Pasqual
Giulia Pasqual, Somerville, MA US
Patent application number | Description | Published |
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20160097773 | INTERCELLULAR LABELING OF LIGAND-RECEPTOR INTERACTIONS - An sortase-mediated intercellular labeling method allowing for tracking ligand-receptor interaction both in vitro and in vivo; and uses thereof for tracking molecule interactions both in vitro and in vivo, identifying modulators of ligand-receptor interaction, identifying potential binding partners of a protein of interest, identifying B cells expressing high affinity B cell receptors to antigens, and identifying the antigen to which a T cell of interest binds. | 04-07-2016 |
Maurizio Francesco Pasqual, Treviso IT
Patent application number | Description | Published |
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20150131978 | HOT WATER HEATER WITH BULKHEAD SCREW FITTING - A hot water heater is provided and includes a tank, a cold water supply, a hot water outlet, and a heating element. The element has a component with incorporated screw bulkhead, plastic terminal block, resistor and Ultem sleeve. | 05-14-2015 |
Nicolas Pasqual, Grenoble FR
Patent application number | Description | Published |
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20110003291 | METHOD FOR STUDYING V(D)J COMBINATORY DIVERSITY - The invention relates to a method for analysing the diversity of the catalogue of T and/or B lymphocytes in an individual, based on the amplification, from a sample, of genomic DNA fragments by PCR multi-n-plexes, with n≧2, carried out with a combination of at least 3 primers defining at least 2 primer couples, each of which includes a primer specifically hybridising upstream and/or in a given V or D gene and a primer specifically hybridising downstream and/or in a given J gene, in order to obtain the amplification of at least two fragments characteristic of two distinct V-J or D-J rearrangements from each primer couple. The invention also relates to the applications of this method, in particular in the treatment follow-up or in the diagnosis and/or prognosis of certain diseases. | 01-06-2011 |
20160068905 | Method for Studying V(D)J Combinatory Diversity - The present invention pertains to a method of visualizing an immunological status of an individual, by combining the degree of immunoglobulin and/or TCR diversity and another biological marker linked to the immunological status of said individual in a two- or three-dimensional graph. | 03-10-2016 |
Nicolas Pasqual, Coublevie FR
Patent application number | Description | Published |
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20120309013 | Use of the Combinatorial Diversity of T-Lymphocyte Repertoire as a Prognostic Marker of Cancer - The present invention relates to a method making it possible to identify the patients, from among those affected by a given solid cancer, that have increased risk of premature death. Said method is based on the ex vivo analysis of the lymphocytic diversity of the patients on the basis of a biological sample containing lymphocytes. In fact, low lymphocytic diversity is related to a poor prognosis. Specifically, it is possible to set a diversity threshold, depending on the analysis technology used and the cancer affecting the patient, beyond which the life expectancy of the patient is significantly less than that, in general, of the patients affected by the same disease. | 12-06-2012 |