Patent application number | Description | Published |
20110091549 | Modulating Drug Release Rate By Controlling The Kinetics Of The pH Transition In Hydrogels - Methods and compositions relate to modulating the release profile of drug molecules from a hydrogel by controlling the kinetics of the pH transition of the hydrogel. The hydrogel is formed by in situ polymerization and includes a drug molecule having a pKa between the pH of the formed hydrogel and the physiologic environment in which the hydrogel is placed. | 04-21-2011 |
20110092899 | Prevention Of Premature Gelling Of Delivery Devices For pH Dependent Forming Materials - The present disclosure provides treatment of an apparatus, in embodiments a delivery device, which prevents premature gelling of any materials or precursor(s) of a pH dependent forming material, in embodiments a hydrogel, dispensed by the delivery device. The pH microenvironment near the surface of a lumen of the device, in embodiments the tip of a spray applicator through which the material to be dispensed is expelled from the device, may be controlled to prevent premature gelling. | 04-21-2011 |
20110093057 | Mitigating Thrombus Formation On Medical Devices By Influencing pH Microenvironment Near The Surface - The present disclosure provides treatments of medical devices which inhibit thrombus formation. At least a portion of a substrate of a medical device includes a surface possessing a functionality and/or surface charge adapted to modulate the pH of the surface of the medical device, as well as the pH microenvironment near the surface of a medical device. | 04-21-2011 |
20120156289 | Biodegradable Osmotic Pump Implant For Drug Delivery - The present disclosure relates to a drug delivery device including a biodegradable housing and a hydrogel within the biodegradable housing. The housing, the hydrogel, or both, may include a bioactive agent. Also disclosed is a method of drug delivery including the steps of forming the biodegradable housing, in embodiments a hydrogel, suspending a bioactive agent in the hydrogel, and introducing a second hydrogel and/or precursors of a second hydrogel into the biodegradable housing. | 06-21-2012 |
20120175810 | Drug Delivery Implants, Systems And Methods For Making - The present disclosure provides implants suitable for drug delivery. In embodiments, the present disclosure provides layered biodegradable drug delivery implants and systems and methods for making these implants. | 07-12-2012 |
20120197028 | Crosslinked Polymers with the Crosslinker as Therapeutic For Sustained Release - Crosslinked polymers, methods for their preparation and use, are described in which the crosslinked polymers are formed from at least two polymer precursors, one of which is designed, upon degradation of the crosslinked polymer, to release the second polymer precursor in its original, unmodified chemical form. | 08-02-2012 |
20130156935 | Methods for Coating Medical Devices - Processes for coating medical devices are provided herein. The processes include heating a surface of the particles used to form the coating as the particles are being applied to the medical device. The resulting coating has improved adherence to the medical device, and does not require the use of solvents and/or water, obviating the need for any steps that otherwise might be required to remove these solvents and/or water. Sufficient adherence of the particles to the medical device may also occur without the need for heating the substrate used to form the medical device. | 06-20-2013 |
20130225857 | Crosslinked Polymers with the Crosslinker as Therapeutic for Sustained Release - Crosslinked polymers, methods for their preparation and use, are described in which the crosslinked polymers are formed from at least two polymer precursors, one of which is designed, upon degradation of the crosslinked polymer, to release the second polymer precursor in its original, unmodified chemical form. | 08-29-2013 |
20140005375 | Medical Devices Based On Oxidized Cellulose | 01-02-2014 |
20140005376 | Dissolution of Oxidized Cellulose and Particle Preparation by Solvent and Non-Solvent Precipitation | 01-02-2014 |
20140005377 | Dissolution of Oxidized Cellulose and Particle Preparation by Dispersion and Neutralization | 01-02-2014 |
20140005378 | Dissolution of Oxidized Cellulose and Particle Preparation by Cross-Linking With Multivalent Cations | 01-02-2014 |
20140274944 | Sprayable Hemostat Using Soluble Oxidized Cellulose With Miniaturized Electrospray System And Method - An applicator for forming a film is disclosed. The applicator includes: a first extension tube coupled to a source of a modified cellulose solution; a shaft coupled to the first extension tube at a proximal end thereof, the shaft defining a first lumen in fluid communication with the first extension tube for transmission of the modified cellulose solution through the shaft; and an atomizer disposed at a distal end of the and configured to atomize the modified cellulose solution into a plurality of particles. | 09-18-2014 |
20140274945 | Resorbable Oxidized Cellulose Embolization Microspheres - A method for forming an embolism within a blood vessel is disclosed. The method includes including: implanting a plurality of oxidized cellulose microspheres into a lumen of a blood vessel to at least partially block the lumen. | 09-18-2014 |