Patent application number | Description | Published |
20100016251 | NUCLEOSIDE PHOSPHORAMIDATE PRODRUGS - Disclosed herein are phosphoramidate prodrugs of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomer, salt (acid or basic addition salt), hydrate, solvate, or crystalline form thereof, represented by the following structure: | 01-21-2010 |
20100048917 | PREPARATION OF ALKYL-SUBSTITUTED 2-DEOXY-2-FLUORO-D-RIBOFURANOSYL PYRIMIDINES AND PURINES AND THEIR DERIVATIVES - The present invention provides (i) a process for preparing a 2-deoxy-2-fluoro-2-methyl-D-ribonolactone derivative, (ii) conversion of the lactone to nucleosides with potent anti-HCV activity, and their analogues, and (iii) a method to prepare the anti-HCV nucleosides containing the 2-deoxy-2-fluoro-2-C-methyl-β-D-ribofuranosyl nucleosides from a preformed, preferably naturally-occurring, nucleoside. | 02-25-2010 |
20100234585 | PREPARATION OF ALKYL-SUBSTITUTED 2-DEOXY-2-FLUORO-D-RIBOFURANOSYL PYRIMIDINES AND PURINES AND THEIR DERIVATIVES - The present invention provides (i) a process for preparing a 2-deoxy-2-fluoro-2-methyl-D-ribonolactone derivative, (ii) conversion of the lactone to nucleosides with potent anti-HCV activity, and their analogues, and (iii) a method to prepare the anti-HCV nucleosides containing the 2-deoxy-2-fluoro-2-C-methyl-β-D-ribofuranosyl nucleosides from a preformed, preferably naturally-occurring, nucleoside. | 09-16-2010 |
20100298257 | NUCLEOSIDE PHOSPHORAMIDATES - Disclosed herein are nucleoside phosphoramidates and their use as agents for treating viral diseases. These compounds are inhibitors of RNA-dependent 5 RNA viral replication and are useful as inhibitors of HCV NS5B polymerase, as inhibitors of HCV replication and for treatment of hepatitis C infection in mammals. | 11-25-2010 |
20110015146 | NUCLEOSIDE PHOSPHORAMIDATES - A nucleoside compound having activity against hepatitis C virus is disclosed. | 01-20-2011 |
20110251152 | NUCLEOSIDE PHOSPHORAMIDATES - Disclosed herein are nucleoside phosphoramidates and their use as agents for treating viral diseases. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful as inhibitors of HCV NS5B polymerase, as inhibitors of HCV replication and for treatment of hepatitis C infection in mammals. | 10-13-2011 |
20110257122 | NUCLEOSIDE PHOSPHORAMIDATE PRODRUGS - Disclosed herein are phosphoramidate prodrugs of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomer, salt (acid or basic addition salt), hydrate, solvate, or crystalline form thereof, represented by the following structure: | 10-20-2011 |
20130225519 | NUCLEOSIDE PHOSPHORAMIDATES - A nucleoside compound having activity against hepatitis C virus is disclosed. | 08-29-2013 |
Patent application number | Description | Published |
20130029929 | NUCLEOSIDE PHOSPHORAMIDATE PRODRUGS - Disclosed herein are phosphoramidate prodrugs of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomer, salt (acid or basic addition salt), hydrate, solvate, or crystalline form thereof, represented by the following structure: | 01-31-2013 |
20130137654 | NUCLEOSIDE PHOSPHORAMIDATES - Disclosed herein are nucleoside phosphoramidates and their use as agents for treating viral diseases. These compounds are inhibitors of RNA-dependent 5 RNA viral replication and are useful as inhibitors of HCV NS5B polymerase, as inhibitors of HCV replication and for treatment of hepatitis C infection in mammals. | 05-30-2013 |
20130165401 | NUCLEOSIDE PHOSPHORAMIDATES - Disclosed herein are nucleoside phosphoramidates and their use as agents for treating viral diseases. These compounds are inhibitors of RNA-dependent 5 RNA viral replication and are useful as inhibitors of HCV NS5B polymerase, as inhibitors of HCV replication and for treatment of hepatitis C infection in mammals. | 06-27-2013 |
20130165644 | NUCLEOSIDE PHOSPHORAMIDATES - Disclosed herein are nucleoside phosphoramidates and their use as agents for treating viral diseases. These compounds are inhibitors of RNA-dependent 5 RNA viral replication and are useful as inhibitors of HCV NS5B polymerase, as inhibitors of HCV replication and for treatment of hepatitis C infection in mammals. | 06-27-2013 |
20130288997 | NUCLEOSIDE PHOSPHORAMIDATES - Disclosed herein are nucleoside phosphoramidates and their use as agents for treating viral diseases. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful as inhibitors of HCV NS5B polymerase, as inhibitors of HCV replication and for treatment of hepatitis C infection in mammals. | 10-31-2013 |
20130310551 | NUCLEOSIDE PHOSPHORAMIDATES - Disclosed herein are nucleoside phosphoramidates and their use as agents for treating viral diseases. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful as inhibitors of HCV NS5B polymerase, as inhibitors of HCV replication and for treatment of hepatitis C infection in mammals. | 11-21-2013 |
20130338349 | PREPARATION OF 2'-FLUORO-2'-ALKYL-SUBSTITUTED OR OTHER OPTIONALLY SUBSTITUTED RIBOFURANOSYL PYRIMIDINES AND PURINES AND THEIR DERIVATIVES - The present invention provides (i) processes for preparing a 2′-deoxy-2′-fluoro-2′-methyl-D-ribonolactone derivatives, (ii) conversion of intermediate lactones to nucleosides with potent anti-HCV activity, and their analogues, and (iii) methods to prepare the anti-HCV nucleosides containing the 2′-deoxy-2′-fluoro-2′-C-methyl-β-D-ribofuranosyl nucleosides from a preformed, preferably naturally-occurring, nucleoside. | 12-19-2013 |
20140045783 | NUCLEOSIDE PHOSPHORAMIDATE PRODRUGS - Disclosed herein are phosphoramidate prodrugs of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomer, salt (acid or basic addition salt), hydrate, solvate, or crystalline form thereof, represented by the following structure: | 02-13-2014 |
20140121366 | NUCLEOSIDE PHOSPHORAMIDATES - Disclosed herein are nucleoside phosphoramidates and their use as agents for treating viral diseases. These compounds are inhibitors of RNA-dependent 5 RNA viral replication and are useful as inhibitors of HCV NS5B polymerase, as inhibitors of HCV replication and for treatment of hepatitis C infection in mammals. | 05-01-2014 |
20140187511 | NUCLEOSIDE PHOSPHORAMIDATE PRODRUGS - Disclosed herein are phosphoramidate prodrugs of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomer, salt (acid or basic addition salt), hydrate, solvate, or crystalline form thereof, represented by the following structure: | 07-03-2014 |
Patent application number | Description | Published |
20140198563 | MAGNETIC TUNNELING JUNCTION NON-VOLATILE REGISTER WITH FEEDBACK FOR ROBUST READ AND WRITE OPERATIONS - A magnetic tunneling junction non-volatile register with feedback for robust read and write operations. In an embodiment, two MTJ devices are configured to store a logical 0 or a logical 1, and are coupled to drive an output node to a voltage indicative of the stored logical 0 or a logical 1. The output of a D flip-flop is fed to the two MTJ devices so that the state of the D flip-flop may be stored in the two MTJ devices during a store operation. During a read operation, the D flip-flop outputs the state of the two MTJ devices. Read disturbances are mitigated with the use of an edge detector coupled to the output node, so that a LOW voltage is provided to the D flip-flop if a rising voltage at the output node is detected. | 07-17-2014 |
20140222880 | METHOD AND APPARATUS FOR GENERATING RANDOM NUMBERS USING A PHYSICAL ENTROPY SOURCE - A method and apparatus for generating random binary sequences from a physical entropy source having a state A and a state B by detecting whether the physical entropy source is in the state A or in the state B, attempting to shift the state of the physical entropy source to the opposite state in a probabilistic manner with less than 100% certainty, and producing one of four outputs based on the detected state and the state of the physical entropy source before the attempted shift. The outputs are placed in first and second queues and extracted in pairs from each queue. Random binary bits are output based on the sequences extracted from each queue. | 08-07-2014 |
20150084972 | CONTACTLESS DATA COMMUNICATION USING IN-PLANE MAGNETIC FIELDS, AND RELATED SYSTEMS AND METHODS - Embodiments described herein are related to contactless data communication. Related systems and methods for contactless data communication are disclosed herein. For example, a magnetic field-based contactless transmitter is disclosed that includes a substrate, a pair of dipole coils disposed on the substrate, and a drive circuit electrically coupled to the pair of dipole coils. To transmit data to a magnetic tunnel junction (MTJ) receiver disposed on a second substrate, the drive circuit is configured to drive the pair of dipole coils so as to generate a magnetic field in-plane to the MTJ receiver. Data can be transmitted from the magnetic field-based contactless transmitter to the MTJ receiver using the magnetic field. | 03-26-2015 |
Patent application number | Description | Published |
20100018097 | Elevating billboard and control method thereof - The present invention relates to an elevating billboard and control method thereof, which includes a hollow column, a billboard stent, and a windlass controlling a motor, forward relay and back relay, wherein a hollow cylinder is fixed with the billboard stent and rings the column so as to slide along the column up and down, a fixed pulley disposed on the top of the column, a free end of a guy cable of the windlass connecting with the hollow cylinder by the fixed pulley. By using the motor of the windlass and the fixed pulleys, the invention is easy to assemble, disassemble or maintain, and is capable of completing the up and down movement easily and quickly. And using the real-time monitor of the anemoscope, the invention completes the up and down movement easily and quickly by wind scale. | 01-28-2010 |
20100018098 | Stormproof billboard and control method thereof - The present invention relates to an stormproof billboard and control method thereof, which includes a column, a billboard stent, a rotating element, a motor, an electromagnetic brake, an anemoscope, a trigger switch, and an electric control assembly, wherein the control element respectively connects with the electromagnetic brake, the motor and the trigger switch, the electric control assembly controls the work of the motor and the electromagnetic brake by the wind speed signal measured by the anemoscope and the signal of the trigger switch. By using above structure, the invention can change the windward section of the stormproof billboard by the wind speed and the wind direction, such that effectively reduces the wind load, makes the stormproof billboard more secure in use. The invention is easy to control and secure to use, makes the advertisement have a good effect, it is worth to use the stormproof billboard. | 01-28-2010 |
20100122481 | WINDPROOF BILLBOARD - A windproof billboard, including at least a body, a pair of first supports, multiple second supports, a rotating shaft, multiple linkage mechanisms, a transmission mechanism, a power mechanism, and at least one brake, wherein the first supports and the second supports are disposed on the ground, the bottom of the body is hinge connected to the first supports, the linkage mechanisms are hinge connected an upper part of the back of the body and fixed on the rotating shaft, and operate to drive the body to rotate with respect to the first supports, the rotating shaft abuts against one of the second supports, the power mechanism is fixed on the transmission mechanism and operates to drive the rotating shaft to rotate via the transmission mechanism, and the brake is disposed on one of the second supports and operates to fix the rotating shaft. | 05-20-2010 |