Paddison
Jeremy Wayne Paddison, New South Wales AU
Patent application number | Description | Published |
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20160099950 | USER AUTHENTICATION - A method, system, server processing system and computer readable medium for authenticating a user attempting to access a secure environment is disclosed. In one aspect, the server processing system is configured to: receive an authentication request to authenticate the user attempting to access the secure environment; transfer, to the user or a user device associated with the user, an index corresponding to a selected key from a keymap; receive data indicative of a code which is based on the selected key presented by the user device and a personal identifier, and determine, using the code whether the user is authenticated. Advantageously, the server processing system never stores nor receives data directly indicative of the personal identifier such that no one else is able to determine the personal identifier, not even an employee of the secure environment which the user is attempting to access. | 04-07-2016 |
Patrick Paddison, Oyster Bay, NY US
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20090217404 | Cell-based RNA interference and related methods and compositions - The invention provides, among other things, methods for performing RNA interference (RNAi) in stem cells (such as embryonic stem cells) and methods for using such stem cells in vivo. The invention also provides various animal models based on conditional/inducible, reversible, tissue-specific/spacial, and/or developmental stage-specific/temporal RNAi of certain target genes, which animal model may be useful for, e.g., drug target identification and/or validation. | 08-27-2009 |
Patrick Paddison, Seattle, WA US
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20120149602 | METHOD FOR MAKING POPULATIONS OF DEFINED NUCLEIC ACID MOLECULES - The present invention provides methods of making a population of nucleic acid molecules, wherein each nucleic acid molecule comprises a predetermined nucleic acid sequence, each of said methods comprising the steps of: (a) synthesizing, on a substrate, a population of nucleic acid molecules wherein: i) each synthesized nucleic acid molecule comprises a predetermined nucleic acid sequence; and ii) each synthesized nucleic acid molecule is localized to a defined area of said substrate; (b) harvesting said population of synthesized nucleic acid molecules from said substrate to yield harvested nucleic acid molecules; and (c) introducing said harvested nucleic acid molecules into vector molecules. | 06-14-2012 |
20130276158 | METHODS AND COMPOSITIONS FOR RNA INTERFERENCE - The present invention provides methods for attenuating gene expression in a cell, especially in a mammalian cell, using gene-targeted double stranded RNA (dsRNA), such as a hairpin RNA. The dsRNA contains a nucleotide sequence that hybridizes under physiologic conditions of the cell to the nucleotide sequence of at least a portion of the gene to be inhibited (the “target” gene). | 10-17-2013 |
20140179560 | DRUG DISCOVERY METHODS AND PLATFORMS - Methods and systems for discovering drug candidates are disclosed. Methods and systems can include generating libraries of potential drug candidates (e.g., libraries of peptides) that can be screened to identify sub-libraries of potential drug candidates (e.g., sub-libraries of peptides) having selected pharmacological properties. Methods of making and using peptide libraries are also provided. D-amino acid chlorotoxins and D-amino acid chlorotoxin variants are also provided. | 06-26-2014 |
20150316536 | METHODS FOR SCREENING - Methods and systems for discovering drug candidates are disclosed. Methods and systems can include generating libraries of potential drug candidates (e.g., libraries of peptides) that can be screened to identify sub-libraries of potential drug candidates (e.g., sub-libraries of peptides) having selected pharmacological properties. Methods of making and using peptide libraries are also provided. D-amino acid chlorotoxins and D-amino acid chlorotoxin variants are also provided. | 11-05-2015 |
Patrick J. Paddison, Seattle, WA US
Patent application number | Description | Published |
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20100186097 | CELL-BASED RNA INTERFERENCE AND RELATED METHODS AND COMPOSITIONS - The invention provides, among other things, methods for performing RNA interference in stem cells and methods for using the stem cells in vivo. | 07-22-2010 |
20150025017 | COMPOSITIONS AND METHODS FOR TREATING CANCER - The present disclosure provides compositions and methods for treating cellular hyperproliferative disorders with a PHF5α inhibitor, such as siRNA, shRNA, antisense oligonucleotides, or pharmaceutical compounds. Exemplary cellular hyperproliferative disorders that can be treated with the PHF5α antagonists of the present disclosure include cancers, such as gliomas, adenocarcinomas, cervical cancer or prostate cancer. | 01-22-2015 |
Patrick J. Paddison, Oyster Bay, NY US
Patent application number | Description | Published |
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20080226553 | Cell-Based Rna Interference and Related Methods and Compositions - This invention provides, among other things, methods for performing RNA interference in stem cells and methods for using stem cells in vivo. | 09-18-2008 |
Patrick J. Paddison, Northport, NY US
Patent application number | Description | Published |
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20080213861 | Methods and compositions for RNA interference - The present invention provides methods for attenuating gene expression in a cell, especially in a mammalian cell, using gene-targeted double stranded RNA (dsRNA), such as a hairpin RNA. The dsRNA contains a nucleotide sequence that hybridizes under physiologic conditions of the cell to the nucleotide sequence of at least a portion of the gene to be inhibited (the “target” gene). | 09-04-2008 |