Patent application number | Description | Published |
20080219892 | Guided Mode Resonant Filter Biosensor Using a Linear Grating Surface Structure - Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also provides optical devices useful as narrow band filters. | 09-11-2008 |
20090148955 | Label-Free High-Throughput Optical Technique for Detecting Biomolecular Interactions - Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also provides optical devices useful as narrow band filters. | 06-11-2009 |
20090264314 | Optical Detection of Label-Free Biomolecular Interactions Using Microreplicated Plastic Sensor Elements - Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also provides optical devices useful as narrow band filters. | 10-22-2009 |
20090316972 | ENGINEERED PHANTOMS FOR PERFUSION IMAGING APPLICATIONS - In various embodiments, microengineered phantoms with microvascular networks serve as calibration standards for perfusion imaging systems. | 12-24-2009 |
20100231907 | Method and Apparatus for Biosensor Spectral Shift Detection - Performing high-resolution determination of the relative shift of the spectral properties of a biosensor. The shift in the resonance peak of the biosensor is indicative of the amount of material bound to the surface of the biosensor. A preferred biosensor is a Guided Mode Resonant Filter Biosensor (GMRFB). In one aspect of the invention, curve fitting is used to determine the relative location of the spectrum of the unexposed biosensor with respect to those spectra that are altered (e.g., shifted) by the presence of materials bound to the surface of the biosensor. In an alternative embodiment, the cross correlation function is used to detect spectral peak offsets between a reference spectrum and a spectrum measured from an exposed biosensor. In yet another alternative, maximal likelihood estimation techniques are used to determine the spectral shift or offs. | 09-16-2010 |
20110201132 | Optical Detection of Label-Free Biomolecular Interactions using Microreplicated Plastic - Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also provides optical devices useful as narrow band filters. | 08-18-2011 |
20110237464 | Guided Mode Resonant Filter Biosensor Using a Linear Grating Surface Structure - Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also provides optical devices useful as narrow band filters. | 09-29-2011 |