Patent application number | Description | Published |
20080204760 | Swept wavelength imaging optical interrogation system and method for using same - A swept wavelength imaging optical interrogation system and a method for using the same to interrogate one or more biosensors are described herein. The swept wavelength imaging optical interrogation system is built upon a swept wavelength optical interrogation technology where a 2-D label free image is extracted from a series of high speed spectral images of the biosensor(s) without the need of performing mechanical scanning. | 08-28-2008 |
20080207466 | System for high throughput GPCR functional assay - A functional assay detection system for membrane bound proteins. The system comprises a biological array including a porous substrate having a plurality of membranes adhered thereto and a first side and a second side, a fluorescent labeling reagent configured to couple to the membrane bound proteins, a pulsed light assembly configured to excite the fluorescent labeling reagent, and a time-delayed imaging device configured to capture emitted fluorescence of the fluorescent labeling reagent. The pulsed light assembly is configured to excite the fluorescent labeling reagent from at least one of the first side and the second side of the porous substrate, and the fluorescent labeling reagent comprises a fluorophore that has an emission lifetime that is in the range of microseconds. | 08-28-2008 |
20090085254 | Laser scoring with flat profile beam - Disclosed are systems and methods for scoring glass sheets. A laser beam can be generated having a substantially uniform peak energy density along at least a portion of its length. The laser beam is moved across the glass sheet to create a score line. Further, the glass sheet can be separated along the score line. In some aspects, the laser beam is bimodal and comprises approximately 60-70% TEM00 mode and approximately 30-40% TEM01* mode. | 04-02-2009 |
20090093013 | Single-Cell Label-Free Assay - The disclosure provides a system and method for characterizing a single live-cell response to a stimulus with a biosensor imaging system having cells immobilized on the biosensor at a resolution level of a single cell, as defined herein. | 04-09-2009 |
20090138205 | OPTIMIZED METHOD FOR LID BIOSENSOR RESONANCE DETECTION - An optical interrogation system is described herein that can interrogate a label-independent-detection (LID) biosensor and monitor a biological event on top of the biosensor without suffering from problematical parasitic reflections and/or problematical pixelation effects. In one embodiment, the optical interrogation system is capable of interrogating a biosensor and using a low pass filter algorithm to digitally remove problematic parasitic reflections contained in the spectrum of an optical resonance which makes it easier to determine whether or not a biological event occurred on the biosensor. In another embodiment, the optical interrogation system is capable of interrogating a biosensor and using an oversampling/smoothing algorithm to reduce oscillations in the estimated location of an optical resonance caused by the problematical pixelation effect which makes it easier to determine whether or not a biological event occurred on the biosensor. | 05-28-2009 |
20090219540 | OPTICAL INTERROGATION SYSTEM AND METHOD FOR USING SAME - An optical interrogation system and a method are described herein that enable the interrogation of one or more biosensors which can be located within the wells of a microplate. In one embodiment, the optical interrogation system has a tunable laser, N-fiber launches, N-lenses and N-detectors that are set-up to interrogate N-biosensors. In another embodiment, the optical interrogation system has a tunable laser, N-fiber launches, N+1 lenses and N-detectors that are set-up to interrogate N-biosensors. | 09-03-2009 |
20090272149 | LASER SCORING WITH CURVED TRAJECTORY - Disclosed are systems and methods for scoring and separating a glass sheet along a curved trajectory using a laser and optics. The system includes a laser that generates a laser beam, a focusing lens, and a conical optical component such as a conical lens or a reflective conical milTor. The laser directs the laser beam through the focusing lens and conical lens to create a curved score line that is projected onto a glass sheet to create a curved score line, along which the glass sheet can be separated. Optionally, the laser directs the laser beam through the focusing lens towards a conical mirror, off of which the laser beam is reflected toward the glass sheet to create a curved score line. | 11-05-2009 |
20090294419 | Scoring of non-flat materials - Disclosed are systems for scoring non-flat materials including non-flat glass sheets ( | 12-03-2009 |
20090325211 | System and method for dual-detection of a cellular response - A system and method as defined herein for dual-detection of evanescent-wave label-free light and evanescent-wave excited-fluorescent label-emitted light in an optical biosensor. | 12-31-2009 |
20100105148 | MULTI-CHANNEL SWEPT WAVELENGTH OPTICAL INTERROGATION SYSTEM AND METHOD FOR USING SAME - A multi-channel swept wavelength optical interrogation system and a method are described herein that enable the interrogation of one or more biosensors which for example could be located within the wells of a microplate. In one embodiment, the optical interrogation system comprises: (a) a tunable laser that emits an optical beam which has a predetermined sequence of distinct wavelengths over a predetermined time period; (b) a distribution unit that splits the optical beam into a plurality of interrogation beams; (c) an array of optical interrogation units that receive and direct the interrogation beams towards an array of biosensors; (d) the array of optical interrogation units receive a plurality of reflected interrogation beams from the array of biosensors; (e) a data processing device that receives and processes information associated with the reflected interrogation beams to determine for example whether or not there was a biochemical interaction on anyone of the biosensors. | 04-29-2010 |
20100129856 | Methods and Devices for Cell Signaling Under Pulse Stimulation - The disclosure provides a device for measuring cellular responses under controlled environments. The disclosure also provides an array of devices for measuring cellular responses under controlled environments. The disclosure also provides methods to study cell signaling using the devices. By using microfluidics, the disclosure enables study of cell signaling under well-defined environment conditions. Such capability can be used for differentiating long-acting ligands from short-acting ligands, for determining the kinetics of receptor resensitization and functional recovery of receptor signaling, and for differentiating the sensitivity of a cell type to laminar flow-induced stress force. Through combination with conventional static label-free cell assays, the full spectrum of a drug compound can be studied in details, thus creating a complete representation of its pharmacology acting on living cells. | 05-27-2010 |
20100296089 | WAVELENGTH TRACKER FOR SWEPT WAVELENGTH SENSOR INTERROGATION SYSTEM - A swept wavelength interrogation system includes a tunable light source for outputting a light beam that is tunable over a range of wavelengths and an optical reader head for distributing the light beam among a plurality of sensors and for measuring response spectra from the sensors. A wavelength-tracking device measures centroid wavelengths of the light beam. A processor calculates a centroid wavelength of the response spectra from the sensors based on the measured centroid wavelengths of the light beam. | 11-25-2010 |
20110109909 | Tunable Light Source For Label-Independent Optical Reader - A tunable light source for interrogating at least one resonant waveguide grating (RWG) biosensor having a resonance linewidth. The tunable light source includes a broadband light source that emits a light beam having a first spectral bandwidth greater than the RWG biosensor resonance linewidth. The broadband light source may be substantially spatially incoherent. A tunable optical filter having a tunable spectral linewidth is arranged to receive and filter the light beam to cause the light beam to have a second spectral bandwidth substantially the same as the RWG biosensor resonance linewidth. Label-independent optical readers that employ the tunable light source are also disclosed. | 05-12-2011 |
20110205422 | HIGH RESOLUTION LABEL FREE IMAGING - An apparatus having an optical reader system and method for label-independent detection having improved spatial resolution of the reader, as defined herein. The system includes an optical configuration for interrogating a sensor on a microplate at an incident angle (θ | 08-25-2011 |
20110238382 | OPTIMIZED METHOD FOR LID BIOSENSOR RESONANCE DETECTION - An optical interrogation system is described herein that can interrogate a label-independent-detection (LID) biosensor and monitor a biological event on top of the biosensor without suffering from problematical parasitic reflections and/or problematical pixelation effects. | 09-29-2011 |
20120000894 | PRECISION LASER SCORING - Method and apparatus for laser scoring a sheet material. An elongated laser beam having S-mode intensity profile in the width direction and a flat-top-mode profile in the length direction is used to achieve high precision scoring. The invention can be used for scoring large-size glass substrates for LCD displays. | 01-05-2012 |
20120064519 | SYSTEM AND METHOD FOR DUAL-DETECTION OF A CELLULAR RESPONSE - A system and method as defined herein for dual-detection of evanescent-wave label-free light and evanescent-wave excited-fluorescent label-emitted light in an optical biosensor. | 03-15-2012 |
20120274820 | COMPACT LABEL FREE IMAGING SYSTEM - A compact microplate imaging system, including: a tunable light source; a lens ensemble to collimate the light source onto the microplate and to transmit light that is reflected from the microplate; a beam splitter to divert a portion of the reflected light; an imaging lens to collect diverted light and to produce an optical image of the at least one sensor of the microplate; and an image sensor for receiving the optical image of the at least one sensor of the microplate. A method for interrogating a sensor using the compact microplate imaging system, as further defined herein, is also disclosed. | 11-01-2012 |
20120301914 | High Resolution Label-Free Sensor - An optical sensor for label-independent detection, having improved spatial resolution and reduced angular sensitivity, the sensor including:
| 11-29-2012 |