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| 20130095096 | NOVEL ANTI- ALPHA5BETA1 ANTIBODIES AND USES THEREOF - The present invention provides new anti-α5β1 antibodies, compositions and kits comprising the antibodies, and methods of making and using the antibodies. | 04-18-2013 |
| 20130336959 | Method to identify a patient with an increased likelihood of responding to an anti-cancer therapy - The invention provides methods for identifying patient who may benefit from treatment with an anti-cancer therapy comprising a VEGF antagonist. The invention also provides methods for monitoring a patients' response to the anti-cancer therapy. The invention also provides kits and articles of manufacture for use in the methods. | 12-19-2013 |
| 20130336960 | Method to identify a patient with an increased likelihood of responding to an anti-cancer therapy - The invention provides methods for identifying patient who may benefit from treatment with an anti-cancer therapy comprising a VEGF antagonist. The invention also provides methods for monitoring a patients' response to the anti-cancer therapy. The invention also provides kits and articles of manufacture for use in the methods. | 12-19-2013 |
| 20130344059 | Method to identify a patient with an increased likelihood of responding to an anti-cancer therapy - The invention provides methods for identifying patient who may benefit from treatment with an anti-cancer therapy comprising a VEGF antagonist. The invention also provides methods for monitoring a patients' response to the anti-cancer therapy. The invention also provides kits and articles of manufacture for use in the methods. | 12-26-2013 |
| 20140017231 | METHOD TO IDENTIFY A PATIENT WITH AN INCREASED LIKELIHOOD OF RESPONDING TO AN ANTI-CANCER THERAPY - The invention provides methods for identifying patient who may benefit from treatment with an anti-cancer therapy comprising a VEGF antagonist. The invention also provides methods for monitoring a patients' response to the anti-cancer therapy. The invention also provides kits and articles of manufacture for use in the methods. | 01-16-2014 |
| 20140017232 | METHOD TO IDENTIFY A PATIENT WITH AN INCREASED LIKELIHOOD OF RESPONDING TO AN ANTI-CANCER THERAPY - The invention provides methods for identifying patient who may benefit from treatment with an anti-cancer therapy comprising a VEGF antagonist. The invention also provides methods for monitoring a patients' response to the anti-cancer therapy. The invention also provides kits and articles of manufacture for use in the methods. | 01-16-2014 |
| 20140023639 | METHOD TO IDENTIFY A PATIENT WITH AN INCREASED LIKELIHOOD OF RESPONDING TO AN ANTI-CANCER THERAPY - The invention provides methods for identifying patient who may benefit from treatment with an anti-cancer therapy comprising a VEGF antagonist. The invention also provides methods for monitoring a patients' response to the anti-cancer therapy. The invention also provides kits and articles of manufacture for use in the methods. | 01-23-2014 |
| 20140056874 | METHOD TO IDENTIFY A PATEINT WITH AN INCREASED LIKELIHOOD OF RESPONDING TO AN ANTI-CANCER THERAPY - The invention provides methods for identifying patient who may benefit from treatment with an anti-cancer therapy comprising a VEGF antagonist. The invention also provides methods for monitoring a patients' response to the anti-cancer therapy. The invention also provides kits and articles of manufacture for use in the methods. | 02-27-2014 |
| 20140056875 | METHOD TO IDENTIFY A PATEINT WITH AN INCREASED LIKELIHOOD OF RESPONDING TO AN ANTI-CANCER THERAPY - The invention provides methods for identifying patient who may benefit from treatment with an anti-cancer therapy comprising a VEGF antagonist. The invention also provides methods for monitoring a patients' response to the anti-cancer therapy. The invention also provides kits and articles of manufacture for use in the methods. | 02-27-2014 |
| 20140193397 | METHOD TO IDENTIFY A PATIENT WITH AN INCREASED LIKELIHOOD OF RESPONDING TO AN ANTI-CANCER THERAPY - The invention provides methods for identifying patient who may benefit from treatment with an anti-cancer therapy comprising a VEGF antagonist. The invention also provides methods for monitoring a patients' response to the anti-cancer therapy. The invention also provides kits and articles of manufacture for use in the methods. | 07-10-2014 |
| 20140341893 | BLOOD PLASMA BIOMARKERS FOR BEVACIZUMAB COMBINATION THERAPIES FOR TREATMENT OF BREAST CANCER - The present invention provides methods for improving the treatment effect of a chemotherapy regimen of a patient suffering from HER2 positive breast cancer, in particular locally recurrent or metastatic HER2 positive breast cancer, by adding bevacizumab (Avastin®) to a chemotherapy regimen by determining the expression level, in particular the blood plasma expression level, of VEGFA and/or VEGFR2 relative to control levels of patients diagnosed with HER2 positive breast cancer, in particular locally recurrent or metastatic HER2 positive breast cancer. The present invention also provides for methods for assessing the sensitivity or responsiveness of a patient to bevacizumab (Avastin®) in combination with a chemotherapy regimen, by determining the expression level, in particular the blood plasma expression level, of VEGFA and/or VEGFR2 relative to control levels in patients diagnosed with HER2 positive breast cancer, in particular locally recurrent or metastatic HER2 positive breast cancer. | 11-20-2014 |
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| 20090181754 | GAMING SYSTEM AND A METHOD OF GAMING - A gaming system is disclosed which includes a display including a plurality of standard display positions and at least one additional display position. Each standard display position includes at least one visible standard symbol and each additional display position includes at least one visible additional symbol. An additional position selector is arranged to facilitate selection by a player of at least one additional display position. Selection of an additional display position causes an additional symbol displayed at the additional display position to be emphasized relative to when the additional display position is not selected. A symbol selector is arranged to select symbols for display at the standard display positions and at the at least one additional display position. An outcome generator is arranged to determine a game outcome based on symbols displayed at the standard display positions and the or each additional symbol displayed at any selected additional symbol position. | 07-16-2009 |
| 20090233694 | METHOD OF GAMING, A GAMING SYSTEM AND A GAME CONTROLLER - A method of gaming including: displaying to a player a potential award and an indicator having an indicator state when active during play of a game; changing the indicator state in response to play of the game; changing the potential award in response to play of the game; and awarding the potential award which is displayed when the indicator state is an award state. | 09-17-2009 |
| 20090305769 | GAMING MACHINE AND METHOD WITH AWARD-ENHANCING SYMBOLS - A gaming machine comprising a game controller that enhances a prize won from a game outcome when a first special symbol occurs in the game outcome. The appearance of the first special symbol in the game outcome causes the game controller to further enhance the game prize if a second special symbol also appears in the game outcome. The first or second special symbols may further be used to substitute for another symbol in the game outcome, so as to create a winning game outcome. | 12-10-2009 |
| 20120157184 | Gaming System and Method With Wager Variability - A gaming machine that provides a wagering game, including a user interface in communication with a game controller, through the operation of which a player selects one of a plurality of wager options that determine a number of symbols to be active and inactive in the wagering game. For at least one said wager option at least one, but not all of the plurality of symbols that define a possible said winning combination are rendered inactive for forming the winning combination. | 06-21-2012 |
| 20140087835 | Gaming System and Method With Wager Variability - A gaming machine that provides a wagering game, including a user interface in communication with a game controller, through the operation of which a player selects one of a plurality of wager options that determine a number of symbols to be active and inactive in the wagering game. For at least one said wager option at least one, but not all of the plurality of symbols that define a possible said winning combination are rendered inactive for forming the winning combination. | 03-27-2014 |
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| 20090155770 | IMPLANTABLE DEVICES FOR FIBER OPTIC BASED DETECTION OF NOSOCOMIAL INFECTION - Disclosed are methods and devices for continuous in vivo monitoring of a potential infection site. Disclosed devices may be utilized to alert patients and/or health care providers to the presence of a pathogen at an early stage of a hospital acquired infection, thereby providing for earlier intervention and improved recovery rates from bacterial infection. Disclosed methods utilize implantable devices for location at an in vivo site. The implantable device is held in conjunction with an optical fiber that detects and transmits an optically detectable signal generated in the presence of a pathogen. Upon generation of the emission, the optically detectable emission signal may be transmitted to a portable detection/analysis device. Analysis of the characteristics of the emission signal produced may be used to determine the presence or concentration of pathogens at the site of inquiry, following which real time information may be transmitted to medical personnel, for instance via a wireless transmission system. | 06-18-2009 |
| 20090156942 | Resonance Energy Transfer Based Detection of Nosocomial Infection - Disclosed herein are methods and devices for detection of hospital acquired infections. Disclosed methods may be utilized for continuous in vivo monitoring of a potential infection site or for periodic in vitro monitoring of tissue or fluid from a patient and may be utilized to alert patients and/or health care providers to the presence of a pathogen at an early stage of infection. Disclosed methods utilize fluorophore pairs that optically interact with one another according to Forster resonance energy transfer (FRET) or bioluminescence resonance energy transfer (BRET) mechanism. One member of the pair or a cofactor that interacts with an enzyme to form a member of the pair may be tethered to a device by a substrate that is specific for an enzyme expressed by a targeted pathogen. Upon interaction of the enzyme with the substrate, an optically detectable signal may be altered or initiated, detection of which may then provide information as to the existence of the pathogen at the site. | 06-18-2009 |
| 20090156943 | FIBER OPTIC BASED DETECTION OF AUTOFLUORESCENT BACTERIAL PATHOGENS - Disclosed are methods and devices for continuous in vivo monitoring of a potential bacterial infection site. Disclosed devices may be utilized to alert patients and/or health care providers to the presence of pathogenic bacteria at an early stage of a hospital acquired infection, thereby providing for earlier intervention and improved recovery rates from bacterial infection. Disclosed methods utilize optical fibers to deliver an excitation signal to an area in which pathogenic bacteria may exist. In the presence of the excitation signal, bacterial pathogens may autofluoresce with a unique spectral signature. Upon generation of a fluorescent emission, an optically detectable emission signal may be transmitted to a detection/analysis device. Analysis of the characteristics of the emission signal produced in response to the excitation signal may be used to determine the presence or concentration of pathogens at the site of inquiry, following which real time information may be transmitted to medical personnel via a wireless transmission system. | 06-18-2009 |
| 20120143024 | Recombinant Bacteriophage for Detection of Nosocomial Infection - Disclosed herein are methods and devices for detection of bacterial HAI. Disclosed methods may be utilized for continuous in vivo monitoring of a potential bacterial infection site and may be utilized to alert patients and/or health care providers to the presence of pathogenic bacteria at an early stage of infection. Disclosed methods include utilization of recombinant bacteriophage to deliver to pathogenic bacteria a translatable genetic sequence encoding an optically detectable marker or an enzyme capable of producing an optically detectable marker. Upon detection of the optical signal produced by the marker, medical personnel may be alerted to the presence of pathogenic bacteria at the site of inquiry. Any bacterial causative agent of HAI may be detected according to disclosed methods. | 06-07-2012 |
| 20120143027 | FIELD EFFECT TRANSISTORS FOR DETECTION OF NOSOCOMIAL INFECTION - Disclosed herein are methods and devices for detection of hospital acquired infections. Disclosed methods may be utilized for continuous in vivo monitoring of a potential infection site and may be utilized to alert patients and/or health care providers to changes in the local environment due to the presence of a pathogen at an early stage of infection. Disclosed methods utilize ion sensitive field effect transistors (ISFETs) to detect changes in ionic concentration at the site due to the presence of a pathogen, for instance at a surgical site. When a pathogen is present, the local ionic concentration, and hence the electrical characteristics of an ISFET may change, causing a detectable signal from the ISFET. An ISFET may be associated with a biological material such as an enzyme or a specific binding partner for an expression product of a pathogen to improve detection. Upon interaction of the expression product with the enzyme or the probe, the electrical characteristics of the ISFET may change, detection of which may then provide information as to the existence a pathogen at the site. | 06-07-2012 |
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| 20110270615 | GLOBAL SPEECH USER INTERFACE - A global speech user interface (GSUI) comprises an input system to receive a user's spoken command, a feedback system along with a set of feedback overlays to give the user information on the progress of his spoken requests, a set of visual cues on the television screen to help the user understand what he can say, a help system, and a model for navigation among applications. The interface is extensible to make it easy to add new applications. | 11-03-2011 |
| 20130211836 | GLOBAL SPEECH USER INTERFACE - A global speech user interface (GSUI) comprises an input system to receive a user's spoken command, a feedback system along with a set of feedback overlays to give the user information on the progress of his spoken requests, a set of visual cues on the television screen to help the user understand what he can say, a help system, and a model for navigation among applications. The interface is extensible to make it easy to add new applications. | 08-15-2013 |
| 20140019130 | GLOBAL SPEECH USER INTERFACE - A global speech user interface (GSUI) comprises an input system to receive a user's spoken command, a feedback system along with a set of feedback overlays to give the user information on the progress of his spoken requests, a set of visual cues on the television screen to help the user understand what he can say, a help system, and a model for navigation among applications. The interface is extensible to make it easy to add new applications. | 01-16-2014 |
| 20140094987 | TIERED LEVEL OF ACCESS TO A SET OF VEHICLES - An access control system allows a plurality of users various tiered levels of access to a set of vehicles, records driving information and the purposes that the vehicles are driven, and provides reports to a select subsets of users. | 04-03-2014 |
| 20140095069 | INTELLIGENT ROUTE PLANNING - The present disclosure relates to computer-implemented methods and systems for intelligent route planning. An example method may include receiving, by a computation system comprising one or more processors, one or more tasks. The one or more tasks may be associated with one or more locations. The method may further include storing, by the computation system, the one or more tasks. The method may further include receiving, by the computation system, current location information associated with a user. The method may further include generating, by the computation system, based upon the one or more tasks and the current location information, one or more notifications associated with at least one task for presentation to the user. | 04-03-2014 |
| 20140095272 | Systems and Methods for Generation of Incentive Offers for On-Road Users - Systems and methods for generating incentive offers for road use are provider. Incentive offers may be generated by a service provider server. The incentive offers may be generated b identifying, by the computer having at least one processor, at least one use-condition associated with a transit point based at least in part on historical transit data. The generating the incentive offers may include generating one or more offers for a plurality of toll collections passes configured to enable the at least one use-condition associated with the transit point. Further, the method may provide for facilitating a distribution for the one or more incentive offers to a use group. | 04-03-2014 |
| 20140096234 | INTELLIGENT TASK ASSIGNMENT AND AUTHORIZATION SYSTEMS & METHODS - The present disclosure relates to computer-implemented methods and systems for intelligent task management. An example method may include identifying one or more authorized entities. The method may further include broadcasting at least one task associated with a user to one or more devices associated with the one or more authorized entities. The method may further include receiving from the one or more authorized entities, via the one or more devices, an indication of acceptance of the at least one task. The method may further include selecting at least one trusted entity among the one or more authorized entities. The method may further include issuing at least one digital certificate to the at least one trusted entity to perform the at least one task. | 04-03-2014 |
| 20140139542 | Display dimming in response to user - In some embodiments a detector is to detect a body of a user. A controller is to determine an area of focus of the user in response to the detector, and to dim a portion of a display that is not in the area of focus. Other embodiments are described and claimed. | 05-22-2014 |
| 20140145940 | Display dimming in response to user - In some embodiments a detector is to detect a body of a user. A controller is to determine an area of focus of the user in response to the detector, and to dim a portion of a display that is not in the area of focus. Other embodiments are described and claimed. | 05-29-2014 |
| 20140204016 | DISPLAY DIMMING IN RESPONSE TO USER - In some embodiments a detector is to detect a body of a user. A controller is to determine an area of focus of the user in response to the detector, and to dim a portion of a display that is not in the area of focus. Other embodiments are described and claimed. | 07-24-2014 |
| 20140317698 | INTELLIGENT TASK ASSIGNMENT AND AUTHORIZATION SYSTEMS & METHODS - The present disclosure relates to computer-implemented methods and systems for intelligent task management. An example method may include identifying one or more authorized entities. The method may further include broadcasting at least one task associated with a user to one or more devices associated with the one or more authorized entities. The method may further include receiving from the one or more authorized entities, via the one or more devices, an indication of acceptance of the at least one task. The method may further include selecting at least one trusted entity among the one or more authorized entities. The method may further include issuing at least one digital certificate to the at least one trusted entity to perform the at least one task. | 10-23-2014 |
| 20150106836 | GLOBAL SPEECH USER INTERFACE - A global speech user interface (GSUI) comprises an input system to receive a user's spoken command, a feedback system along with a set of feedback overlays to give the user information on the progress of his spoken requests, a set of visual cues on the television screen to help the user understand what he can say, a help system, and a model for navigation among applications. The interface is extensible to make it easy to add new applications. | 04-16-2015 |
