O'Boyle, US
Brendan O'Boyle, Milpitas, CA US
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20150239866 | TRIAZOLYL DERIVATIVES AS SYK INHIBITORS - Provided are triazole derivatives of Formula I which are potent inhibitors of spleen tyrosine kinase and pharmaceutical composition. The triazole derivatives are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis, and cancer. | 08-27-2015 |
Brendan O'Boyle, Boston, MA US
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20150266895 | NOVEL COMPOUNDS THAT ARE ERK INHIBITORS - Disclosed are the ERK inhibitors of formula (1): and the pharmaceutically acceptable salts thereof. Also disclosed are methods of treating cancer using the compounds of formula (1). | 09-24-2015 |
20150353535 | THIAZOLE-SUBSTITUTED AMINOPYRIDINES AS SPLEEN TYROSINE KINASE INHIBITORS - The invention provides certain thiazole-substituted aminopyridine compounds of the Formula (I) (I) or pharmaceutically acceptable salts thereof, wherein R | 12-10-2015 |
Brendan O'Boyle US
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20150258074 | NOVEL COMPOUNDS THAT ARE ERK INHIBITORS - Disclosed are the ERK inhibitors of formula (1.0), having a pyrazolopyridine base structure, and the pharmaceutically acceptable salts thereof. Also disclosed are methods of treating cancer using the compounds of formula (1.0). | 09-17-2015 |
Brendan O'Boyle, Pittsburgh, PA US
Patent application number | Description | Published |
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20140296203 | NOVEL COMPOUNDS THAT ARE ERK INHIBITORS - Disclosed are the ERK inhibitors of formula (1): and the pharmaceutically acceptable salts thereof. Also disclosed are methods of treating cancer using the compounds of formula (1). | 10-02-2014 |
20150258074 | NOVEL COMPOUNDS THAT ARE ERK INHIBITORS - Disclosed are the ERK inhibitors of formula (1.0), having a pyrazolopyridine base structure, and the pharmaceutically acceptable salts thereof. Also disclosed are methods of treating cancer using the compounds of formula (1.0). | 09-17-2015 |
20150266895 | NOVEL COMPOUNDS THAT ARE ERK INHIBITORS - Disclosed are the ERK inhibitors of formula (1): and the pharmaceutically acceptable salts thereof. Also disclosed are methods of treating cancer using the compounds of formula (1). | 09-24-2015 |
Brendan M. O'Boyle, Boston, MA US
Patent application number | Description | Published |
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20110245205 | AMINOPYRIMIDINES AS SYK INHIBITORS - The present invention provides novel pyrimidine amines of formula (I) which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis. | 10-06-2011 |
20120277192 | AMINOPYRIMIDINES AS SYK INHIBITORS - The present invention provides novel pyrimidine amines of formula (I) which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis. | 11-01-2012 |
20130096084 | NOVEL HETEROCYCLIC COMPOUNDS AS ERK INHBITORS - The present invention provides a compound of the Formula I: (Formular I should be inserted here) or a pharmaceutically acceptable salt, solvate or ester thereof, wherein R, R1, R2 and R3 are as defined herein. The compounds are ERK inhibitors. Also disclosed are pharmaceutical compositions comprising the above compounds and methods of treating cancer using the same. | 04-18-2013 |
20140243290 | Aminopyrimidines as SYK Inhibitors - The present invention provides novel pyrimidine amines of formula (I) which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis. | 08-28-2014 |
Brian O'Boyle, Wellesley, MA US
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20150235310 | SYSTEM AND METHOD FOR GATHERING AND PRESENTING CREDIT INFORMATION AND LOAN INFORMATION FOR INDIVIDUALS AND SMALL BUSINESSES - Engines, systems and methods are disclosed for capturing inputs from an existing or prospective small business owner through an Internet-based graphical user interface, gathering small business and consumer credit data from external sources, combining with data sourced from a database of lender preferences specifying particular loan application characteristics and delivering an output of information, educational lessons, loan qualification offers, and a heuristic assessment of funding likelihood. | 08-20-2015 |
Brian O'Boyle, Sherwood, OR US
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20110249430 | ILLUMINATING SAFETY AND NOTIFICATION DEVICE - A safety device comprises a light source, a power source coupled to the light source, a controller coupled to the light source and the power source to control operation of the lighting device, and a connection port that transmits and receives power up and control signals. In some embodiments, the connection port transmits and receives a wired signal. In further embodiments, the connection port transmits and receives a wireless signal. In some embodiments, the connection port receives a signal from an external source. In some of these embodiments, the external source is a remote control. In further embodiments, the external source is a program located on a computing device. In still further embodiments, the external source is one or more additional connection port of one or more additional safety devices. In some embodiments, the signal is a signal to power the light source. | 10-13-2011 |
Erin O'Boyle, Redwood City, CA US
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20150359897 | METHOD OF TREATING PATIENTS NON-RESPONSIVE TO PALONOSETRON - A method for treating chemotherapy-induced nausea and vomiting in individuals undergoing chemotherapy and previously treated with, and whom failed to respond to, a 5-HT3 antagonist other than granisetron is described. Individuals who fail to respond to, for example, palonosetron, as evidenced by an inadequate prevention or attenuation of acute or delayed chemotherapy-induced nausea and vomiting, are treated with a semi-solid drug delivery vehicle that provides a sustained release of granisetron. | 12-17-2015 |
Gary O'Boyle, North Andover, MA US
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20110270173 | ARTICULATED CATHETER - Methods and apparatuses for manipulating an elongated flexible shaft of a catheter provide ease and reliability of positioning electrodes against or near tissue. Dual-bend flexible distal tips may be used in combination with flat wires. In some embodiments, flat wires which are free to rotate upon initial bending of shaft segments are employed. In some embodiments, one or more transition segments are used to relocate the satellite lumen-to-main lumen transition of pull wires away from a change in shaft stiffness. | 11-03-2011 |
Kevin J. O'Boyle, Alma, NY US
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20100251942 | REAGENT DRYING VIA EXCESS AIR PREHEAT - A reagent drying system for use with a steam generation system [ | 10-07-2010 |
20100282437 | HEAT TRANSFER SHEET FOR ROTARY REGENERATIVE HEAT EXCHANGER - A heat transfer sheet [ | 11-11-2010 |
20110061831 | SYSTEM AND METHOD FOR NON-CONTACT SENSING TO MINIMIZE LEAKAGE BETWEEN PROCESS STREAMS IN AN AIR PREHEATER - A rotary air preheater | 03-17-2011 |
20110073023 | EXHAUST PROCESSING AND HEAT RECOVERY SYSTEM - A thermally efficiency regenerative air preheater | 03-31-2011 |
Kevin James O'Boyle, Alma, NY US
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20140054003 | HEAT TRANSFER ASSEMBLY FOR ROTARY REGENERATIVE PREHEATER - Disclosed is a heat transfer assembly for a rotary regenerative preheater. The heat transfer assembly, includes, a plurality of heat transfer elements stacked in spaced relationship to each other in a manner such that each notch from a plurality of notches of one of the heat transfer element rests on respective flat sections from a plurality of flat sections of the adjacent heat transfer elements to configure a plurality of closed channels, each isolated from the other, wherein each of the channels has a configuration in a manner such that each of corrugation sections from a plurality of corrugation sections of one of the heat transfer elements faces respective undulation sections from a plurality of undulation sections of the adjacent heat transfer elements. | 02-27-2014 |
Lawrence Edward O'Boyle, Charlotte, NC US
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20100127489 | NOTEBOOK WITH HOLDER FORMED FROM COVER - A notebook includes a front cover, a back cover, an insert retaining panel, and an implement holder. The front and back covers each have first and second major sides and are movable relative to each other between open and closed positions. The panel cooperates with the back cover to form a pocket to receive an insert between the back cover and the panel. The implement holder is formed from a flap portion of the back cover into a sleeve for retaining an implement therein. The front cover and back cover are integrally formed and are foldable along at least one crease therebetween, and the panel is an integrally formed extension of the back cover. The flap defines a raised edge forming a stop against which an edge of an insert rests for proper positioning of the insert between the front and back covers. The notebook includes a spine integrally formed with the front cover and the back cover. | 05-27-2010 |
Lily O'Boyle, Cream Ridge, NJ US
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20090251749 | OVD CONTAINING DEVICE - A holographic overlay is provided, including: a polycarbonate substrate having a first side and a second side, a diffractive structure cast upon the first side of the polycarbonate substrate, and a reflection-enhancing coating on at least a part of the diffractive structure; wherein the second side of the polycarbonate substrate provides a substantially flat external surface of the overlay capable of fusing to a conforming surface in the presence of heat and pressure without an adhesive. Optionally, the overlay is laser-engraved so as to form ablated voids in the metal coating and carbonize the laser engravable polycarbonate under the ablated voids. According to another aspect of the invention, a metal coating on a hologram is made substantially transparent using a laser to form a transparent portion of a hologram. Optionally, it is done after applying the hologram to an object such as a card, a document, etc., in register with underlying information to ensure its visibility and continuity of the hologram. | 10-08-2009 |
20100206953 | DURABLE WASHABLE LABEL HAVING A VISIBLE DIFFRACTION GRATING PATTERN - This invention provides an improved and novel thin and pliable holographic fabric label that possesses durability, high intensity of holographic diffraction, laundering resistance, minimal alteration and degradation to the fabric and the label through extended use, and the ability to be cost-effectively mass produced is described. High bond is formed at multiple inter polymer interfaces and reflective diffractive layer is protected within the construction, superior durability to repetitious laundering, dry clean cycle and mechanical wear with long lasting diffracting effect and visual authentication property is realized. | 08-19-2010 |
20110181928 | DURABLE WASHABLE LABEL HAVING A VISIBLE DIFFRACTION GRATING PATTERN - This invention provides an improved and novel thin and pliable holographic fabric label that possesses durability, high intensity of holographic diffraction, laundering resistance, minimal alteration and degradation to the fabric and the label through extended use, and the ability to be cost-effectively mass produced is described. High bond is formed at multiple inter polymer interfaces and reflective diffractive layer is protected within the construction, superior durability to repetitious laundering, dry clean cycle and mechanical wear with long lasting diffracting effect and visual authentication property is realized. | 07-28-2011 |
20130034707 | MICROSTRUCTURED DEVICE AND METHOD OF FABRICATION - A security device has a support substrate of a first material having a softening temperature t1 and an embossed layer of a second different material supported by the support substrate having a softening temperature t2, wherein t202-07-2013 | |
20130082458 | OVD CONTAINING DEVICE - A holographic overlay is formed using casting a diffractive structure upon a first side of a polycarbonate substrate, and providing a reflection-enhancing coating on at least a part of the diffractive structure. A second side of the substrate provides a substantially flat external surface of the overlay capable of fusing to a conforming surface in the presence of heat and pressure without an adhesive. Optionally, the overlay is laser-engraved so as to form ablated voids in the metal coating and carbonize the laser engravable polycarbonate under the ablated voids. | 04-04-2013 |
20140103634 | STRUCTURED COLOR FILTER DEVICE - A structured color filtering device includes one or more unit cells. Each unit cell includes a substrate having a surface with a step function surface profile having two or more discrete levels formed therein. The step function surface profile forms in the surface a plurality of grooves arranged in a fundamentally symmetric pattern having a periodic groove pitch. When ordinary light is incident on the surface, the surface is structured to diffract light having a predetermined wavelength toward observation points at all polar angles above the surface greater than a predetermined incident angle. | 04-17-2014 |
Martin P. O'Boyle, Cortlandt Manor, NY US
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20080239539 | METHOD AND APPARATUS FOR THREE-DIMENSIONAL MEASUREMENTS - An apparatus and method for measuring the physical quantities of a data center during operation and method for servicing large-scale computing systems is disclosed. The apparatus includes a cart that supports a plurality of sensors. The cart is moveable within the data center. The sensors capture temperature or other physical parameters within the room. The sensor readings, along with position and orientation information pertaining to the cart are transmitted to a computer system where the data is analyzed to select the optimum temperature or other system environmental parameters for the data center. | 10-02-2008 |
20080281551 | METHOD AND APPARATUS FOR THREE-DIMENSIONAL MEASUREMENTS - An apparatus and method for measuring the physical quantities of a data center during operation and method for servicing large-scale computing systems is disclosed. The apparatus includes a cart that supports a plurality of sensors. The cart is moveable within the data center. The sensors capture temperature or other physical parameters within the room. The sensor readings, along with position and orientation information pertaining to the cart are transmitted to a computer system where the data is analyzed to select the optimum temperature or other system environmental parameters for the data center. | 11-13-2008 |
20120270385 | SWITCHING DEVICE HAVING A MOLYBDENUM OXYNITRIDE METAL GATE - A field effect transistor (FET) includes a body region and a source region disposed at least partially in the body region. The FET also includes a drain region disposed at least partially in the body region and a molybdenum oxynitride (MoNO) gate. The FET also includes a dielectric having a high dielectric constant (k) disposed between the body region and the MoNO gate. | 10-25-2012 |
Martin P. O'Boyle, Creamridge, NJ US
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20110042759 | SWITCHING DEVICE HAVING A MOLYBDENUM OXYNITRIDE METAL GATE - A field effect transistor (FET) includes a body region and a source region disposed at least partially in the body region. The FET also includes a drain region disposed at least partially in the body region and a molybdenum oxynitride (MoNO) gate. The FET also includes a dielectric having a high dielectric constant (k) disposed between the body region and the MoNO gate. | 02-24-2011 |
Martin Patrick O'Boyle, Cream Ridge, NJ US
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20080288193 | Techniques for Analyzing Data Center Energy Utilization Practices - Techniques for improving on data center best practices are provided. In one aspect, an exemplary methodology for analyzing energy efficiency of a data center having a raised-floor cooling system with at least one air conditioning unit is provided. The method comprises the following steps. An initial assessment is made of the energy efficiency of the data center based on one or more power consumption parameters of the data center. Physical parameter data obtained from one or more positions in the data center are compiled into one or more metrics, if the initial assessment indicates that the data center is energy inefficient. Recommendations are made to increase the energy efficiency of the data center based on one or more of the metrics. | 11-20-2008 |
Michael O'Boyle, Pitman, NJ US
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20140089187 | BANKING SYSTEM OPERATED RESPONSIVE TO DATA BEARING RECORDS - A system includes a plurality of machines that operate responsive to data bearing records such as user cards ( | 03-27-2014 |
Michael O'Boyle, Dartmouth, MA US
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20110193498 | THERMAL INSULATION DETECTOR - A thermal insulation detector for a recessed luminaire fixture comprises a luminaire frame, a junction box connected to the frame, a mechanical switch connected to one of said frame and the junction box, the mechanical switch in electrical communication with an electrical circuit, the electrical circuit including a lamp socket, at least a portion of the circuit passing through the junction box the electrical circuit receiving multiple input voltages, an actuation device extending from the mechanical switch, the actuation device being movable responsive to thermal insulation disposed about the luminaire fixture, the actuation device having a first position and a second position deflectable from the first position, the actuation device being deflectable by the insulation to the second position and actuating a switch which opens the electrical circuit inhibiting operation of the luminaire fixture. | 08-11-2011 |
Michael Edmund O'Boyle, Howell, MI US
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20090192677 | Vehicle communication system and method - A vehicle communication system and communication steering wheel is provided. The communication steering wheel includes a display, a wireless transceiver configured to operably connect to a wireless device, a sensor, configured to obtain directional steering information and a controller, configured to receive input from the wireless transceiver and the sensor and output a signal to the display based on the received input. | 07-30-2009 |
Michael S. O'Boyle, South Dartmouth, MA US
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20080252234 | TRACK LIGHTING SYSTEM CURRENT LIMITING DEVICE - A current limiting system in accordance with the present invention comprises an accessory or canopy mount device that is permanently installed between a source of electrical power | 10-16-2008 |
20110080750 | T-BAR MOUNTING SYSTEM - A T-bar mounting bracket assembly for a luminaire fixture frame having a bracket, a clip vertically adjustable relative to the bracket, the clip extending through an opening in the bracket, a fastener extending through the bracket and the clip and, the fastener spaced from a location where the clip passes through the opening. | 04-07-2011 |
Michael S. O'Boyle, S. Dartmouth, MA US
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20110133671 | TRACK LIGHTING SYSTEM CURRENT LIMITING DEVICE - A current limiting system in accordance with the present invention comprises an accessory or canopy mount device that is permanently installed between a source of electrical power | 06-09-2011 |
Ryan O'Boyle, Burlington, MA US
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20140359588 | SYSTEMS AND METHODS FOR REMOTE ANALYSIS OF SOFTWARE APPLICATIONS - A system for testing a software application receives one or more object spaces extracted from a development or runtime environment of the software application. The extracted object space includes information about various objects associated with the software application, its dependencies, and/or environment, and some of the objects may be dynamically created and/or modified. The extracted object space does not include any source code. A language dependent extraction component can extract the object space using introspections and/or reflection APIs. The extracted object can be translated into a language-independent format and can be analyzed to identify any vulnerabilities in the software application without access to the source code, compiled binary, and runtime environment of the software application. | 12-04-2014 |
Todd Aaron O'Boyle, Edwardsville, IL US
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20150207812 | SYSTEMS AND METHODS FOR IDENTIFYING AND PERFORMING AN ACTION IN RESPONSE TO IDENTIFIED MALICIOUS NETWORK TRAFFIC - Computer-implemented systems, methods, and computer-readable media are provided for causing an action to be performed in response to a network communication, such as a malicious network communication. In accordance with some embodiments, a first network communication sent from a client device is received, and a protocol used in the first network communication is determined. Once the protocol is determined, the protocol may be implemented to enable a second network communication with the client device. An action to be performed based at least in part on the protocol may be identified, and an instruction may be sent to the client device in the second network communication. | 07-23-2015 |