Papadopoulos, US
Amy Papadopoulos, Ashburn, VA US
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20110025493 | MOBILE WIRELESS CUSTOMIZABLE HEALTH AND CONDITION MONITOR - A method and system for monitoring. The monitoring system may include at least one wearable monitor, which may include an accelerometer, coupled to a user; at least one server communicatively coupled using a network to the at least one wearable monitor, the accelerometer facilitating detection of a fall by the user and transmitting notification of said fall to said at least one server, and the server allowing verification of the fall and adjustment of fall detection parameters either automatically or through a user interface. | 02-03-2011 |
20140155705 | MOBILE WIRELESS CUSTOMIZABLE HEALTH AND CONDITION MONITOR - A method and system for wellness monitoring using one or more wellness indicator inputs and values is provided. One or more wellness indicator monitoring devices may be provided for measuring wellness indicator input. The wellness indicator monitoring devices may have one or more sensors and a microcontroller in communication with the one or more sensors. One or more servers may communicate with the one or more wellness indicator monitoring devices over a network. A processor may be configured to manipulate the wellness indicator input, and one or more output device may create a desired output based on the wellness indicator values. | 06-05-2014 |
Christos G. Papadopoulos, Naperville, IL US
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20090158737 | Power Recovery Process - Processes using multiple expansion turbines for efficient recovery of power from a plurality of very high pressure streams of superheated vapor are disclosed. Beneficially, processes of the invention use at least two classes of expansion turbines. Processes according to this invention are particularly useful for recovery of power from very high pressure streams of superheated steam in an olefins manufacturing process. Such streams are typically produced by thermal cracking of suitable petroleum derived feed stocks, and the olefins being produced and purified are typically ethylene and/or propylene. | 06-25-2009 |
Constantinos Papadopoulos, Roseville, CA US
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20130086595 | TRACKING A SERVER REQUEST - A technique includes inserting ( | 04-04-2013 |
Despina Papadopoulos, New York, NY US
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20100144414 | SYSTEM AND METHOD FOR GATHERING AND ANALYZING OBJECTIVE MOTION DATA - The systems and methods described herein attempt to provide data capture and analysis in a non-intrusive fashion. The captured data can be analyzed for qualitative conclusions regarding an object's actions. For example, a system for analyzing activity of an athlete to permit qualitative assessments of that activity comprises a first processor to receive activity-related data from sensors on the athlete. A first database stores the activity-related data. A second database contains pre-identified motion rules. A second processor compares the received activity-related data to the pre-identified motion rules, wherein the second processor identifies a pre-identified motion from the pre-identified motion rules that corresponds to the received activity-related data. A memory stores the identified pre-selected motion. | 06-10-2010 |
Dimitrios S. Papadopoulos, Township Of Washington, NJ US
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20110087988 | GRAPHICAL CONTROL ELEMENTS FOR BUILDING MANAGEMENT SYSTEMS - A building management system includes graphical control elements for viewing and interacting with the building management system. Graphical control elements conduct analysis of information received from the building management system and may be used to control building equipment, monitor operational statuses, diagnose faults, or conduct other building management system tasks. | 04-14-2011 |
Dimitri S. Papadopoulos, Westwood, NJ US
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20140277773 | SYSTEMS AND METHODS FOR DAMPER PERFORMANCE DIAGNOSTICS - A computerized method for diagnosing a damper condition in a flow control unit includes providing a control signal to a damper. The control signal instructs the damper to move into a target position or to achieve a target flow rate through the flow control unit. The method further includes receiving pressure information including one or more pressure measurements from a differential pressure sensor of the flow control unit and using the pressure information and the control signal to conduct a damper performance diagnostic. The damper performance diagnostic includes at least one of: a stuck damper diagnostic, a predictive damper failure diagnostic, an improperly-sized damper diagnostic, and a damper leakage diagnostic. | 09-18-2014 |
George Papadopoulos, Newport Beach, CA US
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20090057801 | Back-Illuminated, Thin Photodiode Arrays with Trench Isolation - Back-illuminated, thin photodiode arrays with trench isolation. The trenches are formed on one or both sides of a substrate, and after doping the sides of the trenches, are filled to provide electrical isolation between adjacent photodiodes. Various embodiments of the photodiode arrays and methods of forming such arrays are disclosed. | 03-05-2009 |
George Papadopoulos, Nesconset, NY US
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20090302242 | OPTICAL COUPLED SENSORS FOR HARSH ENVIRONMENTS - An optical sensor comprising a light source; a sensor substrate, arranged to receive a force to be detected, the sensor substrate including an interference pattern generator, optically coupled to the light source for receiving light from the light source, and generating an interference pattern, and a detector, optically coupled to the sensor substrate for receiving the interference pattern and providing a signal which can be used to determine the force applied to the sensor substrate. | 12-10-2009 |
20120085173 | NON-INTRUSIVE SENSOR FOR IN-SITU MEASUREMENT OF RECESSION RATE OF ABLATIVE AND ERODING MATERIALS - A non-intrusive sensor for in-situ measurement of recession rate of heat shield ablatives. An ultrasonic wave source is carried in the housing. A microphone is also carried in the housing, for collecting the reflected ultrasonic waves from an interface surface of the ablative material. A time phasing control circuit is also included for time-phasing the ultrasonic wave source so that the waves reflected from the interface surface of the ablative material focus on the microphone, to maximize the acoustic pressure detected by the microphone and to mitigate acoustic velocity variation effects through the material through a de-coupling process that involves a software algorithm. A software circuit for computing the location off of which the ultrasonic waves scattered to focus back at the microphone is also included, so that the recession rate of the heat shield ablative may be monitored in real-time through the scan-focus approach. | 04-12-2012 |
George B. Papadopoulos, Nesconset, NY US
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20140067164 | METHODS AND APPARATUSES FOR AUTONOMOUS FLIGHT TERMINATION - Embodiments include a flight safety assembly onboard an aerial vehicle, which includes a first sensor configured to sense first information related to flight of the aerial vehicle and a second sensor configured to sense second information related to the flight of the aerial vehicle. A sensor input is adapted to receive third information related to the flight of the aerial vehicle. A processor is operably coupled to the first sensor, the second sensor, and the sensor input. The processor is configured to determine three independent instantaneous impact points for the aerial vehicle by independently analyzing each of the first information, the second information and the third information. The processor is also configured to generate three independent onboard flight termination indicators for each of the three independent instantaneous impact points that intersects with a region to be protected. | 03-06-2014 |
20140330457 | METHODS AND APPARATUSES FOR AUTONOMOUS FLIGHT TERMINATION - A flight safety assembly onboard an aerial vehicle includes a first sensor configured to sense first information related to flight of the aerial vehicle and a second sensor configured to sense second information related to the flight of the aerial vehicle. A sensor input is adapted to receive third information related to the flight of the aerial vehicle. A processor is operably coupled to the first sensor, the second sensor, and the sensor input. The processor is configured to determine three independent instantaneous impact points for the aerial vehicle by independently analyzing each of the first information, the second information and the third information. The processor is also configured to generate three independent onboard flight termination indicators for each of the three independent instantaneous impact points that intersects with a region to be protected. | 11-06-2014 |
Georgia Ioannis Papadopoulos, Mclean, VA US
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20140279685 | SYSTEM AND METHOD FOR MONETIZING AN EXTERNALITY - A method is disclosed that includes calculating by an intermediary, using a computing apparatus, an estimated social dividend achieved as a monetization of an externality accruing to the public. The method further includes advancing funds, by a partaking entity, related to the externality. The method also includes paying, by the intermediary, the social dividend as estimated. The method further includes receiving, by the partaking entity, an incentive for advancing funds related to the externality. | 09-18-2014 |
Haralabos Papadopoulos, Sanjose, CA US
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20090213954 | TREE POSITION ADAPTIVE SOFT OUTPUT M-ALGORITHM RECEIVER STRUCTURES - A method and apparatus for tree position adaptive SOMA receiver structures are disclosed herein. In one embodiment, a device for use in a wireless communication system comprises a receiver to receive information-bearing signals from the transmitter wirelessly transmitted using OFDM and bit interleaved coded modulation, where the receiver includes an inner decoder structure having a soft output M-algorithm (SOMA) based multiple-in multiple-out (MIMO) joint demapper that uses a SOMA-based MIMO detection process to perform joint inner demapping over each tone, and wherein the SOMA-based MIMO joint demapper is operable to search a detection tree for each tone using a tree-search symbol order that is adapted for each tone based on channel state information and extrinsic information from the outer decoder, where only a number of best alternatives from every level of the tree are expanded. | 08-27-2009 |
Haralabos Papadopoulos, Los Altos, CA US
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20150365953 | METHOD AND APPARATUS FOR SCALABLE LOAD BALANCING ACROSS WIRELESS HETEROGENEOUS MIMO NETWORKS - A method and apparatus for load balancing in a wireless network is described. In one embodiment, the method comprises receiving, by at least one of the one or more controllers, from at least one of the one or more base stations, information indicative of a rate that can be provided by the at least one base station to at least one client terminal by the at least one base station when serving a group of one or more client terminals, the at least one client terminal being associated to the at least one controller; receiving, by the at least one of the one or more controllers, from the at least one of the one or more base stations, information indicative of the transmission resources provided by the at least one base station for resource allocation among the at least one client terminal by the at least one controller; and determining, by the at least one controller, based on the information indicative of the rate and the information indicative of transmission resources, information indicative of an allocation of base station transmission resources for at least one client terminal from the at least one base station. | 12-17-2015 |
Haralabos C. Papadopoulos, Palo Alto, CA US
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20130061106 | METHOD AND APPARATUS FOR THE JOINT DESIGN AND OPERATION OF ARQ PROTOCOLS WITH USER SCHEDULING FOR USE WITH MULTIUSER MIMO IN THE DOWNLINK OF WIRELESS SYSTEMS - A method and apparatus is disclosed herein for performing wireless communication. In one embodiment, the apparatus comprises a processing unit to run a scheduling selection algorithm to update user terminal scheduling weights in response to scheduling feedback transmitted by a plurality of user terminals by an end of an immediately preceding scheduling event; a scheduler and precoder, responsive to the updated user terminal scheduling weights generated by the scheduling algorithm and channel estimates of user terminals, to choose a set of user terminals for scheduling and to choose precoder beams and their power for such user terminal in the set of user terminals; a plurality of precoding blocks to receive one coded ARQ block for at least one packet for each user terminal in the set and, responsive to the precoder beams, to generate precoded data, where the one coded ARQ block is one of a plurality of ARQ blocks generated for a single packet and being generated using a single ARQ scheme for such each user terminal; and a transmitter to transmit the precoded data using MIMO transmission. | 03-07-2013 |
20140362810 | METHOD AND APPARATUS FOR THE JOINT DESIGN AND OPERATION OF ARQ PROTOCOLS WITH USER SCHEDULING FOR USE WITH MULTIUSER MIMO IN THE DOWNLINK OF WIRELESS SYSTEMS - A method and apparatus is disclosed herein for performing wireless communication. In one embodiment, the apparatus comprises a processing unit to run a scheduling selection algorithm to update user terminal scheduling weights in response to scheduling feedback transmitted by a plurality of user terminals by an end of an immediately preceding scheduling event; a scheduler and precoder, responsive to the updated user terminal scheduling weights generated by the scheduling algorithm and channel estimates of user terminals, to choose a set of user terminals for scheduling and to choose precoder beams and their power for such user terminal in the set of user terminals; a plurality of precoding blocks to receive one coded ARQ block for at least one packet for each user terminal in the set and, responsive to the precoder beams, to generate precoded data, where the one coded ARQ block is one of a plurality of ARQ blocks generated for a single packet and being generated using a single ARQ scheme for such each user terminal; and a transmitter to transmit the precoded data using MIMO transmission. | 12-11-2014 |
Haralabos C. Papadopoulos, San Jose, CA US
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20100056171 | INTER-CELL APPROACH TO OPERATING WIRELESS BEAM-FORMING AND USER SELECTION/SCHEDULING IN MULTI-CELL ENVIRONMENTS BASED ON LIMITED SIGNALING BETWEEN PATTERNS OF SUBSETS OF CELLS - Methods, architectures and techniques of operating a joint beam-forming and user-selection system across multiple cells for downlink communication in a multi-cell environment. The system coordinates beamforming vector and user selection across multiple cells, but is cellular in the sense that users are served only from the transmission signals originating from one cell. There is provided methods, architectures and techniques to control the level and effect of inter-cell interference through a partially coordinated multi-cell process of user scheduling and beam selection based on the division of cells into different subsets. Multi-step techniques are utilized that can scale to large numbers of cells, specifying which operations remain as independent operations within a cell, and which operations, with what cells, require information exchange. | 03-04-2010 |
20110055653 | METHOD AND APPARATUS FOR THE JOINT DESIGN AND OPERATION OF ARQ PROTOCOLS WITH USER SCHEDULING FOR USE WITH MULTIUSER MIMO IN THE DOWNLINK OF WIRELESS SYSTEMS - A method and apparatus is disclosed herein for performing wireless communication. In one embodiment, the apparatus comprises a processing unit to run a scheduling selection algorithm to update user terminal scheduling weights in response to scheduling feedback transmitted by a plurality of user terminals by an end of an immediately preceding scheduling event; a scheduler and precoder, responsive to the updated user terminal scheduling weights generated by the scheduling algorithm and channel estimates of user terminals, to choose a set of user terminals for scheduling and to choose precoder beams and their power for such user terminal in the set of user terminals; a plurality of precoding blocks to receive one coded ARQ block for at least one packet for each user terminal in the set and, responsive to the precoder beams, to generate precoded data, where the one coded ARQ block is one of a plurality of ARQ blocks generated for a single packet and being generated using a single ARQ scheme for such each user terminal; and a transmitter to transmit the precoded data using MIMO transmission. | 03-03-2011 |
20110110449 | RECEIVER TERMINAL DRIVEN JOINT ENCODER AND DECODER MODE ADAPTATION FOR SU-MIMO SYSTEMS - A system, a method and an apparatus are disclosed herein for receiver terminal driven joint encoder and decoder mode adaptation for SU-MIMO transmission. In one embodiment, the system comprises a transmitter that is able to be directed to transmit wireless signals over a multiple-input, multiple output (MIMO) system using any of a plurality of encoding modes; and a user terminal having a receiver comprising a decoding module which has a plurality of decoding modes, each of which can be used to decode communications from the transmitter received over a multiple-input, multiple output (MIMO) channel, wherein at least one encoding mode is operable with multiple of the decoding modes. The system also comprises a joint selection module that is operable to select for the MIMO transmission the decoding mode from the plurality of decoding modes and an encoding mode from the plurality of encoding modes to be used by the transmitter on the channel, the selection being based on receiver-dependent criteria corresponding to the decoding mode associated with the encoding mode and channel information, receiver hardware and state, and application-specific constraints. The joint selection module is operable to send information to identify the encoding mode to the transmitter using a feedback channel. | 05-12-2011 |
20120058788 | METHOD AND APPARATUS FOR COMMUNICATING WITH BLIND INTERFERENCE ALIGNMENT USING POWER ALLOCATION AND/OR TRANSMISSION ARCHITECTURE - A method and system are disclosed herein for power allocation and/or clustering in a wireless communication system that uses blind interference alignment. In one embodiment, the system comprises a plurality of receivers, where each receiver in the plurality has a multi-mode antenna with a single radio frequency (RF) chain that is operable in a plurality of antenna modes, and wherein each receiver shifts between the plurality of antenna modes in a predetermined manner. The system also includes a plurality of base stations to perform cluster-based transmission, each base station in the plurality of base stations having one or more transmitters having a transmit antenna and being operable to communicate with one or more of receivers in the plurality of receivers using a blind interference alignment (BIA) scheme, and wherein the plurality of base stations are grouped in different clusters at different times according to cluster patterns. | 03-08-2012 |
20140036888 | METHOD FOR EFFICIENT MU-MIMO TRANSMISSION VIA BLIND INTERFERENCE ALIGNMENT SCHEMES WITH REDUCED CHANNEL COHERENCE-TIME REQUIREMENTS - A wireless communication system, method and base station for using a multi-user MIMO (MU-MIMO)-based blind interference alignment (BIA) scheme are described. In one embodiment, the wireless communication system comprises a plurality of terminals, wherein each terminal in the plurality has a single radio frequency (RF) chain that is operable in M antenna modes, where M is an integer, and further wherein each terminal shifts between the M antenna modes in a predetermined manner. The wireless communication system also includes one or more base stations to perform downlink transmissions to the plurality of terminals using a transmitter array of M transmit antennas and operable to communicate with one or more of the terminals using a multi-user MIMO (MU-MIMO)-based blind interference alignment (BIA) scheme that uses at least one code BIA code serving K terminals from the transmitter array over L(M+K−1) slots for some L>0, wherein at least one of the one or more base stations transmits L symbols for user k, and where the L symbols for user k are transmitted over M distinct slots, within a set of L(M+D−1) consecutive slots, and where D is an integer less than K. | 02-06-2014 |
Joanne Papadopoulos, Lagrangeville, NY US
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20090156492 | Methods of Using IL-1 Antagonists to Treat Autoinflammatory Disease - Methods of treating, inhibiting, or ameliorating an autoinflammatory disorder, disease, or condition in a subject in need thereof, comprising administering to a subject in need a therapeutic amount of an interleukin 1 (IL-1) antagonist, wherein the autoinflammatory disorder, disease, or condition is treated, inhibited, or ameliorated. The IL-1 antagonist is an IL-1 trap, preferably comprising a sequence selected from the group consisting of SEQ ID NO: 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, or a substantially identical having at least 95% identity to the sequence shown in SEQ ID NO: 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26 and capable of binding and inhibiting IL-1. The therapeutic methods are useful for treating a human adult or child suffering from Neonatal Onset Multisystem Inflammatory Disorder (NOMID/CINCA), Muckle-Wells Syndrome (MWS), Familial Cold Autoinflammatory Syndrome (FCAS), familial mediterranean fever (FMF), or systemic onset juvenile rheumatoid arthritis (Still's Disease). | 06-18-2009 |
20110311537 | METHODS OF USING IL-1 ANTAGONISTS TO TREAT FAMILIAL MEDITERRANEAN FEVER (FMF) - Methods of treating, inhibiting, or ameliorating Familial Mediterranean Fever (FMF) by administering to a subject in need thereof a therapeutically effective amount of an interleukin 1 (IL-1) antagonist, are provided. The IL-1 antagonist can be an antibody or derivative thereof, which is capable of blocking or inhibiting the biological action of IL-1, thereby treating, inhibiting or ameliorating FMF. Also provided are methods of treating, inhibiting, or ameliorating FMF by administering a therapeutically effective amount of an IL-1 antagonist in combination with additional therapeutic agents, including IL-1-specific fusion proteins, TNF inhibitors, NSAIDs, steroids, and the like. | 12-22-2011 |
20110318342 | METHODS OF USING IL-1 ANTAGONISTS TO TREAT AUTOINFLAMMATORY DISEASE - Methods of treating, inhibiting, or ameliorating an autoinflammatory disorder, disease, or condition in a subject in need thereof, comprising administering to a subject in need a therapeutic amount of an interleukin 1 (IL-1) antagonist, wherein the autoinflammatory disorder, disease, or condition is treated, inhibited, or ameliorated. The IL-1 antagonist is a molecule capable of binding and inhibiting IL-1. The therapeutic methods are useful for treating a human adult or child suffering from Neonatal Onset Multisystem Inflammatory Disorder (NOMID/CINCA), Muckle-Wells Syndrome (MWS), Familial Cold Autoinflammatory Syndrome (FCAS), familial mediterranean fever (FMF), tumor necrosis factor receptor-associated periodic fever syndrome (TRAPS), or systemic onset juvenile idiopathic arthritis (Still's Disease). | 12-29-2011 |
Konstantinos Papadopoulos, Chevy Chase, MD US
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20100164747 | METHOD AND APPARATUS FOR ESTABLISHING LOW FREQUENCY/ULTRA LOW FREQUENCY AND VERY LOW FREQUENCY COMMUNICATIONS - A method for generating electromagnetic waves in the ELF/ULF comprising the steps of using a ground-based Horizontal Electric Dipole (HED) antenna to send electromagnetic pulses upwardly in the E-region of the ionosphere to form an oscillatory or pulsed electric field; allowing said pulsed electric field to interact with magnetized plasma of the lower ionosphere to generate a pulsed horizontal and vertical current which have associated Horizontal and Vertical Electric Dipole moment; and allowing them to radiate. | 07-01-2010 |
20110128605 | Radiation-Protection Device - A radiation-protection device is provided that includes a substrate and a surface structure formed on the substrate. The surface structure has an arrangement and interacts with radiation and the substrate to at least (a) substantially transmit or attenuate radiation at a wavelength and an energy below a threshold energy, and (b) substantially reflect radiation at the wavelength and an energy above the threshold energy. | 06-02-2011 |
20120021361 | RADIATION-PROTECTION DEVICE - A radiation-protection device is provided that includes a substrate and a surface structure formed on the substrate. The surface structure has an arrangement and interacts with radiation and the substrate to at least (a) substantially transmit or attenuate radiation at a wavelength and an energy below a threshold energy, and (b) substantially reflect radiation at the wavelength and an energy above the threshold energy. | 01-26-2012 |
20120029884 | RADIATION-PROTECTION DEVICE - A radiation-protection device is provided that includes a substrate and a surface structure formed on the substrate. The surface structure has an arrangement and interacts with radiation and the substrate to at least (a) substantially transmit or attenuate radiation at a wavelength and an energy below a threshold energy, and (b) substantially reflect radiation at the wavelength and an energy above the threshold energy. | 02-02-2012 |
20120223253 | SYSTEM AND METHOD FOR REDUCING TRAPPED ENERGETIC PROTON FLUX AT LOW EARTH ORBITS - A system and method for reducing energetic proton flux trapped in the inner radiation belt by injecting Ultra Low Frequency (ULF) electromagnetic waves is disclosed. The ULF electromagnetic waves is generated by space or ground based transmitters and the frequency range is selected such that the injected waves are in gyrofrequency resonance with trapped 10 to 100 Mev protons. Pitch angle scattering of the trapped protons in gyro-resonance with the injected waves increases their precipitation rate by forcing their orbits into pitch angles inside the atmospheric loss-cone where they are lost by intaracting with the dense neutral atmosphere at altitudes below 100 km. The reduction of energetic proton flux trapped in the inner radiation belt allows use of commercial electronics with submicron feature size on Low Earth Orbit satellites and microsatellites without the operational constraints imposed by the presence of energetic proton fluxes trapped at the inner radiation belts. | 09-06-2012 |
20130181145 | SYSTEM AND METHOD FOR REDUCING TRAPPED ENERGETIC PROTON OR ENERGETIC ELECTRON FLUX AT LOW EARTH ORBITS - A system and method for improving the survivability of space systems following a High Altitude Nuclear Explosion (HANE) incident resulting in energetic electrons being trapped in the inner radiation belt of Earth is disclosed. The ULF electromagnetic waves is generated by space or ground based transmitters and the frequency range is selected such that the injected waves are in gyrofrequency resonance with trapped energetic particles. The Radiation Belt Remediation (RBR) depends on the wave-number of the injected waves and the wave-number of the injected waves increases along their propagation path when they approach the cyclotron frequency of the dominant or minority ions 0 | 07-18-2013 |
20150303651 | ULTRA FAST SEMICONDUCTOR LASER - A laser system includes first and second mirrors, a semiconductor laser and a high frequency pulse generator. The semiconductor laser generates optical power within an optical cavity and reflects the optical power between the first mirror and second mirrors. The optical power has a frequency of f | 10-22-2015 |
Konstantinos Papadopoulos, Lincolnwood, IL US
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20150080775 | LYMPHATIC SYSTEM MOVER - The present invention is comprised of an inflatable sleeve system that may fit around a patient's limb, core or any other portion of his or her body. The system is comprised of a sleeve and pressure intake means that supplies air pressure to the sleeve. The sleeve of the present invention comprises at least three cylindrical inflatable chambers arranged longitudinally along the axis of the sleeve. | 03-19-2015 |
Konstantinos (dennis) Papadopoulos, Chevy Chase, MD US
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20140326900 | QUASI-NEUTRAL PLASMA GENERATION OF RADIOISOTOPES - Methods and apparatus for synthesizing radiochemical compounds are provided. The methods include generating a quasi-neutral plasma jet, and directing the plasma jet onto a radionuclide precursor to provide one or more radionuclides. The radionuclides can be used to prepare radiolabeled compounds, such as radiolabeled biomarkers. | 11-06-2014 |
Larry Papadopoulos, North Plains, OR US
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20110218080 | ROLLER TRAINER ASSEMBLY WITH LINEAR BEARINGS - A bicycle roller assembly, comprising a frame having a length and including two parallel rods running in the lengthwise dimension of said frame and having a front roller and a pair of rear rollers mounted between said parallel rods. In addition, a base assembly including a set of feet is adapted to rest on a surface. Finally, a support assembly is supported by said base assembly, and includes a set of linear bearings, into which said parallel rods are mounted, so as to permit movement in said lengthwise dimension. | 09-08-2011 |
Larry C. Papadopoulos, North Plains, OR US
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20090264261 | Roller trainer assembly with safeguards - Bicycle rollers that include a frame and front and rear rollers mounted in the frame, each having two lateral ends. Also, a pair of bumper/rollers are mounted on the frame adjacent both sides of the front roller. They are mounted so as to be horizontally rotatable, thereby acting to constrain a wheel of a bicycle supported by the front roller from moving laterally off the roller, while not stopping rotation of the bicycle wheel. | 10-22-2009 |
Leonidas P. Papadopoulos, Ridgefield, CT US
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20110075653 | SYSTEMS, METHODS, AND COMPUTER PROGRAM PRODUCTS FOR PROVIDING A MANUAL RING-DOWN COMMUNICATION LINE USING SESSION INITIATION PROTOCOL - Systems, methods, and computer program products are provided for manual ring-down communication using Session Initiation Protocol (SIP). A first SIP user agent transmits a message to a second SIP user agent over an Internet Protocol (IP) network to establish a SIP session. The first SIP user agent determines that a signal key associated with a first communication device has been selected and transmits, to the second SIP user agent over the IP network, a start event message to cause a second communication device to activate an alert. The first SIP user agent determines that the signal key has been released and transmits over the IP network an end event message to deactivate the alert. The first SIP user agent transmits, to the second SIP user agent over the IP network, one or more subsequent INVITE messages at a predetermined repetition rate to refresh the SIP session. | 03-31-2011 |
20110206040 | SYSTEMS, METHODS, AND COMPUTER PROGRAM PRODUCTS FOR PROVIDING A MANUAL RING-DOWN COMMUNICATION LINE USING SESSION INITIATION PROTOCOL - Systems, methods, and computer program products are provided for manual ring-down communication using Session Initiation Protocol (SIP). A first SIP user agent transmits a message to a second SIP user agent over an Internet Protocol (IP) network to establish a SIP session. The first SIP user agent determines that a signal key associated with a first communication device has been selected and transmits, to the second SIP user agent over the IP network, a start event message to cause a second communication device to activate an alert. The first SIP user agent determines that the signal key has been released and transmits over the IP network an end event message to deactivate the alert. The first SIP user agent transmits, to the second SIP user agent over the IP network, one or more subsequent INVITE messages at a predetermined repetition rate to refresh the SIP session. | 08-25-2011 |
Neofytos C. Papadopoulos, Annapolis, MD US
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20120014519 | System and Method for Generating Forecasts and Analysis of Contact Center Behavior for Planning Purposes - A method of predicting expected performance of a processing center system is accessed. The method includes receiving performance information from a performance monitoring system associated with the processing center system. A computer model of the processing center system is developed based on the performance information. The method further includes generating predictions based on the computer model, and analyzing the predictions to generate performance scenarios for the processing center system. | 01-19-2012 |
20120016711 | SYSTEM AND METHOD FOR GENERATING FORECASTS AND ANALYSIS OF CONTACT CENTER BEHAVIOR FOR PLANNING PURPOSES - A method of predicting expected performance of a processing center system is provided. The method includes receiving performance information from a performance monitoring system associated with the processing center system. A computer model of the processing center system is developed based on the performance information. The method further includes generating predictions based on the computer model, and analyzing the predictions to generate performance scenarios for the processing center system. | 01-19-2012 |
20120016712 | System and Method for Generating Forecasts and Analysis of Contact Center Behavior for Planning Purposes - A method of predicting expected performance of a processing center system is provided. The method includes receiving performance information from a performance monitoring system associated with the processing center system. A computer model of the processing center system is developed based on the performance information. The method further includes generating predictions based on the computer model, and analyzing the predictions to generate performance scenarios for the processing center system. | 01-19-2012 |
20130136252 | System and Method for Generating Forecasts and Analysis of Contact Center Behavior For Planning Purposes - A method of predicting expected performance of a processing center system is provided. This method includes receiving performance information from a performance monitoring system associated with the processing center system. A computer model of the processing center system is developed based on the performance information. The method further includes generating predictions based on the computer model, and analyzing the predictions to generate performance scenarios for the processing center system. | 05-30-2013 |
20140219436 | SYSTEM AND METHOD FOR GENERATING FORECASTS AND ANALYSIS OF CONTACT CENTER BEHAVIOR FOR PLANNING PURPOSES - A method of predicting expected performance of a processing center system is accessed. The method includes receiving performance information from a performance monitoring system associated with the processing center system. A computer model of the processing center system is developed based on the performance information. The method further includes generating predictions based on the computer model, and analyzing the predictions to generate performance scenarios for the processing center system. | 08-07-2014 |
Nicholas Papadopoulos, Lagrangeville, NY US
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20130315907 | VEGF-A121 ASSAY - The invention provides a method for determining the level of VEGF-A | 11-28-2013 |
20150330998 | VEGF-A121 ASSAY - The invention provides a method for enriching the level of VEGF-A | 11-19-2015 |
20150330999 | VEGF-A121 ASSAY - The invention provides a method for enriching the level of VEGF-A | 11-19-2015 |
Nickolas Papadopoulos, Towson, MD US
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20110229479 | GENETIC ALTERATIONS IN ISOCITRATE DEHYDROGENASE AND OTHER GENES IN MALIGNANT GLIOMA - We found mutations of the R132 residue of isocitrate dehydrogenase 1 (IDH1) in the majority of grade II and III astrocytomas and oligodendrogliomas as well as in glioblastomas that develop from these lower grade lesions. Those tumors without mutations in IDH1 often had mutations at the analogous R172 residue of the closely related IDH2 gene. These findings have important implications for the pathogenesis and diagnosis of malignant gliomas. | 09-22-2011 |
20120009573 | Antisense Transcriptomes of Cells - Transcription in mammalian cells can be assessed at a genome-wide level, but it has been difficult to reliably determine whether individual transcripts are derived from the Plus- or Minus-strands of chromosomes. This distinction can be critical for understanding the relationship between known transcripts (sense) and the complementary antisense transcripts that may regulate them. Here we describe a technique that can be used to (i) identify the DNA strand of origin for any particular RNA transcript and (ii) quantify the number of sense and antisense transcripts from expressed genes at a global level. We examined five different human cell types and in each case found evidence for antisense transcripts in 2900 to 6400 human genes. The distribution of antisense transcripts was distinct from that of sense transcripts, was non-random across the genome, and differed among cell types. Anti-sense transcripts thus appear to be a pervasive feature of human cells, suggesting that they are a fundamental component of gene regulation. | 01-12-2012 |
20120115735 | Pathways Underlying Pancreatic Tumorigenesis and an Hereditary Pancreatic Cancer Gene - There are currently few therapeutic options for patients with pancreatic cancers and new insights into the pathogenesis of this lethal disease are urgently needed. To this end, we performed a comprehensive analysis of the genes altered in 24 pancreatic tumors. First, we determined the sequences of 23,781 transcripts, representing 20,583 protein-encoding genes, in DNA from these tumors. Second, we searched for homozygous deletions and amplifications using microarrays querying ˜one million single nucleotide polymorphisms in each sample. Third, we analyzed the transcriptomes of the same samples using SAGE and next-generation sequencing-by-synthesis technologies. We found that pancreatic cancers contain an average of 63 genetic alterations, of which 49 are point mutations, 8 are homozygous deletions, and 6 are amplifications. Further analyses revealed a core set of 12 regulatory processes or pathways that were each genetically altered in 70% to 100% of the samples. The data suggest that dysregulation of this core set of pathways is responsible for the major features of pancreatic tumorigenesis. | 05-10-2012 |
20120164638 | Digital Quantification of DNA Methylation - Abnormal DNA methylation can be used as a biomarker in cancer patients. For such purposes, it is important to determine precisely the fraction of methylated molecules in an analyzed sample. A technology we term Methyl-BEAMing achieves this goal. Individual bisulfite-treated DNA molecules can be PCR-amplified within aqueous nanocompartments containing beads, resulting in a population of beads each containing thousands of copies of the template molecule. After hybridization with probes specific for methylated sequences, the beads can be analyzed by flow cytometry. This approach enables detection and enumeration of one methylated molecule in a population of ˜5000 unmethylated molecules. Methyl-BEAMing provides digital quantification of rare methylation events and is generally applicable to the assessment of methylated genes in clinical samples. | 06-28-2012 |
20120202207 | GENETIC ALTERATIONS IN ISOCITRATE DEHYDROGENASE AND OTHER GENES IN MALIGNANT GLIOMA - We found mutations of the R132 residue of isocitrate dehydrogenase 1 (IDH1) in the majority of grade II and III astrocytomas and oligodendrogliomas as well as in glioblastomas that develop from these lower grade lesions. Those tumors without mutations in IDH1 often had mutations at the analogous R172 residue of the closely related IDH2 gene. These findings have important implications for the pathogenesis and diagnosis of malignant gliomas. | 08-09-2012 |
20130210900 | ARID1A and PPP2R1A Mutations in Cancer - Two genes, ARID1A (AT-rich interactive domain-containing protein 1A) and PPP2R1A (protein-phosphatase 2, regulatory subunit 1, alpha), can be used in methods which are useful for detecting cancer, diagnosing cancer, contributing to a diagnosis of cancer, confirming a diagnosis of cancer, identifying appropriate treatments for cancer, monitoring treatment of cancer, and evaluating treatment protocols for cancer, including ovarian clear cell carcinoma, breast cancer, colon cancer, gastric cancer, lung cancer, medulloblastoma, pancreatic cancer, and prostate cancer. | 08-15-2013 |
20130296408 | MEDULLOBLASTOMA GENES AS TARGETS FOR DIAGNOSIS AND THERAPEUTICS - Medulloblastoma (MB) is the most common malignant brain tumor of children. To identify the genetic alterations in this tumor type, we searched for copy number alterations using high density microarrays and sequenced all known protein-coding genes and miRNA genes using Sanger sequencing. We found that, on average, each tumor had 11 gene alterations, markedly fewer than in common adult cancers. In addition to alterations in the Hedgehog and Wnt pathways, our analysis led to the discovery of genes not previously known to be altered in MBs. Most notably, inactivating mutations of the histone H3K4 trimethylase genes MLL2 or MLL3 were identified in 16% of MB patients. These results demonstrate key differences between the genetic landscapes of adult and childhood cancers, highlight dysregulation of developmental pathways as an important mechanism underlying MBs, and identify a role for a specific type of histone methylation in human tumorigenesis. | 11-07-2013 |
20140051105 | Mutant Proteins as Cancer-Specific Biomarkers - Altered protein products resulting from somatic mutations are directly identified and quantified by mass spectrometry. The peptides expressed from normal and mutant alleles are detected by Selected Reaction Monitoring (SRM) of their productions using a triple quadrupole mass spectrometer. As a prototypical example of this approach, we quantify the number and fraction of mutant Ras protein present in cancer cell lines. There were an average of 1.3 million molecules of Ras protein per cell and the ratio of mutant to normal Ras proteins ranged from 0.49 to 5.6. Similarly, we detected and quantified mutant Ras proteins in clinical specimens such as colorectal and pancreatic tumor tissues as well as in pre-malignant pancreatic cyst fluids. These methods are useful for diagnostic applications. | 02-20-2014 |
20140179538 | MUTATIONS IN PANCREATIC NEOPLASMS - To help reveal the pathogenesis of these lesions, we purified the DNA from Intraductal Papillary Mucinous Neoplasm (IPMN) cyst fluids from 19 patients and searched for mutations in 169 genes commonly altered in human cancers. We identified recurrent mutations at codon 201 of GNAS. We found that GNAS mutations were present in 66% of IPMNs and that either KRAS or GNAS mutations could be identified in 96%. In eight cases, we could investigate invasive adenocarcinomas that developed in association with IPMNs containing GNAS mutations. In seven of these eight cases, the GNAS mutations present in the IPMNs were also found in the invasive lesion. GNAS mutations were not found in other types of cystic neoplasms of the pancreas or in invasive adenocarcinomas not associated with IPMNs. These data suggest that GNAS mutations can inform the diagnosis and management of patients with cystic pancreatic lesions. | 06-26-2014 |
20140187764 | GENETIC ALTERATIONS IN ISOCITRATE DEHYDROGENASE AND OTHER GENES IN MALIGNANT GLIOMA - We found mutations of the R132 residue of isocitrate dehydrogenase 1 (IDH1) in the majority of grade II and III astrocytomas and oligodendrogliomas as well as in glioblastomas that develop from these lower grade lesions. Those tumors without mutations in IDH1 often had mutations at the analogous R172 residue of the closely related IDH2 gene. These findings have important implications for the pathogenesis and diagnosis of malignant gliomas. | 07-03-2014 |
20140221219 | OLIGODENDROGLIOMA DRIVE GENES - Oligodendrogliomas are the second most common malignant brain tumor in adults. These tumors often contain a chromosomal abnormality involving a pericentromeric fusion of chromosomes 1 and 19, resulting in losses of the entire short arm of the former and the long arm of the latter. To identify the molecular genetic basis for this alteration, we performed exomic sequencing of seven anaplastic oligodendrogliomas with chromosome 1p and 19q losses. Among other changes, we found that that CIC (homolog of the | 08-07-2014 |
20140323344 | Differential Identification of Pancreatic Cysts - More than 2% of adults harbor a pancreatic cyst, a subset of which progress to invasive lesions with lethal consequences. To assess the genomic landscapes of neoplastic cysts of the pancreas, we determined the exomic sequences of DNA from the neoplastic epithelium of eight surgically resected cysts of each of the major neoplastic cyst types: serous cystadenomas (SCAs), intraductal papillary mucinous neoplasms (IPMNs), mucinous cystic neoplasms (MCNs) and solid pseudo-papillary neoplasms (SPNs). SPNs are low-grade malignancies, and IPMNs and MCNs, but not SCAs, have the capacity to progress to cancer. We found that SCAs, IPMNs, MCNs, and SPNs contained 10=4.6, 27=12, 16=7.6, and 2.9=2.1 somatic mutations per tumor, respectively. Among the mutations identified, E3 ubiquitin ligase components were of particular note. Four of the eight SCAs contained mutations of VHL, a key component of the VHL ubiquitin ligase complex that has previously been associated both with renal cell carcinomas, SCAs, and other neoplasms. Six of the eight IPMNs and three of the eight MCNs harbored mutations of RNF43, a gene coding for a protein with intrinsic E3 ubiquitin ligase activity that has not previously been found to be genetically altered in any human cancer. The preponderance of inactivating mutations in RNF43 unequivocally establish it as a suppressor of both IPMNs and MCNs. SPNs contained remarkably few genetic alterations, but always contained mutations of CTNNB1, previously demonstrated to inhibit degradation of the encoded protein (β-catenin) by E3 ubiquitin ligases. These results highlight the essential role of ubiquitin ligases in these neoplasms and have important implications for the diagnosis and treatment of patients with cystic tumors. | 10-30-2014 |
20150051085 | RAPID ANEUPLOIDY DETECTION - Massively parallel sequencing of cell-free, maternal plasma DNA was recently demonstrated to be a safe and effective screening method for fetal chromosomal aneuploidies. Here, we report an improved sequencing method achieving significantly increased throughput and decreased cost by replacing laborious sequencing library preparation steps with PCR employing a single primer pair. Using this approach, samples containing as little as 4% trisomy 21 DNA could be readily distinguished from euploid samples. | 02-19-2015 |
20150252415 | ARID1B AND NEUROBLASTOMA - Neuroblastomas are tumors of peripheral sympathetic neurons and are the most common solid tumor in children. We performed whole-genome sequencing (6 cases), exome sequencing (16 cases), genome-wide rearrangement analyses (32 cases), and targeted analyses of specific genomic loci (40 cases) using massively parallel sequencing to determine the genetic basis for neuroblastoma. On average, each tumor had 19 somatic alterations in coding genes (range, 3-70). Chromosomal deletions and sequence alterations of chromatin remodeling genes, ARID1A and ARID1B, were identified in 8 of 71 neuroblastomas (11%), and these were associated with early treatment failure and decreased survival. These results highlight dysregulation of chromatin remodeling in pediatric tumorigenesis and provide new approaches for the management of neuroblastoma patients. | 09-10-2015 |
20150292027 | PAPANICOLAOU TEST FOR OVARIAN AND ENDOMETRIAL CANCERS - The recently developed liquid-based Papanicolaou (Pap) smear allows not only cytologic evaluation but also collection of DNA for detection of HPV, the causative agent of cervical cancer. We tested these samples to detect somatic mutations present in rare tumor cells that might accumulate in the cervix once shed from endometrial and ovarian cancers. A panel of commonly mutated genes in endometrial and ovarian cancers was assembled and used to identify mutations in all 46 endometrial or cervical cancer tissue samples. We were able also able to identify the same mutations in the DNA from liquid Pap smears in 100% of endometrial cancers (24 of 24) and in 41% of ovarian cancers (9 of 22). We developed a sequence-based method to query mutations in 12 genes in a single liquid Pap smear without prior knowledge of the tumor's genotype. | 10-15-2015 |
20150361492 | SAFE SEQUENCING SYSTEM - The identification of mutations that are present in a small fraction of DNA templates is essential for progress in several areas of biomedical research. Though massively parallel sequencing instruments are in principle well-suited to this task, the error rates in such instruments are generally too high to allow confident identification of rare variants. We here describe an approach that can substantially increase the sensitivity of massively parallel sequencing instruments for this purpose. One example of this approach, called “Safe-SeqS” for (Safe-Sequencing System) includes (i) assignment of a unique identifier (UID) to each template molecule; (ii) amplification of each uniquely tagged template molecule to create UID-families; and (iii) redundant sequencing of the amplification products. PCR fragments with the same UID are truly mutant (“super-mutants”) if ≧95% of them contain the identical mutation. We illustrate the utility of this approach for determining the fidelity of a polymerase, the accuracy of oligonucleotides synthesized in vitro, and the prevalence of mutations in the nuclear and mitochondrial genomes of normal cells. | 12-17-2015 |
20150361507 | TERT PROMOTER MUTATIONS IN GLIOMAS AND A SUBSET OF TUMORS - We surveyed 1,230 tumors of 60 different types and found that tumors could be divided into types with low (<15%) and high (≧15%) frequencies of TERT promoter mutations. The nine TERT-high tumor types almost always originated in tissues with relatively low rates of self renewal, including melanomas, liposarcomas, hepatocellular carcinomas, urothelial carcinomas, squamous cell carcinomas of the tongue, medulloblastomas, and subtypes of gliomas (including 83% of primary glioblastoma, the most common brain tumor type). TERT and ATRX mutations were mutually exclusive, suggesting that these two genetic mechanisms confer equivalent selective growth advantages. In addition to their implications for understanding the relationship between telomeres and tumorigenesis, TERT mutations provide a biomarker for the early detection of urinary tract and liver tumors and aid in the classification and prognostication of brain tumors. | 12-17-2015 |
Nickolas Papadopoulos, Baltimore, MD US
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20140154683 | Enrichment of Nucleic Acids by Complimentary Capture - Assays can be used to detect mutations found in neoplasms of the pancreas, as well as for other neoplasms and other uses. Nucleic acids can be captured from body fluids such as cyst fluids. Thousands of oligonucleotides can be synthesized in parallel, amplified and ligated together. The ligated products can be further amplified. The amplified, ligated products are used to capture complementary DNA sequences, which can be analyzed, for example by massively parallel sequencing. | 06-05-2014 |
Nikolas Papadopoulos, Towson, MD US
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20140045881 | GENES FREQUENTLY ALTERED IN PANCREATIC NEUROENDOCRINE TUMORS - Pancreatic Neuroendocrine Tumors (PanNETs) are a rare but clinically important form of pancreatic neoplasia. To explore the genetic basis of PanNETs, we determined the exomic sequences of ten non-familial PanNETs and then screened the most commonly mutated genes in 58 additional PanNETs. Remarkably, the most frequently mutated genes specify proteins implicated in chromatin remodeling: 44% of the tumors had somatic inactivating mutations in MEN-1, which encodes menin, a component of a histone methyltransferase complex; and 43% had mutations in genes encoding either of the two subunits of a transcription/chromatin remodeling complex consisting of DAXX (death-domain associated protein) and ATRX (alpha thalassemia/mental retardation syndrome X-linked). Clinically, mutations in the MEN1 and DAXX/ATRX genes were associated with better prognosis. We also found mutations in genes in the mTOR (mammalian target of rapamycin) pathway in 14% of the tumors, a finding that could potentially be used to stratify patients for treatment with mTOR inhibitors. | 02-13-2014 |
Pavlos Papadopoulos, Antioch, IL US
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20140212495 | NANOPARTICULATE COMPOSITIONS OF TUBULIN INHIBITOR COMPOUNDS - The present invention is directed to novel pharmaceutical compositions comprising nano- and micro-particulate formulations of poorly water soluble tubulin inhibitors of the indole chemical class, preferably N-substituted indol-3-glyoxyamides, and more preferably N-(Pyridin-4-yl)-[1-(4-chlorobenzyl)-indol-3-yl]glyoxylic acid amide (D-24851), also known as “Indibulin,” and methods of making and using such compositions for the treatment of anti-tumor agent resistant cancers and other diseases. | 07-31-2014 |
Pavlos George Papadopoulos, Antioch, IL US
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20100086611 | Method for Treating Infectious Organisms Normally Considered to be Resistant to an Antimicrobial Drug - The present invention relates to compositions of submicron- to micron-size particles of antimicrobial agents. More particularly the invention relates to a composition of an antimicrobial agent that renders the agent potent against organisms normally considered to be resistant to the agent. The composition comprises an aqueous suspension of submicron- to micron-size particles containing the agent coated with at least one surfactant selected from the group consisting of: ionic surfactants, non-ionic surfactants, biologically derived surfactants, and amino acids and their derivatives. The particles have a volume-weighted mean particle size of less than 5 μm as measured by laser diffractometry. | 04-08-2010 |
Stephen Papadopoulos, Paradise, AZ US
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20100222780 | METHOD AND APPARATUS FOR RETAINING SCREW IN A PLATE - A retention system for maintaining a screw to a vertebral plate is described herein. One or more screws extend through apertures within the vertebral plate. A cavity is positioned adjacent to and overlaps into the aperture. A ring is positioned within the cavity and held in position by a cap. The cap attaches to the plate to prevent removal of the ring. The ring is deflectable between a first shape to allow the screw to be inserted and removed from the aperture, and a second shape to prevent screw back-out from the aperture. | 09-02-2010 |
Stephen Papadopoulos, Paradise Valley, AZ US
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20100087830 | Endplate Preparation Instruments and Methods of Use - The present application is directed to instruments and methods for preparing a space between vertebral members. One embodiment of the instrument may include an elongated shaft with a proximal end and a distal end. A blade may be positioned at an end of the shaft and may rotate about an axis. The blade may include one or more teeth that include a height and/or contour. During rotation of the blade, the teeth contact and cut into one of the vertebral members. The instrument may also include a depth stop that limits a depth that the teeth can cut into the vertebral member. In some embodiments, the instrument includes a second blade that is configured to cut into the second vertebral member. | 04-08-2010 |
Stephen M. Papadopoulos, Ann Arbor, MI US
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20100222822 | Posterior Fixation System - A posterior fixation system includes a saddle member, an anchoring member, an occipital plate, an occipital rod, and a cross-link connector. The anchoring member anchors the saddle member to bone. The saddle member includes a pair of upright portions that define a channel. The channel is adapted to receive an orthopedic rod, and the saddle member can include a hole to receive the anchoring member. The saddle member and the anchoring member can be coupled so as to allow multi-axial movement of the members. The anchoring member in one embodiment is a screw coupled to the hole of the saddle, and in another embodiment, the anchoring member is a hook. The offset member may be coupled to the saddle member to allow for offset connection of rods. Connection of individual rods can be accomplished by connecting the rods with the cross-link connector. The cross-link connector has an integrally formed cylindrical member that couples a pair of coupling portions together. The cylindrical member can be bent along multiple axes. The occipital plate secures the rods to the occipital bone of the skull. The occipital plate has a cross-shaped plate with a plurality of apertures defined in the plate and at least one saddle member coupled to the plate. Alternatively, the occipital rod can be secured to the occipital bone. | 09-02-2010 |
20140200617 | Posterior Fixation System - A posterior fixation system includes a saddle member, an anchoring member, an occipital plate, an occipital rod, and a cross-link connector. The anchoring member anchors the saddle member to bone. The saddle member includes a channel that is adapted to receive an orthopedic rod. The saddle member and the anchoring member can be coupled so as to allow multi-axial movement of the members. Connection of individual rods can be accomplished by connecting the rods with the cross-link connector. The occipital plate secures the rods to the occipital bone of the skull. Alternatively, the occipital rod can be secured to the occipital bone. | 07-17-2014 |
Vassilios Papadopoulos, North Potomac, MD US
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20090197891 | Use of (4-Alkylpiperazinyl)(phenyl) methanones in the treatment of alzheimer's disease - The invention provides a therapeutic method for treating at least one symptom of Alzheimer's disease in a mammal, such as a human, wherein the toxicity of a pathogen of β amyloid peptide mammalian cells is implicated and inhibition of the subsequently-induced pathological pathways is desired comprising administering to a mammal in need of such therapy, an effective amount of a benzoylpiperazine derivative, including pharmaceutically acceptable salts thereof. | 08-06-2009 |
20090286876 | NEUROPROTECTIVE BENZOATE AND BENZAMIDE COMPOUNDS - The invention provides a therapeutic method for treating at least one symptom of a neurological disorder or disease such as Alzheimer's disease in a mammal, such as a human, wherein the toxicity of a pathogen of β amyloid peptide and/or glutamate in mammalian cells is implicated and inhibition of the subsequently-induced pathological pathways is desired comprising administering to a mammal in need of such therapy, an effective amount of an N-arylamide or an (N-aminoalkyl)benzamide, including pharmaceutically acceptable salts thereof. | 11-19-2009 |
20100015114 | PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR EXPRESSION LEVEL AS AN INDEX OF ORGAN DAMAGE AND REGENERATION - The present invention relates to methods, reagents, and kits for assessing organ damage, such as damage due to ischemia reperfusion injury, in the course of a transplantation therapy and/or for assessing organ regeneration following transplantation therapy. The invention provides a method for determining an index of organ health in the course of transplantation therapy comprising measuring the expression level of peripheral-type benzodiazepine receptor (PBR) in the organ. Measuring the expression level of PBR is also useful for assessing the progress of organ regeneration in the course of transplantation therapy by comparing the index of organ health. The expression level of PBR may be used as a predictor of the outcome of transplantation therapy. | 01-21-2010 |
20110081295 | PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR EXPRESSION LEVEL AS AN INDEX OF ORGAN DAMAGE AND REGENERATION - The present invention relates to methods, reagents, and kits for assessing organ damage, such as damage due to ischemia reperfusion injury, in the course of a transplantation therapy and/or for assessing organ regeneration following transplantation therapy. The invention provides a method for determining an index of organ health in the course of transplantation therapy comprising measuring the expression level of peripheral-type benzodiazepine receptor (PBR) in the organ. Measuring the expression level of PBR is also useful for assessing the progress of organ regeneration in the course of transplantation therapy by comparing the index of organ health. The expression level of PBR may be used as a predictor of the outcome of transplantation therapy. | 04-07-2011 |