Phillips, MA

Alan Phillips, Hopkinton, MA US

Patent application number	Description	Published
20120126974	LOCATION-BASED SERVICES - Provided herein are methods and systems relating to location-based services such as providing a geofencing, outputting location-based information on a mobile device, varying transmissions to and from a mobile device, and providing location-based alerts. More specifically, a method can include receiving a task on a mobile device, associating the task with a location, generating a geofence around the location associated with the task, tracking a current location of a the mobile device, and generating an alert associated with the task when the current location is within the geofence.	05-24-2012
20120129553	LOCATION-BASED SERVICES - Provided herein are methods and systems relating to location-based services such as providing a geofencing, outputting location-based information on a mobile device, varying transmissions to and from a mobile device, and providing location-based alerts. More specifically, a method can include receiving a selected location on a mobile device, monitoring a current location of the mobile device, determining when the current location of the mobile device is within the geofence, and initiating an action on the mobile device associated with the geofence and the selected location.	05-24-2012
20150065177	LOCATION-BASED SERVICES - Provided herein are methods and systems relating to location-based services such as providing a geofencing, outputting location-based information on a mobile device, varying transmissions to and from a mobile device, and providing location-based alerts. More specifically, a method can include receiving data defining a geofence, monitoring a current location, comparing the current location with the geofence, determining that the current location is within the geofence, and in response altering the state of an application on the mobile device.	03-05-2015
20150148078	LOCATION-BASED SERVICES - Provided herein are methods and systems relating to location-based services such as providing a geofence, outputting location-based information on a mobile device, varying transmissions to and from a mobile device, and providing location-based alerts. More specifically, a method can include obtaining a first physical location of a mobile device; and generating a geofence on the mobile device based on the first physical location. The methods and systems also provide the capability to generate a geofence based on one or more physical locations of a mobile device over a course of time.	05-28-2015
20150163632	Location-based services - Provided herein are methods and systems relating to location-based services such as providing a location-aware game environment executing on a mobile device. More specifically, a method can include executing a location-aware game, monitoring a physical location corresponding to a mobile device, and triggering an action or event within the game environment based on information associated with the physical location of the mobile device. The methods and systems also provide the capability to alter the simulated environment within the game based on physical location associated with other players within a multi-player game.	06-11-2015

Albert Lamar Phillips, Fitchburg, MA US

Patent application number	Description	Published
20150081886	DATA NETWORK DEVICE DISCOVERY OPTIMIZATION TO REDUCE DATA TRANSFER VOLUME - There is provided a method of reducing traffic on a data network. The method includes (i) reading an indicator of whether a last attempted communication with a network device was successful, and (ii) performing discovery of the network device at each time specified by a first schedule in response to the indicator indicating that the last attempted communication with the network device was successful, and at each time specified by a second schedule in response to the indicator indicating that the last attempted communication with the network device was not successful. There is also provided a system that performs the method, and a storage device that contains a program that controls a processor to perform the method.	03-19-2015

Allan Phillips, Whitensville, MA US

Patent application number	Description	Published
20080275972	System and Method for Providing Improved Packet Traceability - A method and apparatus is described which enables location information associated with a client to easily be obtained by a service provider in a packet-based network. The location information may be the location of the client itself, or may be location information associated with devices in a communication facility established by the client. Location information associated with the client may be provided to services such as emergency services to facilitate fast dispatch of resources to assist the client. Location information associated with facilities of the client may be used to facilitate lawful interception of client communications. In one embodiment, the location information is obtained using information included in one of a Provider Backbone Bridge (PBB) or Provider Backbone Transport (PBT) packet.	11-06-2008

Brian Phillips, Newton, MA US

Patent application number	Description	Published
20160050514	DYNAMICALLY ADJUSTABLE NODES IN A SENSOR NETWORK - Systems, methods, and computer-readable storage media for dynamically adjusting nodes in a mesh network embedded in objects. The nodes, which are individually capable of sensing and/or transmitting data, are paired together such that when one node is active, the other node is collecting energy via solar, wind, or other energy collecting means. When a node reaches a certain energy level, the nodes can switch status, such that the passive node becomes active and vice versa. Exemplary objects in which the systems can be embedded include benches, receptacles, and light fixtures.	02-18-2016

Brian S. Phillips, Sherborn, MA US

Patent application number	Description	Published
20100241981	SYSTEM AND METHOD FOR DISPLAYING AND USING NON-NUMERIC GRAPHIC ELEMENTS TO CONTROL AND MONITOR A VISION SYSTEM - This invention provides a system and method for employing GUI-based non-numeric slide buttons and bar meters to setup and monitor operating parameters of a vision system (the term “vision system” as used herein including the above-described vision detector). Such parameters can include, but are not limited to the threshold at which a feature is activated in viewing an image. Operating parameters also include the underlying range of contrast values and levels of brightness intensities (or by input inversion, the level of darkness) recognized and acted upon by the vision system. Graphical representations of operating parameters are displayed in a parameter box on the GUI with moving bars that are shaded, patterned or colored so as to provide a relative level between two extremes on a scale of the given operating parameter. The endpoints of the scale can be established by analyzing the relevant extremes on a subject image view. The current level of the given parameter is displayed as a bar that extends a distance along the scale that is proportional to the current level of the parameter along the scale. Input of operating parameter settings with respect to the scale is made by moving a setting slider along the scale between the extremes. The position of the slider establishes the user-input setting relative to the scale. In an illustrative embodiment, scales, level bars and setting sliders can also be displayed on the image view itself, adjacent to a given image view feature, which is the subject of the scale.	09-23-2010
20100318936	HUMAN-MACHINE-INTERFACE AND METHOD FOR MANIPULATING DATA IN A MACHINE VISION SYSTEM - This invention provides a Graphical User Interface (GUI) that operates in connection with a machine vision detector or other machine vision system, which provides a highly intuitive and industrial machine-like appearance and layout. The GUI includes a centralized image frame window surrounded by panes having buttons and specific interface components that the user employs in each step of a machine vision system set up and run procedure. One pane allows the user to view and manipulate a recorded filmstrip of image thumbnails taken in a sequence, and provides the filmstrip with specialized highlighting (colors or patterns) that indicate useful information about the underlying images. The programming of logic is performed using a programming window that includes a ladder logic arrangement.	12-16-2010
20110012030	EBEAM STERILIZATION APPARATUS - Improved electron beam sterilization apparatus and shielding techniques for use in are provided. A controller modulates an ebeam when sterilizing an interior to an object to ensure that adequate dose is received. Sterilization carousels are configured with input/discharge feeds to reduce the possibility of humans being exposed to dangerous levels of radiation. The system reduces the amount of shielding required to thereby lower cost of installation.	01-20-2011
20110012032	ELECTRON BEAM STERILIZATION APPARATUS - Improved electron beam sterilization apparatus and shielding techniques for use in are provided. A controller modulates an electron beam when sterilizing an interior to an object to ensure that adequate dose is received. Sterilization carousels are configured with input/discharge feeds to reduce the possibility of humans being exposed to dangerous levels of radiation. The system reduces the amount of shielding required to thereby lower cost of installation.	01-20-2011
20120120490	Manually Adjustable Ruggedized Focus Mechanism - The invention provides, in some aspects, devices for image acquisition that use seals between concentrically disposed portions of an enclosure and an optics assembly in order to protect image acquisition components from the surrounding environment while providing adequate friction for both adjusting and locking focus. Such devices can include an image capture medium that is disposed within an enclosure and an optics assembly that is also disposed within that enclosure. The optics assembly, which includes at least a lens, can have a cylindrical outer diameter along at least a portion of its length that is received within the enclosure along a length that has a corresponding cylindrical inner diameter. A first seal is disposed between, and in contact with, the optics assembly and the enclosure. That seal permits rotation of the optics assembly for purposes of focusing the lens, while preventing contamination from the environment from entering into the enclosure.	05-17-2012
20130015365	ELECTRON BEAM STERILIZATION APPARATUS - Improved electron beam sterilization apparatus and shielding techniques for use in are provided. A controller modulates an electron beam when sterilizing an interior to an object to ensure that adequate dose is received. Sterilization carousels are configured with input/discharge feeds to reduce the possibility of humans being exposed to dangerous levels of radiation. The system reduces the amount of shielding required to thereby lower cost of installation.	01-17-2013
20130141591	HUMAN-MACHINE-INTERFACE AND METHOD FOR MANIPULATING DATA IN A MACHINE VISION SYSTEM - This invention provides a Graphical User Interface (GUI) that operates in connection with a machine vision detector or other machine vision system, which provides a highly intuitive and industrial machine-like appearance and layout. The GUI includes a centralized image frame window surrounded by panes having buttons and specific interface components that the user employs in each step of a machine vision system set up and run procedure. One pane allows the user to view and manipulate a recorded filmstrip of image thumbnails taken in a sequence, and provides the filmstrip with specialized highlighting (colors or patterns) that indicate useful information about the underlying images. The programming of logic is performed using a programming window that includes a ladder logic arrangement.	06-06-2013

David L. Phillips, Groveland, MA US

Patent application number	Description	Published
20140322029	PUMP USING MULTI VOLTAGE ELECTRONICS WITH RUN DRY AND OVER CURRENT PROTECTION - A pump system features a power adapter and a pump having a signal processor. The power adapter includes voltage settings that respond to a voltage setting by a user and provide a selected voltage. The signal processor receives signaling containing information about the selected voltage supplied to a motor to run the pump, and also containing information about whether a current draw of the pump is lower than a predetermined low current level or is higher than a predetermined high current level; and determines whether to shut off the pump after a predetermined time, based on the signaling received.	10-30-2014
20160048137	AUTOMATIC FILL CONTROL TECHNIQUE - A pump includes a signal processor that receives signaling containing information about a low level of a liquid sensed in an appliance reservoir to be supplied to an appliance that uses the liquid to dispense a flavored beverage, and also about when the appliance reservoir is refilled based upon an indication that forms part of an appliance reservoir refill level calibration procedure programmed by an appliance user; and determines corresponding signaling containing information about automatically refilling the liquid in the appliance reservoir, based upon the signaling received.	02-18-2016

Gary Phillips, Northborough, MA US

Patent application number	Description	Published
20090242173	TEMPERATURE CONTROL SYSTEM - An improved system and method for controlling the temperature of fluids during a mixing procedure or a chemical, pharmaceutical, or biological process is disclosed. One embodiment of the system comprises: a first collapsible bag including	10-01-2009

Judy Phillips, Arlington, MA US

Patent application number	Description	Published
20140302170	COMPOSITIONS AND METHODS FOR PROMOTING SLEEP - Described herein are food formulations and methods, which promote sleep.	10-09-2014

Katherine C.f. Phillips, Cambridge, MA US

Patent application number	Description	Published
20120039560	ALL-OPTICAL LOGIC GATES AND METHODS FOR THEIR FABRICATION - The present invention provides optical devices that employ nonlinear optical effects for processing optical signals. For example, such an optical device can include a nano-sized interferometric component that provides an optical output signal via interference of two input signals subsequent to their asymmetric nonlinear phase accumulation. The interferometric element can have a variety of configurations, such as Sagnac, Mach-Zehnder or Michelson configurations.	02-16-2012

Kathryn Phillips, Boston, MA US

Patent application number	Description	Published
20090286748	ANTI-INFLAMMATORY COMPOUNDS AND USES THEREOF - The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides methods of identifying anti-inflammatory compounds and methods of inhibiting NF-κB-dependent target gene expression in a cell.	11-19-2009
20110071092	ANTI-INFLAMMATORY COMPOUNDS AND USES THEREOF - The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides methods of identifying anti-inflammatory compounds and methods of inhibiting NF-κB-dependent target gene expression in a cell.	03-24-2011

Kathryn Phillips, Marlborough, MA US

Patent application number	Description	Published
20120329720	ANTI-INFLAMMATORY COMPOUNDS AND USES THEREOF - The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides methods of identifying anti-inflammatory compounds and methods of inhibiting NF-κB-dependent target gene expression in a cell.	12-27-2012

Kerry B Phillips, Haverhill, MA US

Patent application number	Description	Published
20100248657	POWER CORRECTION MODULE FOR POWER AMPLIFIERS - A power correction module for use with an amplifier driving a load impedance is configured to sample the supply current and to cause a change in a control voltage, which corrects the supply voltage in response to a change in the load impedance. The supply voltage is corrected to cause the power amplifier to have a substantially constant output power. The power correction module is further configured to output a corrected peak voltage determined by an average value of the supply current.	09-30-2010
20110032030	SYSTEMS AND METHODS FOR SATURATION DETECTION AND CORECTION IN A POWER CONTROL LOOP - Systems and methods are described for detecting and correcting saturation in a power amplification circuit. An exemplary circuit comprises a power amplifier that provides an amplified output signal based upon an input signal and a gain control signal; a power detector that provides a detector signal indicative of the amplified signal magnitude; an error amplifier that generates the gain control signal based upon a setpoint signal and the detector signal; and a saturation detector that provides a saturation detection signal indicating whether gain control signal exceeds a reference signal. In another embodiment the circuit comprises an offset generator that provides a correction to the setpoint signal in response to the saturation detection signal indicating that the gain control signal exceeds the reference signal. In still another embodiment the circuit includes an offset cutoff circuit that freezes the correction to the setpoint signal in response to the correction exceeding a threshold.	02-10-2011
20120218039	SYSTEMS AND METHODS FOR SATURATION CORRECTION IN A POWER CONTROL LOOP - A power amplification circuit includes a power amplifier, an RF detector, an error amplifier, a saturation detector, and an offset circuit. The power amplifier provides an amplified signal based on an input signal and a gain control signal. The RF detector provides a detection signal indicative of a logarithm of the power of the amplified signal. The error amplifier provides the gain control signal based on an amplification control signal and the detection signal. The saturation detector provides a saturation signal in response to the gain control signal differing from a reference signal by less than a first predetermined voltage. The offset circuit decreases a voltage level of the amplification control signal by up to a second predetermined voltage in response to the saturation signal and the amplification control signal differing from the detection signal by less than the second predetermined voltage.	08-30-2012

Kerry Brent Phillips, Haverhill, MA US

Patent application number	Description	Published
20090115520	Temperature compensation of collector-voltage control RF amplifiers - A temperature compensation system for compensating a collector-voltage controlled RF amplifier. To overcome variation that occurs with temperature which can result in signal degradation of the adjacent channel spectrum, a temperature compensated current is utilized to create an offset signal. The offset signal is processed in connection with a control or data signal to generate a temperature compensated voltage source control signal. A differential amplifier may process the data or control signal and the offset signal. The compensated voltage control signal tracks temperature to adapt the applied collector voltage to temperature. This in turn forces the applied collector voltage to vary in response to temperature changes thereby maintaining a constant output power or RF swing. One example environment of use is in an EDGE type GSM system.	05-07-2009

Kevin John Phillips, Somerville, MA US

Patent application number	Description	Published
20100209994	Protein Surface Remodeling - Aggregation is a major cause of the misbehavior of proteins. A system for modifying a protein to create a more stable variant is provided. The method involves identifying non-conserved hydrophobic amino acid residues on the surface of a protein, suitable for mutating to more hydrophilic residues (e.g., charged amino acids). Any number of residues on the surface may be changed to create a variant that is more soluble, resistant to aggregation, has a greater ability to re-fold, and/or is more stable under a variety of conditions. The invention also provides GFP, streptavidin, and GST variants with an increased theoretical net charge created by the inventive technology. Kits are also provided for carrying out such modifications on any protein of interest.	08-19-2010
20120129759	PROTEIN SURFACE REMODELING - Aggregation is a major cause of the misbehavior of proteins. A system for modifying a protein to create a more stable variant is provided. The method involves identifying non-conserved hydrophobic amino acid residues on the surface of a protein, suitable for mutating to more hydrophilic residues (e.g., charged amino acids). Any number of residues on the surface may be changed to create a variant that is more soluble, resistant to aggregation, has a greater ability to re-fold, and/or is more stable under a variety of conditions. The invention also provides GFP, streptavidin, and GST variants with an increased theoretical net charge created by the inventive technology. Kits are also provided for carrying out such modifications on any protein of interest.	05-24-2012

Mark Phillips, Maynard, MA US

Patent application number	Description	Published
20100250703	MEDIA STREAM CAPTURE, MODIFICATION, AND FORWARDING - A transmission delay system, an improvement to a transmission delay system, and a method of delaying a transmission for removing undesired content from an input media stream; for excising, recording, storing, and logging, the undesired content; and for automatically providing message alerts through a network to at least one message alert recipient that an excision event has occurred.	09-30-2010

Mark J. Phillips, Wayland, MA US

Patent application number	Description	Published
20090204264	Method and apparatus for operating an automated biomolecular preparation system - A system automatically prepares and analyzes a macromolecule prepared from a complex liquid mixture. To prepare the macromolecule, a controller executing executable instructions, such as compiled software or firmware, operates a hydraulic subsystem in response to operational input, which may be interpreted by the executable instructions at run-time. To analyze the prepared macromolecule, an apparatus for capillary electrophoresis includes a liquid source, inlet chamber, capillary electrophoresis column, and controller that may operate under control of executable instructions and operational input in a similar manner. The system may require validation and approval by a regulatory body, such as the FDA. Based on the de-coupled configuration of the executable instructions and operational input, the system can be validated and approved with the executable instructions independent of the operational input, and vice-versa. A method for distributing the system based on this feature is also provided.	08-13-2009

Matthew Phillips, Somerville, MA US

Patent application number	Description	Published
20130131683	MINIMALLY INVASIVE SURGICAL APPLICATOR - The present invention provides a minimally invasive surgical applicator device. The device is useful in the application of bone wax during surgical procedures to halt or reduce bone bleeding. The device may be sterilized for re-use or may be made disposable.	05-23-2013

Michael E. Phillips, Brookline, MA US

Patent application number	Description	Published
20080297598	Electronic film editing system using both film and videotape format - A system for generating a digital representation of a video signal comprised of a sequence of video frames which each include two video fields of a duration such that the video plays at a first prespecified rate of frames per second. The sequence of video frames includes a prespecified number of redundant video fields. Redundant video fields in the video frame sequence are identified by a video processor, and the video frame sequence is digitized by an analog to digital converter, excluding the identified redundant video fields. The digitized video frames are then compressed by a video compressor to generate a digital representation of the video signal which plays at a second prespecified rate of frames per second.	12-04-2008

Michael E. Phillips, Melrose, MA US

Patent application number	Description	Published
20110142131	CAPTURE, EDITING AND ENCODING OF MOTION PICTURES ENCODED WITH REPEATING FIELDS OR FRAMES - An image sequence captured at a first image rate is encoded as an encoded image sequence at a second image rate with information in the encoded image sequence indicative of images that are repeated when decoded. To assist in editing a video program using the encoded image sequence, the information in the encoded image sequence indicative of repeated images may be cleared and image index information for the encoded image sequence generated to map a temporal position of an image in a decoded image sequence to a position of corresponding data in the encoded image sequence. Temporal positions used with the image index information correspond to the first image rate. Editing video involves defining a sequence of clips that reference source encoded image sequences using edit points. Each clip has a start and end point in its corresponding source and a position in the edited video program. The temporal resolution of these edit points corresponds to the first image rate. An edited video program may be output as an encoded image sequence, using the source encoded image sequences referenced by the sequence of clips. The encoded image sequence is constructed according to the edited sequence of clips, using the source encoded image sequences.	06-16-2011
20110239107	TRANSCRIPT EDITOR - A transcript editor enables text-based editing of time-based media that includes spoken dialog. It involves an augmented transcript that includes timing metadata that associates words and phrases within the transcript with corresponding temporal locations within the time-based media where the text is spoken, and editing the augmented transcript without the need for playback of the time-based media. After editing, the augmented transcript is processed by a media editing system to automatically generate an edited version of the time-based media that only includes the segments of the time-based media that include the speech corresponding to the edited augmented transcript.	09-29-2011
20110239119	SPOT DIALOG EDITOR - Automated methods are used to augment an original script of a time-based media program that contains speech with timing metadata and an indication of a confidence level with which script portions are matched with the speech in the program audio track. An editor uses a spot dialog editor tool to produce a word-accurate spot dialog master by reviewing and editing script portions displayed next to the corresponding portions of the time-based media. The spot dialog editor tool selects for review and editing the parts of the script having a low confidence match with the speech in the program.	09-29-2011
20120246704	MOBILE SOFTWARE ENTITLEMENTS MANAGER - A mobile entitlements manager implemented on a mobile device stores the software entitlements belonging to a user of the mobile device. The mobile device communicates with client computers on which the user wishes to run software applications. Messages are exchanged between the client and the mobile device to enable activation, continued running, and to deactivate client applications in accordance with the entitlements available to the user. The mobile entitlements manager updates its entitlement information by communicating with a remote entitlements server, and informs the entitlement server of the status of programs running on clients in communication with the device. The entitlements manager handles entitlements for multiple applications and for multiple licensed entities, such as individual users, sites, client computers, or organizations.	09-27-2012
20130007043	VOICE DESCRIPTION OF TIME-BASED MEDIA FOR INDEXING AND SEARCHING - Methods and systems for time-synchronous voice annotation of video and audio media enable effective searching of time-based media content. A user record one or more types voice annotation onto corresponding named voice annotation tracks, which are stored within a media object comprising the time-based media and the annotations. The one or more annotation tracks can then be selectively searched for content using speech or text search terms. Various workflows enable voice annotation to be performed using media editing systems, or one or more stand alone voice annotations systems that permit multiple annotators to operate in parallel, generating different kinds of annotations, and returning their annotation tracks to a central location for consolidation.	01-03-2013
20130047059	TRANSCRIPT EDITOR - A transcript editor enables text-based editing of time-based media that includes spoken dialog. It involves an augmented transcript that includes timing metadata that associates words and phrases within the transcript with corresponding temporal locations within the time-based media where the text is spoken, and editing the augmented transcript without the need for playback of the time-based media. After editing, the augmented transcript is processed by a media editing system to automatically generate an edited version of the time-based media that only includes the segments of the time-based media that include the speech corresponding to the edited augmented transcript.	02-21-2013

Michael Stuart Phillips, Belmont, MA US

Patent application number	Description	Published
20140047001	VIRTUAL AGENT COMMUNICATION FOR ELECTRONIC DEVICE - Methods and apparatus for communicating between virtual agents associated with users of electronic devices connected via at least one network. A first user may instruct an associated first virtual agent to invoke a communication session with a second virtual agent associated with a second user. To invoke the communication session, the first virtual agent may send an outgoing communication to the second virtual agent and the outgoing communication may instruct the second virtual agent to perform at least one action on behalf of the first user. Virtual agents associated with different users may alternatively communicate with each other in the absence of user interaction to perform a collaborative action.	02-13-2014

Michael W. Phillips, Tyngsborough, MA US

Patent application number	Description	Published
20090050566	Media for membrane ion exchange chromatography based on polymeric primary amines, sorption device containing that media, and chromatography scheme and purification method using the same - Media and devices, such as anion exchangers including such media, wherein the media is a membrane having a surface coated with a polymer such as a polyallylamine. The resulting membrane offers stronger binding of protein impurities and superior removal of host cell proteins from biological samples than conventional ligands based on quaternary ammonium salts, including trimethylammonium ligands. Also described is a chromatography scheme and method for purifying monoclonal antibodies, wherein the anion exchange sorber is placed downstream of an affinity column (such as Protein A or Protein G affinity column) and optionally one or more polishing devices such as cationic exchange columns. Little or no dilution of the cation exchanger pool (or affinity column exchange pool where no cation exchanger is used) is necessary to lower the conductivity of the sample. The sorber functions well to strongly bind host cell proteins and other impurities in biological samples even at high conductivities and pH.	02-26-2009
20100200507	Media For Membrane Ion Exchange Chromatography Based On Polymeric Primary Amines, Sorption Device Containing That Media, And Chromatography Scheme And Purification Method Using The Same - Media and devices, such as anion exchangers including such media, wherein the media is a membrane having a surface coated with a polymer such as a polyallylamine. The resulting membrane offers stronger binding of protein impurities and superior removal of host cell proteins from biological samples than conventional ligands based on quaternary ammonium salts, including trimethylammonium ligands. Also described is a chromatography scheme and method for purifying monoclonal antibodies, wherein the anion exchange sorber is placed downstream of an affinity column (such as Protein A or Protein G affinity column) and optionally one or more polishing devices such as cationic exchange columns. Little or no dilution of the cation exchanger pool (or affinity column exchange pool where no cation exchanger is used) is necessary to lower the conductivity of the sample. The sorber functions well to strongly bind host cell proteins and other impurities in biological samples even at high conductivities and pH.	08-12-2010
20110284446	Media For Membrane Ion Exchange Chromatography Based On Polymeric Primary Amines, Sorption Device Containing That Media, And Chromatography Scheme And Purification Method Using The Same - Media and devices, such as anion exchangers including such media, wherein the media is a membrane having a surface coated with a polymer such as a polyallylamine. The resulting membrane offers stronger binding of protein impurities and superior removal of host cell proteins from biological samples than conventional ligands based on quaternary ammonium salts, including trimethylammonium ligands. Also described is a chromatography scheme and method for purifying monoclonal antibodies, wherein the anion exchange sorber is placed downstream of an affinity column (such as Protein A or Protein G affinity column) and optionally one or more polishing devices such as cationic exchange columns. Little or no dilution of the cation exchanger pool (or affinity column exchange pool where no cation exchanger is used) is necessary to lower the conductivity of the sample. The sorber functions well to strongly bind host cell proteins and other impurities in biological samples even at high conductivities and pH.	11-24-2011
20110288277	Media For Membrane Ion Exchange Chromatography Based On Polymeric Primary Amines, Sorption Device Containing That Media, And Chromatography Scheme And Purification Method Using The Same - Media and devices, such as anion exchangers including such media, wherein the media is a membrane having a surface coated with a polymer such as a polyallylamine. The resulting membrane offers stronger binding of protein impurities and superior removal of host cell proteins from biological samples than conventional ligands based on quaternary ammonium salts, including trimethylammonium ligands. Also described is a chromatography scheme and method for purifying monoclonal antibodies, wherein the anion exchange sorber is placed downstream of an affinity column (such as Protein A or Protein G affinity column) and optionally one or more polishing devices such as cationic exchange columns. Little or no dilution of the cation exchanger pool (or affinity column exchange pool where no cation exchanger is used) is necessary to lower the conductivity of the sample. The sorber functions well to strongly bind host cell proteins and other impurities in biological samples even at high conductivities and pH.	11-24-2011
20120121819	Media For Membrane Ion Exchange Chromatography Based On Polymeric Primary Amines, Sorption Device Containing That Media, And Chromatography Scheme And Purification Method Using The Same - Media and devices, such as anion exchangers including such media, wherein the media is a membrane having a surface coated with a polymer such as a polyallylamine. The resulting membrane offers stronger binding of protein impurities and superior removal of host cell proteins from biological samples than conventional ligands based on quaternary ammonium salts, including trimethylammonium ligands. Also described is a chromatography scheme and method for purifying monoclonal antibodies, wherein the anion exchange sorber is placed downstream of an affinity column (e.g., Protein A or Protein G) and optionally one or more polishing devices such as cationic exchange columns. Little or no dilution of the cation exchanger pool (or affinity column exchange pool where no cation exchanger is used) is necessary to lower the conductivity of the sample. The sorber functions well to strongly bind host cell proteins and other impurities in biological samples even at high conductivities and pH.	05-17-2012
20120193278	Media For Membrane Ion Exchange Chromatography Based On Polymeric Primary Amines, Sorption Device Containing That Media, And Chromatography Scheme And Purification Method Using The Same - Media and devices, such as anion exchangers including such media, wherein the media is a membrane having a surface coated with a polymer such as a polyallylamine. The resulting membrane offers stronger binding of protein impurities and superior removal of host cell proteins from biological samples than conventional ligands based on quaternary ammonium salts, including trimethylammonium ligands. Also described is a chromatography scheme and method for purifying monoclonal antibodies, wherein the anion exchange sorber is placed downstream of an affinity column (such as Protein A or Protein G affinity column) and optionally one or more polishing devices such as cationic exchange columns. Little or no dilution of the cation exchanger pool (or affinity column exchange pool where no cation exchanger is used) is necessary to lower the conductivity of the sample. The sorber functions well to strongly bind host cell proteins and other impurities even at high conductivities and pH.	08-02-2012

Paul Phillips, Westboro, MA US

Patent application number	Description	Published
20150149559	Systems and Methods for Customizing SIP Message Processing - System, methods, and computer program products are provided for configuring a computing system that processes messages according to the Session Initiation Protocol (SIP). The method includes defining, by a scripting-type computer processing language, one or more variables, where each variable is configured to store state data based on at least a portion of a SIP message and is associated with the SIP message flow. Once configuration is complete, a series of SIP messages belonging to the SIP message flow is received by the computer system. As each SIP message in the series is received, each SIP message is processed where the message processing includes modifying the state data stored in at least one of the variables based on data included in the respective SIP message	05-28-2015
20150149647	Systems and Methods for Providing Context to SIP Messages - Systems, methods, and computer program products are provided for providing context through a scripting-type programming language to data included in a SIP message. The method includes defining one or more contexts through a scripting-type computer programming language. The one or more contexts reference a particular pre-defined portion of a SIP message and are provided by the scripting-type computer programming language. A series of SIP messages may then be received, where each SIP message in the series belongs to the same SIP message flow. After a particular SIP message in the series is received, the message is parsed to identify whether it includes any portion of data that can be referenced via one or more contexts. Any particular portion of data that can be referenced via a context is associated with a respective context such that the respective portion of data can be referenced by the context.	05-28-2015
20150149648	Systems and Methods for Processing SIP Message Flows - Systems, methods, and computer program products are provided for modifying a Session Initiation Protocol (SIP) messages. The method includes providing a scripting-type computer programming language that includes contexts that reference pre-defined portions of data of a SIP message and variables that store data associated with a SIP message flow. An interface for configuring rules to be executed when processing SIP messages is provided. Each rule includes an action that describes a modification to be made to a particular SIP message. When a SIP message is received, it is parsed to determine at least a context of a portion of the message. The parsing includes associating the portion of the message with a particular context. It is then determined whether a rule should be applied to the data associated referenced by the contexts, and if so, the SIP message is modified based on the actions associated with the rule.	05-28-2015

Paul Phillips, Westborough, MA US

Patent application number	Description	Published
20110222440	METHODS, SYSTEMS AND COMPUTER READABLE MEDIA FOR UTILIZING A STANDARD SPANNING TREE PROTOCOL TO INDICATE AN ACTIVE SWITCHING FABRIC IN A NETWORK NODE - Methods, systems, and computer readable media for utilizing a standard spanning tree protocol to designate an active switching device in a network node are disclosed. In one example, the method includes generating a virtual network topology representation that includes a payload processing device connected to each of a first switching device and a second switching device, which share a virtual link that indicates that the first and second switching devices provide the same network access in the virtual network topology representation. The method also includes transmitting, from each of the first and second switching devices to the payload processing device, a standard spanning tree protocol signaling message that contains the virtual network topology representation and a bridge root priority identifier, wherein the bridge root priority identifier has been derived using an algorithm that considers whether the transmitting switching device is a preferred active switching device or a preferred standby switching device. The method further includes receiving the transmitted spanning tree protocol signaling messages and utilizing a standard spanning tree protocol at the payload processing device to construct a logical spanning tree using the virtual network topology representation and to select the preferred active switching device as a root bridge of the logical spanning tree based on comparing the bridge root priority identifiers as required by the standard spanning tree protocol, wherein the payload processing device only communicates application data via a link to the switching device designated as the root bridge.	09-15-2011

Paul G. Phillips, Westborough, MA US

Patent application number	Description	Published
20080259555	MODULAR BLADE SERVER - A blade server includes a chassis; a first plurality of bays in the chassis, wherein the first plurality of bays is adapted to receive and at least partially house a plurality of CPU modules, and wherein the first plurality of bays is accessible through a first side of the chassis; a second plurality of bays in the chassis, wherein the second plurality of bays is adapted to receive and at least partially house a plurality of PCI-Express modules, and wherein the second plurality of bays is accessible through a second side of the chassis; and a midplane board arranged to pass a PCI-Express signal between at least one of the plurality of CPU modules and at least one of the plurality of PCI-Express modules.	10-23-2008
20090089464	MODULAR I/O VIRTUALIZATION FOR BLADE SERVERS - An apparatus includes a server comprising n operating system images and an IOV aware root complex; a plurality of physical I/O devices comprising n virtual I/O functions; and a PCI Express bus operatively connected to the server and the plurality physical I/O devices via the root complex, wherein the root complex is operable to provide communication between the n operating system images and the n virtual I/O function, and wherein the server and the plurality of physical I/O devices are modules in a chassis.	04-02-2009

Peter V. Phillips, Leominster, MA US

Patent application number	Description	Published
20110199107	METHOD AND APPARATUS FOR CALIBRATING A TEST SYSTEM FOR MEASURING A DEVICE UNDER TEST - Methods and apparatus for calibrating a vector network analyzer (VNA) and characterizing a device under test. In one example, a device fixture including a pair of embedded device adapters provides an interface between a device under test (DUT) with non-coaxial connectors and the coaxial connectors of the VNA, and moves the calibration reference plane from the coaxial connectors of the VNA to a DUT reference plane at the leads/connectors of the DUT. A through fixture having a pair of similar through adapters is used to establish the DUT reference plane and to facilitate characterizing the device adapters such that they can be de-embedded from measurements of the device fixture.	08-18-2011

Richard Phillips, Sudbury, MA US

Patent application number	Description	Published
20110172950	INTEGRATED RATE ISOLATION SENSOR - In one embodiment, a system for providing fault-tolerant inertial measurement data includes a sensor for measuring an inertial parameter and a processor. The sensor has less accuracy than a typical inertial measurement unit (IMU). The processor detects whether a difference exists between a first data stream received from a first inertial measurement unit and a second data stream received from a second inertial measurement unit. Upon detecting a difference, the processor determines whether at least one of the first or second inertial measurement units has failed by comparing each of the first and second data streams to the inertial parameter.	07-14-2011

Robert A. Phillips, Acton, MA US

Patent application number	Description	Published
20090011066	Three-Dimensional Printer - A three-dimensional printer uses inkjet-type printheads to rapidly prototype, or print, a three-dimensional model. A powder feeder includes a conveyor system and a metering system to deliver powder to a build area in measured quantities. The powder feeder also includes a vacuum system for loading powder into a feed reservoir or chamber. The vacuum system can also be used to cleanup excess powder. Other powder control features include powder gutters and magnetic powder plows. During printing, a cleaning system operates to remove powder from the printheads. In the event of a printhead or jet failure, the failure can be detected and corrective measures taken automatically. After printing, the model can be depowdered and infiltrated in an enclosure.	01-08-2009

Robert S. Phillips, Brookfield, MA US

Patent application number	Description	Published
20080256090	DYNAMIC DIRECTORY SERVICE - In a network of computer nodes, a directory service provides both the physical location of directory information around the network and the directory information itself in a single data structure. This single data structure is distributed throughout the network, and continuously redistributed, so as to create a directory service that is both more flexible, and more robust, than prior art directory services.	10-16-2008

Scott T. Phillips, Cambridge, MA US

Patent application number	Description	Published
20090298191	Lateral Flow and Flow-through Bioassay Devices Based On Patterned Porous Media, Methods of Making Same, and Methods of Using Same - Embodiments of the invention provide lateral flow and flow-through bioassay devices based on patterned porous media, methods of making same, and methods of using same. Under one aspect, an assay device includes a porous, hydrophilic medium; a fluid impervious barrier comprising polymerized photoresist, the barrier substantially permeating the thickness of the porous, hydrophilic medium and defining a boundary of an assay region within the porous, hydrophilic medium; and an assay reagent in the assay region.	12-03-2009
20100285606	DENSITY-BASED METHODS FOR SEPARATION OF MATERIALS, MONITORING OF SOLID SUPPORTED REACTIONS AND MEASURING DENSITIES OF SMALL LIQUID VOLUMES AND SOLIDS - The ability to levitate, to separate, and to detect changes in density using diamagnetic particles suspended in solutions containing paramagnetic cations using an inhomogeneous magnetic field is described. The major advantages of this separation device are that: i) it is a simple apparatus that does not require electric power (a set of permanent magnets and gravity are sufficient for the diamagnetic separation and collection system to work); ii) it is compatible with simple optical detection (provided that transparent materials are used to fabricate the containers/channels where separation occurs; iii) it is simple to collect the separated particles for further processing; iv) it does not require magnetic labeling of the particles/materials; and v) it is small, portable. The method and kits provided provide for separation and collection of materials of different densities, diagnostics for detection of analytes of interest, monitoring of solid-supported chemical reactions and determination of densities of solid and liquid mixtures.	11-11-2010
20110111517	PAPER-BASED MICROFLUIDIC SYSTEMS - Paper-based microfluidic systems and methods of making the same are described.	05-12-2011
20110123398	THREE-DIMENSIONAL MICROFLUIDIC DEVICES - Three-dimensional microfluidic devices including by a plurality of patterned porous, hydrophilic layers and a fluid-impermeable layer disposed between every two adjacent patterned porous, hydrophilic layers are described. Each patterned porous, hydrophilic layer has a fluid-impermeable barrier which substantially permeates the thickness of the porous, hydrophilic layer and defines boundaries of one or more hydrophilic regions within the patterned porous, hydrophilic layer. The fluid-impermeable layer has openings which are aligned with at least part of the hydrophilic region within at least one adjacent patterned porous, hydrophilic layer. Microfluidic assay device, microfluidic mixer, microfluidic flow control device are also described.	05-26-2011
20130034869	DEVICES AND METHODS FOR MULTIPLEXED ASSAYS - The disclosure provides low cost, portable three-dimensional devices for performing multiplexed assays. The devices comprise at least two substantially planar layers disposed in parallel planes, wherein one of the layers is movable relative to each other parallel to the planes to permit the establishment of fluid flow communication serially between the two layers.	02-07-2013
20130128036	Lateral Flow and Flow-through Bioassay Devices Based on Patterned Porous Media, Methods of Making Same, and Methods of Using Same - Embodiments of the invention provide lateral flow and flow-through bioassay devices based on patterned porous media, methods of making same, and methods of using same. Under one aspect, an assay device includes a porous, hydrophilic medium; a fluid impervious barrier comprising polymerized photoresist, the barrier substantially permeating the thickness of the porous, hydrophilic medium and defining a boundary of an assay region within the porous, hydrophilic medium; and an assay reagent in the assay region.	05-23-2013
20140234881	LATERAL FLOW AND FLOW-THROUGH BIOASSAY DEVICES BASED ON PATTERNED POROUS MEDIA, METHODS OF MAKING SAME, AND METHODS OF USING SAME - Embodiments of the invention provide lateral flow and flow-through bioassay devices based on patterned porous media, methods of making same, and methods of using same. Under one aspect, an assay device includes a porous, hydrophilic medium; a fluid impervious barrier comprising polymerized photoresist, the barrier substantially permeating the thickness of the porous, hydrophilic medium and defining a boundary of an assay region within the porous, hydrophilic medium; and an assay reagent in the assay region.	08-21-2014

Sean Landis Phillips, Lancaster, MA US

Patent application number	Description	Published
20080290040	Methods and Apparatus for Foam Control in a Vacuum Filtration System - A flow diverter, vacuum control and tilting of the liquid filtering system are used alternatively or in conjunction to reduce foam production in a filtered liquid sample. A liquid filtering system includes an upper sample reservoir, a filter and a lower storage bottle. A vacuum is applied below the sample filter to draw sample liquid through the sample filter into the storage bottle. A flow diverter may be used to direct flow of the filtered liquid sample onto a sidewall of the storage bottle or guide flow to a bottom of the storage bottle. The vacuum may be regulated to reduce foaming. The liquid filtering system may be tilted to direct fluid to the sidewall of the lower storage bottle and reduce foaming.	11-27-2008
20090026126	Vacuum Base and Related Methods and Apparatus for Vacuum Filtration - Liquid filter assemblies including an upper sample reservoir, a sample filter and a lower storage bottle are supported by a vacuum base. The base has a vacuum inlet port and, for connection to the liquid filter assembly, a vacuum outlet port. A vacuum is provided through the base to below the sample filter to draw sample liquid through the sample filter into the storage bottle. The base may include an auxiliary vacuum outlet port for connection with additional devices. The bases may be connected from one to another through auxiliary vacuum outlets and the vacuum inlets to make a chain of liquid filter assemblies supplied from one vacuum source. Alternatively, one base may include multiple vacuum outlet ports so that it may support and supply vacuum to a plurality of liquid filter assemblies.	01-29-2009
20120267301	Method and Apparatus for Filtrate Storage Handling - A method of removing a filtrate storage bottle from a water bath includes inserting at least two finger underneath a radially protruding lip of a filtrate storage bottle sealing cap and raising the at least two fingers to lift the bottle from the water bath. A side wall portion of the filtrate storage bottle sealing cap is smaller in perimeter than a circle surrounding the radially protruding lip. The cap creates a liquid tight seal with the filtrate storage bottle.	10-25-2012
20120294781	Vacuum Base and Related Methods and Apparatus for Vacuum Filtration - Liquid filter assemblies including an upper sample reservoir, a sample filter and a lower storage bottle are supported by a vacuum base. The base has a vacuum inlet port and, for connection to the liquid filter assembly, a vacuum outlet port. A vacuum is provided through the base to below the sample filter to draw sample liquid through the sample filter into the storage bottle. The base may include an auxiliary vacuum outlet port for connection with additional devices. The bases may be connected from one to another through auxiliary vacuum outlets and the vacuum inlets to make a chain of liquid filter assemblies supplied from one vacuum source. Alternatively, one base may include multiple vacuum outlet ports so that it may support and supply vacuum to a plurality of liquid filter assemblies.	11-22-2012

Stephen C. Phillips, Southborough, MA US

Patent application number	Description	Published
20090204264	Method and apparatus for operating an automated biomolecular preparation system - A system automatically prepares and analyzes a macromolecule prepared from a complex liquid mixture. To prepare the macromolecule, a controller executing executable instructions, such as compiled software or firmware, operates a hydraulic subsystem in response to operational input, which may be interpreted by the executable instructions at run-time. To analyze the prepared macromolecule, an apparatus for capillary electrophoresis includes a liquid source, inlet chamber, capillary electrophoresis column, and controller that may operate under control of executable instructions and operational input in a similar manner. The system may require validation and approval by a regulatory body, such as the FDA. Based on the de-coupled configuration of the executable instructions and operational input, the system can be validated and approved with the executable instructions independent of the operational input, and vice-versa. A method for distributing the system based on this feature is also provided.	08-13-2009

Steven E. Phillips, Boylston, MA US

Patent application number	Description	Published
20110193282	METHOD AND APPARATUS FOR SECURING A WORKPIECE TO A FIXTURE PLATE USING AN ADJUSTABLE, LOW-PROFILE, LIGHT-DUTY WORKPIECE CLAMP - A workpiece clamp comprising:	08-11-2011
20110210494	METHOD AND APPARATUS FOR SECURING A WORKPIECE TO A FIXTURE PLATE USING A NOVEL WORKPIECE HOLD-DOWN CLAMP - A workpiece hold-down clamp for securing a workpiece to a fixture plate, the workpiece hold-down clamp comprising: a clamp post for mounting to the fixture plate; and a clamp finger which is adjustably mounted to the clamp post, wherein the clamp finger is configured for selective movement along the clamp post, and wherein the clamp finger comprises a portion for engaging the workpiece; wherein the clamp finger comprises a cantilever beam which is flexible.	09-01-2011
20140248113	MODULAR FIXTURE PLATE SYSTEM FOR POSITIONING A WORKPIECE DURING A MANUFACTURING AND/OR INSPECTION PROCESS - A modular fixture plate system comprising:	09-04-2014
20150352675	METHOD AND APPARATUS FOR SECURING A WORKPIECE TO A FIXTURE PLATE USING AN ADJUSTABLE, LOW-PROFILE, LIGHT-DUTY WORKPIECE CLAMP - A workpiece clamp comprising:	12-10-2015
20150352690	METHOD AND APPARATUS FOR SECURING A WORKPIECE TO A FIXTURE PLATE USING A NOVEL WORKPIECE HOLD-DOWN CLAMP - A workpiece hold-down clamp for securing a workpiece to a fixture plate, the workpiece hold-down clamp comprising:	12-10-2015

Walter Phillips, Arlington, MA US

Patent application number	Description	Published
20080232545	TOMOSYNTHESIS IMAGING SYSTEM AND METHOD - A system for three-dimensional tomosynthesis imaging of a target element is provided having an image acquisition element and a processor. The image acquisition element obtains a plurality of images of the target element from a plurality of angles and includes a radiation source that is positionable at a plurality of angles with respect to the target element and a radiation detector. The radiation detector is positioned so as to detect radiation emitted by the radiation source passing through the target element and determine a plurality of attenuation values for radiation passing through the target element to establish a radiation absorbance projection image of the target element for a particular radiation source angle. The processor is configured to apply an iterative reconstruction algorithm to the radiation absorbance projection images of the target element obtained from a plurality of radiation source angles to generate a three-dimensional reconstruction of the target element. The system can gain further accuracy where the iterative reconstruction algorithm is applied using cone-beam forward projection and back projection.	09-25-2008