Patent application number | Description | Published |
20080275455 | Apparatus and Methods for Inserting an Implant - A system and method for inserting an implant into a cavity is disclosed, which may include advancing an implant insertion instrument toward a pair of adjacent bodies, the implant insertion instrument having two opposed ramps, wherein each ramp has a distal tip and wherein the longitudinal axes of the opposed ramps are separated by an initial angle; inserting the distal tips of the opposed ramps between the adjacent bodies, thereby creating an initial interbody cavity between the adjacent bodies; expanding the interbody cavity while maintaining the initial angle between the longitudinal axes of the opposed ramps; placing the implant in a final location between the adjacent bodies; transferring a compressive force urging the adjacent bodies together from the opposed ramps to the implant; and extracting the implant insertion instrument from the interbody cavity. | 11-06-2008 |
20100160984 | Insertion tool for Inter-body Vertebral Prosthetic Device With Self-Deploying Screws - An apparatus for inserting an intervertebral prosthesis within a spine of a mammal includes: a handle disposed at a proximal end of the tool and including a drive nut operating to produce rotational torque in response to user-input about a central axis; a first drive shaft including proximal and distal ends; the proximal end in communication with the drive nut, receiving rotational torque therefrom, and imparting rotational torque to the first drive shaft about a first axis, which is laterally offset from the central axis; and the distal end of the first drive shaft including a first drive head; and a chuck disposed at a distal end of the tool and being sized and shaped to engage the intervertebral prosthesis during implantation, wherein the first drive shaft extends through the chuck and the first drive head engages a first gear of the intervertebral prosthesis, such that rotation of the first gear causes rotation and deployment of a first anchoring element of the intervertebral prosthesis. | 06-24-2010 |
20100161057 | Interbody Vertebral Prosthetic Device With Self-Deploying Screws - An intervertebral prosthesis includes: a body including first and second spaced apart major surfaces and at least anterior and posterior sidewalls extending therebetween, the first major surface for engaging an endplate of a first vertebral bone of a spine, and the second major surface for engaging an endplate of an adjacent, second vertebral bone of the spine, and the first and second major surfaces defining a longitudinal axis extending substantially normal to said surfaces; a first aperture extending from within the body, transversely with respect to the longitudinal axis, and opening at the first major surface; a first anchoring element disposed within the first aperture and including a threaded shaft having proximal and distal ends; and a first gear disposed adjacent to and in meshed, threaded communication with the threaded shaft of the first anchoring element such that rotation of the first gear causes rotation of the first anchoring element, wherein a driving rotational force on the first gear causes the first anchoring element to rotate, deploy from the body, and thread into the first vertebral bone in a direction transverse to the longitudinal axis of the body and the spine. | 06-24-2010 |
20120029642 | Apparatus and Methods for Inserting an Implant - Methods and apparatus for inserting an implant into a cavity provide for: disposing an implant between opposing first and second ramps of an implant insertion instrument; orienting first and second vertebral contact surfaces of the ramps such that they define an initial, non-zero angle therebetween; inserting the first and second ramps into an intervertebral space of a spine; advancing the implant distally along and between the ramps such that the first and second vertebral contact surfaces of the first and second ramps separate while holding the initial angle substantially constant. | 02-02-2012 |
20130245768 | Apparatus and Methods for Inserting an Implant - A system and method for inserting an implant into a cavity is disclosed, which may include advancing an implant insertion instrument toward a pair of adjacent bodies, the implant insertion instrument having two opposed ramps, wherein each ramp has a distal tip and wherein the longitudinal axes of the opposed ramps are separated by an initial angle; inserting the distal tips of the opposed ramps between the adjacent bodies, thereby creating an initial interbody cavity between the adjacent bodies; expanding the interbody cavity while maintaining the initial angle between the longitudinal axes of the opposed ramps; placing the implant in a final location between the adjacent bodies; transferring a compressive force urging the adjacent bodies together from the opposed ramps to the implant; and extracting the implant insertion instrument from the interbody cavity. | 09-19-2013 |
20140058514 | Insertion tool for Inter-body Vertebral Prosthetic Device With Self-Deploying Screws - An apparatus for inserting an intervertebral prosthesis within a spine of a mammal includes: a handle including a drive nut operating to produce rotational torque in response to user-input about a central axis; a first drive shaft including a proximal end in communication with the drive nut, receiving rotational torque therefrom, and imparting rotational torque to the first drive shaft about a first axis, which is laterally offset from the central axis; and a distal end of the first drive shaft including a first drive head; and a chuck disposed at a distal end of the tool for engaging the intervertebral prosthesis during implantation, wherein the first drive shaft extends through the chuck and the first drive head engages a first gear of the intervertebral prosthesis, such that rotation of the first gear causes rotation and deployment of a first anchoring element of the intervertebral prosthesis. | 02-27-2014 |
Patent application number | Description | Published |
20140251482 | Fluid Supply Hoses Having a Heat-Shrunk, Antifungal Outer Cover and Method for Making Same - A fluid supply hose includes a hose body having a first end for connection to a fixture and a second end for connection to a water supply. The fluid supply hose includes a tubular cover formed of a heat-shrinkable, antifungal material, which is heat shrunk in place to cover at least a portion of the hose body. The cover could include a decorative exterior. A method of making a fluid supply hose involves inserting a fluid supply hose having a hose body, a first end for connection to a fixture, and a second end for connection to a water supply, into a heat-shrinkable, antifungal tubular cover. The cover is positioned over a portion of the supply hose, and heat is applied to the cover to heat shrink the cover in place to cover at least a portion of the supply hose body. The cover could include a decorative exterior. | 09-11-2014 |
20140352815 | Channel Drain With Integral Weep Path - A channel drain assembly includes a channel drain and a grate. The channel drain includes a body having at least one sidewall and a bottom wall, a flange extending about a periphery of the body, and a drain pipe. The grate is positionable within the body and includes at least one side wall and a top wall that has a plurality of apertures extending therethrough. When the grate is positioned within the body a first flow path and a second flow path are formed that provide a path for fluid to flow into the channel drain and out the drain pipe. The first flow path is formed across the plurality of apertures, while the second flow path is formed between the at least one side wall of the grate and at least one sidewall of the body. | 12-04-2014 |
20150247312 | Adjustable Channel Drain Grate and Associated Methods - The present disclosure relates to an adjustable channel drain grate that includes a grate body and a plurality of support legs connected to the grate body. A height of each of the plurality of support legs can be adjustable relative to the grate body. In one embodiment, a plurality of apertures in the grate body and the plurality of support legs include complementary threads to permit adjustable threading of the plurality of support legs through the plurality of apertures. The present disclosure also relates to a method of adjusting a height of a channel drain grate. | 09-03-2015 |
Patent application number | Description | Published |
20080228495 | Enabling Dynamic VoiceXML In An X+ V Page Of A Multimodal Application - Enabling dynamic VoiceXML in an X+V page of a multimodal application implemented with the multimodal application operating in a multimodal browser on a multimodal device supporting multiple modes of interaction including a voice mode and one or more non-voice modes, the multimodal application operatively coupled to a VoiceXML interpreter, including representing by the multimodal browser an XML element of a VoiceXML dialog of the X+V page as an ECMAScript object, the XML element comprising XML content; storing by the multimodal browser the XML content of the XML element in an attribute of the ECMAScript object; and accessing the XML content of the XML element in the attribute of the ECMAScript object from an ECMAScript script in the X+V page. | 09-18-2008 |
20090024498 | Establishing A Financial Market Data Component In A Financial Market Data System - Methods, apparatus, and products are disclosed for establishing a financial market data component in a financial market data system that include: retrieving, by a configuration module from a configuration repository, at least a portion of a global system configuration for a financial market data system, the financial market data system comprising a plurality of financial market data components; identifying, by the configuration module in dependence upon the retrieved portion of the global system configuration, component characteristics of a particular financial market data component in the financial market data system, the component characteristics further comprise a system identifier, a component functional group identifier, and a component business group identifier; and deploying, by the configuration module, the financial market data component in the financial market data system in dependence upon the component characteristics. | 01-22-2009 |
20110202349 | ESTABLISHING A MULTIMODAL ADVERTISING PERSONALITY FOR A SPONSOR OF A MULTIMODAL APPLICATION - Establishing a multimodal advertising personality for a sponsor of a multimodal application, including associating one or more vocal demeanors with a sponsor of a multimodal application and presenting a speech portion of the multimodal application for the sponsor using at least one of the vocal demeanors associated with the sponsor. | 08-18-2011 |
20120022875 | SYNCHRONIZING VISUAL AND SPEECH EVENTS IN A MULTIMODAL APPLICATION - Exemplary methods, systems, and products are disclosed for synchronizing visual and speech events in a multimodal application, including receiving from a user speech; determining a semantic interpretation of the speech; calling a global application update handler; identifying, by the global application update handler, an additional processing function in dependence upon the semantic interpretation; and executing the additional function. Typical embodiments may include updating a visual element after executing the additional function. Typical embodiments may include updating a voice form after executing the additional function. Typical embodiments also may include updating a state table after updating the voice form. Typical embodiments also may include restarting the voice form after executing the additional function. | 01-26-2012 |
20120046953 | ESTABLISHING A MULTIMODAL PERSONALITY FOR A MULTIMODAL APPLICATION - Methods, apparatus, and computer program products are described for establishing a multimodal personality for a multimodal application that include selecting, by the multimodal application, matching vocal and visual demeanors and incorporating, by the multimodal application, the matching vocal and visual demeanors as a multimodal personality into the multimodal application. | 02-23-2012 |
20120151326 | ESTABLISHING A PREFERRED MODE OF INTERACTION BETWEEN A USER AND A MULTIMODAL APPLICATION - Establishing a preferred mode of interaction between a user and a multimodal application, including evaluating, by a multimodal application operating on a multimodal device supporting multiple modes of interaction including a voice mode and one or more non-voice modes, user modal preference, and dynamically configuring multimodal content of the multimodal application in dependence upon the evaluation of user modal preference. | 06-14-2012 |
20120271642 | ESTABLISHING A MULTIMODAL ADVERTISING PERSONALITY FOR A SPONSOR OF A MULTIMODAL APPLICATION - Establishing a multimodal advertising personality for a sponsor of a multimodal application, including associating one or more vocal demeanors with a sponsor of a multimodal application and presenting a speech portion of the multimodal application for the sponsor using at least one of the vocal demeanors associated with the sponsor. | 10-25-2012 |
20130204620 | ESTABLISHING A MULTIMODAL PERSONALITY FOR A MULTIMODAL APPLICATION IN DEPENDENCE UPON ATTRIBUTES OF USER INTERACTION - Establishing a multimodal personality for a multimodal application, including evaluating, by the multimodal application, attributes of a user's interaction with the multimodal application; selecting, by the multimodal application, a vocal demeanor in dependence upon the values of the attributes of the user's interaction with the multimodal application; and incorporating, by the multimodal application, the vocal demeanor into the multimodal application. | 08-08-2013 |
Patent application number | Description | Published |
20130283172 | ESTABLISHING A PREFERRED MODE OF INTERACTION BETWEEN A USER AND A MULTIMODAL APPLICATION - Establishing a preferred mode of interaction between a user and a multimodal application, including evaluating, by a multimodal application operating on a multimodal device supporting multiple modes of interaction including a voice mode and one or more non-voice modes, user modal preference, and dynamically configuring multimodal content of the multimodal application in dependence upon the evaluation of user modal preference. | 10-24-2013 |
20140052449 | ESTABLISHING A MULTIMODAL ADVERTISING PERSONALITY FOR A SPONSOR OF A ULTIMODAL APPLICATION - Establishing a multimodal advertising personality for a sponsor of a multimodal application, including associating one or more vocal demeanors with a sponsor of a multimodal application and presenting a speech portion of the multimodal application for the sponsor using at least one of the vocal demeanors associated with the sponsor. | 02-20-2014 |
20140122091 | ESTABLISHING A MULTIMODAL PERSONALITY FOR A MULTIMODAL APPLICATION IN DEPENDENCE UPON ATTRIBUTES OF USER INTERACTION - Establishing a multimodal personality for a multimodal application, including evaluating, by the multimodal application, attributes of a user's interaction with the multimodal application; selecting, by the multimodal application, a vocal demeanor in dependence upon the values of the attributes of the user's interaction with the multimodal application; and incorporating, by the multimodal application, the vocal demeanor into the multimodal application. | 05-01-2014 |
20140208210 | DISPLAYING SPEECH COMMAND INPUT STATE INFORMATION IN A MULTIMODAL BROWSER - Methods, systems, and products are disclosed for displaying speech command input state information in a multimodal browser including displaying an icon representing a speech command type and displaying an icon representing the input state of the speech command. In typical embodiments, the icon representing a speech command type and the icon representing the input state of the speech command also includes attributes of a single icon. Typical embodiments include accepting from a user a speech command of the speech command type, changing the input state of the speech command, and displaying another icon representing the changed input state of the speech command. Typical embodiments also include displaying the text of the speech command in association with the icon representing the speech command type. | 07-24-2014 |
Patent application number | Description | Published |
20110274327 | Breast Skin Line Detection in Radiographic Images - An image segmentation embodiment comprises applying a second derivative operator to the pixels of an image, growing a set of contours using seeding grid points as potential contour starting points, determining a contour strength vector for each of the contour pixels, generating a partial ellipse representing an estimated location of an object in the image, dividing the partial ellipse into a plurality of support sectors with control points, determining a contour strength and position for each contour, adjusting a position of each sector control point based on the contour positions weighted by the contour strengths of the contours centered in the respective sector, fitting the partial ellipse to the adjusted positions of the control points, and generating a segmentation mask of the object based on the partial fitted ellipse. | 11-10-2011 |
20110280465 | Breast Segmentation in Radiographic Images - An image segmentation embodiment comprises generating a start model comprising a set of model points approximating an outline of an object in an initial image, smoothing the image at a first smoothing level, generating a curvature image by applying a second derivative operator, locating second derivative local maxima in the curvature image that are orthogonal to a respective model point and within a search region having a first boundary on one side of the start model and a second boundary on an opposite side of the start model, generating a set of contours, shifting the start model to an outer boundary of the contours, and generating a segmentation mask of the object based on the shifted start model. | 11-17-2011 |
20130202165 | Malignant Mass Detection and Classification in Radiographic Images - An image analysis embodiment comprises subsampling a digital image by a subsample factor related to a first anomaly size scale, thereby generating a subsampled image, smoothing the subsampled image to generate a smoothed image, determining a minimum negative second derivative for each pixel in the smoothed image, determining each pixel having a convex down curvature based on a negative minimum negative second derivative value for the respective pixel, joining each eight-neighbor connected pixels having convex down curvature to identify each initial anomaly area, selecting the initial anomaly areas having strongest convex down curvatures based on a respective maximum negative second derivative for each of the initial anomaly areas, extracting one or more classification features for each selected anomaly area, and classifying the selected anomaly areas based on the extracted one or more classification features. | 08-08-2013 |
20150023580 | Microcalcification Detection and Classification in Radiographic Images - An analysis of a digitized image is provided. The digitized image is repeatedly convolved to form first convolved images, which first convolved images are convolved a second time to form second convolved images. Each first convolved image and the respective second convolved image representing a stage, and each stage represents a different scale or size of anomaly. As an example, the first convolution may utilize a Gaussian convolver, and the second convolution may utilize a Laplacian convolver, but other convolvers may be used. The second convolved image from a current stage and the first convolved image from a previous stage are used with a neighborhood median determined from the second convolved image from the current stage by a peak detector to detect peaks, or possible anomalies for that particular scale. | 01-22-2015 |
Patent application number | Description | Published |
20110179002 | System and Method for a Vector-Space Search Engine - A system and method for a search engine is disclosed. A method for operating a search engine may include calculating a plurality of document vectors, receiving a search request, calculating a search request vector, calculating a distance between the search request vector and the plurality of document vectors, and returning a list of documents that are within a predetermined distance of the search request vector. An information handling system for a search engine may include a central processing unit that is coupled to a general purpose graphical processing unit. The central processing unit is able to calculate a plurality of document vectors, receive a search request, calculate a search vector, and return a list of documents that are within a predetermined distance of the search request vector. The general purpose graphical processing unit is able to calculate a distance between the search request vector and the plurality of document vectors. | 07-21-2011 |
20120116590 | RACK-LEVEL MODULAR SERVER AND STORAGE FRAMEWORK - A modular rack-level server and storage framework is disclosed. The modular rack system includes a plurality of chassis placed in one or more racks and a plurality of sleds placed in each chassis. Each sled includes an information handling system, a shared fan module, a shared power module, and a shared management module. The shared fan module cools the plurality of sleds in each chassis and the shared power module supplies power to one or more sleds in one or more chassis. The shared management module manages the operation of the plurality of chassis. | 05-10-2012 |
20130325998 | System and Method for Providing Input/Output Functionality by an I/O Complex Switch - An input/output (I/O) device includes a management controller interface, a plurality of network switching interfaces, a storage interface, a component controller interface, and a plurality of multifunction modules. The multifunction modules further include a processing node interface, a first endpoint coupled to the management controller interface, a second endpoint coupled to one of the plurality of network switching interfaces, a third endpoint coupled to a remote direct memory access (RDMA) block, a fourth endpoint coupled to the storage interface, and a fifth endpoint coupled to the component controller interface. | 12-05-2013 |
20130332719 | System and Method for Providing Input/Output Functionality to a Processing Node - A remote component controller of a server rack includes a real time clock information unit to maintain real clock time and to respond to requests for real time clock information, and a communication module to receive over a communication link a request from a processing node of the server rack for real time clock information, to forward the request to the real time clock information unit, to receive from the real time clock information unit a response to the request, and to transmit the response to the request to the processing node over the communication link. | 12-12-2013 |
20130339479 | System and Method for Providing a Processing Node with Input/Output Functionality by an I/O Complex Switch - A system includes first and second processing nodes and a network switch coupled to the first and second processing nodes via respective first and second interfaces. The network switch includes a management controller coupled to the interfaces to provide management functions to the processing nodes, first and second network interfaces coupled respectively to the first and second interfaces to provide network access for the processing nodes, a message passing interface between the first processing node and the second processing node, a storage interface coupled to the first and second interfaces to provide a storage capacity to the processing nodes, and a remote component controller coupled to the interfaces. | 12-19-2013 |
20130339714 | System and Method for Providing a Processing Node with Input/Output Functionality Provided by an I/O Complex Switch - A processing node of a server rack includes a processor to generate processing node management requests and to process responses to the node management requests, and a communication module to receive the processing node management requests, to transmit over a communication link to a management controller of the server rack external to the processing node a processing node management request, to receive over the communication link from the management controller processing node management information, and to transmit the processing node management information to the processor. | 12-19-2013 |
20140019661 | System and Method for Providing Network Access for a Processing Node - A network interface controller includes a plurality of host interfaces configured to communicate with a plurality of processing nodes, a plurality of network interfaces configured to provide network communication for the processing nodes to a network, and a shared resource configured to provide link based services and stateless offload services for the processing nodes when communicating with the network. | 01-16-2014 |
20140218858 | Stand Alone Immersion Tank Data Center with Contained Cooling - A stand-alone immersion tank datacenter (SITDC) includes: a multi-phase heat transfer immersion cooling tank having external walls surrounding a tank volume within which a dielectric liquid is maintained and heated to a boiling point temperature; a plurality of servers having one or more processing and memory components submerged within the dielectric liquid for cooling of the one or more components via heat dissipation from the one or more components into the dielectric liquid when the one or more components are connected to an electric power supply; and a condenser located vertically above the plurality of servers and in a direct path of rising dielectric vapor created when the dielectric liquid absorbs sufficient heat from the one or more components to reach a boiling point temperature of the liquid. The condenser can be a passive heat exchanger, created by providing a heat conductive material as a top lid of the tank. | 08-07-2014 |
20150062806 | Immersion Server, Immersion Server Drawer, and Rack-Mountable Immersion Server Drawer-Based Cabinet - An information handling system includes: an immersion server drawer (ISD) having: an impervious enclosure which holds a volume of dielectric cooling liquid within/at the enclosure bottom. The ISD is configured with dimensions that enable insertion of liquid-cooled servers within the enclosure bottom. A plurality of liquid-cooled servers can be placed in a side-by-side configuration along one dimension of the ISD, with one or more heat dissipating components of the servers being placed below a surface layer of the cooling liquid. Submerged components of the immersion server are liquid-cooled, while the other heat generating components above the liquid surface are air cooled by rising vapor generated by boiling and vaporization of the cooling liquid. The ISD is placed in an ISD cabinet, which is configured with an upper condenser that allows for multi-phase cooling of the electronic devices placed within the immersion server drawer. The ISD cabinet can be rack-mountable. | 03-05-2015 |
20150181748 | SINGLE UNIT HEIGHT STORAGE SLED WITH LATERAL STORAGE DEVICE ASSEMBLY SUPPORTING HOT-REMOVAL OF STORAGE DEVICES AND SLIDABLE INSERTION AND EXTRACTION FROM AN INFORMATION HANDLING SYSTEM RACK - A rack-based information handling system (IHS) includes a rack containing at least one chassis having a plurality of bays open to laterally receive sleds that contain a plurality of information technology (IT) components that, when operational, enable the rack to function as an IHS. A storage sled including a stationary tray received in the chassis and a moveable trace received in the stationary tray. One or more hot swap bays that are horizontally arrayed in the storage sled in less than one (1) Server System Infrastructure (SSI) rack unit of height, wherein the moveable tray is extendable from the rack to a service position to expose all of its hot swap bays. Storage devices are insertable into a respective one of the hot swap bays of the storage sled. Each storage device may include a latching handle to lift and downward position the storage device in the corresponding hot swap bay. | 06-25-2015 |
20150189787 | MODULAR, SCALABLE, EXPANDABLE, RACK-BASED INFORMATION HANDLING SYSTEM - A modular, scalable and expandable (MSE) rack-based information handling system (RIHS) includes: a rack assembly having a frame that defines: a front bay chassis with height, depth and width dimensions that enable insertion of a plurality of different sizes of IT gear; and a rear bay that accommodates power and cooling components to support operation of the different sizes of IT gear. The power and cooling for the IT gear are provided from the rear bay and are separate from and independent of the IT gear installed within the front bay chassis. The rack assembly further includes a power and management chassis in which is inserted a power and management module having power and management components located thereon to provide rack-level power and management. A modular configuration of fan modules are inserted within fan receptacles within the rear bay to provide block level cooling of adjacent blocks of IT gear. | 07-02-2015 |
20160044819 | COMBINED POWER AND MANAGEMENT MODULE FOR USE IN A RACK-CONFIGURED INFORMATION HANDLING SYSTEM - A scalable power and management module (PMM) includes a chassis configured to be slideably inserted into a power and management bay within a rack. The PMM provides scalable power distribution and rack-level management functions that are shared by several information technology (IT) gear. Several power supply units (PSUs) are mounted in the chassis. The number of PSUs is scalable based on the number of IT gear. A management controller is mounted in the chassis to provide rack-level management of the IT gear and at least one associated block controller within the rack. A power controller is mounted in the chassis and is communicatively coupled to the PSUs and the management controller. The power controller controls power functions of the PMM. | 02-11-2016 |
Patent application number | Description | Published |
20120213660 | High Temperature Low Thermal Expansion Ni-Mo-Cr Alloy - An alloy designed for use in gas turbine engines which has high strength and a low coefficient of thermal expansion is disclosed. The alloy may contain in weight percent 7% to 9% chromium, 21% to 24% molybdenum, greater than 5% tungsten, up to 3% iron, with a balance being nickel and impurities. The alloy must further satisfy the following compositional relationship: 31.9508-23-2012 | |
20160002752 | Fabricable, High Strength, Oxidation Resistant Ni-Cr-Co-Mo-Al Alloys - Ni—Cr—Co—Mo—Al based alloys are disclosed which contain 15 to 20 wt. % chromium, 9.5 to 20 wt. % cobalt, 7.25 to 10 wt. % molybdenum, 2.72 to 3.9 wt. % aluminum, along with typical impurities, a tolerance for up to 10.5 wt. % iron, minor element additions and a balance of nickel. These alloys are readily fabricable, have high creep strength, and excellent oxidation resistance up to as high as 2100° F. (1149° C.). This combination of properties is useful for a variety of gas turbine engine components, including, for example, combustors. | 01-07-2016 |
Patent application number | Description | Published |
20090269846 | Inhibitors of tyrosine kinase receptor dimerization - The teachings relate to methods of identifying inhibitors of dimerization of tyrosine receptor kinases such as EGFR. The methods comprise providing, on a digital computer, a molecular model comprising a complex of extracellular dimerization domains of an RTK, docking a chemical databases to the molecular model, scoring the compounds comprised by the database, and identifying one or more high-scoring compounds. The methods further comprise testing a compound for RTK inhibitory activity in vitro, and testing a compound for specificity as an RTK inhibitor. Also disclosed are compounds selected by the described methods, and methods of treatment using the compounds. Two compounds (NSC11241 and NSC56452) are disclosed that inhibit EGF receptor kinase activation in a dose-dependent manner. | 10-29-2009 |
20110312919 | INHIBITORS OF TYROSINE KINASE RECEPTOR DIMERIZATION - The teachings relate to methods of identifying inhibitors of dimerization of tyrosine receptor kinases such as EGFR. The methods comprise providing, on a digital computer, a molecular model comprising a complex of extracellular dimerization domains of an RTK, docking a chemical databases to the molecular model, scoring the compounds comprised by the database, and identifying one or more high-scoring compounds. The methods further comprise testing a compound for RTK inhibitory activity in vitro, and testing a compound for specificity as an RTK inhibitor. Also disclosed are compounds selected by the described methods, and methods of treatment using the compounds. Two compounds (NSC11241 and NSC56452) are disclosed that inhibit EGF receptor kinase activation in a dose-dependent manner. | 12-22-2011 |
Patent application number | Description | Published |
20080272073 | RACK SYSTEM AND SUPPORT MEMBER FOR SUPPORTING A FOLDING RACK IN A DISHWASHER - A support member is provided that includes a body defining a first channel configured to engage a main spine of a folding rack and a second channel perpendicularly disposed with respect to the first channel and configured to engage a wire member of a dishwasher rack so as to secure the folding rack thereto. The body further defines an aperture configured to receive therethrough one of a plurality of tines of the folding rack. The aperture can define horizontal and vertical support portions configured to support the tine when the folding rack is in folded and unfolded positions, respectively. The aperture can further define an arcuate channel extending between the horizontal support portion and the vertical support portion, the arcuate channel being configured to axially displace the tine along the longitudinal axis as the tine is moved between the horizontal support portion and the vertical support portion. | 11-06-2008 |
20090120883 | SHELF ACCESSORY FOR A DISHWASHER RACK - A shelf accessory for a dishwasher rack is provided, comprising a spine extending in parallel with a structural member of the rack. A plurality of loops extends perpendicularly from the spine, and the loops are spaced apart in relation to each other along the spine, and cooperate therewith to define a shelf member. A clip member is operably engaged between the shelf member and the structural member, and is configured to be capable of rotating about the structural member such that the shelf member correspondingly orbits about the structural member. The clip member further comprises at least one retention member operably engaged therewith. The at least one retention member is configured to cooperate with the rack so as to retain and support the shelf member in at least one of a plurality of angular positions with respect to and about the structural member. Associated apparatuses are also provided. | 05-14-2009 |
20090151758 | LOWER RACK FOR A DISHWASHER AND ASSOCIATED APPARATUSES - A lower rack for a dishwasher is provided, comprising a rack member movable into and out of the dishwasher along first and second tracks extending from the tub to an interior portion of the dishwasher door. The lower rack includes at least one rack roller mechanism on each laterally-opposed side portion of the rack member, for facilitating movement of the rack member with respect to the lower end of the tub and the interior portion of the open door. One of the rack roller mechanisms includes a leadingly-disposed stop portion, as the rack member is moved out of the lower end of the tub and along the interior portion of the open door for interacting with a stop feature of the corresponding one of the first and second tracks to limit egress of the rack member from the tub along the first and second tracks. Associated apparatuses are also provided. | 06-18-2009 |
20100126166 | ACTUATOR ASSEMBLY AND ASSOCIATED APPARATUSES - An actuator assembly, adapted to move a movable member between a first position and a second position, is provided. Such an actuator assembly comprises an actuator device configured to selectively provide an actuation signal, and an actuatable member operably engaged with the actuator device. The actuator member is operably engaged with a fixed member and extends therefrom into communication with the movable member. The actuatable member is further configured to receive the actuation signal and to change in dimension in response thereto, so as to provide a linear force for moving the movable member, with respect to the fixed member, between the first and second positions. Associated apparatuses are also provided. | 05-27-2010 |
20100326471 | DISHWASHER APPLIANCE, AND ASSOCIATED METHOD - A dishwasher appliance is provided, and includes a control device configured to direct one of a series of automatic wash cycles to be executed by the dishwasher appliance. Each successive wash cycle within the series having an increased energy usage level over a previous automatic wash cycle, wherein each energy usage level is determined from at least one operational parameter associated with the respective automatic wash cycle. An actuator device is operably engaged with the control device, and is configured to be responsive to the user to select a subsequent automatic wash cycle to be executed by the dishwasher appliance as directed by the control device, the subsequent automatic wash cycle comprising one of a previous automatic wash cycle and a successive automatic wash cycle in the series of automatic wash cycles, with respect to the one of the series of automatic wash cycles. An associated method is also provided. | 12-30-2010 |
20120138101 | DETERGENT DISPENSER FOR IMPROVED DETERGENT REMOVAL - Embodiments of the present invention are related to a detergent dispenser configured to attach to an interior surface of a dishwasher door. The detergent dispenser may comprise a reservoir configured to hold detergent, wherein a portion of the upper wall of the reservoir has been removed to reduce a cross-sectional length thereof such that water flowing down the dishwasher door is encouraged into the reservoir. The detergent dispenser may also comprise a dispenser door comprising a closed configuration and an open configuration, wherein the dispenser door is configured to cover the reservoir in the closed configuration. The detergent dispenser may be configured to encourage water flowing down the interior surface of the dishwasher door to enter the reservoir when the dispenser door is in the open or closed configuration. | 06-07-2012 |
Patent application number | Description | Published |
20080290003 | Product flow control apparatus for sorting - A product flow control apparatus for use in sorting of products, and particularly relatively small products. The apparatus includes a reservoir of products to be sorted, a flow-rate control passage at which a flow restrictor limits the flow rate of products passing to a slide before imaging by a product viewer and sorting by ejector. A flow valve operates to provide products to a flow-rate control passage at a flow rate at which the product viewer and the ejector can operate. | 11-27-2008 |
20090200214 | Adjustable slide width reducer for gravity slide sorter - An apparatus, and method of use, for reducing the operable width of the inclined slide of a gravity fed sorting machine includes an upper section for reducing the flow rate into the slide and for directing the reduced flow to the operable portion of the slide and a lower section for delimiting the operable portion of the slide. The upper section includes a body proximate the gravity fed sorting machine and which is connected to a product flow rate adjustment assembly and a partition so the product flow into the slide may be controlled and the flow of materials directed to the operable portion of the lower section, which includes a slide width control guide to limit the operable width of the inclined slide. | 08-13-2009 |
20100208936 | System to determine in near real-time product density in a continuous dispensing product flow - A system for determining in near real-time the product density value of a zone of preferable small fungible products within an acceptable size range in a flow of products includes a sample input piping from a bin or piping of products, a sampling volume for fixing the size of a sample, a scale, a processor, an imaging table and an associated camera. The system may include a sample output pipe, and may include or be associated with a bagger/scale. Operation of these components provides for successively sampling of each zone in the bin to determine the quantity of acceptable product per unit weight and to control the flow of those products. The system therefore can compensate for variations among supplying entities where product supplies are subsequently piled atop one another. The system makes the density calculation available to the plant information system and an automated packaging system, which may be via a 16 bit scaled analoge or a serial interface, among other systems. In addition the image information is stored for future analysis, audit support, and process improment activities. | 08-19-2010 |
20120218403 | System to determine product density - A system for determining the product density value of a zone of preferable small fungible products within an acceptable size range and potentially in an acceptable color range. The system differentiates among products even if in close contact to determine acceptable product. The system may store data for later review or for dispensing of product in real time. The system includes a scale to determine a sample's weight, a camera to image the sample, an imaging table to permit viewing of the sample, a processor to determine the number of products in the sample, and a processor to determine the density of desired product. | 08-30-2012 |
20140169629 | System to determine product characteristics, counts, and per unit weight details - A system for determining the characteristics of a volume of preferable small fungible products within an acceptable size range. The system differentiates among products even if in close contact to identify acceptable product. The system may store data for later review or for dispensing of product in real time. The system may include a scale to determine a sample's weight, a camera to image the sample, an imaging table to permit viewing of the sample, a processor to determine the number of products in the sample, and a processor to determine the density of desired product. The system may also determine product count-per-weight, product volume-per-weight, and/or product surface-area-per-weight. These determinations may be useful, including in determining product processing and packaging options. | 06-19-2014 |
Patent application number | Description | Published |
20130247509 | SHELTER AND CONTAINER STRUCTURAL ELEMENTS AND ASSEMBLIES - Systems for wall sections, wall panels assembled from sections, walls assembled from panels, and shelters assembled from walls. In embodiments, a wall for a shelter is disclosed, the wall comprising a frame comprising frame segments forming an n-sided closed polygon; at least one wall panel, each wall panel contained within the frame; and a plurality of flats, each flat attached to and overlapping a frame segment and a portion of a wall section, thereby retaining each wall panel within the frame. In embodiments, a shelter is disclosed, the shelter comprising a plurality of walls, each wall comprising a frame comprising frame segments forming an n-sided closed polygon; at least one wall panel, each wall panel contained within the frame; and a plurality of flats, each flat attached to and overlapping a frame segment and a portion of a wall section, thereby retaining each wall panel within the frame. | 09-26-2013 |
20130305625 | SHELTER EXPANDABLE COMPONENT SUPPORTS - A portable shelter including an expandable component and an expandable component support. The expandable component including at least one structural element, e.g., a wall, configured to extend from, and retract into, an opening in a wall of the portable shelter. The expandable component support including a first non-roller bearing assembly affixed to the portable shelter to bear at least a portion of the weight of the at least one structural element. | 11-21-2013 |
20130305627 | TELESCOPIC SUPPORT FOR AN EXPANDABLE SHELTER - A telescopic support assembly including tube assemblies and bearing assemblies. The tube assemblies are arranged telescopically from a largest cross section rear tube assembly to a smallest cross section front tube assembly. The bearing assemblies include a non-roller bearing for each tube assembly other than the front tube assembly. Each bearing assembly is configured to present a surface of the non-roller bearing at the bottom interior of a tube assembly, proximate the front of the tube. Some embodiments include a drive assembly for extending and retracting the telescopic support assembly. | 11-21-2013 |
20150315807 | SHELTER EXPANDABLE COMPONENT SUPPORTS - A portable shelter including an expandable component and an expandable component support. The expandable component including at least one structural element, e.g., a wall, configured to extend from, and retract into, an opening in a wall of the portable shelter. The expandable component support including a first non-roller bearing assembly affixed to the portable shelter to bear at least a portion of the weight of the at least one structural element. | 11-05-2015 |
Patent application number | Description | Published |
20100251253 | PRIORITY-BASED MANAGEMENT OF SYSTEM LOAD LEVEL - Systems, methods, and computer program products are described herein for managing computer system resources. A plurality of modules (e.g., virtual machines or other applications) may be allocated across multiple computer system resources (e.g., processors, servers, etc.). Each module is assigned a priority level. Furthermore, a designated utilization level is assigned to each resource of the computer system. Each resource supports one or more of the modules, and prioritizes operation of the supported modules according to the corresponding assigned priority levels. Furthermore, each resource maintains operation of the supported modules at the designated utilization level. | 09-30-2010 |
20140157281 | PRIORITY-BASED MANAGEMENT OF SYSTEM LOAD LEVEL - Systems, methods, and computer program products are described herein for managing computer system resources. A plurality of modules (e.g., virtual machines or other applications) may be allocated across multiple computer system resources (e.g., processors, servers, etc.). Each module is assigned a priority level. Furthermore, a designated utilization level is assigned to each resource of the computer system. Each resource supports one or more of the modules, and prioritizes operation of the supported modules according to the corresponding assigned priority levels. Furthermore, each resource maintains operation of the supported modules at the designated utilization level. | 06-05-2014 |
Patent application number | Description | Published |
20090319688 | PARTICIPATING IN CLOUD AS TOTALLY STUBBY EDGE - A Totally Stubby Edge (TSE) participates in a cloud under the condition that the TSE may select paths for frames that the TSE introduces to the cloud, but may not transit frames between nodes in the cloud. The edge submits, to an administrator of the cloud, a request to join the cloud. If the administrator allows the request, then the edge is given access to the address tables that define the structure of the cloud, and may insert itself into the structure. The edge may use the address tables to select paths for frames that the edge introduces to the cloud. Normally path decisions are made by devices that the administrator trusts and controls. However, since the TSE selects paths for its own frames but does not transit frames between other nodes in the cloud, the TSE may select paths even if it is untrusted by the administrator. | 12-24-2009 |
20100281482 | APPLICATION EFFICIENCY ENGINE - A system and a method are provided. Performance and capacity statistics, with respect to an application executing on one or more VMs, may be accessed and collected. The collected performance and capacity statistics may be analyzed to determine an improved hardware profile for efficiently executing the application on a VM. VMs with a virtual hardware configuration matching the improved hardware profile may be scheduled and deployed to execute the application. Performance and capacity statistics, with respect to the VMs, may be periodically analyzed to determine whether a threshold condition has occurred. When the threshold condition has been determined to have occurred, performance and capacity statistics, with respect to VMs having different configurations corresponding to different hardware profiles, may be automatically analyzed to determine an updated improved hardware profile. VMs for executing the application may be redeployed with virtual hardware configurations matching the updated improved profile. | 11-04-2010 |
20100293349 | CONVERTING LUNS INTO FILES OR FILES INTO LUNS IN REAL TIME - A LUN is provided that can store multiple datasets (e.g., data and/or applications, such as virtual machines stored as virtual hard drives). The LUN is partitioned into multiple partitions. One or more datasets may be stored in each partition. As a result, multiple datasets can be accessed through a single LUN, rather than through a number of LUNs proportional to the number of datasets. Furthermore, the datasets stored in the LUN may be pivoted. A second LUN may be generated that is dedicated to storing a dataset of the multiple datasets stored in the first LUN. The dataset is copied to the second LUN, and the second LUN is exposed to a host computer to enable the host computer to interact with the dataset. Still further, the dataset may be pivoted from the second LUN back to a partition of the first LUN. | 11-18-2010 |
20120066452 | CONVERTING LUNS INTO FILES OR FILES INTO LUNS IN REAL TIME - A LUN is provided that can store multiple datasets (e.g., data and/or applications, such as virtual machines stored as virtual hard drives). The LUN is partitioned into multiple partitions. One or more datasets may be stored in each partition. As a result, multiple datasets can be accessed through a single LUN, rather than through a number of LUNs proportional to the number of datasets. Furthermore, the datasets stored in the LUN may be pivoted. A second LUN may be generated that is dedicated to storing a dataset of the multiple datasets stored in the first LUN. The dataset is copied to the second LUN, and the second LUN is exposed to a host computer to enable the host computer to interact with the dataset. Still further, the dataset may be pivoted from the second LUN back to a partition of the first LUN. | 03-15-2012 |
20130290631 | CONVERTING LUNS INTO FILES OR FILES INTO LUNS IN REAL TIME - A LUN is provided that can store multiple datasets (e.g., data and/or applications, such as virtual machines stored as virtual hard drives). The LUN is partitioned into multiple partitions. One or more datasets may be stored in each partition. As a result, multiple datasets can be accessed through a single LUN, rather than through a number of LUNs proportional to the number of datasets. Furthermore, the datasets stored in the LUN may be pivoted. A second LUN may be generated that is dedicated to storing a dataset of the multiple datasets stored in the first LUN. The dataset is copied to the second LUN, and the second LUN is exposed to a host computer to enable the host computer to interact with the dataset. Still further, the dataset may be pivoted from the second LUN back to a partition of the first LUN. | 10-31-2013 |
20140074834 | Storage Block Metadata Tagger - A storage management system may monitor file activity from a file system and tag storage blocks with metadata. The metadata may be used by the storage management system to apply various policies to the blocks. The tagging operation may intercept or monitor file system interaction to classify storage blocks as operating system, application, and data files, as well as other classifications. Some embodiments may include file types, restrictions for physical location, access frequency, block size, and other metadata. The tags may be appended to storage blocks, stored in a separate database, or otherwise associated with the storage blocks. A storage management system may manage storage over many computing devices by handling the storage blocks according to the metadata tags. | 03-13-2014 |
20140075111 | Block Level Management with Service Level Agreement - A storage management system may create a logical storage unit from blocks of storage provided from multiple storage devices. The storage management system may operate using a service level agreement that defines a preferred or minimum performance standard for accesses to the logical storage unit. The service level agreement may include minimum replications, system performance, and system operation characteristics. As read and write operations are performed against the logical storage unit, the configuration of the logical storage unit may be changed to meet the service level agreement. The storage management system may assess and map the capabilities of all available storage devices for a system, then provision a logical storage unit that may initially meet the target service level agreement. When system performance does not meet the service level agreement, read operations may be striped, alternative storage devices may be used, or the location of replicated blocks may be changed. | 03-13-2014 |
20140075149 | Storage Mechanism with Variable Block Size - A file system may access a logical unit by addressing storage space using a constant block size, but the underlying logical unit may physically store information using different block sizes for different types of files. Certain file types may be stored using large blocks sizes for performance, while other file types may be stored using smaller block sizes for storage efficiency. A storage management system may create the logical unit from different block extents on various storage devices, where each block extent may be created with different block sizes. The system may place a file in a block extent that may be appropriate for the file type, and may perform a translation between the file system's request for a specific block and the manner in which the block is stored on the media. | 03-13-2014 |
20140164323 | Synchronous/Asynchronous Storage System - A storage system with a duplicate network storage device may change to and from a synchronous to asynchronous write connection based on a service level agreement. Degradation of a network connection or device performance may cause synchronous writes to be changed to asynchronous network writes, and synchronous writes may be performed on a second device. During the asynchronous operation, a differencing set may be created on a local storage device and used to update the network storage device. When the network storage device becomes able to meet the service level agreement with synchronous writes, the system may include the network storage device for synchronous writes. | 06-12-2014 |
20140164581 | Dispersed Storage System with Firewall - A remotely managed storage system may configure logical units using a low level storage controller on each managed computer system plus a target driver for each shared storage device. The storage controller may present logical units to operating systems running on a computer system and may operate on a lower level than a host operating system or hypervisor. A target driver may allow remote devices to use the local storage devices for other logical units. A storage master may configure the various components across a group of computers to create logical units of storage that are backed by multiple storage devices. | 06-12-2014 |
20140310434 | Enlightened Storage Target - An enlightened storage target may operate as a conventional storage target device, and may have additional capabilities to manage an initiator-target relationship under a service level agreement or quality of service agreement. An initiator may negotiate a service level agreement with the enlightened target, then the target may manage storage within the target device to meet the service level agreement. The target may also include a monitoring system that may monitor actual performance and compare the performance against the service level agreement. When the service level agreement is not being met, the target may alert the initiator and, in some cases, take precautionary or other actions until the service level agreement is either changed or is met. | 10-16-2014 |
Patent application number | Description | Published |
20110180082 | METHOD FOR PREPARING FUEL ELEMENT FOR SMOKING ARTICLE - The invention provides a method for making a fuel element for a smoking article including the steps of mixing a metal-containing catalyst precursor with a filler material or graphite or a combination thereof to form a pre-treated fuel element component; optionally calcining the pre-treated fuel element component in order to convert the catalyst precursor to a catalytic metal compound; after the optional calcining step, combining the pre-treated fuel element component with a carbonaceous material and a binder to produce a fuel element composition; and forming the fuel element composition into a fuel element adapted for use in a smoking article. Examples of metal-containing catalyst precursors include iron nitrate, copper nitrate, cerium nitrate, cerium ammonium nitrate, manganese nitrate, magnesium nitrate, and zinc nitrate. Fuel elements treated according to the invention, and smoking articles including such fuel elements, are also provided. | 07-28-2011 |
20140083439 | METHOD FOR PREPARING FUEL ELEMENT FOR SMOKING ARTICLE - The invention provides a method for making a fuel element for a smoking article including the steps of mixing a metal-containing catalyst precursor with a filler material or graphite or a combination thereof to form a pre-treated fuel element component; optionally calcining the pre-treated fuel element component in order to convert the catalyst precursor to a catalytic metal compound; after the optional calcining step, combining the pre-treated fuel element component with a carbonaceous material and a binder to produce a fuel element composition; and forming the fuel element composition into a fuel element adapted for use in a smoking article. Examples of metal-containing catalyst precursors include iron nitrate, copper nitrate, cerium nitrate, cerium ammonium nitrate, manganese nitrate, magnesium nitrate, and zinc nitrate. Fuel elements treated according to the invention, and smoking articles including such fuel elements, are also provided. | 03-27-2014 |
20150059780 | CARBON CONDUCTIVE SUBSTRATE FOR ELECTRONIC SMOKING ARTICLE - The present disclosure provides components useful in heating, particularly heating of an aerosol precursor solution so as to vaporize the solution and form an aerosol. The disclosure particularly provides an electrically conductive, porous carbon heater. The heater may be combined with an aerosol precursor transport element that also is formed of carbon. The heater and transport element may form an atomizer that can be useful in an electronic smoking article, such as in a cartridge that is adapted for attachment to a control body. In some embodiments, the disclosure provides a cartridge of an electronic smoking article, the cartridge being formed substantially completely of carbon. | 03-05-2015 |
Patent application number | Description | Published |
20090274624 | RADIOTRACERS FOR IMAGING P-GLYCOPROTEIN FUNCTION - P-glycoprotein transporter (P-gp) acts as a pump at the blood-brain barrier to exclude a wide range of xenobiotics (e.g., toxins, drugs, etc.) from the brain and is also expressed in a tumor in response to exposure to established or prospective chemotherapeutics (a phenomenon known as multidrug resistance). This invention concerns the preparation and use of radiotracers for imaging P-gp function in vitro and in vivo. Radiotracers of the present invention are avid substrates for P-gp and have structures based on N-Desmethyl-loperamide. | 11-05-2009 |
20110008255 | BETA-AMYLOID PET IMAGING AGENTS - Novel derivatives of imidazopyridinylbenzeneamines and novel derivatives of benzothiazolylbenzeneamines are disclosed that offer improved behavior when used as imaging agents for positron emission tomography of beta-amyloids. Also disclosed is a palladium-catalyzed reaction scheme under microwave conditions for aryl thioethers in general that provides a high ratio of substitution relative to reduction and can be used for the imidazopyridinylbenzeneamine derivatives as well as other compounds of related structure. | 01-13-2011 |
20110098326 | 2-FLUOROTHIAZOLE DERIVATIVES USEFUL AS IMAGING AGENTS; METHODS OF SYNTHESIS, AND METHODS OF USE | 04-28-2011 |
20140341812 | BETA-AMYLOID PET IMAGING AGENTS - Novel derivatives of imidazopyridinylbenzeneamines and novel derivatives of benzothiazolylbenzeneamines are disclosed that offer improved behavior when used as imaging agents for positron emission tomography of beta-amyloids. Also disclosed is a palladium-catalyzed reaction scheme under microwave conditions for aryl thioethers in general that provides a high ratio of substitution relative to reduction and can be used for the imidazopyridinylbenzeneamine derivatives as well as other compounds of related structure. | 11-20-2014 |
20140348748 | BETA-AMYLOID IMAGING AGENTS, METHODS OF MANUFACTURE, AND METHODS OF USE THEREOF - Derivatives of benzothiazolylbenzeneamines useful as imaging agents for nuclear imaging such as positron emission tomography of beta-amyloids are described. Methods of detecting amyloid using the compounds are described. Also disclosed is a radiolabeling method for selected compounds. | 11-27-2014 |