | 08-09-2012 |
| 20130090269 | DENDRITIC COMB-SHAPED POLYMER THICKENING AGENT, PREPARATON OF THE SAME AND APPLICATION THEREOF - The present invention relates to a dendritic comb-shaped polymer thickening agent and preparation and application thereof; it is a copolymer obtained by copolymerization of monomer (A) and monomer (B). Monomer (A) is one or more water-soluble unsaturated monomers with olefin chain, and monomer (B) is at least one monomer with the following general structure: | 04-11-2013 |
| 20150043833 | IMAGE PROCESSING METHOD AND ELECTRONIC DEVICE - The embodiments of the present invention provide an image processing method and an electronic device. The method comprises: obtaining all image characteristics contained in each of N captured images and determining at least one image characteristic from the all image characteristics; searching the N images for at least two images each containing the at least one image characteristic based on the at least one image characteristic; determining a reference image from the at least two images and obtaining image residue information characterizing an image difference parameter between the reference image and each of the at least two images; and applying data compression to the reference image and the image residue information. In this way, it is possible to solve the problem associated with limited image compression scheme and large space occupation by pictures. | 02-12-2015 |
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| 20090087839 | LONG DISTANCE POLYMERASE CHAIN REACTION-BASED ASSAY FOR DETECTING CHROMOSOMAL REARRANGEMENTS - Methods are presented for determining the presence of an inversion in the factor VIII gene which cause hemophilia A. The methods encompass long distance, multiplex PCR (including overlapping PCR). The use of deaza-dGTP, high levels of DNA polymerases and high levels of DMSO aid in successfully performing the PCR. The use of a novel technique called subcycling PCR can also be applied as part of the methods. The technique allows for the determination of whether a person is homozygous or hemizygous for the inversion and has hemophilia A or whether a person is heterozygous for the inversion and is a carrier. The technique of long distance, multiplex PCR including use of deaza-dGTP, high levels of DNA polymerases and high levels of DMSO are applicable to the determination of the presence of other gross chromosomal aberrations such as deletions/inversions, translocations and inversions. The use of subcycling PCR can achieve efficient and more even amplification than normal two or three temperature PCR and is applicable to long distance, multiplex PCR. | 04-02-2009 |
| 20090239283 | PYROPHOSPHOROLYSIS ACTIVATED POLYMERIZATION (PAP) - A novel method of pyrophosphorolysis activated polymerization (PAP) has been developed. In PAP, pyrophosphorolysis and polymerization by DNA polymerase are coupled serially for each amplification by using an activatable oligonucleotide P* that has a non-extendible 3′-deoxynucleotide at its 3′ terminus. PAP can be applied for exponential amplification or for linear amplification. PAP can be applied to amplification of a rare allele in admixture with one or more wild-type alleles by using an activatable oligonucleotide P* that is an exact match at its 3′ end for the rare allele but has a mismatch at or near its 3′ terminus for the wild-type allele. PAP is inhibited by a mismatch in the 3′ specific sequence as far as 16 nucleotides away from the 3′ terminus. PAP can greatly increase the specificity of detection of an extremely rare mutant allele in the presence of the wild-type allele. Specificity results from both pyrophosphorolysis and polymerization since significant nonspecific amplification requires the combination of mismatch pyrophosphorolysis and misincorporation by the DNA polymerase, an extremely rare event. Using genetically engineered DNA polymerases greatly improves the efficiency of PAP. | 09-24-2009 |
| 20100129871 | PYROPHOSPHOROLYSIS ACTIVATED POLYMERIZATION (PAP) - A novel method of pyrophosphorolysis activated polymerization (PAP) has been developed. In PAP, pyrophosphorolysis and polymerization by DNA polymerase are coupled serially for each amplification by using an activatable oligonucleotide P* that has a non-extendible 3′-deoxynucleotide at its 3′ terminus. PAP can be applied for exponential amplification or for linear amplification. PAP can be applied to amplification of a rare allele in admixture with one or more wild-type alleles by using an activatable oligonucleotide P* that is an exact match at its 3′ end for the rare allele but has a mismatch at or near its 3′ terminus for the wild-type allele. PAP is inhibited by a mismatch in the 3′ specific sequence as far as 16 nucleotides away from the 3′ terminus. PAP can greatly increase the specificity of detection of an extremely rare mutant allele in the presence of the wild-type allele. Specificity results from both pyrophosphorolysis and polymerization since significant nonspecific amplification requires the combination of mismatch pyrophosphorolysis and misincorporation by the DNA polymerase, an extremely rare event. Using genetically engineered DNA polymerases greatly improves the efficiency of PAP. | 05-27-2010 |
| 20110124051 | PYROPHOSPHOROLYSIS ACTIVATED POLYMERIZATION (PAP) - A novel method of pyrophosphorolysis activated polymerization (PAP) has been developed. In PAP, pyrophosphorolysis and polymerization by DNA polymerase are coupled serially for each amplification by using an activatable oligonucleotide P* that has a non-extendible 3′-deoxynucleotide at its 3′ terminus. PAP can be applied for exponential amplification or for linear amplification. PAP can be applied to amplification of a rare allele in admixture with one or more wild-type alleles by using an activatable oligonucleotide P* that is an exact match at its 3′ end for the rare allele but has a mismatch at or near its 3′ terminus for the wild-type allele. PAP is inhibited by a mismatch in the 3′ specific sequence as far as 16 nucleotides away from the 3′ terminus. PAP can greatly increase the specificity of detection of an extremely rare mutant allele in the presence of the wild-type allele. Specificity results from both pyrophosphorolysis and polymerization since significant nonspecific amplification requires the combination of mismatch pyrophosphorolysis and misincorporation by the DNA polymerase, an extremely rare event. Using genetically engineered DNA polymerases greatly improves the efficiency of PAP. | 05-26-2011 |
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| 20110262920 | METHODS FOR PREDICTING SURVIVAL IN CANCER PATIENTS - A method for survival prediction in cancer patients is provided. In one embodiment, the survival prediction is determined by the presence or absence of KRAS gene region deletion and/or loss of Chromosome 12 (Ch. 12) in cancer tumor tissue. In another embodiment, the presence or absence of KRAS gene region deletion and/or loss of Ch. 12 in cancer tumor tissue is used to predict survival in non-small-cell lung cancer (NSCLC) patients. | 10-27-2011 |
| 20140179908 | Chromatography column and method for isolating nucleic acid - The present invention provides a chromatography column and a method for isolating nucleic acid molecules. In one embodiment, the present invention provides a double-layer column of a first anion exchange membrane and a second serially coupled silica membrane. Upon flowing a nucleic acid-containing solution through the first anion exchange membrane, the nucleic acid binds to and then elutes from the first membrane. The eluted solution then flows serially through the second silica membrane, which the nucleic acid binds to and then elutes from. Due to this novel serial coupled double-layer principle, the present invention is particularly suitable for co-isolating RNA and DNA, for isolating nucleic acid embraced by proteins, e.g., viruses, and for isolating diluted nucleic acid in a large volume, e.g., plasma. In addition, the eluted nucleic acid is ready for downstream applications. | 06-26-2014 |
| 20140186840 | Pyrophosphorolysis-activated polymerization (PAP) using ribonucleic acid (RNA) template - A new method of RNA-PAP was developed that can directly amplify RNA template without additional treatment. RNA-PAP brings in a new mechanism for amplification of RNA template in which RNA-dependent DNA pyrophosphorolysis and RNA-dependent DNA polymerization are serially coupled using 3′ blocked primers. Due to this serial coupling, RNA-PAP has high selectivity against mismatches on the RNA template, providing highly specific amplification of RNA template. In addition, mutant polymerases were genetically engineered for higher efficiency of RNA-dependent DNA pyrophosphorolysis and RNA-dependent DNA polymerization. | 07-03-2014 |
| 20150126373 | ULTRA-HIGH SENSITIVE MONITORING OF EARLY TRANSPLANTATION FAILURE - The present invention provides a method for detecting transplantation failure of a transplanted organ or cells which comprises detecting a donor-positive but recipient-negative DNA marker in the recipient's plasma using pyrophosphorolysis activated polymerization. Because of the high sensitivity, specificity and selectivity of pyrophosphorolysis activated polymerization, transplantation failure can be detected at early stages and treatment can be initiate earlier. | 05-07-2015 |
| 20150299678 | Pyrophosphorolysis-activated polymerization (PAP) using ribonucleic acid (RNA) template - A new method of RNA-PAP was developed that can directly amplify RNA template without additional treatment. RNA-PAP brings in a new mechanism for amplification of RNA template in which RNA-dependent DNA pyrophosphorolysis and RNA-dependent DNA polymerization are serially coupled using 3′ blocked primers. Due to this serial coupling, RNA-PAP has high selectivity against mismatches on the RNA template, providing highly specific amplification of RNA template. In addition, mutant polymerases were genetically engineered for higher efficiency of RNA-dependent DNA pyrophosphorolysis and RNA-dependent DNA polymerization. | 10-22-2015 |
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| 20130290425 | METHOD FOR A CONNECTOR PROVIDING TRANSACTIONAL INTEROPERABILITY TO MULTIPLE MESSAGING PROVIDERS TO MULTIPLE APPLICATION SERVERS USING THE SAME IMPLEMENTATION - A system includes a resource adapter module in the form of executable code by a processor, the resource adapter module to, interact with an application running on an application server by receiving calls from applications, and provide communication between the application and any JMS provider by relaying the calls to the JMS provider. | 10-31-2013 |
| 20130290524 | SYSTEM AND METHOD FOR CLUSTERED TRANSACTIONAL INTEROPERABILITY OF MULTIPLE MESSAGING PROVIDERS USING A SINGLE CONNECTOR MECHANISM - A system has at least one requesting application residing upon a requesting application server, a cluster of processing message servers, a resource adapter in the form of executable code being executed by a processor on a first computer, the resource adapter to receive a request from the requesting application; transmit the request to the cluster of processing message servers; monitor processing of the request on the cluster of processing message servers; handling any exception in the processing of the request; and responding to the requesting application when the processing is complete. The system also includes an interposed transaction manager in the form of executable code being executed by a processor, the interposed transaction manager to receive transactional operations associated with the requests, and providing transaction guarantees related to the transactional operations. | 10-31-2013 |
| 20130290983 | SYSTEM AND METHOD FOR CLUSTERED TRANSACTIONAL INTEROPERABILITY OF PROPRIETARY NON-STANDARD FEATURES OF A MESSAGING PROVIDER USING A CONNECTOR MECHANISM - A computer-controlled method of handling proprietary features in a messaging system includes receiving an object from a requesting application, determining that the object invokes proprietary features of a messaging system, accessing a wrapper library and wrapping the object in an appropriate wrapper for the messaging system to produce a wrapped object, the wrapper to preserve the proprietary feature, and transmitting the wrapped object to the messaging system. | 10-31-2013 |
