Patent application number | Description | Published |
20140220110 | REMOTE LOADING OF SPARINGLY WATER-SOLUBLE DRUGS INTO LIPOSOMES - The present invention provides liposome compositions containing sparingly soluble drugs that are used to treat life-threatening diseases. A preferred method of encapsulating a drug inside a liposome is by remote or active loading. Remote loading of a drug into liposomes containing a transmembrane electrochemical gradient is initiated by co-mixing a liposome suspension with a solution of drug, whereby the neutral form of the compound freely enters the liposome and becomes electrostatically charged thereby preventing the reverse transfer out of the liposome. There is a continuous build-up of compound within the liposome interior until the electrochemical gradient is dissipated or all the drug is encapsulated in the liposome. However, this process as described in the literature has been limited to drugs that are freely soluble in aqueous solution or solubilized as a water-soluble complex. This invention describes compositions and methods for remote loading drugs with low water solubility (<2 mg/mL). In the preferred embodiment the drug in the solubilizing agent is mixed with the liposomes in aqueous suspension so that the concentration of solubilizing agent is lowered to below its capacity to completely solubilize the drug. This results in the drug precipitating but remote loading capability is retained. The process is scalable and, in liposomes in which the lipid composition and remote loading agent are optimized, the resulting drug-loaded liposomes are characterized by a high drug-to-lipid ratios and prolonged drug retention when the liposome encapsulated drug is administered to a subject. | 08-07-2014 |
20140220111 | REMOTE LOADING OF SPARINGLY WATER-SOLUBLE DRUGS INTO LIPOSOMES - The present invention provides liposome compositions containing sparingly soluble drugs that are used to treat life-threatening diseases. A preferred method of encapsulating a drug inside a liposome is by remote or active loading. Remote loading of a drug into liposomes containing a transmembrane electrochemical gradient is initiated by co-mixing a liposome suspension with a solution of drug, whereby the neutral form of the compound freely enters the liposome and becomes electrostatically charged thereby preventing the reverse transfer out of the liposome. There is a continuous build-up of compound within the liposome interior until the electrochemical gradient is dissipated or all the drug is encapsulated in the liposome. However, this process as described in the literature has been limited to drugs that are freely soluble in aqueous solution or solubilized as a water-soluble complex. This invention describes compositions and methods for remote loading drugs with low water solubility (<2 mg/mL). In the preferred embodiment the drug in the solubilizing agent is mixed with the liposomes in aqueous suspension so that the concentration of solubilizing agent is lowered to below its capacity to completely solubilize the drug. This results in the drug precipitating but remote loading capability is retained. The process is scalable and, in liposomes in which the lipid composition and remote loading agent are optimized, the resulting drug-loaded liposomes are characterized by a high drug-to-lipid ratios and prolonged drug retention when the liposome encapsulated drug is administered to a subject. | 08-07-2014 |
20140220112 | TRANSFORMATION OF DRUG CYCLODEXTRIN COMPLEX COMPOSITIONS INTO COMPOSITIONS OF MIXTURES OF LIPID VESICLE ENCAPSULATED DRUG AND CYCLODEXTRIN DRUG COMPLEXES - Sparingly water-soluble agents can be formulated as cyclodextrin complexes, however, these water-soluble drug-cyclodextrin complexes dissociate when the complex is administered into patients. The dilution of the complex in the patient leads to the drug being released from the complex, so the drug is not effectively targeted. In contrast, drugs encapsulated in the aqueous core of a lipid vesicles are not released when the liposome is diluted in blood. This invention describes compositions and methods whereby cyclodextrin or polyanionic beta-cyclodextrin drug-complexes are mixed with a preformed liposome containing the amine salts of an acidic compound. This results in the drug cyclodextrin complex being transferred into the liposome where it is stably retained. The liposome-encapsulated drug can then be injected into a patient. | 08-07-2014 |
20140271825 | PHARMACEUTICAL FORMULATIONS OF CHELATING AGENTS AS A METAL REMOVAL TREATMENT SYSTEM - The present invention provides liposomes loaded with chelating agents, pharmaceutical formulations including these liposomes and methods of making chelating agent liposomes. Because the chelating agents are loaded in the liposome with high efficiencies, the liposomes are of use in treatment of metal ion overload in subjects. The liposomes can include two or more different chelating agents of different structures and affinities for metal ions. | 09-18-2014 |
Patent application number | Description | Published |
20120218191 | MULTI-DISPLAY TYPE DEVICE INTERACTIONS - An electronic device including two or more display elements can provide enhanced functionality with improved rates of power consumption. A user can cause information that does not change rapidly to be provided or moved to a relatively static display element, such as an electronic ink display, which enables that information to be displayed for a period of time with little additional power consumption. Similarly, content (e.g., video) that changes rapidly can be displayed on a relatively dynamic display element, such as and LCD or OLED display. Each display can be touch sensitive, such that a user can move content between the displays by pressing on, or making a motion in contact with, at least one of the displays. Various modes can be activated which cause certain types of content to be displayed on the dynamic and/or static display element. | 08-30-2012 |
20130016102 | SIMULATING THREE-DIMENSIONAL FEATURES - Image information displayed on an electronic device can be modified based at least in part upon a relative position of a user with respect to a device. Mapping, topological or other types of positional data can be used to render image content from a perspective that is consistent with a viewing angle for the current relative position of the user. As that viewing angle changes, as a result of movement of the user and/or the device, the content can be re-rendered or otherwise updated to display the image content from a perspective that reflects the change in viewing angle. Simulations of effects such as parallax and occlusions can be used with the change in perspective to provide a consistent user experience that provides a sense of three-dimensional content even when that content is rendered on a two-dimensional display. Lighting, shading and/or other effects can be used to enhance the experience. | 01-17-2013 |
20130342459 | FINGERTIP LOCATION FOR GESTURE INPUT - A user can use a finger, or other such object, to provide input to a computing device. The finger does not have to contact the device, but can be positioned and/or oriented in such a way that the device can determine an input that the user is attempting to provide, such as an element or icon that the user is intended to select. One or more cameras can capture image information, which can be analyzed to attempt to determine the location and/or orientation of the finger. If the finger is at least partially outside a field of view of the camera(s), the device can use a sensor (e.g., EMF) to attempt to determine a location of at least a portion of the finger, which can be used with the image information to determine the location and/or orientation of the finger. Other estimation processes can be used as well. | 12-26-2013 |
20140085245 | DISPLAY INTEGRATED CAMERA ARRAY - Motions or gestures can provide input to an electronic device by capturing images of a feature used to provide the motions or gestures, then analyzing the images. Conventional cameras have a limited field of view, creating a “dead zone” near the device that is outside the field of view. Various embodiments utilize an array of detectors positioned behind a display screen that are configured to operate as a large, low resolution camera. The array can resolve objects within a distance of the device sufficient to cover at least a portion of the dead zone. In some embodiments the device can include one or more infrared (IR) emitters to emit IR light that can be reflected by an object in the dead zone and detected by the detectors. The use of multiple emitters at different locations enables at least some depth information to be determined from the array images. | 03-27-2014 |
20150049017 | GESTURE RECOGNITION FOR DEVICE INPUT - A user can make a symbol with their hand, or other such gesture, at a distance from a computing device that can be captured by at least one imaging element of the device. The captured information can be analyzed to attempt to determine the location of distinguishing features of the symbol in the image information. The image information is then compared to hand gesture information stored in, for example, a library of hand gestures for the user. Upon identifying a match, an input to an application executing on the computing device is provided when the image information contains information matching at least one hand gesture with at least a minimum level of certainty. The hand gesture could include a single “static” gesture, such as a specific letter in sign language, for example, or include two or more “static” gestures. The gesture could also include motion, such as hand movement. | 02-19-2015 |
20150177834 | LOW DISTRACTION INTERFACES - A low distraction interface can be provided for an electronic device by monitoring information such as a gaze direction of a user. A device can be configured to only display information to a user when the user is looking substantially toward the device, and can be configured to present that information in a way that is of minimal distraction to others nearby. The user can control aspects of the display by looking away from the device, continuing to look at the device for a period of time, or otherwise providing input without physically interacting with the device. Such an approach can be beneficial for settings such as business meetings where a user might want to obtain information from the device but does not want to appear inconsiderate by picking up and checking information on the device. | 06-25-2015 |
20150186711 | USER AUTHENTICATION THROUGH VIDEO ANALYSIS - A user of a computing device can be authenticated using image information captured by at least one camera of the computing device. In addition to analyzing the image information using a facial recognition algorithm, for example, variations in color of a portion of the captured image information corresponding to a user's face can be monitored over a period of time. The variations can be analyzed to determine whether the captured image information likely corresponds to an actual human user instead of a representation (e.g., photo) of a human user, such as where the chroma variations in at least a red channel occur with an oscillation frequency and amplitude consistent with changes due to a pulse or heartbeat. | 07-02-2015 |
Patent application number | Description | Published |
20100326935 | Merchandizing hanger - The invention provides a merchandise hanger including a first hanging portion including a first arm, a second hanging portion including a second arm, and a center portion connected to the first hanging portion and the second hanging portion. The first arm, the second arm and the center portion are configured to connect to merchandise. | 12-30-2010 |
20120066811 | HI-VISIBILITY WORK GEAR - The invention provides an apparatus and method for high-visibility work gear. The apparatus includes a main body portion. High-visibility elements are connected to the main body portion. The high-visibility portions including a night-time light reflecting material and day-time high-visibility surrounding offset material. | 03-22-2012 |
20120187130 | VEHICLE BOX ORGANIZER - The invention provides a vehicle box organizer system. The system includes a removable organizing bag including a handle. The organizing bag has a length sized to fit within a width of a vehicle box. | 07-26-2012 |
20120187134 | VEHICLE BOX ORGANIZER - The invention provides a truck box organizer assembly removably connected to a truck box. The truck box organizer includes many storage pockets. The truck box organizer is connected to the truck box via fastening elements. | 07-26-2012 |
20120217250 | AIR COMPRESSOR ORGANIZERS - An air compressor device organizer including an organizing panel having a storage portion and an air compressor tank attachment element. | 08-30-2012 |
20130021786 | UTILITY BAG LIGHTING - A lighting device for a utility bag including at least one moveable light source, a bracket connected to a utility bag, and a hinge device connected to the bracket and the moveable light source. The moveable light source is adjustable for targeting lighting. | 01-24-2013 |
20130021787 | HANDLE LIGHT - A lighting device including at least one light source and a light source body attached to the light source. The light source body rotates for multi-positional lighting. | 01-24-2013 |
20130107499 | KNEEPAD CAP | 05-02-2013 |
20130107500 | LIGHTED GLOVE APPARATUS AND SYSTEM | 05-02-2013 |
20130145514 | KNEEPAD CAP - A kneepad cap includes an upper portion with a curved front portion with a first curve radius. A center portion is attached to the upper portion. The center portion includes a first platform portion and curved side portions having a second curve radius. A lower portion is attached to the center portion. The lower portion includes a curved back portion having a third curve radius. | 06-13-2013 |
20130146725 | MERCHANDIZING HANGER - A merchandise hanger includes a first hanging portion having a first arm and a second arm. A second hanging portion includes a third arm and a fourth arm. A center portion is attached to the first hanging portion and the second hanging portion. The first hanging portion and the second hanging portion removably attach to merchandise. | 06-13-2013 |
20130148339 | PORTABLE LIGHT SOURCE - A lighting device including at least one light source. A flexible arm is attached to the light source. A light source body is attached to the flexible arm. The light source body rotates for multi-positional lighting. | 06-13-2013 |
20130156251 | UTILITY BAG SPEAKER SYSTEM - A speaker system for a utility bag includes a mounting platform. The mounting platform includes an audio plug receiving portion. A pair of speakers is connected with the audio plug receiving portion. The mounting platform includes an audio device placement portion that includes a protective cover. | 06-20-2013 |
20140326562 | ROLLER BAG HANDLE WITH LIGHTING - One embodiment includes an extendible handle having a lighting device. The extendible handle is connected to two or more pairs of connected telescoping arms. A pair of base arms is connected to the two or more pairs of connected telescoping arms. A storage container includes one or more rolling elements and is connected to the pair of base arms. | 11-06-2014 |
20140327401 | UTILITY BAGS WITH BATTERY PACK-TO-UNIVERSAL SERIAL BUS POWER DEVICES - One embodiment includes a battery pack receptacle that removably connects to a battery pack used for a cordless device. A universal serial bus (USB) receptacle is connected to the battery pack receptacle. The battery pack is used as a power source for the USB receptacle. | 11-06-2014 |
20150084578 | BATTERY PACK-TO-UNIVERSAL SERIAL BUS POWER DEVICES - A device includes a battery pack receptacle that removably connects to a battery pack used for a cordless device. A universal serial bus (USB) port is connected to the battery pack receptacle. The battery pack is used as a power source for the USB port. An attachment device is connected to the battery pack receptacle that attaches the battery pack receptacle to a utility bag. | 03-26-2015 |
20150084592 | BATTERY PACK-TO-UNIVERSAL SERIAL BUS POWER DEVICES - A device includes a battery pack receptacle that removably connects to a battery pack used for a cordless device. A universal serial bus (USB) port is connected to the battery pack receptacle. The battery pack is used as a power source for the USB port. An attachment device is connected to the battery pack receptacle. that attaches the battery pack receptacle to a utility bag. The attachment device is configured for attaching the battery pack receptacle to a platform. | 03-26-2015 |
20150084596 | ADAPTIVE BATTERY PACK-TO-UNIVERSAL SERIAL BUS POWER DEVICES - A device includes a battery pack receptacle that removably connects to a particular adapter of multiple adapters for a particular associated battery pack that is used for a cordless device. A universal serial bus (USB) port is connected to the battery pack receptacle. The battery pack is used as a power source for the USB port. | 03-26-2015 |
20150313332 | COLLAPSIBLE ROLLER BAGS - One embodiment includes a collapsible storage container including one or more rolling elements. The collapsible storage container includes one or more support arms attached to interior portions of the collapsible storage container. The support arms are configured to be placed in a first state and a second state. An extendible handle is connected to two or more pairs of connected telescoping arms that are attached to the collapsible storage container. | 11-05-2015 |
20150318716 | ADAPTIVE BATTERY PACK-TO-UNIVERSAL SERIAL BUS POWER DEVICES - A battery pack receptacle removably connects to a particular one of multiple battery pack adapters for particular battery packs used for cordless power tool devices. A universal serial bus (USB) receptacle is connected to the battery pack receptacle. The battery pack is used as a power source for the USB receptacle. Each of the multiple battery pack adapters is configured for a different type of battery pack. | 11-05-2015 |
Patent application number | Description | Published |
20090255205 | Engineered Molded Fiberboard Panels and Methods of Making and Using the Same - A fiberboard panel is formed from at least one corrugated sheet of molded cellulose fiber material having alternating ribs and grooves. Spaced slits are cut through the ribs on one face of the sheet and terminate short of the opposite face so as to form at least one slotted portion of more flexibility which may be bent to form a curve. The corrugated sheet is sandwiched between two flat sheets of the same material to form a composite panel. The corrugated sheet or panel is formed by a wet processing method including successive cold and hot press steps in which a wet mat is pressed between an opposing perforated platen and non-perforated, elastomeric material platen of cross-sectional shape substantially matching the desired panel shape and dimensions. | 10-15-2009 |
20100078985 | Engineered Molded Fiberboard Panels. Methods of Making the Panels, and Products Fabricated From the Panels - A honeycomb-shaped panel is formed from a plurality of generally sinusoidally shaped strips of molded fiberboard material each having spaced, oppositely directed flat peaks, the peaks of adjacent strips being secured together to form a plurality of hexagonally shaped cells extending perpendicular to the surfaces of the sheet. The strips may be cut from a single sheet of corrugated fiberboard sheet material and then secured together to form the honeycomb panel, or a plurality of such panels may be secured together face to face with their ribs aligned to form a stack, and selected cuts may be made through the secured, stacked panels to form a plurality of honeycomb panels of desired surface shape and height dimensions. The strips forming the cells are substantially rigid and resistant to collapse of the cells, and form a substantially rigid core when assembled between two flexible fiberboard skins, while the panel is bendable to adopt a desired panel curvature. | 04-01-2010 |
20130284357 | METHOD OF MAKING MOLDED FIBERBOARD PANELS AND PRODUCTS FABRICATED FROM THE PANELS - A honeycomb-shaped panel is formed from a plurality of generally sinusoidally shaped strips of molded fiberboard material each having spaced, oppositely directed flat peaks, the peaks of adjacent strips being secured together to form a plurality of hexagonally shaped cells extending perpendicular to the surfaces of the sheet. The strips may be cut from a single sheet of corrugated fiberboard sheet material and then secured together to form the honeycomb panel, or a plurality of such panels may be secured together face to face with their ribs aligned to form a stack, and selected cuts may be made through the secured, stacked panels to form a plurality of honeycomb panels of desired surface shape and height dimensions. | 10-31-2013 |
20130291480 | Engineered Molded Fiberboard Panels - A fiberboard panel is formed from at least one corrugated sheet of molded cellulose fiber material formed from a mixture of at least two different cellulose fibers, one of the fibers comprising bovine processed fiber (BPF). The panel has opposite first and second faces and is formed with alternating ribs and grooves. The ribs on the first face each have a first, flat peak and the ribs on the second face each have a second, flat peak facing in the opposite direction to the first peaks, the opposing first and second flat peaks forming opposing faces of the sheet. Each first peak is connected to adjacent second peaks by angled webs forming opposite side faces of ribs. The corrugated sheet may be sandwiched between two flat sheets of the same material to form a composite panel. | 11-07-2013 |
20130333854 | Engineered Molded Fiberboard Panels and Methods of Making and Using the Same - A fiberboard panel is formed from at least one corrugated sheet of molded cellulose fiber material having alternating ribs and grooves. The corrugated sheet or panel is formed by a wet processing method including successive cold and hot press steps in which a wet mat is pressed between an opposing perforated platen and non-perforated, elastomeric material platen of cross-sectional shape substantially matching the desired panel shape and dimensions. | 12-19-2013 |
20140134394 | VOID CONTAINING STRUCTURAL MEMBER - A void containing structural member and method of fabrication that provides for structural elements, such as beams, columns and rafters of varying shapes containing voids within the structure. In one embodiment, cellulosic materials are used, a flange type of beam configuration is provided, which includes internal longitudinally extending voids. | 05-15-2014 |
20140308473 | THREE DIMENSIONAL STRUCTURES DERIVED FROM PLANAR PANELS - A three-dimensional structure comprising a plurality of substantially planar sections and an adhesive layer. The planar sections are oriented in stacked relation with one another. The adhesive layer binds the sections in substantially fixed relation with one another. In exemplary embodiments, the sections may be formed from a single piece or from plural pieces. The three-dimensional structure is formed by positioning the respective sections on a retainer and affixing them in place in relation to one another. | 10-16-2014 |
Patent application number | Description | Published |
20090050194 | SUPPORT SYSTEM FOR A PHOTOVOLTAIC SYSTEM - A method and modular assembly provide shade and generate electricity using photovoltaic cells. In the method, a kit includes a plurality of columns, a truss assembly, a rack, and a plurality of photovoltaic cells for converting solar energy into electricity. First, four columns are erected at a distance from one another to define an area. Then, the truss assembly is suspended between the columns. Thereafter, the rack is mounted to the truss assembly to form an open roof. To enclose the roof, the photovoltaic cells are arranged on the rack to block sunlight to shade the area, while converting the sunlight to electricity. | 02-26-2009 |
20090194669 | SUN TRACKING SOLAR PANELS - A system is provided for maximizing solar energy utilization by moving a solar panel to track movement of the sun from sunrise to sunset. Preferably, the solar panel is inclined from the horizontal plane by a fixed angle of about ten degrees. And, movements of the solar panel are accomplished, daily, in accordance with a programmed schedule of consecutive cycles. In this schedule, each cycle has a start time (i.e. sunrise) and a start point that is determined by the sun's direction from the solar panel. | 08-06-2009 |
20120279550 | Device for Continuously Reorienting a Solar Panel - A system and method are provided for continuously reorienting a solar panel array while maintaining a substantially stationary footprint for the solar panel. A cylindrically shaped knuckle is provided that is formed with a bottom surface and a top surface that is slanted relative to the bottom surface at a slant angle φ. One end of an upper pole is positioned against the top surface of the knuckle, and one end of a lower pole is positioned against the bottom surface of the knuckle. An upper and lower motor respectively connect the knuckle to the upper pole and the lower pole. These motors are used to continuously rotate the knuckle at an angular velocity ω relative to the upper and lower poles. When the knuckle rotates, the upper and lower poles remain stationary to allow the solar panel to continuously reorient while maintaining a substantially stationary footprint. | 11-08-2012 |
Patent application number | Description | Published |
20160026261 | MACHINE-LEARNING BASED TAP DETECTION - An electronic device can be configured to enable a user to provide input via a tap of the device without the use of touch sensors (e.g., resistive, capacitive, ultrasonic or other acoustic, infrared or other optical, or piezoelectric touch technologies) and/or mechanical switches. Such a device can include other sensors, including inertial sensors (e.g., accelerometers, gyroscopes, or a combination thereof), microphones, proximity sensors, ambient light sensors, and/or cameras, among others, that can be used to capture respective sensor data. Feature values with respect to the respective sensor data can be extracted, and the feature values can be analyzed using machine learning to determine when the user has tapped on the electronic device. Detection of a single tap or multiple taps performed on the electronic device can be utilized to control the device. | 01-28-2016 |
Patent application number | Description | Published |
20090306894 | Track prediction and identification via particle motion with intent - Provided is a system and method for tracking and identifying a target in an area of interest based on a comparison of predicted target behavior or movement and sensed target behavior or movement. Incorporating aspects of both particle diffusion and mobility constraint models with target intent derivations, the system may continuously track a target while simultaneously refining target identification information. Alternatively, the system and method are applied to reacquire a target track based on prioritized intents and predicted target location. | 12-10-2009 |
20110001658 | SYSTEM AND METHOD FOR PRECISION GEOLOCATION UTILIZING MULTIPLE SENSING MODALITIES - A system and method for determining the geolocation of a signal emitter moving at an unknown velocity by combining signal data of a target detection platform (e.g., a radar system) and signal data collected by two or more moving signal collection platforms (e.g., RF signal receivers). In one embodiment, the target detection platform determines tentative location and velocity of the signal emitter, and the signal collection platforms are configured to perform TDOA and/or FDOA analysis of the collected signal data corresponding to a signal of the signal emitter. In one embodiment, solutions provided from the TDOA and/or FDOA analysis are unbiased by using the tentative velocity of the signal emitter, and the geolocation of the signal emitter is determined by matching the TDOA/FDOA solutions and the detected tentative location. | 01-06-2011 |
20120200379 | SYSTEM FOR TRANSFERRING POWER AND/OR DATA THROUGH A NON-FERROUS SKIN OF A VEHICLE - A system for transferring power and/or data through a skin of a vehicle includes a first module for disposition on an external surface of the vehicle, a first magnet arrangement attached to the first module, a second module for disposition on an internal surface of the vehicle, and a second magnet arrangement attached to the second module. The first magnet arrangement and the second magnet arrangement are selected to provide sufficient magnetic attraction therebetween to maintain the first module at a fixed position on the external surface of the vehicle by overcoming an air load force when the vehicle is in motion. When the first module and the second module are in registration with each other though the non-ferrous skin, at least one inductive coupling circuit through the non-ferrous skin is formed to provide one or more bidirectional paths therebetween for transfer of data signals, electrical power or both. | 08-09-2012 |
20130181857 | MEMORY BASED ELECTRONICALLY SCANNED ARRAY ANTENNA CONTROL - A system for controlling an active electronically scanned array (AESA) antenna, which enables the AESA antenna to switch rapidly between different antenna states, includes memories ( | 07-18-2013 |
20130281145 | Phased Array Antenna Having Assignment Based Control and Related Techniques - Disclosed subject matter relates to techniques for allowing multiple transmit/receive assignments to share antenna resources in an efficient manner. The techniques may be used with, for example, transmit/receive assignments that are non-deterministic in nature. In some implementations, transmit/receive assignments each have a corresponding priority value. Transmit/receive assignments are permitted to contend for available antenna resources based, at least in part, on priority. | 10-24-2013 |