Peer, IL
Boaz Peer, Gan Haim IL
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20100100468 | SYSTEM AND METHOD FOR MULTI LAYER RULE PROCESSING BACKGROUND - A system and method for processing a digital transaction using a layered rule architecture. Any number of rules may be applied to or tested against a transaction record. Rules and associated actions may be associated with priorities. A conflict resolution method or logic may be used to select one or more actions from a set of actions resulting from applying a set of rules to a transaction record. | 04-22-2010 |
Dan Peer, Kiryat Uno IL
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20080248092 | Formulations of Water Insoluble or Poorly Water Soluble Drugs in Lipidated Glycosaminoglycan Particles and Their Use for Diagnostic and Therapy - The invention provides a formulation of water insoluble or poorly water soluble drugs encapsulated in lipidated glycosaminoglycan particles for targeted drug delivery. | 10-09-2008 |
20120171261 | FORMULATIONS OF WATER INSOLUBLE OR POORLY WATER SOLUBLE DRUGS IN LIPIDATED GLYCOSAMINOGLYCAN PARTICLES AND THEIR USE FOR DIAGNOSTICS AND THERAPY - The invention provides a formulation of water insoluble or poorly water soluble drugs encapsulated in lipidated glycosaminoglycan particles for targeted drug delivery. | 07-05-2012 |
Dan Peer, Kiryat Ono IL
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20100008937 | TARGETED DELIVERY TO LEUKOCYTES USING NON-PROTEIN CARRIERS - Disclosed are delivery agents for selective delivery to leukocytes. The leukocyte-selective delivery agents comprise a targeting moiety that selectively binds LFA-I, a non-protein carrier moiety covalently linked to the targeting moiety and a therapeutic agent associated with the carrier moiety. The non-protein carrier moiety comprises a liposome, a micelle, or a polymeric nanoparticle comprised of PLA or PLGA. The delivery agent may be further selective for activated leukocytes by using a targeting moiety that selectively binds LFA-I in its activated conformation. The targeting moiety may comprise an antibody or functional fragment thereof such as an scFV. Appropriate therapeutic agents include a nucleic acid, a small molecule, a polypeptide, and an antibody or functional fragment thereof. Additional examples of therapeutic agents are a small RNA, an antagomir, an LNA, or an antisense oligonucleotide. One such therapeutic agent is an RNA interference molecule such as siRNA, dsRNA, stRNA, shRNA, miRNA. Specific delivery agents are provided. Methods for in vivo, in vitro and ex vivo leukocyte-selective delivery using the delivery agents are also disclosed. | 01-14-2010 |
20100285002 | TREATMENT OR PREVENTION OF INFLAMMATION BY TARGETING CYCLIN D1 - In one aspect, the invention relates to the treatment and/or prevention of inflammation by inhibition of cyclin D1. In one embodiment, Th1-mediated inflammation is selectively inhibited or reduced by a method comprising administering an agent that inhibits cyclin D1. In another embodiment, an autoimmune disease or a disorder characterized by or involving a Th1 inflammatory response is treated or prevented in a subject by a method comprising administering to the subject an agent that inhibits cyclin D1. | 11-11-2010 |
20110177155 | METHODS OF DELIVERY OF AGENTS TO LEUKOCYTES AND ENDOTHELIAL CELLS - The present invention generally relates to methods and compositions for the simultaneous delivery of at least one insoluble agent and at least one soluble agent to a cell. In particular the present invention relates to methods and compositions for the dual delivery of an insoluble agent and a soluble agent to a particular target cell, for example, a leukocyte or endothelial cell. In particular, methods and compositions for simultaneous delivery of a hydrophilic (i.e. soluble) agent and/or a hydrophobic (i.e. insoluble) agent to a leukocyte cell or endothelia cell are disclosed. | 07-21-2011 |
20120129916 | CELL-TARGETING NANOPARTICLES COMPRISING POLYNUCLEOTIDE AGENTS AND USES THEREOF - A method of generating a particle is disclosed, the particle being for delivery of a polynucleotide to a target cell. The method comprises (a) contacting the polynucleotide with a composition comprising cationic molecules, wherein the cationic molecules condense the polynucleotide by electrostatic interactions to generate a complex, wherein the cationic molecules are not comprised in a liposome; and (b) covalently binding the complex to a targeting moiety at a pH equal to or below about 4.5, thereby generating the particle for delivery of the polynucleotide agent to the target cell. Use of the particles and compositions comprising same are also disclosed. | 05-24-2012 |
20130129752 | TARGETED DELIVERY TO LEUKOCYTES USING PROTEIN CARRIERS - Disclosed herein are is a leukocyte-selective delivery agent comprising, a targeting moiety that selectively binds LFA-I, a protein carrier moiety covalently linked to the targeting moiety, and a therapeutic agent associated with the carrier moiety. The delivery agent may be further selective for activated leukocytes, wherein the targeting moiety selectively binds LFA-I in its activated conformation. The targeting moiety comprises an antibody or functional fragment thereof, such as an scFV. Examples of antibodies or fragments thereof which selectively bind LFA-I activated conformation bind to the locked open I domain of LFA-I, or binds to the leg domain of the β2 subunit of LFA-I ((ILP2)—The antibody or functional fragment thereof may alternatively bind non-selectively to both low affinity and high affinity LFA-I. Examples of a non-protein carrier are a basic polypeptide such as protamine or a functional fragment thereof. One such fragment is RSQSRSRYYRQRQRSRRRRRRS. The therapeutic agent may comprise one or more of a nucleic acid, a small molecule, a polypeptide, and an antibody or functional fragment thereof. An example of a nucleic acid delivery agent comprises an RNA interference molecule. Examples of RNA interference molecules are siRNA, dsRNA, StRNA, shRNA, miRNA, and combinations thereof. Specific siRNAs are provided. Other examples of a nucleic acid delivery agent are a small RNA, an antagomir, an LNA, and an antisense oligonucleotide. Methods for leukocyte-selective delivery, or activated leukocyte-selective delivery in vivo, in vitro and ex vivo are also provided. | 05-23-2013 |
20140161896 | PARTICLES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES - A composition of matter comprising non-cellular particles, which comprise a lysosomal enzyme and/or a small molecule which increases an amount and/or activity of a lysosomal enzyme. | 06-12-2014 |
20150140108 | LIPIDATED GLYCOSAMINOGLYCAN PARTICLES FOR THE DELIVERY OF NUCLEIC ACIDS - There are provided compositions comprising lipidated glycosaminoglycan particles, methods for their preparation and uses thereof for the efficient in-vivo and in-vitro delivery of nucleic acids, such as, siRNA molecules. | 05-21-2015 |
20150202348 | OMENTUM BASED SCAFFOLD AND DELIVERY SYSTEM - Compositions of matter comprising decellularized omentum are disclosed. The compositions may be scaffolds, hydrogels or hydrogel precursor compositions. Methods of generating the compositions are disclosed as well as uses thereof. | 07-23-2015 |
20150216998 | ENDO180-TARGETED PARTICLES FOR SELECTIVE DELIVERY OF THERAPEUTIC AND DIAGNOSTIC AGENTS - Disclosed herein are compositions comprising lipid based particles and anti-ENDO180 antibodies and to methods of using the same for targeted delivery of therapeutic agents to cancer and fibrotic cells useful for treating cell proliferative diseases or disorders including fibrosis, cancer and to attenuate tumor progression. | 08-06-2015 |
20150246135 | IMMUNOPARTICLES AND METHODS OF GENERATING AND USING SAME - A pharmaceutical composition comprising an immunoparticle is provided. The pharmaceutical composition comprising a monoclonal secondary antibody immunocomplexed with a primary antibody, wherein said monoclonal secondary antibody is coupled on an outer surface of a particle and wherein said particle is loaded with a pharmaceutical agent. | 09-03-2015 |
20150366979 | POSITIVELY CHARGED POLYSACCHARIDES FOR RNA TRANSFECTION - A complex includes RNA and a positively charged modified polysaccharide selected from starch, amylose, amylopectin, galactan, chitosan, or dextrin. The complex can be formed into a pharmaceutical composition. The complex can be used in methods for RNA transfection, gene therapy and treatment of a disease, disorder or condition. The positively charged modified polysaccharide can be used in connection with RNA transfection into cells. | 12-24-2015 |
Dan Peer, Qiryat Ono IL
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20090022656 | Lipidated glycoprotein particles and methods of use - Lipidated micro- or macroparticles are prepared by covalently linking a glycoprotein, typically collagen, with at least one lipid. An amino group in the glycoprotein is joined with a primary amine in the lipid. These particles can be used to encapsulate active ingredients, such as drugs. | 01-22-2009 |
20090155178 | LIPIDATED GLYCOSAMINOGLYCAN PARTICLES AND THEIR USE IN DRUG AND GENE DELIVERY FOR DIAGNOSIS AND THERAPY - Lipidated glycosaminoglycan particles, prepared by reacting a glycosaminoglycan with at least one lipid to cross-link the carboxylic acid groups in the glycosaminoglycan with a primary amine in the lipid, are used to encapsulate drugs for use in the treatment of pathological conditions in an animal. | 06-18-2009 |
20130095032 | LIPIDATED GLYCOSAMINOGLYCAN PARTICLES AND THEIR USE IN DRUG AND GENE DELIVERY FOR DIAGNOSIS AND THERAPY - Lipidated glycosaminoglycan particles, prepared by reacting a glycosaminoglycan with at least one lipid to cross-link the carboxylic acid groups in the glycosaminoglycan with a primary amine in the lipid, are used to encapsulate drugs for use in the treatment of pathological conditions in an animal. | 04-18-2013 |
Dan Peer, Qirylat Ono IL
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20140356439 | LIPIDATED GLYCOPROTEIN PARTICLES AND METHODS OF USE - Lipidated micro- or macroparticles are prepared by covalently linking a glycoprotein, typically collagen, with at least one lipid. An amino group in the glycoprotein is joined with a primary amine in the lipid. These particles can be used to encapsulate active ingredients, such as drugs. | 12-04-2014 |
Eitan Peer, Jerusalem IL
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20110016099 | COMPARING VERSIONS OF A HIERARCHICAL OBJECT - A hierarchical object is exported from a first electronic system to a second electronic system, where the hierarchical object is modifiable at each of the first and second electronic systems, and where a baseline version of the hierarchical object is created. A first version of the hierarchical object at the first electronic system is compared against the baseline version, to form a first data structure identifying any changes between the first version of the hierarchical object and the baseline version. A second data structure is received identifying changes between a second version of the hierarchical object at the second electronic system and the baseline version. A visualization based on the first and second data structures is provided. | 01-20-2011 |
Elad Peer, Haifa IL
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20120171755 | FABRICATION OF HOLLOW NANONEEDLES - The present invention provides a method of fabricating a device having hollow nanoneedles which extend through a supporting membrane. The device can be used as a molecular delivery system. | 07-05-2012 |
Gal Peer, Haifa IL
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20090049470 | Method and device for interactive operation of television - Image processing or image analysis to produce real time effects on images on a screen. The user shoots an imaginary gun, points a wooden stick, points his finger that has a colored paper attached etc, at the screen and effects happen to the images on the screen. The effects could be bullet holes, arrows, clothes, a raw egg, dripping blood, band-aids, etc. The effects move with the image on the screen as if the effect was really physically on the body. When the image leaves the screen temporarily and returns, the effect could still be in place on the image and move with the image. The identifying camera could be on the gun, stick and the like facing the images on the screen or the identifying camera could be on the screen of the TV, computer and the like facing the user with his stick or colored finger. | 02-19-2009 |
Joram Peer, Herzlia IL
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20080273113 | Integrated graphics and KVM system - Apparatus for display processing includes a host interface, which is arranged to accept graphical information from a first computer. A first display head is arranged to produce a first digital video signal including first frames representing the graphical information at a first frame rate, for displaying the graphical information on a local display of the first computer. A second display head is arranged to produce a second digital video signal including second frames representing the graphical information at a second frame rate that is lower than the first frame rate. A video redirection module is arranged to regulate a transmission rate of the second digital video signal from the second display head, to capture the second frames that are generated by the second display head and to forward the captured frames to a second computer. | 11-06-2008 |
Livnat Peer, Ramat-Hasharon IL
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20110252418 | HOST CONTROLLER USING REDUCED NETWORK RESOURCES TO MONITOR HOSTS - A host controller sends a request for first status information to a host. The host controller receives first status information from the host along with a unique identifier that is associated with the first status information. After a time period, the host controller sends a new request for second status information to the host, the new request including the unique identifier. When second status information and the first status information are associated with the same unique identifier, the host controller receives a response from the host indicating that the second status information is the same as the first status information. When the second status information and first status information are not associated with the same unique identifier, the host controller receives the second status information and a new unique identifier from the host. | 10-13-2011 |
20130246516 | HOST CONTROLLER USING REDUCED NETWORK RESOURCES TO MONITOR HOSTS - A host controller generates and sends a request for first status information to a host. The host controller receives first status information from the host along with a unique identifier that is associated with the first status information. After a time period, the host controller generates and sends a new request for second status information to the host, the new request including the unique identifier. When second status information and the first status information are associated with the same unique identifier, the host controller receives a response from the host indicating that the second status information is the same as the first status information. | 09-19-2013 |
Livnat Peer, Raanana IL
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20140075029 | VIRTUAL RESOURCE ALLOCATION AND RESOURCE AND CONSUMPTION MANAGEMENT - Clients access compute resources in a data center organized in logical clusters. A cluster level quota governs access to the compute resources, regardless of the location of the resources which can be part of multiple computers or part of multiple data centers. The cluster level quota can manage allocation and usage of storage, memory, and CPU resources in multi-tenant data center environments. A user requests a computing resource from a logical compute cluster in a data center of host machines hosting virtual machines. According to permissions associated with the user for the logical compute cluster and a cluster quota, the system grants access to the computing resource to the user in response to the request when the cluster quota permits an expected use of the computing resource according to the request. | 03-13-2014 |
20140108722 | VIRTUAL MACHINE INSTALLATION IMAGE CACHING - The subject matter of this specification can be implemented in, among other things, a computer-implemented method including sending, from a virtual desktop server manager at a data center and over a network, at least one request to a virtual machine storage domain for virtual machine installation images. The virtual machine storage domain stores the virtual machine installation images separate from the data center. The method further includes receiving, from the virtual machine storage domain over the network, the virtual machine installation images. The method further includes caching the virtual machine installation images in a data storage domain within the data center. The method further includes receiving a request to present a list of the virtual machine installation images. The method further includes in response to receiving the request to present the list, presenting the list of the cached virtual machine installation images. | 04-17-2014 |
20150188788 | EXTERNAL SERVICE PROVIDER - An apparatus identifies a connector configuration event. Responsive to the connector configuration event, the apparatus sends an external service information request. The apparatus receives an external service reply to the external service information request. The apparatus performs connector configuration, wherein the connector configuration employs information included in the external service reply, and wherein the performing connector configuration yields a connector employable in consumer external service access. | 07-02-2015 |
20150242079 | USER INTERFACE WITH AN EXPANDABLE NAVIGATION TREE - A graphical user interface (GUI) may be provided. The GUI may include a navigation tree in a first portion and a link in a second portion. The navigation tree may include multiple nodes. A selection of the link in the section portion may be received. In response to the selection of the link, the navigation tree in the first portion may be expanded to a hierarchical level displaying the node corresponding to the selected link. | 08-27-2015 |
Michael Peer, Nahariya IL
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20130209959 | INTER LOCKING IMPLANTS - The present invention relates to a method of joining two implants together so as to enhance the immediate stability of both implants, allowing immediate loading. Both implants are inserted in an angle to the jaw and are locked together, thus forming a compound structure that improves stability and enhances resistance to rotational, occlusal and lateral forces. | 08-15-2013 |
Mordechai Peer, Tzur-Yigal IL
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20120285858 | DEVICE FOR DRUG DISTRIBUTION AND METHOD OF USING THEREOF - A medicament dispensing device comprises (a) at least one container adapted for accommodating and dispensing at least one elongate packagible elongate blister pack carrying a plurality of blisters containing the medicament; (b) transporting means adapted for transporting the blister pack toward opening of the container; (c) dispensing means adapted for releasing a fragment of the blister pack bearing a predetermined number of the blisters from the container through the opening to a patient; and (d) controlling means adapted for identifying the patient before dispensing the blister to the patient, activating the dispensing means, recording actions of dispensing. The substrate is foldable and configured to be folded within the container. In the folded configuration, non-foldable portions bearing the blisters face each other. | 11-15-2012 |
Mordechai Peer, Kokhav Ya'Ir IL
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20110121019 | Device for Drug Distribution and Method of Using Thereof - A medicament dispensing device comprises (a) at least one container adapted for accommodating and dispensing at least one elongate packagible elongate blister pack carrying a plurality of blisters containing the medicament; (b) transporting means adapted for transporting the blister pack toward opening of the container; (c) dispensing means adapted for releasing a fragment of the blister pack bearing a predetermined number of the blisters from the container through the opening to a patient; and (d) controlling means adapted for identifying the patient before dispensing the blister to the patient, activating the dispensing means, recording actions of dispensing. The substrate is foldable and configured to be folded within the container. The dispensing means is adapted to cut off the blister bearing fragment. The dispensing means adapted to cut off the blister bearing fragment such that the blisters remain intact. | 05-26-2011 |
Ofer Peer, Herzliya IL
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20120207207 | Method, system and associated modules for transmission of complimenting frames - Disclosed are methods, circuits, devices and systems for transmission of two visually complimenting video frames (e.g. left-eye frame data and right-eye frame data) of a three dimensional video stream. A set of visually complimenting video frames intended to make a substantially three dimensional image may be referred to as a three dimensional impression set. A video signal/stream in a first (e.g. 3D) format may be processed for transmission over a wireless link, wherein processing may include generating one or more transmission frames including data for at least two complimenting video frames. The data for both complimenting video frames is uncompressed. | 08-16-2012 |
Roni Peer, Yehud IL
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20160073929 | GAS SAMPLING CONNECTOR - A connector includes a memory configured to store data. The connector further includes a first portion configured to connect to a ground connection in a gas sampling monitor. The connector further includes a second portion configured to connect to a positive connection in the gas sampling monitor. The second portion is configured to transfer data to and from the memory. The connector further includes an end configured to connect with a sampling tube, which is configured to transmit gas to the monitor. | 03-17-2016 |