Penn
Charles Penn, Salisbury GB
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20090291457 | RE-TARGETED TOXIN CONJUGATES - The present invention provides a method for designing a re-targeted toxin conjugate for use in treating a medical condition or disease. Also provided, is the use of said conjugates in the manufacture of a medicament for treating medical conditions or diseases. The conjugates include a Targeting Moiety, which directs the conjugate to a desired target cell, and are characterised by a Targeting Moiety that increases exocytic fusion in the target cell. The present invention also provides methods for identifying agonists suitable for use as Targeting Moieties, and methods for preparing conjugates comprising said Targeting Moieties. | 11-26-2009 |
20110177053 | NON-CYTOTOXIC PROTEIN CONJUGATES - The present invention is directed to non-cytotoxic protein conjugates for inhibition or reduction of exocytic fusion in a nociceptive sensory afferent cell. The protein conjugates comprise: (i) a Targeting Moiety (TM), wherein the TM is an agonist of a receptor present on a nociceptive sensory afferent cell, and wherein the receptor undergoes endocytosis to be incorporated into an endosome within the nociceptive sensory afferent cell; (ii) a non-cytotoxic protease or a fragment thereof, wherein the protease or protease fragment is capable of cleaving a protein of the exocytic fusion apparatus of the nociceptive sensory afferent cell; and (iii) a Translocation Domain, wherein the Translocation Domain translocates the protease or protease fragment from within the endosome, across the endosomal membrane, and into the cytosol of the nociceptive sensory afferent cell. Nucleic acid sequences encoding the protein conjugates, methods of preparing same and uses thereof are also described. | 07-21-2011 |
20120156186 | NON-CYTOTOXIC PROTEIN CONJUGATES - The present invention is directed to non-cytotoxic protein conjugates for inhibition or reduction of exocytic fusion in a nociceptive sensory afferent cell. The protein conjugates comprise: (i) a galanin Targeting Moiety (TM), wherein the TM is an agonist of a receptor present on a nociceptive sensory afferent cell, and wherein the receptor undergoes endocytosis to be incorporated into an endosome within the nociceptive sensory afferent cell; (ii) a non-cytotoxic protease or a fragment thereof, wherein the protease or protease fragment is capable of cleaving a protein of the exocytic fusion apparatus of the nociceptive sensory afferent cell; and (iii) a Translocation Domain, wherein the Translocation Domain translocates the protease or protease fragment from within the endosome, across the endosomal membrane, and into the cytosol of the nociceptive sensory afferent cell. Nucleic acid sequences encoding the protein conjugates, methods of preparing same and uses thereof are is also described. | 06-21-2012 |
20120207735 | NON-CYTOTOXIC PROTEIN CONJUGATES - The present invention is directed to non-cytotoxic protein conjugates for inhibition or reduction of exocytic fusion in a nociceptive sensory afferent cell. The protein conjugates comprise: (i) a Targeting Moiety (TM), wherein the TM is an agonist of a receptor present on a nociceptive sensory afferent cell, and wherein the receptor undergoes endocytosis to be incorporated into an endosome within the nociceptive sensory afferent cell; (ii) a non-cytotoxic protease or a fragment thereof, wherein the protease or protease fragment is capable of cleaving a protein of the exocytic fusion to apparatus of the nociceptive sensory afferent cell; and (iii) a Translocation Domain, wherein the Translocation Domain translocates the protease or protease fragment from within the endosome, across the endosomal membrane, and into the cytosol of the nociceptive sensory afferent cell wherein the Targeting Moiety is selected from the group consisting of BAM, β-endorphin, bradykinin, substance P, dynorphin and/or nociceptin. | 08-16-2012 |
20130122526 | METHOD OF PREPARING A FUSION PROTEIN FOR THE INHIBITION OR REDUCTION OF SECRETION OF AN EXTRACELLULAR MEDIATOR FROM A TARGET CELL - The present invention provides a method for designing a re-targeted toxin conjugate for use in treating a medical condition or disease. Also provided, is the use of said conjugates in the manufacture of a medicament for treating medical conditions or diseases. The conjugates include a Targeting Moiety, which directs the conjugate to a desired target cell, and are characterised by a Targeting Moiety that increases exocytic fusion in the target cell. The present invention also provides methods for identifying agonists suitable for use as Targeting Moieties, and methods for preparing conjugates comprising said Targeting Moieties. | 05-16-2013 |
20140294797 | NON-CYTOTOXIC PROTEIN CONJUGATES - The present invention is directed to non-cytotoxic protein conjugates for inhibition or reduction of exocytic fusion in a nociceptive sensory afferent cell. The protein conjugates comprise: (i) a Targeting Moiety (TM), wherein the TM is an agonist of a receptor present on a nociceptive sensory afferent cell, and wherein the receptor undergoes endocytosis to be incorporated into an endosome within the nociceptive sensory afferent cell; (ii) a non-cytotoxic protease or a fragment thereof, wherein the protease or protease fragment is capable of cleaving a protein of the exocytic fusion apparatus of the nociceptive sensory afferent cell; and (iii) a Translocation Domain, wherein the Translocation Domain translocates the protease or protease fragment from within the endosome, across the endosomal membrane, and into the cytosol of the nociceptive sensory afferent cell wherein the Targeting Moiety is selected from the group consisting of BAM, β-endorphin, bradykinin, substance P, dynorphin and/or nociceptin. | 10-02-2014 |
Charles Penn, Wiltshire GB
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20090162341 | Non-Cytotoxic Protein Conjugates - A non-cytotoxic protein conjugate for inhibition or reduction of exocytic fusion in a nociceptive sensory afferent cell, comprising: (i) a Targeting Moiety (TM), wherein said TM is an agonist of a receptor present on said nociceptive sensory afferent cell, and wherein said receptor undergoes endocytosis to be incorporated into an endosome within the nociceptive sensory afferent cell; (ii) a non-cytotoxic protease or a fragment thereof, wherein the protease or protease fragment is capable of cleaving a protein of the exocytic fusion apparatus of said nociceptive sensory afferent cell; and (iii) a Translocation Domain, wherein the Translocation Domain translocates the protease or protease fragment from within the endosome, across the endosomal membrane, and into the cytosol of the nociceptive sensory afferent cell. Nucleic acid sequences encoding the protein conjugates, methods of preparing same and uses thereof are also described. | 06-25-2009 |
Charles Penn, Abingdon GB
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20120058098 | NON-CYTOTOXIC PROTEIN CONJUGATES - The present invention is directed to non-cytotoxic protein conjugates for inhibition or reduction of exocytic fusion in a nociceptive sensory afferent cell. The protein conjugates comprise: (i) a dynorphin Targeting Moiety (TM), wherein the TM is an agonist of a receptor present on a nociceptive sensory afferent cell, and wherein the receptor undergoes endocytosis to be incorporated into an endosome within the nociceptive sensory afferent cell; (ii) a non-cytotoxic protease or a fragment thereof, wherein the protease or protease fragment is capable of cleaving a protein of the exocytic fusion apparatus of the nociceptive sensory afferent cell; and (iii) a Translocation Domain, wherein the Translocation Domain translocates the protease or protease fragment from within the endosome, across the endosomal membrane, and into the cytosol of the nociceptive sensory afferent cell. Nucleic acid sequences encoding the protein conjugates, methods of preparing same and uses thereof are also described. | 03-08-2012 |
20130295643 | NON-CYTOTOXIC PROTEIN CONJUGATES - The present invention is directed to non-cytotoxic protein conjugates for inhibition or reduction of exocytic fusion in a nociceptive sensory afferent cell. The protein conjugates comprise: (i) a dynorphin Targeting Moiety (TM), wherein the TM is an agonist of a receptor present on a nociceptive sensory afferent cell, and wherein the receptor undergoes endocytosis to be incorporated into an endosome within the nociceptive sensory afferent cell; (ii) a non-cytotoxic protease or a fragment thereof, wherein the protease or protease fragment is capable of cleaving a protein of the exocytic fusion apparatus of the nociceptive sensory afferent cell; and (iii) a Translocation Domain, wherein the Translocation Domain translocates the protease or protease fragment from within the endosome, across the endosomal membrane, and into the cytosol of the nociceptive sensory afferent cell. Nucleic acid sequences encoding the protein conjugates, methods of preparing same and uses thereof are also described. | 11-07-2013 |
David Penn, Point Piper AU
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20130239978 | DENTAL DEVICE - A dental device which comprises both an upper part fitted to the upper jaw of a wearer and a lower part fitted to the lower jaw of the wearer, wherein the upper part includes an upper magnet, the lower part includes a lower magnet, and the magnets are arranged so as to establish a magnetic repulsion between the magnets which opposes the closing of the jaw, thereby opposing direct contact between the upper part and the lower part. | 09-19-2013 |
Gerald Bradley Penn, Thornhill CA
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20140195227 | SYSTEM AND METHOD FOR ACOUSTIC TRANSFORMATION - An acoustic transformation system and method. A specific embodiment is the transformation of acoustic speech signals produced by speakers with speech disabilities in order to make those utterances more intelligible to typical listeners. These modifications include the correction of tempo or rhythm, the adjustment of formant frequencies in sonorants, the removal of adjustment of aberrant voicing, the deletion of phoneme insertion errors, and the replacement of erroneously dropped phonemes. These methods may also be applied to general correction of musical or acoustic sequences. | 07-10-2014 |
Gerald Bradley Penn, Scarborough CA
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20140288928 | SYSTEM AND METHOD FOR APPLYING A CONVOLUTIONAL NEURAL NETWORK TO SPEECH RECOGNITION - A system and method for applying a convolutional neural network (CNN) to speech recognition. The CNN may provide input to a hidden Markov model and has at least one pair of a convolution layer and a pooling layer. The CNN operates along the frequency axis. The CNN has units that operate upon one or more local frequency bands of an acoustic signal. The CNN mitigates acoustic variation. | 09-25-2014 |
Gerhard Penn, Oberwil CH
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20090216047 | Purification process - Purification process for the preparation of the allylamine pharmaceutical terbinafine of formula I | 08-27-2009 |
20100087545 | PURIFICATION PROCESS - Process for the preparation of pure allylamine pharmaceutical terbinafine of formula I | 04-08-2010 |
20110144352 | PROCESSES FOR THE PREPARATION OF 4-OXO-OCTAHYDRO-INDOLE-1-CARBOCYCLIC ACID METHYL ESTER AND DERIVATIVES THEREOF - The present invention relates to a process for the production of carbamic acid (2-chloroethyl)(3-oxocyclohexyl)-alkyl ester enantiomers and of 1-carbalkoxy-4-ketoperhydroindole enantiomers. | 06-16-2011 |
Gerhard Penn, Basel CH
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20090054653 | ENANTIOSELEKTIVE PREPARATION OF QUINOLINE DERIVATIVE - A process for preparing 8-substituted oxy-5-((R)-2-halo-1-hydroxy-ethyl)-(1H)-quinolin-2-ones or acceptable solvates thereof. The process involves reacting a 5-(α-haloacetyl)-8-substituted oxy-(1H)-quinolin-2-one with a reducing agent in the presence of a chiral agent and a base to form a 8-(substituted oxy)-5-((R)-2-halo-1-hydroxy-ethyl)-(1H)-quinolin-2-one, said chiral agent having a formula I or II | 02-26-2009 |
20120220775 | ENANTIOSELECTIVE PREPARATION OF QUINOLINE DERIVATIVES - A process for preparing 8-substituted oxy-5-((R)-2-halo-1-hydroxy-ethyl)-(1H)-quinolin-2-ones or acceptable solvates thereof. The process involves reacting a 5-(α-haloacetyl)-8-substituted oxy-(1H)-quinolin-2-one with a reducing agent in the presence of a chiral agent and a base to form a 8-(substituted oxy)-5-((R)-2-halo-1-hydroxy-ethyl)-(1H)-quinolin-2-one, said chiral agent having a formula I or II | 08-30-2012 |
Ian M. Penn, Vancouver CA
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20090036974 | EXPANDABLE STENT AND METHOD FOR DELIVERY OF SAME - An expandable stent having a proximal end and a distal end in communication with one another, and a tubular wall disposed between the proximal end and the distal end. The tubular wall has a longitudinal axis and a porous surface defined by a plurality of intersecting members comprising a series of longitudinal struts disposed substantially parallel to the longitudinal axis of the stent. Each longitudinal strut in the series comprises flexure members for substantially complementary extension and compression of a diametrically opposed pair of the longitudinal struts upon flexure of the stent. The flexure members may comprise first and second curved sections which are of a different size. At least one of the curved sections may comprise an arc of greater than about 180°. | 02-05-2009 |
20090192590 | EXPANDABLE STENT AND METHOD FOR DELIVERY OF SAME - An expandable stent comprising a proximal end and a distal end in communication with one another and a tubular wall disposed between the proximal end and the distal end. The tubular wall has a longitudinal axis and a porous surface defined by a plurality of intersecting members comprising a series of longitudinal struts disposed substantially parallel to the longitudinal axis of the stent. Each longitudinal strut in the series comprises flexure means for substantially complementary extension and compression of a diametrically opposed pair of the longitudinal struts upon flexure of the stent. The stent is expandable from a first, contracted position to a second, expanded position upon the application of a radially outward force on the stent. The provision of such flexure means in the series of longitudinal struts leads to a very desirable balance of lateral flexibility of the unexpanded stent and radial rigidity of the expanded stent. | 07-30-2009 |
20090254167 | BIFURCATED STENT DELIVERY SYSTEM AND METHOD OF USE - An endovascular sleeve which can be utilized to navigate a pair of guidewires to a bifurcated body passageway such that, once in place, the guidewires are substantially untwisted or untangled. This greatly facilitates delivery of the bifurcated stent to the bifurcated artery. | 10-08-2009 |
20140128962 | ENDOVASCULAR PROSTHESIS AND DELIVERY DEVICE - In one of its aspects, the present invention relates to an endovascular prosthesis. The endovascular prosthesis comprises a first expandable portion expandable from a first, unexpanded state to a second, expanded state to urge the first expandable portion against a vascular lumen and a retractable leaf portion attached to the first expandable portion. The retractable leaf portion comprises at least one spine portion and a plurality of rib portions attached to the spine portion. Longitudinally adjacent pairs of rib portions are free of interconnecting struts. The endovascular prosthesis that can be unsheathed and re-sheathed for repositioning of the endovascular prosthesis prior to final deployment thereof. There is also described a delivery device that that is particularly well suited to delivering the present endovascular prosthesis through tortuous vasculature in the body. | 05-08-2014 |
Johann Penn, Altenberg AT
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20100314421 | APPARATUS FOR THE INTERCHANGEABLE CONNECTION OF A CASTING TUBE TO A SPOUT OF A MELT VESSEL - A device for interchangeable connection of a casting tube to a spout of a melt vessel with a sliding closure fastened on a melt vessel. The closure is formed by at least one stationary closure plate and a closure plate that can be displaced relative thereto, wherein the displaceable closure plate is coupled to a sliding drive system and carries the casting tube. To improve the changeover process of a casting tube and to make it safer, the displaceable closure plate carries a connecting ring for the centered accommodation of the casting tube and the displaceable closure plate carries a changing device for the casting tube. The changing device is synchronously displaceable with the displaceable plate. A tensioning device presses the casting tube onto the displaceable closure plate. | 12-16-2010 |
Julia Penn, Berkshire GB
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20080318267 | Methods and Compositions for Ultra-High Throughput Screening of Natural Products - The present invention provides cells having more than two drug resistance genes and at least two different resistance genes that have been recombined into the chromosome of a cell. It also teaches the processes for preparing cells by recombining two or more different drug resistance genes into the chromosome of a cell. The invention further shows a screening method using the cells of described herein that may be used to accomplish high throughput screening of, among other things, natural products and/or whole cells isolated from the environment. | 12-25-2008 |
Julia Penn, Maidenhead GB
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20100311107 | Ultra-High Throughput Screening of Natural Products - The present invention provides cells having more than two drug resistance genes and at least two different resistance genes that have been recombined into the chromosome of a cell. It also teaches the processes for preparing cells by recombining two or more different drug resistance genes into the chromosome of a cell. The invention further shows a screening method using the cells of described herein that may be used to accomplish high throughput screening of, among other things, natural products and/or whole cells isolated from the environment. | 12-09-2010 |
Laurence Richard Penn, Leicestershire GB
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20120018454 | ROTARY METERING DEVICE AND SYSTEM - A modular rotary metering unit comprising: a housing having at least one liquid inlet and liquid outlet; a rotatable member arranged to rotate about a longitudinal axis thereof with respect to the housing; and at least one bore passing through the rotatable member, the or each bore having two opposing ends and a shuttle element received therein, the shuttle element being movable between two terminal positions, each towards a respective end of the bore, wherein, when the rotatable member rotates, each bore moves in communication with a liquid inlet of the housing and a liquid outlet of the housing such that liquid can be received from the liquid inlet by the bore at the one end of the bore and the shuttle element can eject liquid from the other end of the bore to the liquid outlet, wherein respective first and second engagement elements are provided at first and second ends of the unit, each of the engagement elements being rotationally linked to the rotatable member. Also disclosed is a rotary metering device comprising: a housing having at least one liquid inlet and liquid outlet; a rotatable member arranged to rotate about a longitudinal axis thereof with respect to the housing; and first and second bores passing through the rotatable member, each bore having a two opposing ends and a shuttle element received therein, the shuttle element being movable between two terminal positions, each towards a respective end of the bore, wherein, when the rotatable member rotates, each bore moves into communication with a liquid inlet of the housing and a liquid outlet of the housing such that liquid can be received from the liquid inlet by the bore at the one end of the bore and the shuttle element can eject liquid from the other end of the bore to the liquid outlet. | 01-26-2012 |
Linda Penn, Toronto CA
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20130131088 | TREATING CANCER WITH STATINS AND COMPOUNDS HAVING DIPYRIDAMOLE ACTIVITY - The disclosure pertains to methods of treating a cancer comprising administering to a subject in need thereof an effective amount of a statin in combination with an effective amount of a dipyridamole and/or a compound that has dipyridamole activity. | 05-23-2013 |
Linda Z. Penn, Toronto CA
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20120004116 | METHODS FOR BIOMARKER IDENTIFICATION AND BIOMARKER FOR NON-SMALL CELL LUNG CANCER - There is provided a method for identifying a biomarker, such as a gene signature, associated with a biological parameter A 6-gene signature for non-small cell lung cancer (NSCLC) is also provided, as well as a method of prognosing or classifying a subject with non-small cell lung cancer into a poor survival group or a good survival group, using said gene signature | 01-05-2012 |
Markus Penn, Boehl-Iggelheim DE
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20140006304 | CONSISTENT INTERFACE FOR BUSINESS PARTNER RELATIONSHIP AND BUSINESS PARTNER HIERARCHY | 01-02-2014 |
Michal Penn, Haifa IL
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20100042726 | FLUID BASED RESOURCE ALLOCATION AND APPOINTMENT SCHEDULING SYSTEM AND METHOD - A scheduling system and method for managing resource allocation by service providers. The system includes a type-constrained appointment book wherein appointment windows are assigned to client types and a scheduler for receiving scheduling requests clients, identifying their characteristic client-type and allocating at least one appointment window assigned to the characteristic client-type to the client. The appointment book is constrained using a fluid model of client flow and may be optimized to suit various requirements. | 02-18-2010 |
20140337079 | FLUID BASED RESOURCE ALLOCATION AND APPOINTMENT SCHEDULING SYSTEM AND METHOD - A scheduling system and method for managing resource allocation by service providers. The system includes a type-constrained appointment book wherein appointment windows are assigned to client types and a scheduler for receiving scheduling requests clients, identifying their characteristic client-type and allocating at least one appointment window assigned to the characteristic client-type to the client. The appointment book is constrained using a fluid model of client flow and may be optimized to suit various requirements. | 11-13-2014 |
Oded Penn, Ramat Hasharon IL
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20140069269 | ANTI-BALLISTIC PROTECTIVE ASSEMBLIES - Provided is an anti-ballistic protective assembly including a plurality of layers of anti-ballistic material including at least two types of anti-ballistic materials, and an enclosure which is at least partially injection molded over the plurality of layers of anti-ballistic material and retains the plurality of layers of anti-ballistic material in a mutually compressed operative orientation. | 03-13-2014 |
Richard Francis Penn, Kanata CA
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20090037030 | GRAPHICAL INTERFACE FOR CONFIGURING A POWER SUPPLY CONTROLLER - Information for configuring control apparatus for a power system including a plurality of controlled power supplies is produced using a graphical interface which displays the topology and sequencing of the power supplies in the power system. A database is used to select power supplies to add in determining the power system topology. Sequencing is represented by displacing icons representing the power supplies along lines representing their input and output voltages, and arrows representing startup sequence dependencies. A processor produces the configuration information, consistent with the displayed topology and sequencing, using information for the selected power supplies from the database, for downloading to the control apparatus. | 02-05-2009 |
Robert Penn, Eichenau DE
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20100303618 | WIND POWER STATION WITH DARRIEUS-ROTOR - The power output of a wind power station with a Darrieus Rotor is enhanced by wind guides positioned around the Darrieus Rotor to form a wind concentrator. The wind guides include at least two parallel wind deflection plates, displaced along parallel direction with respect to each other. | 12-02-2010 |
Roni Penn, Haifa IL
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20100294717 | POST TREATMENT FOR DESALINATED AND SOFT WATER FOR BALANCED WATER COMPOSITION SUPPLY - An H2S04-based calcite dissolution post-treatment process and apparatii for desalinated water are provided. The process comprises separating cations from seawater by ion exchange resin (s) ( | 11-25-2010 |