Patent application number | Description | Published |
20100260733 | NOVEL ANTI AGING AGENTS AND METHODS TO IDENTIFY THEM - The present invention discloses novel mechanisms in the aging process and describes novel methods for high-throughput screening to identify, detect, and purify agents to be used for improving mitochondrial function, maintaining the cell cycle-arrested state in senescent and post mitotic cells, and thus preventing or treating age-related diseases or disorders associated with accelerated mitochondrial function loss, telomere dysfunction, and/or deterioration of the growth-arrested state. The present invention also discloses a number of compounds or compositions identified from this method. The present invention further provides the use of low doses of rapamycin or its analogs as a mimic of caloric restriction in preventing age-related diseases or disorders. | 10-14-2010 |
20120071349 | NOVEL ANTI-AGING AGENTS AND METHODS TO IDENTIFY THEM - The present invention discloses novel mechanisms in the aging process and describes novel methods for high-throughput screening to identify, detect, and purify agents to be used for improving mitochondrial function, maintaining the cell cycle-arrested state in senescent and post mitotic cells, and thus preventing or treating age-related diseases or disorders associated with accelerated mitochondrial function loss, telomere dysfunction, and/or deterioration of the growth-arrested state. The present invention also discloses a number of compounds or compositions identified from this method. The present invention further provides the use of low doses of rapamycin or its analogs as a mimic of caloric restriction in preventing age-related diseases or disorders. | 03-22-2012 |
Patent application number | Description | Published |
20090258884 | Substituted amides - Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as centrally acting drugs in the treatment of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, movement disorders, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, the treatment of obesity or eating disorders, as well as the treatment of asthma, constipation, chronic intestinal pseudo-obstruction, and cirrhosis of the liver. | 10-15-2009 |
Patent application number | Description | Published |
20080287506 | Insecticidal N,N-Di(Heteroarylalkyl) Amine Derivatives - Certain novel N,N-di(heteroarylalkyl)amine derivatives have provided unexpected insecticidal and acaricidal activity. These compounds are represented by formula (I): wherein Ar Ar | 11-20-2008 |
20100125065 | CARBOLINE DERIVATIVES USEFUL IN THE INHIBITION OF ANGIOGENESIS - In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the inhibition of angiogenesis, and/or in the treatment of cancer, diabetic retinopathy or exudative macular degeneration are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the inhibition of angiogenesis, and/or the treatment of cancer, diabetic retinopathy or exudative macular degeneration using the compounds of the invention. | 05-20-2010 |
20100179132 | CARBOLINE DERIVATIVES USEFUL IN THE INHIBITION OF ANGIOGENESIS - In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the treatment of solid tumor cancer, and in reducing plasma and/or tumor VEGF levels, are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the treatment of cancer, and the reduction of plasma and/or tumor VEGF levels, using the compounds of the invention. | 07-15-2010 |
20110160190 | CARBOLINE DERIVATIVES USEFUL IN THE INHIBITION OF ANGIOGENESIS - In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the treatment of solid tumor cancer, and in reducing plasma and/or tumor VEGF levels, are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the treatment of cancer, and the reduction of plasma and/or tumor VEGF levels, using the compounds of the invention. | 06-30-2011 |
20120136154 | PROCESSES FOR THE PREPARATION OF SUBSTITUTED TETRAHYDRO BETA-CARBOLINES - Provided herein are improved processes for the synthesis of substituted tetrahydro beta-carboline derivatives. In particular, provided herein are improved processes useful for the preparation of (S)-4-chlorophenyl 6-chloro-1-(4-methoxyphenyl)-3,4-dihydro-1H-pyrido[3,4- | 05-31-2012 |
20120202763 | METHODS FOR TREATING CANCER AND NON-NEOPLASTIC CONDITIONS - Compounds that selectively inhibit pathological production of human vascular endothelial growth factor (VEGF) and compositions comprising such Compounds are described. Compounds that inhibit viral replication or the production of viral RNA or DNA or viral protein and compositions comprising such Compounds are described. Also described are methods of reducing VEGF using such Compounds and methods for treating cancer and non-neoplastic conditions involving the administration of such Compounds. Further described are methods of inhibiting viral replication or the production of viral RNA or DNA or viral protein using such Compounds and methods for treating viral infections involving the administration of such Compounds. The Compounds may be administered as a single agent therapy or in combination with one or more additional therapies to a human in need of such treatments. | 08-09-2012 |
20150038437 | ANTIBACTERIAL COMPOUNDS AND METHODS FOR USE - The present description relates to compounds and forms and pharmaceutical compositions thereof and methods for use thereof to treat or ameliorate bacterial infections caused by wild-type and multi-drug resistant Gram-negative and Gram-positive pathogens. | 02-05-2015 |
20150080362 | ANTIBACTERIAL COMPOUNDS AND METHODS FOR USE - The present description relates to compounds and forms and pharmaceutical compositions thereof and methods for use thereof to treat or ameliorate bacterial infections caused by wild-type and multi-drug resistant Gram-negative and Gram-positive pathogens. | 03-19-2015 |
20150080383 | COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY - Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy. | 03-19-2015 |
Patent application number | Description | Published |
20080219376 | Methods and arrangements for communicating in a multiple input multiple output system - Systems and methods for utilizing new communication standards in wireless local area networks are provided that also support legacy wireless stations. The method can include user equipment determining channel state information, selecting a unitary channel decomposition precoder format based on the determined channel state information and transmitting the precoder format information to a base station. During a return transmission the user equipment can receive user data with the precoder format information and utilize a non-linear detector to demodulate and decode the user data. Based on the reception the user equipment can estimate channel quality; and transmitting channel quality information as feedback. | 09-11-2008 |
20110090996 | METHOD AND SYSTEM FOR INTERFERENCE SUPPRESSION IN WCDMA SYSTEMS - Aspects of a method and system for interference suppression in WCDMA systems may include one or more circuits that are operable to receive a plurality of multipath signals via one or more receiving antennas. A plurality of weighting factor values may be computed based on the received multipath signals. Estimated signals may be based on the weighting factor values. Residual signals may be generated based on received signals and the estimated signals. Addback signals may be generated based on the estimated signals and the residual signals. Updated estimated signals may be generated based on the addback signals and the weighting factor values. Incremental signals may be generated based on the updated estimated signals and addback signals. Updated residual signals may be generated based on the incremental signals and previous residual signals. The interference suppressed signals may be generated based on the updated residual signals and updated estimated signals. | 04-21-2011 |
20120307872 | METHOD AND SYSTEM FOR INTERFERENCE SUPPRESSION IN WCDMA SYSTEMS - Aspects of a method and system for interference suppression in WCDMA systems may include one or more circuits that are operable to receive a plurality of multipath signals via one or more receiving antennas. A plurality of weighting factor values may be computed based on the received multipath signals. Estimated signals may be based on the weighting factor values. Residual signals may be generated based on received signals and the estimated signals. Addback signals may be generated based on the estimated signals and the residual signals. Updated estimated signals may be generated based on the addback signals and the weighting factor values. Incremental signals may be generated based on the updated estimated signals and addback signals. Updated residual signals may be generated based on the incremental signals and previous residual signals. The interference suppressed signals may be generated based on the updated residual signals and updated estimated signals. | 12-06-2012 |
20130150112 | ENHANCED MULTIPLE SIM TIME TRACKING - A technique for time tracking helps a mobile communication device with multiple SIMs to more accurately maintain synchronization with a base station. By utilizing synchronization information from both SIMs, the technique is able to more frequently and more accurately adjust timing information for each SIM. As a result, the mobile communication device exhibits an increased ability to accurately synchronize without the need for a higher precision reference or increased power consumption. | 06-13-2013 |
Patent application number | Description | Published |
20110266529 | Remote doping of organic thin film transistors - Organic electronic devices comprising “remotely” doped materials comprising a combination of at least three layers. Such devices can include “remotely p-doped” structures comprising: a channel layer comprising at least one organic semiconductor channel material; a dopant layer, which comprises at least one p-dopant material and optionally at least one organic hole transport material; and a spacer layer disposed between and in electrical contact with both the channel layer and the dopant layer, comprising an organic semiconducting spacer material; or alternatively can include “remotely n-doped” structures comprising a combination of at least three layers: a channel layer comprising at least one organic semiconductor channel material; a dopant layer which comprises at least one organic electron transport material doped with an n-dopant material; and a spacer layer disposed between and in electrical contact with the channel layer and the dopant layer, comprising an organic semiconducting spacer material. Such devices include “remotely doped” field effect transistors comprising the doped structures described above. | 11-03-2011 |
20140231765 | REMOTE DOPING OF ORGANIC THIN FILM TRANSISTORS - Organic electronic devices comprising “remotely” doped materials comprising a combination of at least three layers. Such devices can include “remotely p-doped” structures comprising: a channel layer comprising at least one organic semiconductor channel material; a dopant layer, which comprises at least one p-dopant material and optionally at least one organic hole transport material; and a spacer layer disposed between and in electrical contact with both the channel layer and the dopant layer, comprising an organic semiconducting spacer material; or alternatively can include “remotely n-doped” structures comprising a combination of at least three layers: a channel layer comprising at least one organic semiconductor channel material; a dopant layer which comprises at least one organic electron transport material doped with an n-dopant material; and a spacer layer disposed between and in electrical contact with the channel layer and the dopant layer, comprising an organic semiconducting spacer material. Such devices include “remotely doped” field effect transistors comprising the doped structures described above. | 08-21-2014 |
20140302635 | N-DOPING OF ORGANIC SEMICONDUCTORS BY BIS-METALLOSANDWICH COMPOUNDS - The various inventions disclosed, described, and/or claimed herein relate to the field of methods for n-doping organic semiconductors with certain bis-metallosandwich compounds, the doped compositions produced, and the uses of the doped compositions in organic electronic devices. Metals can be manganese, rhenium, iron, ruthenium, osmium, rhodium, or iridium. Stable and efficient doping can be achieved. | 10-09-2014 |
Patent application number | Description | Published |
20110270604 | SYSTEMS AND METHODS FOR SEMI-SUPERVISED RELATIONSHIP EXTRACTION - Systems and methods are disclosed to perform relation extraction in text by applying a convolution strategy to determine a kernel between sentences; applying one or more semi-supervised strategies to the kernel to encode syntactic and semantic information to recover a relational pattern of interest; and applying a classifier to the kernel to identify the relational pattern of interest in the text in response to a query. | 11-03-2011 |
20120191632 | SYSTEM AND METHODS FOR FINDING HIDDEN TOPICS OF DOCUMENTS AND PREFERENCE RANKING DOCUMENTS - Systems and methods are disclosed to perform preference learning on a set of documents includes receiving raw input features from the set of documents stored on a data storage device; generating polynomial combinations from the raw input features; generating one or more parameters; applying the parameters to one or more classifiers to generate outputs; determining a loss function and parameter gradients and updating parameters determining one or more sparse regularizing terms and updating the parameters; and expressing that one document is preferred over another in a search query and retrieving one or more documents responsive to the search query. | 07-26-2012 |
20120253792 | Sentiment Classification Based on Supervised Latent N-Gram Analysis - A method for sentiment classification of a text document using high-order n-grams utilizes a multilevel embedding strategy to project n-grams into a low-dimensional latent semantic space where the projection parameters are trained in a supervised fashion together with the sentiment classification task. Using, for example, a deep convolutional neural network, the semantic embedding of n-grams, the bag-of-occurrence representation of text from n-grams, and the classification function from each review to the sentiment class are learned jointly in one unified discriminative framework. | 10-04-2012 |
20120310627 | DOCUMENT CLASSIFICATION WITH WEIGHTED SUPERVISED N-GRAM EMBEDDING - Methods and systems for document classification include embedding n-grams from an input text in a latent space, embedding the input text in the latent space based on the embedded n-grams and weighting said n-grams according to spatial evidence of the respective n-grams in the input text, classifying the document along one or more axes, and adjusting weights used to weight the n-grams based on the output of the classifying step. | 12-06-2012 |
20120323825 | SYSTEM AND METHODS FOR FINDING HIDDEN TOPICS OF DOCUMENTS AND PREFERENCE RANKING DOCUMENTS - Systems and methods are disclosed to perform preference learning on a set of documents includes receiving raw input features from the set of documents stored on a data storage device; generating polynomial combinations from the raw input features; generating one or more parameters; applying the parameters to one or more classifiers to generate outputs; determining a loss function and parameter gradients and updating parameters determining one or more sparse regularizing terms and updating the parameters; and expressing that one document is preferred over another in a search query and retrieving one or more documents responsive to the search query. | 12-20-2012 |
20130091081 | LATENT FACTOR DEENDENCY STRUCTURE DETERMINATION - Disclosed is a general learning framework for computer implementation that induces sparsity on the undirected graphical model imposed on the vector of latent factors. A latent factor model SLFA is disclosed as a matrix factorization problem with a special regularization term that encourages collaborative reconstruction. Advantageously, the model may simultaneously learn the lower-dimensional representation for data and model the pairwise relationships between latent factors explicitly. An on-line learning algorithm is disclosed to make the model amenable to large-scale learning problems. Experimental results on two synthetic data and two real-world data sets demonstrate that pairwise relationships and latent factors learned by the model provide a more structured way of exploring high-dimensional data, and the learned representations achieve the state-of-the-art classification performance | 04-11-2013 |
20130325786 | SPARSE HIGHER-ORDER MARKOV RANDOM FIELD - Systems and methods are provided for identifying combinatorial feature interactions, including capturing statistical dependencies between categorical variables, with the statistical dependencies being stored in a computer readable storage medium. A model is selected based on the statistical dependencies using a neighborhood estimation strategy, with the neighborhood estimation strategy including generating sets of arbitrarily high-order feature interactions using at least one rule forest and optimizing one or more likelihood functions. A damped mean-field approach is applied to the model to obtain parameters of a Markov random field (MRF); a sparse high-order semi-restricted MRF is produced by adding a hidden layer to the MRF; indirect long-range dependencies between feature groups are modeled using the sparse high-order semi-restricted MRF; and a combinatorial dependency structure between variables is output. | 12-05-2013 |
20140309122 | KNOWLEDGE-DRIVEN SPARSE LEARNING APPROACH TO IDENTIFYING INTERPRETABLE HIGH-ORDER FEATURE INTERACTIONS FOR SYSTEM OUTPUT PREDICTION - Systems and methods are disclosed for Knowledge-Driven Sparse Learning to Identify Interpretable High-Order Feature Interactions. This is done by generating one or more functional groups from gene features and gene and protein interaction grouping; selecting informative genes and functional interactions that exhibit differential patterns for the target disease and to generate a reduced feature space; and searching exhaustively on the reduced feature space by examining all possible pairs of interacting features (and possibly higher-order feature interactions) to identify combination of markers and complex patterns of feature interactions that are informative about the phenotypes in a sparse learning framework to select informative interactions and genes. | 10-16-2014 |