Patent application number | Description | Published |
20100136647 | METHOD FOR PRODUCTION OF CELL ATTACHMENT AND CULTURE SURFACES - The present invention relates to the field of adherent cell culture. More closely, the invention relates to a method for production of a cell attachment and culture surface, such as a microcarrier, comprising a guanidino-containing ligand, wherein the ligand is coupled via reaction involving a primary amine to the surface which is activated by activation groups such that the final molar ratio of grafted ligand and ungrafted activation groups is above 1.5. Preferably, the ligand density is above 0.5 mmol/g cell culture surface and the remaining activation groups after coupling is less than 0.6 mmol/g cell culture surface. The cell culture surface may be used for various purposes, primarily cell cultivation and virus production. | 06-03-2010 |
20110003941 | METHOD FOR PREPARATION OF A BIOMOLECULE ADSORBENT - The present invention is relates to method for production of a biomolecule adsorbent with a pentadentate ligand with very strong chelating properties, and to methods for use thereof for, for example, protein purification, detection or binding. The biomolecule adsorbent comprises the formula: | 01-06-2011 |
20130338339 | AFFINITY CHROMATOGRAPHY MATRIX - The present invention relates to a method of separating one or more immunoglobulin containing proteins from a liquid. The method includes first contacting the liquid with a separation matrix comprising ligands immobilised to a support; allowing the immunoglobulin containing proteins to adsorb to the matrix by interaction with the ligands; followed by an optional step of washing the matrix containing the immunoglobulin containing proteins adsorbed thereon; and recovering said immunoglobulin containing proteins by contacting the matrix with an eluent which releases the proteins. The method improves upon previous separation methods in that each of the ligands comprises one or more of a protein A domain (E, D, A, B, C), or protein Z, or a functional variant thereof, with at least one of the monomers having a substitution of the Asparagine or Histidine at the position corresponding to H18 of B domain of Protein A or Protein Z, and wherein the ligand provides an increase in elution pH compared to non-substituted ligand. | 12-19-2013 |
Patent application number | Description | Published |
20080267845 | Multipurpose Flow Module - The present invention relates to a multipurpose flow module comprising flow plates and/or heat exchanger plates stacked together, which flow plate having a flow channel and one or more connection ports. To each flow plate or heat exchanger plate one or more barrier plates may be attached. The present invention further relates to a method for extraction, for reaction, for mixing, or combinations thereof in the multipurpose flow module, and to uses of the multipurpose flow module. | 10-30-2008 |
20080314567 | Heat Exchanger Mixing Systen - The present invention relates to a heat exchanger mixing system comprising at least one heat exchanger zone, at least one connection plate having one or more mixing units, at least four corners per connection plate, wherein each corner being either blind passage corner, a through-passage corner, a single passage corner, or a double passage corner, and the one or more mixing units are provided with static mixing elements. Present invention relates further to use of a heat exchanger mixing system, and a process for mixing fluids. | 12-25-2008 |
20100012310 | SECTIONED FLOW DEVICE - The present invention relates to a sectioned heat exchanger plate, sectioned flow module or sectioned plate reactor, which comprises one or more heat exchanger sections and one or more regulating valves, which regulating valves are connected to the inlet of each heat exchanger section or are connected to the outlet of each heat exchanger section or are connected to the inlet and outlet of each heat exchanger section, each heat exchanger section being at an angle of 90° relative to a main direction of flow for a process flow in at least one flow plate or relative to a main direction of flow for a process flow in said sectioned flow module or relative to a main direction of flow for a process flow in said sectioned plate reactor. The present invention also relates to a method for regulating the temperature in a sectioned heat exchanger plate, flow module or plate reactor. | 01-21-2010 |
20100065251 | CLAMPING DEVICE FOR FLOW MODULE PLATES, REACTOR PLATES OR HEAT EXCHANGER PLATES - The present invention relates to a clamping device comprising two end plates ( | 03-18-2010 |
20120058023 | MULTIFUNCTIONAL MODULE - The present invention relates to a multifunctional module comprising one or more units selected from the group consisting of reactor units, filter units, membrane units, reactor-separator units, clarificator units, purificator units, extractor units, and mixer units. The units are connected parallel or in series or both to each other, and each unit has at least one member having a surface, which surface is rotating with the member. The member is rotating around an axis making the unit operate under centrifugal force. One or more chambers for fluids are co-rotating with the rotating member. The present invention relates further to units which could be used in a spinning multifunctional module, and use of a spinning multifunctional module. | 03-08-2012 |
20120269704 | CLAMPING SYSTEM - The present invention relates to a clamping system comprising two or more grids of springs in a flow module or in a plate reactor. The invention also relates to methods for opening and closing a clamping system, a frame arrangement, a control system for pressure release, and a use of the clamping system as a plate reactor. | 10-25-2012 |
20140020883 | SECTIONED FLOW DEVICE - A flow module or plate reactor includes one or more sectioned or un-sectioned heat exchanger plates. Each sectioned heat exchanger plates has a plurality of sections, each of which has a heat exchanger inlet and a heat exchanger outlet configured to flow one or more fluids therein in a first direction. The flow module or plate reactor includes one or more thermocouples and/or sensors and a regulating valve positioned either downstream of each of the heat exchanger outlets or upstream of one of the heat exchanger inlets. The flow module or plate reactor includes one or more serpentine configured process flow channels which have a channel inlet point and a channel outlet point which define a line oriented in a second direction which is at an angle of ninety degrees relative to the first direction. The flow module or plate reactor includes one or more flow plates and/or reactor plates. | 01-23-2014 |