Patent application number | Description | Published |
20090325928 | 6,6-Bicyclic Ring Substituted Heterobicyclic Protein Kinase Inhibitors - Compounds of the formula | 12-31-2009 |
20110098304 | Small molecule inhibitors of PARP activity - Componds and pharmaceutical compositions are provided that inhibit the activity of poly ADP-ribose synthetase (PARP). Such componds are useful in the treatment of various diseases, conditions and injuries such as stroke, myocardial infarction, ischemia-perfusion injury in various organs, traumatic brain injury, atherosclerosis, inflammatory diseases and cancer. | 04-28-2011 |
20110184038 | METHODS AND COMPOSITIONS OF SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY - The present invention provides compositions and formulations of compounds having formula (I) and pharmaceutically acceptable derivatives thereof, wherein p, R | 07-28-2011 |
20110190496 | FUSED BICYCLIC mTOR INHIBITORS - Compounds represented by Formula (I) | 08-04-2011 |
20110218183 | Fused Bicyclic mTOR Inhibitors - Compounds represented by Formula (I) | 09-08-2011 |
20110237633 | SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY - The present invention provides compounds and pharmaceutically acceptable compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases in which hepatocyte growth factor/scatter factor (HGF/SF) or the activities thereof, or agonists or antagonists thereof, have a therapeutically useful role. | 09-29-2011 |
20120046267 | 7-AMINOFUROPYRIDINE DERIVATIVES - Compounds of Formula 1, as shown below and defined herein: | 02-23-2012 |
20120077979 | 6,6-Bicyclic Ring Substituted Heterobicyclic Protein Kinase Inhibitors - Compounds of the formula | 03-29-2012 |
20120184533 | SMALL MOLECULE INHIBITORS OF PARP ACTIVITY - Compounds and pharmaceutical compositions are provided that inhibit the activity of poly ADP-ribose synthetase (PARP). Such compounds are useful in the treatment of various diseases, conditions and injuries such as stroke, myocardial infarction, ischemia-perfusion injury in various organs, traumatic brain injury, atherosclerosis, inflammatory diseases and cancer. | 07-19-2012 |
20120190716 | METHODS AND USES OF CYTOCHROME P450 INHIBITORS - Methods are provided for treating or preventing chronic obstructive pulmonary diseases such as emphysema, and fibrotic diseases including heart, liver, kidney and vascular diseases, by administering to a subject a pharmaceutical composition comprising a compound that inhibits cytochrome P450RA or CYP26. | 07-26-2012 |
20120196847 | 6,6-Bicyclic Ring Substituted Heterobicyclic Protein Kinase Inhibitors - Compounds of the formula | 08-02-2012 |
20130165651 | FUSED BICYCLIC mTOR INHIBITORS - Compounds represented by Formula (I) | 06-27-2013 |
20130303567 | SMALL MOLECULE INHIBITORS OF PARP ACTIVITY - Compounds and pharmaceutical compositions are provided that inhibit the activity of poly ADP-ribose synthetase (PARP). Such compounds are useful in the treatment of various diseases, conditions and injuries such as stroke, myocardial infarction, ischemia-perfusion injury in various organs, traumatic brain injury, atherosclerosis, inflammatory diseases and cancer. | 11-14-2013 |
20140018401 | CYTOCHROME P450 INHIBITORS AND USES THEREOF - The present invention provides compounds having the general structural formula (I) | 01-16-2014 |
20140256727 | METHODS AND COMPOSITIONS OF SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY - The present invention provides compositions and formulations of compounds having formula (I) and pharmaceutically acceptable derivatives thereof, wherein p, R | 09-11-2014 |
20140288136 | METHODS AND USES OF CYTOCHROME P450 INHIBITORS - Methods are provided for treating or preventing chronic obstructive pulmonary diseases such as emphysema, and fibrotic diseases including heart, liver, kidney and vascular diseases, by administering to a subject a pharmaceutical composition comprising a compound that inhibits cytochrome P450RA or CYP26. | 09-25-2014 |
20140309234 | SMALL MOLECULE ANTI-FIBROTIC COMPOUNDS AND USES THEREOF - The present invention provides methods for treating fibrotic diseases by administering a compound having the general structural formula (I) | 10-16-2014 |
20140329871 | SMALL MOLECULE ANTI-FIBROTIC COMPOUNDS AND USES THEREOF - The present invention provides compounds having the general structural Formula (I): | 11-06-2014 |
20140371234 | ANTIFIBROTIC COMPOUNDS AND USES THEREOF - The present invention provides compounds having the general structural formula (I), and pharmaceutically acceptable derivatives thereof, as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases involving abnormal or excessive fibrosis. | 12-18-2014 |
20150158853 | CYTOCHROME P450 INHIBITORS AND USES THEREOF - The present invention provides compounds having the general structural formula (I) | 06-11-2015 |
20150306078 | ANTIFIBROTIC COMPOUNDS AND USES THEREOF - The present invention provides compounds having the general structural formula (I) | 10-29-2015 |
Patent application number | Description | Published |
20150317088 | SYSTEMS AND METHODS FOR NVME CONTROLLER VIRTUALIZATION TO SUPPORT MULTIPLE VIRTUAL MACHINES RUNNING ON A HOST - A new approach is proposed that contemplates systems and methods to virtualize a physical NVMe controller associated with a computing device or host so that every virtual machine running on the host can have its own dedicated virtual NVMe controller. First, a plurality of virtual NVMe controllers are created on a single physical NVMe controller, which is associated with one or more storage devices. Once created, the plurality of virtual NVMe controllers are provided to VMs running on the host in place of the single physical NVMe controller attached to the host, and each of the virtual NVMe controllers organizes the storage units to be accessed by its corresponding VM as a logical volume. As a result, each of the VMs running on the host has its own namespace(s) and can access its storage devices directly through its own virtual NVMe controller. | 11-05-2015 |
20150317091 | SYSTEMS AND METHODS FOR ENABLING LOCAL CACHING FOR REMOTE STORAGE DEVICES OVER A NETWORK VIA NVME CONTROLLER - A new approach is proposed that contemplates systems and methods to support mapping/importing remote storage devices as NVMe namespace(s) via an NVMe controller using a storage network protocol and utilizing one or more storage devices locally coupled to the NVMe controller as caches for fast access to the mapped remote storage devices. The NVMe controller exports and presents the NVMe namespace(s) of the remote storage devices to one or more VMs running on a host attached to the NVMe controller. Each of the VMs running on the host can then perform read/write operations on the logical volumes. During a write operation, data to be written to the remote storage devices by the VMs is stored in the locally coupled storage devices first before being transmitted over the network. The locally coupled storage devices may also cache data intelligently pre-fetched from the remote storage devices based on reading patterns and/or pre-configured policies of the VMs in anticipation of read operations. | 11-05-2015 |
20150317176 | SYSTEMS AND METHODS FOR ENABLING VALUE ADDED SERVICES FOR EXTENSIBLE STORAGE DEVICES OVER A NETWORK VIA NVME CONTROLLER - A new approach is proposed that contemplates systems and methods to support a plurality of value-added services for storage operations on a plurality of remote storage devices virtualized as extensible/flexible storages and NVMe namespace(s) via an NVMe controller in real time. First, the NVMe controller virtualizes and presents the remote storage devices to one or more VMs running on a host attached to the NVMe controller as logical volumes so that each of the VMs running on the host can perform read/write operations on the emote storage devices as if they were local storage devices. The NVMe controller then monitors and meters the resources consumed by the activities/operations by the VMs to the virtualized remote storage devices as well as the data being transmitted during such operations in real time and creates analytics for billing purposes. In addition, the NVMe controller performs one or more of crypto operations, checksum operations, and compression and/or decompression operations on the data written to and/or read from the remote storage devices by the VMs as part of the value-added services to improve security, integrity, and efficient transmission of the data. | 11-05-2015 |
20150317177 | SYSTEMS AND METHODS FOR SUPPORTING MIGRATION OF VIRTUAL MACHINES ACCESSING REMOTE STORAGE DEVICES OVER NETWORK VIA NVME CONTROLLERS - A new approach is proposed that contemplates systems and methods to support (live or quiesced) migration of virtual machines (VMs) accessing a set of remote storage devices over a network via non-volatile memory express (NVMe) controllers from a current host to a destination host. At the time of the VM migration, a first virtual NVMe controller running on a first physical NVMe controller enables a first VM running on the current host to access and perform a plurality of storage operations to one or more logical volumes mapped to the remote storage devices over the network as if they were local storage volumes. During the VM migration process, the current host puts the first virtual NVMe controller serving the first VM into a quiesce state, captures and saves an image of states of the first virtual NVMe controller on the first host. A second virtual NVMe controller is then created on a second physical NVMe controller using the saved image, wherein the second virtual NVMe controller is configured to serve a second VM on the destination host and has exactly the same states as the first virtual NVMe controller. The second virtual NVMe controller then initiates and/or resumes the storage operations to the remote storage devices without being interrupted by the migration of the first VM on the first host to the second VM on the second host. | 11-05-2015 |
20150319237 | SYSTEMS AND METHODS FOR ENABLING ACCESS TO EXTENSIBLE STORAGE DEVICES OVER A NETWORK AS LOCAL STORAGE VIA NVME CONTROLLER - A new approach is proposed that contemplates systems and methods to support extensible/flexible storage access in real time by virtualizing a plurality of remote storage devices as NVMe namespace(s) via an NVMe controller using a storage network protocol. The NVMe controller exports and presents the remote storage devices to one or more VMs running on a host attached to the NVMe controller as the NVMe namespace(s), wherein these remote storage devices appear virtually as one or more logical volumes of a collection of logical blocks in the NVMe namespace(s) to the VMs. As a result, each of the VMs running on the host can access these remote storage devices to perform read/write operations as if they were local storage devices via the NVMe namespace(s). | 11-05-2015 |
20150319243 | SYSTEMS AND METHODS FOR SUPPORTING HOT PLUGGING OF REMOTE STORAGE DEVICES ACCESSED OVER A NETWORK VIA NVME CONTROLLER - A new approach is proposed that contemplates systems and methods to support hot plugging and/or unplugging one or more of remote storage devices virtualized as extensible/flexible storages and NVMe namespace(s) via an NVMe controller during operation. First, the NVMe controller virtualizes and presents a set of remote storage devices to one or more VMs running on a host attached to the NVMe controller as logical volumes in the NVMe namespace(s) so that each of the VMs running on the host can access these remote storage devices to perform read/write operations as if they were local storage devices. When the one or more remote storage devices are added to or removed from the set of remote storage devices based on storage space needs of the VMs, the NVMe controller updates the logical volumes in the NVMe namespace(s) accordingly and enables these remote storage devices to be hot plugged or unplugged from the plurality of remote storage devices at runtime without requiring shutting down and restarting any of the VMs, the host, and/or the NVMe controller. The VMs may then perform read/write operations on the NVMe namespace(s) updated to reflect the changes in the configuration of the set of remote storage devices dynamically without any interruption. | 11-05-2015 |
Patent application number | Description | Published |
20090075224 | CONVEYOR OVEN APPARATUS AND METHOD - An oven according to some embodiments includes an oven chamber in which food is cooked, a heating element, a fan, a sensor for sensing the temperature of the oven chamber, a remote input device, and a controller configured to receive a signal from the remote input device and to change the fan or heating element based at least in part upon the signal received from the remote input device. In a method of operating the oven according to some embodiments, the oven enters an operating mode from an energy-savings mode responsive to receiving an signal from a remote device. | 03-19-2009 |
20110269085 | CONVEYOR OVEN APPARATUS AND METHOD - An oven with a sensor positioned to detect an event that will cause a decrease in the internal temperature of a tunnel. The oven includes a controller configured to increase the thermal output of a heating element in anticipation of the upcoming decrease in the internal temperature. In some embodiments, the oven is a conveyor over and the sensor is positioned to detect a food item approach the tunnel on a conveyor. In some embodiments, the amount of current provided to an electric heating element is increased by increasing the target temperature. In some embodiments, the amount of current provided to the electric heating element is increased by a predetermined offset. | 11-03-2011 |
20120073558 | CONVEYOR OVEN APPARATUS AND METHOD - An oven according to some embodiments includes an oven chamber in which food is cooked, a heating element, a fan, a sensor for sensing the temperature of the oven chamber, a remote input device, and a controller configured to receive a signal from the remote input device and to change the fan or heating element based at least in part upon the signal received from the remote input device. In a method of operating the oven according to some embodiments, the oven enters an operating mode from an energy-savings mode responsive to receiving an signal from a remote device. | 03-29-2012 |
20130008424 | CONVEYOR OVEN APPARATUS AND METHOD - A conveyor oven according to some embodiments has a first mode and a second mode of operation and includes a tunnel in which food is cooked, a conveyor for moving the food through the tunnel, a first set and a second set of one or more burners, each set configured to generate heat for the tunnel, and a controller responsive to the detection of an absence of food in the tunnel, the controller configured to change operation of the first set of one or more burners and the second set of one or more burners from the first mode of operation to the second mode of operation based at least in part upon the detection of the absence of food product from the tunnel. | 01-10-2013 |
20140360381 | CONVEYOR OVEN APPARATUS AND METHOD - A conveyor oven according to some embodiments has a first mode and a second mode of operation and includes a tunnel in which food is cooked, a conveyor for moving the food through the tunnel, a first set and a second set of one or more burners, each set configured to generate heat for the tunnel, and a controller responsive to the detection of an absence of food in the tunnel, the controller configured to change operation of the first set of one or more burners and the second set of one or more burners from the first mode of operation to the second mode of operation based at least in part upon the detection of the absence of food product from the tunnel. | 12-11-2014 |
Patent application number | Description | Published |
20090102203 | SYSTEM AND METHOD FOR POWER PRODUCTION USING A HYBRID HELICAL DETONATION DEVICE - The system and method described herein uses a hybrid pulsed detonation engine (PDE) system to drive a turbine that powers an electric generator. The combustion chamber of the PDE is shaped in a helical form, so that the external length of the section is reduced, while maintaining the distance for acceleration to detonation. This allows the achievement of deflagration to detonation transition without the help of turbulence enhancing obstacles, while keeping the overall size of the detonation tube small. The PDE output can be scaled by: increasing the cross sectional area of the detonation chamber; increasing the number of detonation tubes; and increasing the frequency of operation of the PDE. The replacement of conventional deflagrative internal combustion engines, including gas turbines and reciprocating engines, with pulsed detonation engines for electric power generation, may provide fuel savings and have a lower environmental impact. | 04-23-2009 |
20090126343 | Internal Detonation Reciprocating Engine - A method of rotating a crank shaft and in internal detonation engine are provided. The internal detonation engine comprises a deflagration to detonation transition section. The deflagration to detonation transition section is connected to a main cylinder, which houses a piston. Inducing a detonation wave from the deflagration wave and passing the detonation wave through a fluid, gives rise to high pressure and temperature in a cylinder and pushes a piston towards bottom dead center. An internal detonation reciprocating engine may be a single cylinder and may be either a two or four stroke engine. A two-stroke internal detonation reciprocating engine is similar to a four-stroke internal detonation reciprocating engine but has different valve placements. Detonations produce a more thorough combustion of the fuel and may, thereby, yield reduced emissions of carbon monoxide as compared to internal combustion engines. | 05-21-2009 |
20090320812 | Internal Detonation Reciprocating Engine - A method of rotating a crank shaft and in internal detonation engine are provided. The internal detonation engine comprises a deflagration to detonation transition section. The deflagration to detonation transition section is connected to a main cylinder, which houses a piston. Inducing a detonation wave from the deflagration wave and passing the detonation wave through a fluid, gives rise to high pressure and temperature in a cylinder and pushes a piston towards bottom dead center. An internal detonation reciprocating engine may be a single cylinder and may be either a two or four stroke engine. A two-stroke internal detonation reciprocating engine is similar to a four-stroke internal detonation reciprocating engine but has different valve placements. Detonations produce a more thorough combustion of the fuel and may, thereby, yield reduced emissions of carbon monoxide as compared to internal combustion engines. | 12-31-2009 |
20090322102 | System and Method for Power Production Using a Hybrid Helical Detonation Device - The system and method described herein uses a hybrid pulsed detonation engine (PDE) system to drive a turbine that powers an electric generator. The combustion chamber of the PDE is shaped in a helical form, so that the external length of the section is reduced, while maintaining the distance for acceleration to detonation. This allows the achievement of deflagration to detonation transition without the help of turbulence enhancing obstacles, while keeping the overall size of the detonation tube small. The PDE output can be scaled by: increasing the cross sectional area of the detonation chamber; increasing the number of detonation tubes; and increasing the frequency of operation of the PDE. The replacement of conventional deflagrative internal combustion engines, including gas turbines and reciprocating engines, with pulsed detonation engines for electric power generation, may provide fuel savings and have a lower environmental impact. | 12-31-2009 |
Patent application number | Description | Published |
20140127196 | Anti-Complement C1s Antibodies and Uses Thereof - The present disclosure provides antibodies that bind complement C1s protein; and nucleic acid molecules that encode such antibodies. The present disclosure also provides compositions comprising such antibodies, and methods to produce and use such antibodies, nucleic acid molecules, and compositions. | 05-08-2014 |
20140127208 | Anti-Complement C1s Antibodies and Uses Thereof - The present disclosure provides antibodies that bind complement C1s protein; and nucleic acid molecules that encode such antibodies. The present disclosure also provides compositions comprising such antibodies, and methods to produce and use such antibodies, nucleic acid molecules, and compositions. | 05-08-2014 |
20140140933 | ANTI-COMPLEMENT C1S ANTIBODIES AND USES THEREOF - The present disclosure provides antibodies that bind complement C1s protein; and nucleic acid molecules that encode such antibodies. The present disclosure also provides compositions comprising such antibodies, and methods to produce and use such antibodies, nucleic acid molecules, and compositions. | 05-22-2014 |
20150104448 | Anti-Complement C1s Antibodies and Uses Thereof - The present disclosure provides antibodies that bind complement C1s protein; and nucleic acid molecules that encode such antibodies. The present disclosure also provides compositions comprising such antibodies, and methods to produce and use such antibodies, nucleic acid molecules, and compositions. | 04-16-2015 |
20150259437 | ANTI-COMPLEMENT C1S ANTIBODIES AND USES THEREOF - The present disclosure provides antibodies that bind complement C1s protein; and nucleic acid molecules that encode such antibodies. In some embodiments, such anti-complement C1s antibodies inhibit proteolytic activity of C1s. The present disclosure also provides compositions comprising such antibodies, and methods to produce and use such antibodies, nucleic acid molecules, and compositions. | 09-17-2015 |
20150307626 | ANTI-COMPLEMENT C1S ANTIBODIES AND USES THEREOF - The present disclosure provides antibodies that bind complement C1s protein; and nucleic acid molecules that encode such antibodies. The present disclosure also provides compositions comprising such antibodies, and methods to produce and use such antibodies, nucleic acid molecules, and compositions. | 10-29-2015 |
20150329645 | ANTI-COMPLEMENT C1S ANTIBODIES AND USES THEREOF - The present disclosure provides antibodies that bind complement C1s protein; and nucleic acid molecules that encode such antibodies. In some embodiments, such anti-complement C1s antibodies inhibit proteolytic activity of C1s. The present disclosure also provides compositions comprising such antibodies, and methods to produce and use such antibodies, nucleic acid molecules, and compositions. | 11-19-2015 |