Parkin, CA
Michael Parkin, San Ramon, CA US
Patent application number | Description | Published |
---|---|---|
20140188971 | METHODS, DEVICES AND SYSTEMS ENABLING A SECURE AND AUTHORIZED INDUCTION OF A NODE INTO A GROUP OF NODES IN A DISTRIBUTED COMPUTING ENVIRONMENT - A messaging model and node induction methods and corresponding devices and systems are disclosed herein that are effective to enable an inductor node to induct an inductee node into a distributed computing system and to enable the inducted node to carry out predetermined tasks. | 07-03-2014 |
20140189004 | METHODS, DEVICES AND SYSTEMS FOR INITIATING, FORMING AND JOINING MEMBERSHIPS IN DISTRIBUTED COMPUTING SYSTEMS - A computer-implemented method of deploying a membership of nodes in a distributed computing system may comprise selecting nodes to be part of a membership of nodes; creating a membership task identifying a membership creator node as the node that is creating the membership and comprising a membership target identifying at least one node of the distributed computing system that is to become a member of the membership; and creating a beacon configured to send a create membership message to each identified node, the create membership message comprising at least an identity of the membership task and an identification of the membership. Upon receiving a response from a node in the membership target, the node from which the response was received may be removed from the beacon. The membership may be deployed when a response has been received from each of the nodes identified in the membership target. | 07-03-2014 |
20140280452 | METHODS, DEVICES AND SYSTEMS FOR DYNAMICALLY MANAGING MEMBERSHIPS IN REPLICATED STATE MACHINES WITHIN A DISTRIBUTED COMPUTING ENVIRONMENT - A computer-implemented method may comprise processing agreements received over a computer network at a first replicated state machine deployed on processes belonging to a first membership in an order defined by a first globally ordered set of agreements associated with the first membership; receiving an agreement to change membership that is configured to cause the first replicated state machine to be deployed on processes belonging to a second membership that is associated with a second globally ordered set of agreements; and processing the agreement to change membership at a point within the first globally ordered set of agreements. | 09-18-2014 |
Neil T. Parkin, Belmont, CA US
Patent application number | Description | Published |
---|---|---|
20080293038 | Method for Determining Resistance of Hiv to Nucleoside Reverse Transcriptase Inhibitor Treatment - The present invention provides methods and devices for predicting whether an HIV-1 is resistant to an antiviral drug based on the HIV-1's genotype. In one aspect, the invention provides methods comprising determining whether a mutation or combination of mutations associated with NRTI resistance are present, as disclosed herein, thereby assessing the effectiveness of FTC therapy in the HIV-infected subject. Computer implemented methods comprising determining HIV-1 resistance are provided. | 11-27-2008 |
20090136915 | Methods and compositions for determining altered susceptibility of HIV-1 to anti-HIV drugs - This invention relates, in part, to methods and compositions for determining altered susceptibility of a human immunodeficiency virus (“HIV”) to the non-nucleoside reverse transcriptase inhibitors (“NNRTIs”) efavirenz (“EFV”), nevirapine (“NVP”), and delavirdine (“DLV”), the nucleoside reverse transcriptase inhibitor AZT, and the integrase strand transfer inhibitors diketo acid 1, diketo acid 2, and L-870,810 by detecting the presence of a mutation or combinations of mutations in the gene encoding HIV reverse transcriptase that are associated with altered susceptibility to the anti-HIV drugs. | 05-28-2009 |
20090208925 | Methods and Compositions for Determining Hypersusceptibility of HIV-1 to Non-Nucleoside Reverse Transcriptase Inhibitors - This invention relates to methods for determining hypersusceptibility of HIV-1 viruses to non-nucleoside reverse transcriptase inhibitors (NNRTIs) based on the viral genotypes. The methods generally comprise detecting, in a gene encoding reverse transcriptase of the HIV-1, the presence of a mutation at codon 65, 69, or 74 alone or in combination with one or more mutations at certain other codons. Combinations of mutation associated with hypersusceptibility to NNRTIs are also disclosed. | 08-20-2009 |
20100227313 | Methods and Compositions for Determining Altered Susceptibility of HIV-1 to Protease Inhibitor Treatment - This invention relates to methods for determining altered susceptibility of HIV-I viruses to protease inhibitors (PIs) based on the viral genotypes. The methods generally comprise detecting, in a gene encoding protease and/or gag of the HIV-I, the presence of mutations correlated with altered susceptibility to amprenavir and/or darunavir. | 09-09-2010 |
20110033836 | METHODS FOR DETERMINING THE PRESENCE OF ANTIBODIES BLOCKING VIRAL INFECTION - The present invention provides a method for identifying whether a compound inhibits entry of a virus into a cell which comprises: (a) obtaining nucleic acid encoding a viral envelope protein from a patient infected by the virus; (b) co-transfecting into a first cell (i) the nucleic acid of step (a), and (ii) a viral expression vector which lacks a nucleic acid encoding an envelope protein, and which comprises an indicator nucleic acid which produces a detectable signal, such that the first cell produces viral particles comprising the envelope protein encoded by the nucleic acid obtained from the patient; (c) contacting the viral particles produced in step (b) with a second cell in the presence of the compound, wherein the second cell expresses a cell surface receptor to which the virus binds; (d) measuring the amount of signal produced by the second cell in order to determine the infectivity of the viral particles; and (e) comparing the amount of signal measured in step (d) with the amount of signal produced in the absence of the compound, wherein a reduced amount of signal measured in the presence of the compound indicates that the compound inhibits entry of the virus into the second cell. | 02-10-2011 |
20110229906 | Means and methods for monitoring protease inhibitor antiretroviral therapy and guiding therapeutic decisions in the treatment of HIV/AIDS - This invention relates to antiviral drug susceptibility and resistance tests to be used in identifying effective drug regimens for the treatment of human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS), particularly treatment regimens including a protease inhibitor. The invention further relates to the means and methods of monitoring the clinical progression of HIV infection and its response to antiretroviral therapy using phenotypic or genotypic susceptibility assays. | 09-22-2011 |
20120135395 | Methods and Compositions for Determining Altered Susceptibility of HIV-1 to Anti-HIV Drugs - This invention relates, in part, to methods and compositions for determining altered susceptibility of a human immunodeficiency virus (“HIV”) to the non-nucleoside reverse transcriptase inhibitors (“NNRTIs”) efavirenz (“EFV”), nevirapine (“NVP”), and delavirdine (“DLV”), the nucleoside reverse transcriptase inhibitor AZT, and the integrase strand transfer inhibitors diketo acid 1, diketo acid 2, and L-870,810 by detecting the presence of a mutation or combinations of mutations in the gene encoding HIV reverse transcriptase that are associated with altered susceptibility to the anti-HIV drugs. | 05-31-2012 |
20120283250 | Methods and Compositions for Determining Hypersusceptibility of HIV-1 to Non-Nucleoside Reverse Transcriptase Inhibitors - This invention relates to methods for determining hypersusceptibility of HIV-1 viruses to non-nucleoside reverse transcriptase inhibitors (NNRTIs) based on the viral genotypes. The methods generally comprise detecting, in a gene encoding reverse transcriptase of the HIV-1, the presence of a mutation at codon 65, 69, or 74 alone or in combination with one or more mutations at certain other codons. Combinations of mutations associated with hypersusceptibility to NNRTIs are also disclosed. | 11-08-2012 |
Rob Parkin, San Francisco, CA US
Patent application number | Description | Published |
---|---|---|
20090327037 | System and Methods for Pricing Markdown with Model Refresh and Reoptimization - A system and method for tuning markdown plans is provided. Such a system and method may include configuring initial rule set. Initial Demand models are generated. A first optimization for inventory pricing may be received from the price optimization system. The first optimization uses the initial demand models and cost data. A markdown plan is generated by applying the initial rule set to the first optimization. The plan is implemented. Updated data may be received which mandates a re-optimization of the plan. Demand models are refreshed using the updated data. Initial rule set is updated by cross referencing plan history with the initial rule set and subtracting rule events that have previously occurred. A second optimization is received which uses the refreshed demand models and cost data. Then, the markdown plan is re-optimized by applying the updated rule set to the second optimization. The re-optimized markdown plan is reported, approved and implemented. | 12-31-2009 |
Robert Parkin, San Francisco, CA US
Patent application number | Description | Published |
---|---|---|
20110131079 | System and Method for Modeling by Customer Segments - The present invention relates to a system and method for the system and method for modeling demand by consumer segments. In some embodiments a segment data organizer may receive transaction data. Transaction data may include transaction logs (T logs) from point of sales records from a retailer. These transaction logs, for the most part, include identification information for each transaction. The segment data organizer may also receive customer identification data which includes groupings of customers by consumer segments. The identification information within the transaction logs may be cross referenced by the customer identification data in order to generate groupings of transactions belonging to consumers in each segment. The organizer may then also aggregate the transaction logs by location, time series and product. The aggregated data may be supplied to an econometric engine capable of generating elasticity coefficients for each set of aggregate data. These coefficients may be stored or utilized to generate optimized pricing, lifts, and demand models. | 06-02-2011 |
20120259675 | System and Method for a Retail Collaboration Network Platform - The present invention relates to a system and method for a retail collaboration network platform. In some embodiments, the system and method for a retail collaboration network platform includes a portal which the user is able to log in to via a network. The system includes connectivity to a plurality of retailer and vendor analytic tools. These analytic tools may include tools for promotion analysis, price optimization, product assortment, and market analysis. In addition to analytic tools, the platform may include collaborative tools which may interface with the analytic tools. These collaborative tools enable retailers and vendors to work together and with partners to share information and develop and implement strategies based on analytic tools to achieve their respective business objectives. The collaborative tools may be enabled to create at least one workgroup, generate a contact list, monitor the workgroup and contact list for activity and display any such activity. Moreover, the activity may be sorted into actions and alerts and displayed as an activity feed and notification, respectively. | 10-11-2012 |
Stuart Parkin, San Jose, CA US
Patent application number | Description | Published |
---|---|---|
20080253161 | SEQUENCE OF CURRENT PULSES FOR DEPINNING MAGNETIC DOMAIN WALLS - A method and structure for depinning a domain wall that is in spatial confinement by a pinning potential to within a local region of a magnetic device. At least one current pulse applied to the domain has a pulse length sufficiently close to a precession period of the domain wall motion and the current pulses are separated by a pulse interval sufficiently close to the precession period such that: the at least one current pulse causes a depinning of the domain wall such that the domain wall escapes the spatial confinement; and each current pulse has an amplitude less than the minimum amplitude of a direct current that would cause the depinning if the direct current were applied to the domain wall instead of the at least one current pulse. The pulse length and pulse interval may be in a range of 25% to 75% of the precession period. | 10-16-2008 |
20090103347 | SEQUENCE OF CURRENT PULSES FOR DEPINNING MAGNETIC DOMAIN WALLS - A method and structure for depinning a domain wall that is in spatial confinement by a pinning potential to within a local region of a magnetic device. At least one current pulse applied to the domain has a pulse length sufficiently close to a precession period of the domain wall motion and the current pulses are separated by a pulse interval sufficiently close to the precession period such that: the at least one current pulse causes a depinning of the domain wall such that the domain wall escapes the spatial confinement; and each current pulse has an amplitude less than the minimum amplitude of a direct current that would cause the depinning if the direct current were applied to the domain wall instead of the at least one current pulse. The pulse length and pulse interval may be in a range of 25% to 75% of the precession period. | 04-23-2009 |
20100046268 | MAGNETIC RACETRACK WITH CURRENT-CONTROLLED MOTION OF DOMAIN WALLS WITHIN AN UNDULATING ENERGY LANDSCAPE - A method for use with a magnetic racetrack device includes placing domain walls having a first structure and domain walls having a second, different structure along the racetrack at stable positions corresponding to different regions within the device. The domain walls having the first structure and the domain walls having the second structure occupy alternating positions along the racetrack. A current pulse is applied to the racetrack, so that each of the domain walls moves to an adjacent region. This results in a transformation of the domain walls having the first structure into domain walls having the second structure, and vice versa. The first structure may be a vortex structure and the second structure may be a transverse structure. | 02-25-2010 |
Stuart P. Parkin, San Jose, CA US
Patent application number | Description | Published |
---|---|---|
20140110765 | FIELD EFFECT TRANSISTOR HAVING PHASE TRANSITION MATERIAL INCORPORATED INTO ONE OR MORE COMPONENTS FOR REDUCED LEAKAGE CURRENT - Disclosed is a metal oxide semiconductor field effect transistor (MOSFET) having phase transition material incorporated into one or more components and an associated method. The MOSFET can comprise an asymmetric gate electrode having a phase transition material section (e.g., a chromium or titanium-doped vanadium dioxide (VO | 04-24-2014 |
Stuart S.p. Parkin, San Jose, CA US
Patent application number | Description | Published |
---|---|---|
20080241369 | METHOD OF FABRICATING A MAGNETIC SHIFT REGISTER - A magnetic data track used in a magnetic shift register memory system may be fabricated by forming a multilayered stack of alternating dielectric and/or silicon layers. A trench is etched in the multi-layer stack structure. A selective etching process is used to corrugate the walls of trench. A seed layer is applied to the walls and bottom of the trench; the seed layer is covered with a magnetic layer. The trench is filled with an insulating material. A patterned layer is applied and portions of insulating material exposed by the pattern are removed, forming holes. Magnetic material and seed layer exposed in holes is selectively removed. The holes are filled with insulating material and connecting leads are attached to data tracks. | 10-02-2008 |
20100220523 | STOCHASTIC SYNAPSE MEMORY ELEMENT WITH SPIKE-TIMING DEPENDENT PLASTICITY (STDP) - An active memory element is provided. One embodiment of the invention includes a bi-polar memory two-terminal element having polarity-dependent switching. A probability of switching of the bi-polar memory element between a first state and a second state decays exponentially based on time delay and a difference between received signals at the two terminals and a switching threshold magnitude. | 09-02-2010 |
Stuart S. P. Parkin, San Jose, CA US
Patent application number | Description | Published |
---|---|---|
20120008362 | Magnetic Spin Shift Register Memory - A method for forming a memory device includes forming a cavity having an inner surface with an undulating profile in a substrate, depositing a ferromagnetic material in the cavity, forming a reading element on the substrate proximate to a portion of the ferromagnetic material, and forming a writing element on the substrate proximate to a second portion of the ferromagnetic material. | 01-12-2012 |
20130005053 | Magnetic Spin Shift Register Memory - A method for forming a memory device includes forming a cavity having an inner surface with an undulating profile in a substrate, depositing a ferromagnetic material in the cavity, forming a reading element on the substrate proximate to a portion of the ferromagnetic material, and forming a writing element on the substrate proximate to a second portion of the ferromagnetic material. | 01-03-2013 |