Patent application number | Description | Published |
20100048463 | TEMPLATE-FIXED PEPTIDOMIMETICS - The template-fixed B-hairpin peptidomimetics Cyclo(-Tyr-His-X-Cys-Ser-Ala- | 02-25-2010 |
20100093644 | TEMPLATE-FIXED PEPTIDOMIMETICS - Template-fixed β-hairpin peptidomimetics of the general formula (I) wherein Z is a template-fixed chain of 4 α-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid) are Gly, or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have the property to agonize or to antagonize GPCR receptors such as CXCR3, urotensin and CCR10. They can be used as medicaments to treat or prevent diseases such as cardiovascular disorders, dermatological disorders, endocrine system and hormone disorders, metabolic diseases, inflammatory diseases, neurological diseases, respiratory diseases, haematological diseases and cancer. These β-hairpin peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy. | 04-15-2010 |
20100240592 | TEMPLATE-FIXED PEPTIDOMIMETICS WITH ANTIMICROBIAL ACTIVITY - Template-fixed β-hairpin peptidomimetics of the general formula (I) wherein Z is a template-fixed chain of 12 α-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid) are Gly, or Pro, or of certain types which, as the remaining Symbols in the above formula, are defined in the description and the claims, and salts thereof, have the property to selectively inhibit the growth of or to kill microorganisms such as | 09-23-2010 |
20130150299 | TEMPLATE-FIXED PEPTIDOMIMETICS - The template-fixed β-hairpin peptidomimetics Cyclo(-Tyr-His-X-Cys-Ser-Ala- | 06-13-2013 |
20140087994 | TEMPLATE-FIXED PEPTIDOMIMETICS WITH ANTIMICROBIAL ACTIVITY - Template-fixed β-hairpin peptidomimetics of the general formula | 03-27-2014 |
20140107031 | TEMPLATE-FIXED PEPTIDOMIMETICS - Template-fixed β-hairpin peptidomimetics of the general formula | 04-17-2014 |
20140187471 | TEMPLATE-FIXED PEPTIDOMIMETICS WITH ANTIMICROBIAL ACTIVITY - Template-fixed β-hairpin peptidomimetics of the general formula | 07-03-2014 |
20140187472 | TEMPLATE-FIXED PEPTIDOMIMETICS WITH ANTIMICROBIAL ACTIVITY - Template-fixed β-hairpin peptidomimetics of the general formula | 07-03-2014 |
20150080317 | TEMPLATE-FIXED PEPTIDOMIMETICS - The template-fixed B-hairpin peptidomimetics Cyclo(-Tyr-His-X-Cys-Ser-Ala- | 03-19-2015 |
Patent application number | Description | Published |
20090054345 | Template-Fixed Beta-Hairpin Peptidomimetics With Protease Inhibitory Activity - Templates-fixed β-hairpin peptidomimetics of the general formulae (I), wherein Z is a chain of 11α-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid) are Gly, or Pro, or Pro(4NHCOPhe), or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have the property to inhibit proteases, in particular serine proteases, especially Cathepsin G or Elastase or Tryptase. These β-hairpin peptidomimetics can be manufactured by processes which are based on a mixed solid- and solution phase synthetic strategy. | 02-26-2009 |
20100056432 | TEMPLATE-FIXED PEPTIDOMIMETICS WITH ANTIBACTERIAL ACTIVITY - Template-fixed β-hairpin peptidomimetics of the general formula (I) wherein Z is a template-fixed chain of | 03-04-2010 |
20110135576 | DYE CONJUGATES OF TEMPLATE-FIXED PEPTIDOMIMETICS - Dye conjugates of template-fixed β-hairpin peptidomimetics of the general formula (I) wherein Z is a template-fixed chain of 14 α-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid), are Gly, or Pro or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have CXCR4 antagonizing properties, and are useful for cancer therapy; diagnostic imaging; for detection of tumors and other abnormalities; for photoacoustic tumor imaging, detection and therapy; and for sonofluorescence tumor imaging, detection and therapy. The various dyes forming part of these conjugates are useful over the range of 300-1200 nm, the exact range being dependent upon the particular dye. These dye conjugates of β-hairpin peptidomimetic can be manufactured by processes which are based on a mixed solid- and solution phase synthetic strategy. | 06-09-2011 |
20110230426 | TEMPLATE-FIXED PEPTIDOMIMETICS - Template-fixed β-hairpin peptidomimetics of the general formula | 09-22-2011 |
20110245155 | TEMPLATE-FIXED BETA-HAIRPIN PEPTIDOMIMETICS WITH CXCR4 ANTAGONIZING ACTIVITY - Template-fixed β-hairpin peptidomimetics of the general formula (I) | 10-06-2011 |
20110312879 | TEMPLATE-FIXED BETA-HAIRPIN PEPTIDOMIMETICS WITH CXCR4 ANTAGONIZING ACTIVITY - Template-fixed peptidomimetics formula (Ia) formula (Ib) wherein Z is a template-fixed chain of 14 α-amino and/or α-hydroxy acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid), are Pro, Gly, a glycolic acid residue or of certain types which, as the remaining symbols in the above formulae, are defined in the description and the claims, and salts thereof, have CXCR4 antagonizing properties and can be used for preventing HIV infections in non-infected individuals or for slowing and halting viral progression in infected patients; or where cancer is mediated or resulting from CXCR4 receptor activity; or where immunological diseases are mediated or resulting from CXCR4 receptor activity; or for treating immuno suppression; or during apheresis collections of peripheral blood stem cells and/or as agents to induce mobilization of stem cells to regulate tissue repair. These depsipeptides can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy. | 12-22-2011 |
20120135942 | BETA-HAIRPIN PEPTIDOMIMETICS - β-Hairpin peptidomimetics of the general formula Cyclo(-Xaa | 05-31-2012 |
20120202821 | CONFORMATIONALLY CONSTRAINED, FULLY SYNTHETIC MACROCYCLIC COMPOUNDS - Conformationally restricted, spatially defined 12-30 membered macrocyclic ring systems of type (I) are constituted by three distinct building blocks: an aromatic template a, a conformation modulator b and a spacer moiety c as detailed in the description and the claims. Macrocycles of type (I) are readily manufactured by parallel synthesis or combinatorial chemistry. They are designed to interact with specific biological targets. In particular, they show agonistic or antagonistic activity on the motilin receptor (MR receptor), on the serotonin receptor of subtype 5-HT | 08-09-2012 |
20120270881 | CONFORMATIONALLY CONSTRAINED, FULLY SYNTHETIC MACROCYCLIC COMPOUNDS - Conformationally restricted, spatially defined 12-30 membered macrocyclic ring systems of formulae Ia and Ib are constituted by three distinct molecular parts: Template A, conformation Modulator B and Bridge C. These macrocycles Ia and Ib are readily manufactured by parallel synthesis or combinatorial chemistry in solution or on solid phase. They are designed to interact with a variety of specific biological target classes, examples being the agonistic or antagonistic activity on G-protein coupled receptors (GPCRs), ion channels and signal transduction pathways. In particular, these macrocycles act as antagonists of the motilin receptor, the FP receptor and the purinergic receptors P2Y | 10-25-2012 |
20120283168 | TEMPLATE-FIXED PEPTIDOMIMETICS WITH CCR10 ANTAGONISTIC ACTIVITY - Novel template-fixed β-hairpin peptidomimetics of the general formula (I) wherein the single elements T or P are α-amino acid residues connected in either direction which, depending on their positions in the chain, are as defined in the description and the claims, and salts thereof, have the property to antagonize the receptor CCR10. They can be used as medicaments to treat or prevent diseases or conditions in the area of dermatological and cutaneous disorders, inflammation, allergic disorders, respiratory diseases, diseases of the gastro-intestinal tract, ophthalmic diseases, haematology and cancer. These β-hairpin peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy. | 11-08-2012 |
20120283196 | BETA-HAIRPIN PEPTIDOMIMETICS - β-Hairpin peptidomimetics of the general formula Cyclo(-Xaa | 11-08-2012 |
20130023483 | TEMPLATE-FIXED PEPTIDOMIMETICS WITH CXCR7 MODULATING ACTIVITY - Specific template-fixed β-hairpin peptidomimetics of the general formula (I) wherein the single elements T or P are α-amino acid residues connected from the carbonyl (C═O) point of attachment to the nitrogen (N) of the next element in clockwise direction and wherein said elements, depending on their positions in the chain, are defined in the description and the claims have the property to act on the receptor CXCR7. Thus, these β-hairpin peptidomimetics can be useful in the treatment or prevention of diseases or conditions in the area of dermatological disorders, metabolic diseases, inflammatory diseases, fibrotic diseases, infectious diseases, neurological diseases, cardiovascular diseases, respiratory diseases, gastro-intestinal tract disorders, urological diseases, ophthalmic diseases, stomatological diseases, haematological diseases and cancer; or the mobilisation of stem cells. | 01-24-2013 |
20130189363 | BETA-HAIRPIN PEPTIDOMIMETICS - β-Hairpin peptidomimetics of the general formula Cyclo (-Xaa | 07-25-2013 |
20130225506 | TEMPLATE-FIXED PEPTIDOMIMETICS WITH CXCR7 MODULATING ACTIVITY - Novel template-fixed β-hairpin peptidomimetics of the general formula (I), wherein the single elements T or P are α-amino acid residues connected from the carbonyl (C═O) point of attachment to the nitrogen (N) of the next element in clockwise direction and wherein said elements, depending on their positions in the chain, are defined in the description and the claims have the property to act on the receptor CXCR7. Thus, these β-hairpin peptidomimetics can be useful in the treatment or prevention of diseases or conditions in the area of dermatological disorders, metabolic diseases, inflammatory diseases, fibrotic diseases, infectious diseases, neurological diseases, cardiovascular diseases, respiratory diseases, gastro-intestinal tract disorders, urological diseases, ophthalmic diseases, stomatological diseases, haematological diseases and cancer; or the mobilisation of stem cells. | 08-29-2013 |
20140213509 | BETA-HAIRPIN PEPTIDOMIMETICS AS CXC4 ANTAGONISTS - β-Hairpin peptidomimetics of the general formula cyclo(-Tyr | 07-31-2014 |
20140213531 | TEMPLATE-FIXED BETA-HAIRPIN PEPTIDOMIMETICS WITH PROTEASE INHIBITORY ACTIVITIY - Template-fixed β-hairpin peptidomimetics of the general formulae | 07-31-2014 |
20140350012 | PIPERIDINE/PIPERAZINE DERIVATIVES - The invention further relates to a DGAT inhibitor of formula | 11-27-2014 |
20140364583 | BETA-HAIRPIN PEPTIDOMIMETICS HAVING CXCR4 ANTAGONIZING ACTIVITY - β-Hairpin peptidomimetics of the general formula Cyclo(—Xaa | 12-11-2014 |
20150051183 | CONFORMATIONALLY CONSTRAINED, FULLY SYNTHETIC MACROCYCLIC COMPOUNDS - The conformationally restricted, spatially defined macrocyclic ring system of formula (I) is constituted by three distinct molecular parts: Template A, conformation Modulator B and Bridge C. Macrocycles described by this ring system I are readily manufactured by parallel synthesis or combinatorial chemistry in solution or on solid phase. They are designed to interact with a variety of specific biological target classes, examples being agonistic or antagonistic activity on G-protein coupled receptors (GPCRs), inhibitory activity on enzymes or antimicrobial activity. In particular, these macrocycles show inhibitory activity on endothelin converting enzyme of subtype 1 (ECE-1) and/or the cysteine protease cathepsin S (CatS), and/or act as antagonists of the oxytocin (OT) receptor, thyrotropin-releasing hormone (TRH) receptor and/or leukotriene B4 (LTB4) receptor, and/or as agonists of the bombesin 3 (BB3) receptor, and/or show antimicrobial activity against at least one bacterial strain. Thus they are showing great potential as medicaments for a variety of diseases. | 02-19-2015 |
20150087577 | TEMPLATE-FIXED BETA-HAIRPIN PEPTIDOMIMETICS WITH CXCR4 ANTAGONIZING ACTIVITY - Template-fixed β-hairpin peptidomimetics of the general formula (I) | 03-26-2015 |
20150218219 | BETA-HAIRPIN PEPTIDOMIMETICS - β-Hairpin peptidomimetics of the general formula cyclo(-Tyr | 08-06-2015 |
20150224168 | COMBINATIONS WITH A BACKBONE-CYCLIZED PEPTIDE - A novel combination comprising a β-hairpin peptidomimetic of the formula cyclo(-Thr-Trp-Ile-Dab-Orn- | 08-13-2015 |
20150266924 | BETA-HAIRPIN PEPTIDOMIMETICS AS CXC4 ANTAGONISTS - β-Hairpin peptidomimetics of the general formula cyclo(-Tyr | 09-24-2015 |
20150307556 | TEMPLATE-FIXED PEPTIDOMIMETICS WITH CXCR7 MODULATING ACTIVITY - Novel template-fixed β-hairpin peptidomimetics of the general formula (I) | 10-29-2015 |
20150322088 | PIPERIDINE/PIPERAZINE DERIVATIVES - The invention further relates to a DGAT inhibitor of formula | 11-12-2015 |
Patent application number | Description | Published |
20090324325 | DEVICE FOR LOCKING A VEHICLE SEAT - A device for locking a vehicle seat has a pawl which can be pivoted about a first pivot axis and, in a closed position, is in engagement with a positionally fixed fitting and, in an open position, is free from the fitting, wherein the pawl has a first clamping surface, furthermore a locking element for locking the pawl in the closed position, which locking element can be pivoted about a second pivot axis and has a second clamping surface which, in a locking position, bears against the first clamping surface and, in the process, keeps the pawl in the closed position, and, in an unlocking position, is free from the first clamping surface, and an actuating element which interacts with the locking element in order to transfer the locking element into the unlocking position. A stop is provided for the actuating element in such a manner that, upon action of a torque exerted by the pawl on the locking element, the actuating element interacts in a blocking manner with the stop and blocks the further movement of the locking element before the latter reaches the unlocking position. In the region of the second clamping surface, the locking element has a material which is softer than a material which the pawl has in the region of the first clamping surface, and the pawl has a projection on which the first clamping surface is at least partially formed. | 12-31-2009 |
20100206676 | SHOCK ABSORBER HOUSING - A shock absorber housing for a shock absorber of a vehicle comprises a tube, which has a tubular wall, and an attaching element joined onto the tubular wall, the attaching element determining a critical force introduction area of an introduction of a force into the tubular wall, the tube in a longitudinal direction being built up from a first tube section having a first tubular wall and at least a second tube section having a second tubular wall, the first tube section and the second tube section being joined together by their ends facing one another. The first tube section and the second tube section are joined together with a tubular wall overlap of the first and second tubular wall, which overlap extends in a longitudinal direction, the tubular wall overlap being situated in the critical force introduction area of the attaching element. | 08-19-2010 |
20100270455 | Device for Locking a Vehicle Seat - A device for locking a vehicle seat comprises a locking pawl which may be pivoted about a first pivot axis, and which is in engagement with a fitting part in a closed position and is released from the fitting part in an open position, and a locking element which may be pivoted about a second pivot axis, the locking element, in a first pivoted position being in contact with the locking pawl and clamping said locking pawl into the closed position, and in a second pivoted position releasing the locking pawl, so that the locking pawl may adopt its open position. The locking element is additionally movable in a translatory manner, and a clamping element is associated with the locking element, which moves the locking element in the first pivoted position thereof in a translatory manner increasingly against the locking pawl until the locking pawl is clamped into the closed position. | 10-28-2010 |
20110210528 | STABILIZING STRUT FOR A CHASSIS OF A VEHICLE - A stabilizing strut for a chassis of a vehicle has an elongated strut body made of sheet metal which has at least one first eye at a first longitudinal end and at least one second eye at a second longitudinal end. The strut body has a curvature at least such that the strut body lies completely outside an imaginary connecting straight line between the at least one first and the at least one second eye at least in a partial region. The strut body is built up from two individual sheet metal parts which are arranged one on each side of a longitudinal centre plane. The two sheet metal parts are joined to one another between the at least one first eye and the at least one second eye at their peripheral edges on a longitudinal side of the sheet metal parts oriented towards the imaginary connecting straight line, at least over a partial length of this longitudinal side of the strut body which amounts to at least 50% of the total length of this longitudinal side of the strut body. The surfaces oriented towards one another of the two sheet metal parts are spaced from one another. The peripheral edges of the sheet metal parts on the longitudinal side oriented away from the imaginary connecting straight line are not joined to one another, or at most are joined over a partial length of this longitudinal side of the strut body which amounts to not more than 50% of the total length of this longitudinal side. | 09-01-2011 |
Patent application number | Description | Published |
20080298951 | AIR REINJECTION COMPRESSOR - Reinjecting air to the inlet of a compressor in order to improve its pumping margin. The inlet stator of the compressor includes injection holes passing through at least some of the vanes in the vicinity of their pivots. | 12-04-2008 |
20120201692 | ROTOR OF A TURBOMACHINE COMPRESSOR, WITH AN OPTIMISED INNER END WALL - A rotor of a turbomachine compressor, including a bladed rotor disk fitted at its radially external end with a wall forming the inner end of an annual flow channel of a primary gas flow, and formed from multiple angular sectors, each of which is delimited between two blades of the disk which are consecutive in a circumferential direction and includes a bulging portion which is convex in the axial direction and in the circumferential direction, together with, upstream from the bulging portion, a troughed portion which is concave in the axial direction and in the circumferential direction and which has a base which is roughly punctiform. | 08-09-2012 |
20150078889 | COMPRESSOR CASING COMPRISING CAVITIES HAVING AN OPTIMISED UPSTREAM SHAPE - A casing for a turbine engine compressor, including: cavities in a thickness of the casing, extending in parallel to one another from an inner face of the casing along a circumference thereof, the cavities not being in communication with one another. The cavities, which are elongate and extend along a main direction of orientation between two side walls, are closed upstream and downstream by upstream and downstream faces respectively, and an upstream border and a downstream border are formed at the intersections between same and the inner face of the casing. The upstream border of the cavities takes a form of a wavy line including at least two alternate undulations over a length thereof between the side walls. | 03-19-2015 |
20150078890 | COMPRESSOR CASING COMPRISING CAVITIES WITH OPTIMISED SETTING - A compressor for a turbine engine, including: a casing, at least one compressor stage including an impeller having stationary blades and an impeller having moving blades positioned downstream of the stationary blade impeller, and cavities in a thickness of the casing that are disposed along a circumference of the casing opposite the moving blades. The cavities, which are elongate and extend along a main direction of orientation, are closed upstream and downstream by upstream and downstream faces respectively, and an upstream border and a downstream border are formed at the intersections between same and the casing. The cavities are offset in relation to the moving blades to overlap the moving blade impeller in the upstream portion, thereby covering the upstream end thereof. The downstream border of the cavities is oriented parallel to the chord at the head of the moving blade. | 03-19-2015 |