Pachter
Jonathan A. Pachter, Maplewood, NJ US
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20110060130 | NEUTRALIZING HUMAN ANTI-IGFR ANTIBODY - The present invention includes fully human, neutralizing, monoclonal antibodies against human Insulin-like Growth Factor Receptor-I (IGFR1). The antibodies are useful for treating or preventing cancer in a subject. Also included are methods of using and producing the antibodies of the invention. | 03-10-2011 |
Jonathan A. Pachter, East Setauket, NY US
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20110014117 | ANTI-IGF1R - The present invention relates in part to anti-IGF1R antibodies and antigen-binding compositions thereof along with methods of use thereof. For example, methods of treating medical disorders such as cancer are covered. | 01-20-2011 |
Jonathan A. Pachter, Setauket, NY US
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20090286850 | Inhibition of EMT induction in tumor cells by anti-cancer agents - The present invention provides methods of identifying an agents that inhibit tumor cells from undergoing an epithelial to mesenchymal transition, impair tumor cell mobility, and thus inhibit tumorigenicity. The present invention also provides compositions comprising said agents, and methods for their preparation and use. The present invention also provides methods for inhibiting tumor cells in a patient from undergoing an epithelial to mesenchymal transition by administration of inhibitors of PAK2 kinase, that optionally also inhibit PAK1 kinase. Such methods may be employed in combination with other anti-cancer agents such as EGFR or IGF-1R kinase inhibitors. | 11-19-2009 |
Jonathan A. Pachter, Wayland, MA US
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20120189641 | COMBINATION ANTI-CANCER THERAPY - The present invention provides a method for treating tumors or tumor metastases in a patient, comprising administering to said patient simultaneously or sequentially a therapeutically effective amount of a combination of either an anti-IGF-1R antibody or an IGF binding protein (e.g. IGFBP3), and a small molecule IGF-1R kinase inhibitor (e.g. OSI-906). The present invention also provides a pharmaceutical composition comprising either an anti-IGF-1R antibody or an IGF binding protein (e.g. IGFBP3), and a small molecule IGF-1R kinase inhibitor (e.g. OSI-906), with a pharmaceutically acceptable carrier. | 07-26-2012 |
Jonathan A. Pachter, Cambridge, MA US
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20150030615 | BIOMARKERS FOR CANCER STEM CELLS AND RELATED METHODS OF USE - Novel methods of classifying subjects as candidates for treatment with a cancer associated mesenchymal cell, tumor initiating cancer cell, or cancer stem cell inhibitor treatment and subsequent administration of the cancer associated mesenchymal cell, tumor initiating cancer cell, or cancer stem cell inhibitor are disclosed within. | 01-29-2015 |
20150071947 | METHODS OF IDENTIFYING GENE ISOFORMS FOR ANTI-CANCER TREATMENTS - Novel methods of classifying subjects as candidates for treatment with agent that inhibits or kills cancer associated mesenchymal cells, tumor initiating cancer cells, or cancer stem cells treatment and subsequent administration of the agent that inhibits or kills cancer associated mesenchymal cells, tumor initiating cancer cells, or cancer stem cells are disclosed within. | 03-12-2015 |
Nir Pachter, Moshav Gealia IL
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20100070317 | ARCHITECTURAL DESIGN FOR SELL FROM STOCK APPLICATION SOFTWARE - Methods, systems, and apparatus, including computer program products, for implementing a software architecture design for a software application implementing sell from stock software useful to process quotations, capture orders, process delivery and invoice. The application is structured as multiple process components interacting with each other through service interfaces, and multiple service operations, each being implemented for a respective process component. The process components include an Accounting process component; a Financial Accounting Master Data Management process component; an Outbound Delivery Processing process component; a Site Logistics Processing process component; an Inventory Processing process component; a Customer Requirement Processing process component; a Supply and Demand Matching process component; a Logistics Execution Control process component; a Due Item Processing process component; a Balance of Foreign Payment Management process component; a Payment Processing process component; a Customer Invoice Processing process component; a Customer Quote Processing process component; and a Sales Order Processing process component. | 03-18-2010 |
20100070318 | PROVIDING LOGISTICS EXECUTION APPLICATION AS ENTERPRISE SERVICES - Methods and apparatus, including systems and computer program products, for a service architecture design that provides enterprise services having logistics execution functionality at the level of an enterprise application. The design includes a set of service operations, process components, and optionally deployment units. Suitable business objects are also described. | 03-18-2010 |
20100070331 | ARCHITECTURAL DESIGN FOR SERVICE REQUEST AND ORDER MANAGEMENT APPLICATION SOFTWARE - Methods, systems, and apparatus, including computer program products, for implementing a software architecture design for a software application implementing service request and order management. The application is structured as multiple process components interacting with each other through service interfaces, and multiple service operations, each being implemented for a respective process component. The process components include an Outbound Delivery process component, a Site Logistics Processing process component, an Inventory Processing process component, a Customer Requirement Processing process component, a Supply and Demand Matching process component, a Logistics Execution Control process component, a Service Request Processing process component, a Service Order Processing process component, and a Service Confirmation Processing process component. | 03-18-2010 |