Ottinger
Daniele Ottinger, Charlottesville, VA US
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20140238413 | NEONATAL THERMAL DEVICE AND RELATED METHOD THEREOF - The neonatal drape device provides protection for a neonatal subject by providing a barrier to the environment that protects the subject from the loss of heat, water and moisture. The neonatal drape device functions as protection primarily by providing a barrier to the environment from the neonatal subject. The neonatal drape device for wrapping a neonatal subject provides the ability of the neonatal drape device to be repeatably self-adhesive and repeatably wrap around medical devices, tools, instruments, implements, parts of anatomy, or any other object protruding from the inside of the neonatal drape device to the outside of the neonatal drape device. The pliable nature of the material allows it to conform to the protruding object or a portion of anatomy, providing protection to the neonatal subject while also allowing repeatable access to the neonatal subject by the protruding object, or the uncovering of select portions of anatomy. | 08-28-2014 |
Elizabeth A. Ottinger, Harleysville, PA US
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20110014226 | HIGH THROUGHPUT PROTEIN INTERACTION ASSAY - A method to identify small molecules useful as therapeutics and/or vaccines to prevent, alleviate or ameliorate a pathogenic infection or an autoimmune disorder. The method can be used to screen small molecule test compounds for the ability to disrupt particular antigen-antibody interactions of interest. In one embodiment, the antigen is a pathogen-derived antigen and the antibody decreases or inhibits virulence of the pathogen when bound to the antigen (e.g., a neutralizing antibody, antibody with serum bactericidal activity, etc.). In another embodiment, the antigen is a self-antigen (autoantigen) and the antibody is an autoantibody that is known to be associated with a pathological condition (e.g., autoimmune disorder). Compounds that bind to the antigen or antibody disrupt binding can be used as therapeutics to decrease or inhibit the autoimmune disorder. | 01-20-2011 |
Elizabeth A. Ottinger, Potomac, MD US
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20150071954 | STABLE PEPTIDE MIMETICS OF THE HIV-1 GP41 PRE-HAIRPIN INTERMEDIATE - The present invention relates to a gp41 trivalent peptide mimetic having three gp41 N-peptides on a chemical scaffold which conformationally constrains the N-peptides into a trimeric coiled-coil to mimic gp41 presentation. The present invention also relates to N-peptides having the entire HIV gp41 NH2-terminal heptad repeat region and which are capable of forming gp41 peptide mimetics. Such peptide mimetics of HIV-1 gp41 pre-hairpin intermediates can be utilized in a vaccine for the treatment or prevention of HIV-1 infection through eliciting neutralizing antibodies. | 03-12-2015 |
Greg Ottinger, Noblesville, IN US
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20150088235 | DEVICE AND METHOD FOR WARMING AND STERILIZING SKIN FOR VEIN ACCESS - A device and method are disclosed for improving vein access. An exemplary device includes a porous substrate saturated with a disinfectant. The device may maintain a temperature sufficient to cause vasodilation for an extended period of time after removal from a heat source. | 03-26-2015 |
Isabel Ottinger, Basel CH
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20100015225 | SOLID DISPERSION OF A NEUROKININ ANTAGONIST - Solid dispersion comprising (4R)-4-[N′-methyl-N′-(3,5-bistrifluoromethyl-benzoyl)-amino]-4-(3,4-dichlorobenzyl)-but-2-enoic acid N—[(R)-epsilon-caprolactam-3-yl]-amide or a pharmaceutically acceptable salt or solvate thereof and a carrier. Pharmaceutical compositions comprising such solid dispersion are useful to treat patients who have functional motility disorders of the viscera, especially irritable bowel syndrome or functional dyspepsia, or urinary bladder disorders, especially urinary incontinence. | 01-21-2010 |
Jill A. Ottinger, Roslyn, PA US
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20100037399 | Aldehyde reduction in aqueous coating and leather finishing compositions - The present invention provides methods for reducing the level of free aldehydes in coatings for flexible substrates, such as tanned leather, and substantially aldehyde free substrates. The methods comprise applying to the substrate a composition of one or more aqueous emulsion or suspension composition of an acrylic polymer or silicon containing polymer that is made from, or contains one or more lower alkyl alcohol or degrades on storage or in use to form such an alcohol, and one or more water-insoluble to slightly water soluble aldehyde scavenger compound, followed by drying or curing the applied composition to form a coating. In addition, the methods provide enhanced aldehyde scrubbing, especially for acetaldehyde, by applying to a substrate an aqueous acrylic polymer or silicon containing polymer emulsion or suspension comprising a aldehyde scavenger compound that is substantially deprotonated, i.e. by raising the pH composition to 5.5 or higher. The present invention also provides treated and coated substrates made by the inventive methods. | 02-18-2010 |
20100068541 | Aldehyde scrubbing in crust leather and tanned leather - The present invention provides aqueous flesh coating compositions comprising one or more aqueous acid-functional acrylic or vinyl copolymer and from 0.03 and up to 1.0 equivalent, based on equivalents of carboxylic acid in the polymer, of one or more active compound chosen from an aminoguanidine, semicarbazide, dihydrazide, guanamine, hydrazine and a salt thereof. Further, the invention provides methods of applying the coating composition to leather crust or to tanned leather, and to the flesh coated leather or coated leather crust produced thereby. The leather crust and tanned leather produced by the invention, for example fleshcoated or finished leather, will emit greatly reduced levels of aldehydes over time and especially valuable in scrubbing aldehydes from perforated leather for automotive use. | 03-18-2010 |
Nathan Ottinger, Madison, WI US
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20140065041 | EMISSIONS AFTERTREATMENT COMPONENT RECOVERY SYSTEM AND METHOD - Methods and systems include an operation to interpret a face-plugging index and/or a reduction in an expected oxidation efficiency of an oxidation catalyst disposed in an internal combustion engine aftertreatment system, and in response to the face-plugging index or the reduction oxidation efficiency reaching a threshold value, an operation to provide a catalyst element reversal command. | 03-06-2014 |