Orford
Keith W. Orford, Philadelphia, PA US
Patent application number | Description | Published |
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20160106835 | COMBINATION THERAPIES FOR CANCER - A novel combination comprising a B-Raf inhibitor, particularly N-{3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide or a pharmaceutically acceptable salt thereof, the MEK inhibitor N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodo-phenylamino)6,8-dimethyl; -2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide, or a pharmaceutically acceptable salt or solvate thereof, and a PD-1 antagonist; pharmaceutical compositions comprising the same and methods of using such combinations and compositions in the treatment of conditions in which the inhibition of MEK and/or B-Raf and/or immune modulation through PD-1 is beneficial, e.g., cancer. | 04-21-2016 |
Michael P. Orford, Bristol GB
Patent application number | Description | Published |
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20150240650 | ROTOR FOR A TURBO-MACHINE AND A RELATED METHOD - A rotor for a turbo-machine, the rotor having a rotational axis and circumferentially spaced-apart radially extending blades of aerofoil configuration, each blade having a suction side, an oppositely directed pressure side, and a pair of oppositely directed snubbers each of which extends from a respective side towards a circumferentially adjacent blade and presents an abutment surface for abutment with the abutment surface of a respective adjacent snubber extending from the adjacent blade. Each snubber is configured such that its abutment surface makes an acute snubber angle to the axis of rotation. At least one pair of adjacent snubbers are configured such that their abutment surfaces are at an equal first snubber angle, with all of the other snubbers being configured such that their abutment surfaces are at equal second snubber angles. The first snubber angle is larger than the second snubber angle. | 08-27-2015 |
Robert Baker Orford, Bury St. Edmunds GB
Patent application number | Description | Published |
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20100107955 | MOORING AID - This invention relates to a mooring aid for use at marine installations, such as jetties and the like, wherein the mooring aid comprises a support ( | 05-06-2010 |