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Niu, US

Baohua Niu, Portland, OR US

Patent application numberDescriptionPublished
20120249859THROUGH SILICON IMAGING AND PROBING - Through silicon imaging and probing. A light source provides unpolarized light to be projected on a device under test (DUT). Light reflected from the DUT may be captured by a camera or other image capture device. A pellicle is utilized to reflect light from the light source toward the DUT. The pellicle also passes light reflected by the DUT to the camera. One or more linear polarizers or half wave plates may be used to provide the desired light polarization. The ability to provide the desired polarization provides an improved image that can be captured by the camera.10-04-2012

Bo Niu, Kearny, NJ US

Patent application numberDescriptionPublished
20090005028SUM RATE OF BROADCAST CHANNELS WITH OUTDATED 1-BIT FEEDBACK - A single-input single-output (SISO) downlink channel with K users is analyzed in the presence of Rayleigh flat fading. A limited channel state information (CSI) feedback scheme is included, where only an outdated 1-bit feedback per user is available at the base station for each fading block. A closed-form expression for the achievable ergodic sum-rate of the 1-bit feedback scheme is presented for any number of users, as a function of the fading temporal correlation coefficient, the threshold of the 1-bit CSI quantizer and the SNR. The sum-rate scales with increasing number of users as log logK, which is the same scaling law achieved by the optimal non-delayed full CSI feedback scheme.01-01-2009

Cheng Niu, Redmond, WA US

Patent application numberDescriptionPublished
20100082511JOINT RANKING MODEL FOR MULTILINGUAL WEB SEARCH - Described is a technology in which a classifier is built to rank documents of different languages found in a query based at least in part on similarity to other documents and the relevance of those other documents to the query. A joint ranking model, e.g., based upon a Boltzmann machine, is used to represent the content similarity among documents, and to help determine joint relevance probability for a set of documents. The relevant documents of one language are thus leveraged to improve the relevance estimation for documents of different languages. In one aspect, a hidden layer of units (neurons) represents clusters (corresponding to relevant topics) among the retrieved documents, with an output layer representing the relevant documents and their features, and edges representing a relationship between clusters and documents.04-01-2010

Chengyu Niu, Niskayuna, NY US

Patent application numberDescriptionPublished
20150061135COPPER INTERCONNECT WITH CVD LINER AND METALLIC CAP - A structure having a diffusion barrier positioned adjacent to a sidewall and a bottom of an opening being etched in a layer of dielectric material. The structure also having a metal liner positioned directly on top of the diffusion barrier, a seed layer positioned directly on top of the metal liner, wherein the seed layer is made from a material comprising copper, a copper material positioned directly on top of the seed layer, a metallic cap positioned directly on top of and selective to the copper material, and a capping layer positioned directly on top of and adjacent to the metallic cap.03-05-2015

Chengyu Niu, Fishkill, NY US

Patent application numberDescriptionPublished
20100073122DUAL THIN FILM PRECISION RESISTANCE TRIMMING - A trimmable resistor for use in an integrated circuit is trimmed using a heater. The heater is selectively coupled to a voltage source. The application of voltage to the heater causes the heater temperature to increase and produce heat. The heat permeates through a thermal separator to the trimmable resistor. The resistance of the trimmable resistor is permanently increased or decreased when the temperature of the resistor is increased to a value within a particular range of temperatures.03-25-2010
20140138832COPPER SEED LAYER FOR AN INTERCONNECT STRUCTURE HAVING A DOPING CONCENTRATION LEVEL GRADIENT - A trench is opened in a dielectric layer. The trench is then lined with a barrier layer and a metal seed layer. The metal seed layer is non-uniformly doped and exhibits a vertical doping gradient varying as a function of trench depth. The lined trench is then filled with a metal fill material. A dielectric cap layer is then deposited over the metal filled trench. Dopant from the non-uniformly doped metal seed layer is then migrated to an interface between the metal filled trench and the dielectric cap layer to form a self-aligned metal cap.05-22-2014
20140138837SANDWICHED DIFFUSION BARRIER AND METAL LINER FOR AN INTERCONNECT STRUCTURE - A trench is opened in a dielectric layer. The trench is then lined with a sandwiched diffusion barrier and metal liner structure and a metal seed layer. The sandwiched diffusion barrier and metal liner structure includes a conformal metal liner layer sandwiched between a first diffusion barrier layer and a second diffusion barrier layer. The metal seed layer is at least lightly doped. The lined trench is then filled by electroplating with a metal fill material. A dielectric cap layer is then deposited over the metal filled trench. Dopant from the doped metal seed layer is then migrated to an interface between the metal filled trench and the dielectric cap layer to form a self-aligned metal cap.05-22-2014
20140299938METHODS AND DEVICES FOR ENHANCING MOBILITY OF CHARGE CARRIERS - Methods and devices for enhancing mobility of charge carriers. An integrated circuit may include semiconductor devices of two types. The first type of device may include a metallic gate and a channel strained in a first manner. The second type of device may include a metallic gate and a channel strained in a second manner. The gates may include, collectively, three or fewer metallic materials. The gates may share a same metallic material. A method of forming the semiconductor devices on an integrated circuit may include depositing first and second metallic layers in first and second regions of the integrated circuit corresponding to the first and second gates, respectively.10-09-2014

Chengyu Niu, Hopewell Junction, NY US

Patent application numberDescriptionPublished
20120266452DUAL THIN FILM PRECISION RESISTANCE TRIMMING - A trimmable resistor for use in an integrated circuit is trimmed using a heater. The heater is selectively coupled to a voltage source. The application of voltage to the heater causes the heater temperature to increase and produce heat. The heat permeates through a thermal separator to the trimmable resistor. The resistance of the trimmable resistor is permanently increased or decreased when the temperature of the resistor is increased to a value within a particular range of temperatures.10-25-2012

Chengyu Charles Niu, Hopewell Junction, NY US

Patent application numberDescriptionPublished
20130277842COPPER INTERCONNECT WITH CVD LINER AND METALLIC CAP - A structure having a diffusion barrier positioned adjacent to a sidewall and a bottom of an opening being etched in a layer of dielectric material. The structure also having a metal liner positioned directly on top of the diffusion barrier, a seed layer positioned directly on top of the metal liner, wherein the seed layer is made from a material comprising copper, a copper material positioned directly on top of the seed layer, a metallic cap positioned directly on top of and selective to the copper material, and a capping layer positioned directly on top of and adjacent to the metallic cap.10-24-2013

Chuan S. Niu, Cheshire, CT US

Patent application numberDescriptionPublished
20080221181COMPOUNDS FOR TREATING TUMORS - The invention provides compounds of formula (I):09-11-2008

Patent applications by Chuan S. Niu, Cheshire, CT US

Chuansheng Niu, Cheshire, CT US

Patent application numberDescriptionPublished
200902703632-Aryl- and 2-Heteroarylthiazolyl Compounds, Methods for Their Preparation and Use Thereof - The present invention discloses fused bicyclic 2-aryl- or 2-heteroarylthiazolyl compounds and their pharmaceutically acceptable salts and esters thereof, which are useful for inhibiting the growth of cancerous cells, inhibiting human breast carcinoma tumor growth in particular and to treat diseases or disorders associated with securin, including elevated securin levels.10-29-2009
200902704472-Aryl-and 2-Heteroarylthiazolyl Compounds, Methods for Their Preparation and Use Thereof - The present invention discloses fused heterobicyclic 2-aryl- and 2-heteroarylthiazolyl compounds and their pharmaceutically acceptable salts and esters thereof, which are useful for inhibiting the growth of cancerous cells, inhibiting human breast carcinoma tumor growth in particular and to treat diseases or disorders associated with securin.10-29-2009
20110028455Indole-substituted 3-cyanopyridines As Kinase Inhibitors - Disclosed are compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein X is —O—, —N(R02-03-2011

Chunming Niu, Lexington, MA US

Patent application numberDescriptionPublished
20080224101POLYVINYLIDENE FLUORIDE COMPOSITES AND METHODS FOR PREPARING SAME - An electrically conductive composite comprising a polyvinylidene fluoride polymer or copolymer and carbon nanotubes is provided. Preferably, carbon nanotubes may be present in the range of about 0.5-20% by weight of the composite.09-18-2008
20140162040Oxidized Carbon Nanotube Structures - Provided are oxidized carbon nanotube structures including aggregates, networks, assemblages, rigid porous structures, electrodes, and mats. Oxidized carbon nanotubes may be formed by conducting gas-phase oxidation on carbon nanotubes. Gas-phase oxidation may be conducted by contacting carbon nanotubes with gas-phase oxidizing agents, such as CO06-12-2014

Patent applications by Chunming Niu, Lexington, MA US

David Niu, Seattle, WA US

Patent application numberDescriptionPublished
20140122183PULSED-SURVEY SERVICE SYSTEMS AND METHODS - A pulsed-survey service may be provided by obtaining a question sequence including a number of survey questions, and determining a base survey-pulse rate, such as once per week, but no more frequent than once per day. During each pulse period, for each of a number of subscriber entities, a pulsed survey is performed. Each survey pulse poses and collects responses for at least one, but no more than ten percent of the survey questions. Both intra- and inter-entity benchmark statistics are determined for the pulsed-survey responses, and the statistics and survey results are provided for presentation to the subscriber entity via a survey-results interface.05-01-2014

Dequiang Niu, Lexington, MA US

Patent application numberDescriptionPublished
20100185419ALGORITHM FOR DESIGNING IRREVERSIBLE INHIBITORS - The invention is an algorithm and method for designing an inhibitor that covalently binds a target polypeptide. The algorithm and method can be used to rapidly and efficiently convert reversible inhibitors into irreversible inhibitors.07-22-2010
201401354856-11 BICYCLIC KETOLIDE DERIVATIVES - The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof:05-15-2014

Dong Niu, West Linn, OR US

Patent application numberDescriptionPublished
20110236594In-Situ Deposition of Film Stacks - Methods and hardware for depositing film stacks in a process tool in-situ (i.e., without a vacuum break or air exposure) are described. In one example, a method for depositing, on a substrate, a film stack including films of different compositions in-situ in a process station using a plasma is described, the method including, in a first plasma-activated film deposition phase, depositing a first layer of film having a first film composition on the substrate; in a second plasma-activated deposition phase, depositing a second layer of film having a second film composition on the first layer of film; and sustaining the plasma while transitioning a composition of the plasma from the first plasma-activated film deposition phase to the second plasma-activated film deposition phase.09-29-2011
20110236600Smooth Silicon-Containing Films - Methods and hardware for depositing ultra-smooth silicon-containing films and film stacks are described. In one example, an embodiment of a method for forming a silicon-containing film on a substrate in a plasma-enhanced chemical vapor deposition apparatus is disclosed, the method including supplying a silicon-containing reactant to the plasma-enhanced chemical vapor deposition apparatus; supplying a co-reactant to the plasma-enhanced chemical vapor deposition apparatus; supplying a capacitively-coupled plasma to a process station of the plasma-enhanced chemical vapor deposition apparatus, the plasma including silicon radicals generated from the silicon-containing reactant and co-reactant radicals generated from the co-reactant; and depositing the silicon-containing film on the substrate, the silicon-containing film having a refractive index of between 1.4 and 2.1, the silicon-containing film further having an absolute roughness of less than or equal to 4.5 Å as measured on a silicon substrate.09-29-2011
20130157466SILICON NITRIDE FILMS FOR SEMICONDUCTOR DEVICE APPLICATIONS - The embodiments herein relate to plasma-enhanced chemical vapor deposition methods and apparatus for depositing silicon nitride on a substrate. The disclosed methods provide silicon nitride films having wet etch rates (e.g., in dilute hydrofluoric acid or hot phosphoric acid) suitable for certain applications such as vertical memory devices. Further, the methods provide silicon nitride films having defined levels of internal stress suitable for the applications in question. These silicon nitride film characteristics can be set or tuned by controlling, for example, the composition and flow rates of the precursors, as well as the RF power supplied to the plasma and the pressure in the reactor. In certain embodiments, a boron-containing precursor is added.06-20-2013
20130171834IN-SITU DEPOSITION OF FILM STACKS - Disclosed herein are methods of forming a film stack which may include the plasma accelerated deposition of a silicon nitride film formed from the reaction of nitrogen containing precursor with silicon containing precursor, the plasma accelerated substantial elimination of silicon containing precursor from the processing chamber, the plasma accelerated deposition of a silicon oxide film atop the silicon nitride film formed from the reaction of silicon containing precursor with oxidant, and the plasma accelerated substantial elimination of oxidant from the processing chamber. Also disclosed herein are process station apparatuses for forming a film stack of silicon nitride and silicon oxide films which may include a processing chamber, one or more gas delivery lines, one or more RF generators, and a system controller having machine-readable media with instructions for operating the one or more gas delivery lines, and the one or more RF generators.07-04-2013
20130267081POST-DEPOSITION SOFT ANNEALING - The methods and apparatus disclosed herein concern a process that may be referred to as a “soft anneal.” A soft anneal provides various benefits. Fundamentally, it reduces the internal stress in one or more silicon layers of a work piece. Typically, though not necessarily, the internal stress is a compressive stress. A particularly beneficial application of a soft anneal is in reduction of internal stress in a stack containing two or more layers of silicon. Often, the internal stress of a layer or group of layers in a stack is manifest as wafer bow. The soft anneal process can be used to reduce compressive bow in stacks containing silicon. The soft anneal process may be performed without causing the silicon in the stack to become activated.10-10-2013
20140357064TENSILE STRESSED DOPED AMORPHOUS SILICON - The method and apparatus disclosed herein relate to preparing a stack structure for an electronic device on a semiconductor substrate. A particularly beneficial application of the method is in reduction of internal stress in a stack containing multiple layers of silicon. Typically, though not necessarily, the internal stress is a compressive stress, which often manifests as wafer bow. In some embodiments, the method reduces the internal stress of a work piece by depositing phosphorus doped silicon layers having low internal compressive stress or even tensile stress. The method and apparatus disclosed herein can be used to reduce compressive bow in stacks containing silicon.12-04-2014
20150013607IN-SITU DEPOSITION OF FILM STACKS - An apparatus for depositing film stacks in-situ (i.e., without a vacuum break or air exposure) are described. In one example, a plasma-enhanced chemical vapor deposition apparatus configured to deposit a plurality of film layers on a substrate without exposing the substrate to a vacuum break between film deposition phases, is provided. The apparatus includes a process chamber, a plasma source and a controller configured to control the plasma source to generate reactant radicals using a particular reactant gas mixture during the particular deposition phase, and sustain the plasma during a transition from the particular reactant gas mixture supplied during the particular deposition phase to a different reactant gas mixture supplied during a different deposition phase.01-15-2015

Patent applications by Dong Niu, West Linn, OR US

Feng Niu, Weston, FL US

Patent application numberDescriptionPublished
20080240116Method and Apparatus for Determining the Locating of Nodes in a Wireless Network - A method and apparatus for determining the relative locations of nodes in a wireless network is disclosed. A list of neighboring nodes of a master node of the wireless network is generated and, from this list, a list of independent nodes is generated. An adjacency table for the independent nodes is then generated by examining the neighbors of dependent nodes. Two independent nodes are determined to be adjacent nodes only if they are the only neighboring nodes of a dependent node. Relative locations of nodes in wireless network may be determined from the adjacency table.10-02-2008

Patent applications by Feng Niu, Weston, FL US

Fenghui Niu, Lawrence, KS US

Patent application numberDescriptionPublished
20140296140Equipment Assembly for and Method of Processing Particles - An equipment assembly for preparing, harvesting and collecting particles is disclosed. The assembly comprises a tandem filter system with one or more high pressure filters, one or more low pressure filters and one or more collection vessel. Particles can be prepared, harvested and collected continuously, semi-continuously or in a batch-type operation. A tandem filter system and its method of use are also disclosed. Particles made with the assembly and according the instant methods are also disclosed. The assembly provides improved particle harvesting and collection over other systems and permits continuous particle formation, in particular by dispersion of a solute-containing process fluid within a supercritical anti-solvent.10-02-2014

Fenghul Niu, Lawrence, KS US

Patent application numberDescriptionPublished
20120022287Spray Process for Selective Oxidation - Oxidation process can include: introducing small droplets of liquid reaction mixture having oxidizable reactant, catalyst, and solvent into a reaction zone containing oxygen and diluent gas; and oxidizing the reactant with the oxygen at a suitable reaction temperature and a suitable reaction pressure to produce an oxidized product. The liquid reaction mixture can have an aromatic feedstock having an oxidizable substituent as the oxidizable reactant. The oxidized product can include an aromatic compound having at least one carboxylic acid. For example, the aromatic feedstock can include a benzene ring having at least one oxidizable alkyl substituent, furan hetero-ring having at least one oxidizable alkyl substituent, a naphthalene poly-ring having at least one oxidizable alkyl substituent, derivatives thereof, and mixtures thereof.01-26-2012

Guoguang Niu, Winston-Salem, NC US

Patent application numberDescriptionPublished
20140377326FABRICATION OF GELATIN HYDROGEL SHEET FOR THE TRANSPLANTATION OF CORNEAL ENDOTHELIUM - The invention provides a corneal endothelial composition comprising a transparent hydrogel scaffold and a single layer of cultured corneal endothelial cells on the surface of the scaffold. The hydrogel scaffold I comprised of at least one biopolymer, preferably gelatin. Also provided are methods of making a corneal endothelial scaffold12-25-2014

Huifeng Niu, Scotch Plains, NJ US

Patent application numberDescriptionPublished
20080207563METHOD FOR INHIBITING PROLIFERATION OF TUMOR CELLS - Disclosed are methods for synergistically inhibiting the proliferation of tumor cells by contacting the tumor cells with a MEK inhibitor compound and erlotinib, either sequentially or simultaneously. Also disclosed are methods for inhibiting the proliferation of tumor cells in a human, by administering to the human, sequentially or simultaneously, an amount of erlotinib and a MEK inhibitor compound, wherein the amounts are effective, in combination, to synergistically inhibit the proliferation of the tumor cells in the human.08-28-2008
20140370019BISPECIFIC ANTIBODIES SPECIFIC FOR FAP AND DR5, ANTIBODIES SPECIFIC FOR DR5 AND METHODS OF USE - The present invention relates to bispecific antibodies comprising at least one antigen binding site specific for DR5 and at least one antigen binding site specific for FAP, antibodies specific for DR5, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.12-18-2014

Jianli Niu, Orlando, FL US

Patent application numberDescriptionPublished
20100041736Isolated MCPIP and Methods of Use - A monocyte chemoattractant protein (MCP-1)-inducible protein, MCPIP, its polynucleotide and amino acid sequences from mouse and human, and methods for its use are disclosed.02-18-2010
20110002981MCPIP Protection Against Cardiac Dysfunction - Disclosed herein are methods and compositions of treating a patient at risk of experiencing sepsis induced cardiac dysfunction. In exemplary examples, the method involves elevating MCPIP levels in a patient in need. Elevating MCPIP levels may involve direct administration (e.g. delivery of protein) or indirect administration (e.g. delivery vehicle capable of increasing expression of MCPIP).01-06-2011
20130295076MCPIP AS WOUND THERAPY - Disclosed herein are methods and compositions of treating a subject suffering from a wound. In exemplary examples, the method involves elevating MCPIP levels in a subject in need. Elevating MCPIP levels may involve direct administration (e.g. delivery of protein) or indirect administration (e.g. delivery vehicle capable of increasing expression of MCPIP).11-07-2013
20140341877MCPIP AS WOUND THERAPY - Disclosed herein are methods and compositions of treating a subject suffering from a wound. In exemplary examples, the method involves elevating MCPIP levels in a subject in need. Elevating MCPIP levels may involve direct administration (e.g. delivery of protein) or indirect administration (e.g. delivery vehicle capable of increasing expression of MCPIP).11-20-2014
20140341914ISOLATED MCPIP AND METHODS OF USE - A monocyte chemoattractant protein (MCP-1)-inducible protein, MCPIP, its polynucleotide and amino acid sequences from mouse and human, and methods for its use are disclosed.11-20-2014

Patent applications by Jianli Niu, Orlando, FL US

Joseph H.y. Niu, Houston, TX US

Patent application numberDescriptionPublished
20080200353Viscoelastic surfactant fluids and related methods of use - Viscoelastic surfactant based aqueous fluid systems useful as thickening agents in various applications, e.g. to suspend particles produced during the excavation of geologic formations. The surfactants are zwitterionic/amphoteric surfactants such as dihydroxyl alkyl glycinate, alkyl ampho acetate or propionate, alkyl betaine, alkyl amidopropyl betaine and alkylimino mono- or di-propionates derived from certain waxes, fats and oils. The thickening agent is used in conjunction with an inorganic water-soluble salt or organic additive such as phthalic acid, salicylic acid or their salts.08-21-2008
20110092398VISCOELASTIC SURFACTANT FLUIDS AND RELATED METHODS OF USE - Viscoelastic surfactant based aqueous fluid systems useful as thickening agents in various applications, e.g. to suspend particles produced during the excavation of geologic formations. The surfactants are zwitterionic/amphoteric surfactants such as dihydroxyl alkyl glycinate, alkyl ampho acetate or propionate, alkyl betaine, alkyl amidopropyl betaine and alkylimino mono- or di-propionates derived from certain waxes, fats and oils. The thickening agent is used in conjunction with an inorganic water-soluble salt or organic additive such as phthalic acid, salicylic acid or their salts.04-21-2011

Joseph H. Y. Niu, Houston, TX US

Patent application numberDescriptionPublished
20130327531Viscoelastic Surfactant Fluids and Related Methods of Use - Viscoelastic surfactant based aqueous fluid systems useful as thickening agents in various applications, e.g. to suspend particles produced during the excavation of geologic formations. The surfactants are zwitterionic/amphoteric surfactants such as dihydroxyl alkyl glycinate, alkyl ampho acetate or propionate, alkyl betaine, alkyl amidopropyl betaine and alkylimino mono- or di-propionates derived from certain waxes, fats and oils. The thickening agent is used in conjunction with an inorganic water-soluble salt or organic additive such as phthalic acid, salicylic acid or their salts.12-12-2013

Li Niu, Loudonville, NY US

Patent application numberDescriptionPublished
20100099749Nucleic Acid Inhibitors Of Glutamate Receptors - The present invention relates to novel nucleic acid ligands or aptamers that bind to and inhibit the activation of the α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) subtype of ionotropic glutamate receptors. Also disclosed is a novel combination of technologies, i.e., SELEX and laser pulse photolysis for the selection and screening of aptamers that inhibit receptor function and are useful therefore, in the treatment of diseases associated with excessive activation of ionotropic glutamate receptors.04-22-2010
20120088818CONFORMATION-SELECTIVE NUCLEIC ACID INHIBITORS OF AMPA GLUTAMATE RECEPTORS - The present invention relates to novel nucleic acid ligands or aptamers that demonstrate potent and selective inhibition of the open-channel conformation of the α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) subtype of ionotropic glutamate receptors.04-12-2012
20130158105CONFORMATION-SELECTIVE NUCLEIC ACID INHIBITORS OF AMPA GLUTAMATE RECEPTORS - The present invention relates to novel nucleic acid ligands or aptamers that demonstrate potent and selective inhibition of the open-channel conformation of the α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) subtype of ionotropic glutamate receptors.06-20-2013
20130289100SUBUNIT-SELECTIVE NUCLEIC ACID INHIBITORS OF GLUTAMATE RECEPTORS - Inhibitors of AMPA-type glutamate ion channels are useful as biochemical probes for structure-function studies and as drug candidates for a number of neurological disorders and diseases. Disclosed herein is the identification of an RNA inhibitor or aptamer by an in vitro evolution approach and characterization of its mechanism of inhibition on the sites of interaction by equilibrium binding and on the receptor channel-opening rate by a laser-pulse photolysis technique. The aptamer of the invention is a noncompetitive inhibitor of AMPA-type glutamate ion channels, one that selectively inhibits the GluA2Q10-31-2013

Patent applications by Li Niu, Loudonville, NY US

Li Niu, Loundonville, NY US

Patent application numberDescriptionPublished
20120225929Nucleic Acid Inhibitors Of Glutamate Receptors - The present invention relates to novel nucleic acid ligands or aptamers that bind to and inhibit the activation of the α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) subtype of ionotropic glutamate receptors. Also disclosed is a novel combination of technologies, i.e., SELEX and laser pulse photolysis for the selection and screening of aptamers that inhibit receptor function and are useful therefore, in the treatment of diseases associated with excessive activation of ionotropic glutamate receptors.09-06-2012

Ling Niu, Redmond, WA US

Patent application numberDescriptionPublished
20090213206Aggregation of Video Receiving Capabilities - Video receiving capabilities of participants and source capabilities are compared and conference capabilities for providing different resolutions, frame rates, bit rate, and number of streams are determined by maintaining a conference receiving capability list updated as number and capability of participants' changes. Preferred receiving capabilities of participants are also taken into account in determining conference characteristics based on comparison with allowed capabilities.08-27-2009
20090231415Multiple Video Stream Capability Negotiation - Video send and receive capabilities of participants are determined by the respective machines determining available combinations, as well as preferences for the receivers. Receiver capabilities are forwarded to the source for computation of negotiated video capabilities through a logic intersection of the determined capabilities based on desired number of streams and resolutions. If a resolution of a send capability exists within the receive capability, the highest frame and/or bit rate may be selected for transmission.09-17-2009
20120154516AGGREGATION OF VIDEO RECEIVING CAPABILITIES - Video receiving capabilities of participants and source capabilities are compared and conference capabilities for providing different resolutions, frame rates, bit rate, and number of streams are determined by maintaining a conference receiving capability list updated as number and capability of participants' changes. Preferred receiving capabilities of participants are also taken into account in determining conference characteristics based on comparison with allowed capabilities.06-21-2012
20120176469MULTIPLE VIDEO STREAM CAPABILITY NEGOTIATION - Video send and receive capabilities of participants are determined by the respective machines determining available combinations, as well as preferences for the receivers. Receiver capabilities are forwarded to the source for computation of negotiated video capabilities through a logic intersection of the determined capabilities based on desired number of streams and resolutions. If a resolution of a send capability exists within the receive capability, the highest frame and/or bit rate may be selected for transmission.07-12-2012

Mei Niu, Tampa, FL US

Patent application numberDescriptionPublished
20110020863BIOREACTOR ASSEMBLY AND ASSOCIATED METHODS - A bioreactor assembly, including: a housing internally defining a plurality of reaction chambers; a medium flow supply line associated with each of the plurality of reaction chambers, wherein the medium flow supply line associated with each of the plurality of reaction chambers is operable for delivering a medium flow to each of the plurality of reaction chambers; and one or more framed membrane cartridges selectively disposed within each of the plurality of reaction chambers, wherein each of the one or more framed membrane cartridges disposed within each of the plurality of reaction chambers is operable for holding a biochemically active material that is reacted when exposed to the medium flow.01-27-2011

Qiang Niu, Novi, MI US

Patent application numberDescriptionPublished
20120249128MAGNETIC SENSOR SYSTEM - A linear sensor system includes a first field sensor displaced linearly from a second field sensor. A member having high magnetic permeability is disposed between the first field sensor and the second field sensor. The member is optimized in shape and material to completely remove any redirection or interference of the magnetic flux in the field sensors. A torque transmitting device incorporating the linear sensor system is also disclosed.10-04-2012
20120286613ASYMMETRIC STATOR TEETH IN AN ELECTRIC MOTOR - A permanent magnet motor includes a permanent magnet rotor, a stator surrounding the rotor having a plurality of teeth radially inwardly oriented toward a longitudinal axis of the stator wherein each tooth has a tooth length and a tooth tip surface geometry. An asymmetric air gap is defined by variations in the tooth lengths and tooth tip surface geometries.11-15-2012
20120293105ROTOR SLOT ASYMMETRY IN AN ELECTRIC MOTOR - An electric motor includes a stator configured to receive electrical energy and generate an electromagnetic field in accordance with the electrical energy received. A rotor is in electromagnetic communication with the stator and is configured to rotate in accordance with the electromagnetic field generated by the stator. The rotor includes a plurality of poles including a first set of poles and a second set of poles. The first set of poles defines a first slot and the second set of poles defines a second slot that has a different configuration than the first slot to reduce a torque ripple effect. The electric motor may be used in a system having a power source configured to output direct current energy and an inverter configured to convert direct current energy to alternating current energy.11-22-2012
20130020896ROTOR FOR A PERMANENT MAGNET ELECTRIC MACHINE - A rotor for a permanent magnet electric machine includes an axis of rotation, an outer surface, and a cross-section orthogonal to the axis of rotation with a non-circular contour of the outer surface defined by a plurality of radii angularly distributed around the axis of rotation.01-24-2013
20130069470INTERIOR PERMANENT MAGNET MACHINE WITH RADIALLY ASYMMETRIC MAGNET CONFIGURATION - An interior permanent magnet machine is provided with a rotor that includes a plurality of slots and at least one barrier defined by the plurality of slots. A plurality of first and second magnets are disposed within the barrier. The rotor is configured such that at least one of the first magnets is located at a different radial distance from the center of the rotor relative to at least one of the second magnets. The rotor may be configured to produce an averaging effect similar to that achieved through traditional skewing of rotor magnets. The rotor includes a plurality of poles defined by respective pole axes in the rotor and may be configured to reflect radial asymmetry between poles (pole-to-pole) and/or radial asymmetry within a pole.03-21-2013
20130147309ROTOR GEOMETRY FOR REDUCTION OF TORQUE RIPPLE IN A WOUND FIELD MACHINE - An electric machine is provided with a rotor configured to be rotatable within a stator. A first and second tooth are disposed circumferentially along an outer perimeter of the rotor and at least partially define a first slot. The first and the second tooth define a respective first and second outer edge extending between a respective tooth base and a respective tooth tip. An arc radius from the origin to the outer perimeter of the rotor varies along the first outer edge of the first tooth, thereby creating a first non-uniform gap between the rotor and the stator. The arc radius from the origin to the outer perimeter of the rotor varies along the second outer edge of the second tooth, thereby creating a second non-uniform gap between the rotor and the stator. The rotor geometry is configured to reduce torque ripple without skewing either the rotor or the stator.06-13-2013
20130154622MAGNETIC LINEAR POSITION SENSOR - A magnetic linear position sensor includes an array of N number of magnets. The array of magnets is distributed along a line to form a magnetic field relay along the line. The sizes and positions of the magnets in the array of magnets are symmetric along the line, and the size of the magnets decreases from the sides of the array of magnets towards the center of the array of magnets. The magnetic linear position sensor further includes a magnetic field sensor spaced apart and positioned above the array of magnets. The magnetic field sensor moves back and forth over the array of magnets to sense the magnetic field of the array of magnets.06-20-2013
20130270952AXIALLY ASYMMETRIC PERMANENT MAGNET MACHINE - A permanent magnet machine is provided with a rotor positioned at least partially within a stator. The rotor includes first and second ring segments oriented axially around a central axis. The rotor defines first and second configurations in the first and second ring segments, respectively. The first configuration is sufficiently different from the second configuration such that torque ripple may be minimized. A first layer of slots, defining a slot outer edge, may be formed in the rotor. In one embodiment, a stator-to-slot gap varies between the first and second ring segments. In another embodiment, a stator-rotor gap varies between the first and second ring segments. In another embodiment, a bridge thickness varies between the first and second ring segments. Thus the rotor exhibits axial asymmetry.10-17-2013
20140217848INTERIOR PERMANENT MAGNET MACHINE - An interior permanent magnet machine includes a stator including a plurality of electrical conductors. The interior permanent magnet machine further includes a rotor concentrically disposed in relation to the stator. The rotor is configured to rotate relative to the stator about a rotational axis and includes a plurality of polar pieces arranged annularly about the rotational axis. At least one of the polar pieces includes a magnetic layer configured to magnetically interact with the electrical conductors. The magnetic layer has a substantially conic section shape.08-07-2014

Patent applications by Qiang Niu, Novi, MI US

Qiwen Niu, Staten Island, NY US

Patent application numberDescriptionPublished
20150074847ENHANCING PROTEIN STABILITY IN TRANSGENIC PLANTS - The present invention provides compositions and methods for enhancing protein stability in transgenic plants. The compositions are nucleic acid constructs which encode fusion proteins, fusion proteins, transgenic plant cells and transgenic plants. A fusion protein in accordance with the present invention comprises a protein of interest and a UBA1 or UBA2 domain of an 03-12-2015

Qi-Wen Niu, Staten Island, NY US

Patent application numberDescriptionPublished
20100169997PROMOTION OF SOMATIC EMBRYOGENESIS IN PLANTS BY WUSCHEL GENE EXPRESSION - The present invention relates to methods for promoting somatic embryogenesis from a tissue or organ of a plant, by overexpressing a Wuschel gene in said tissue or organ. In one embodiment, such overexpression can be used as a silent selectable marker for transgenic plants. In another embodiment, such expression can be used to confer apomixis to a plant. In another embodiment, such overexpression can be used to create haploid plants, which can be used to produce dihaploid plants.07-01-2010
20110078823PROMOTION OF SOMATIC EMBRYOGENESIS IN PLANTS BY WUSCHEL GENE EXPRESSION - The present invention relates to methods for promoting somatic embryogenesis from a tissue or organ of a plant, by overexpressing a Wuschel gene in said tissue or organ. In one embodiment, such overexpression can be used as a silent selectable marker for transgenic plants. In another embodiment, such expression can be used to confer apomixis to a plant. In another embodiment, such overexpression can be used to create haploid plants, which can be used to produce dihaploid plants.03-31-2011
20110252506PROMOTION OF SOMATIC EMBRYOGENESIS IN PLANTS BY WUSCHEL GENE EXPRESSION - The present invention relates to methods for promoting somatic embryogenesis from a tissue or organ of a plant, by overexpressing a Wuschel gene in said tissue or organ. In one embodiment, such overexpression can be used as a silent selectable marker for transgenic plants. In another embodiment, such expression can be used to confer apomixis to a plant. In another embodiment, such overexpression can be used to create haploid plants, which can be used to produce dihaploid plants.10-13-2011
20120102594PROMOTION OF SOMATIC EMBRYOGENESIS IN PLANTS BY WUSCHEL GENE EXPRESSION - The present invention relates to methods for promoting somatic embryogenesis from a tissue or organ of a plant, by overexpressing a Wuschel gene in said tissue or organ. In one embodiment, such overexpression can be used as a silent selectable marker for transgenic plants. In another embodiment, such expression can be used to confer apomixis to a plant. In another embodiment, such overexpression can be used to create haploid plants, which can be used to produce dihaploid plants.04-26-2012
20130205442PROMOTION OF SOMATIC EMBRYOGENESIS IN PLANTS BY WUSCHEL GENE EXPRESSION - The present invention relates to methods for promoting somatic embryogenesis from a tissue or organ of a plant, by overexpressing a Wuschel gene in said tissue or organ. In one embodiment, such overexpression can be used as a silent selectable marker for transgenic plants. In another embodiment, such expression can be used to confer apomixis to a plant. In another embodiment, such overexpression can be used to create haploid plants, which can be used to produce dihaploid plants.08-08-2013

Patent applications by Qi-Wen Niu, Staten Island, NY US

Qi-Wen Niu, New York, NY US

Patent application numberDescriptionPublished
20080313773PRODUCTION OF ARTIFICIAL MICRORNAS USING SYNTHETIC MICRORNA PRECURSORS - The invention provides methods and compositions useful in target sequence suppression, target sequence validation and target sequence down regulation. The invention provides polynucleotide constructs useful for producing artificial microRNA (amiRNA) using synthetic amiRNA precursors.12-18-2008

Sanjun Niu, Lincoln, NE US

Patent application numberDescriptionPublished
20100237325Highly resolved, low noise, room-temperature coulomb-staircase and blockade up to 2.2V in isolated 50 micron long one dimensional necklace of 10 NM AU particles - Coulomb blockade in metal nanoparticles isolated by a tunneling barrier is considered to be a potential solution to low power, robust, high-speed electronic switching device operating at single-electron transport. However, the switching voltage equal to the threshold voltage to overcome coulomb blockade for these devices is typically in the 10 mV range and/or operating at currents well below 1 nA, which inhibits their application as a practical device. Theoretically, a one dimensional nanoparticle necklace is predicted to be an ideal structure to achieve higher switching voltages. The present invention provides a single-electron device composed of a necklace of about 5000 nanoparticles. The linear necklace is self-assembled by interfacial phenomena along a triple-phase line of fiber, a substrate and electrolyte containing nanoparticles. The I-V measurements on the system show both coulomb blockade and staircase, with high currents and high threshold voltage of 1-3 V. The present invention also provides methods for constructing such a device.09-23-2010

Sanjun Niu, Mundelein, IL US

Patent application numberDescriptionPublished
20100120236FABRICATION OF ULTRA LONG NECKLACE OF NANOPARTICLES - The present invention provides a single-electron device composed of a necklace of about 5000 nanoparticles. The linear necklace is self-assembled by interfacial phenomena along a triple-phase line of fiber, a substrate and electrolyte containing nanoparticles. A variety of combinations of nanoparticles, such as Au and CdS nanoparticles, may be used to form a necklace. The I-V measurements on the system show both coulomb blockade and staircase, with high currents and high threshold voltage of 1-3 V. The present invention also provides methods for constructing such a device.05-13-2010
20100243984Live bioelectronic cell gated nanodevice - This invention is directed toward a bioelectronic cell gated nanodevice. The bioelectronic cell gated nanodevice comprises a plurality of bioelectric cells deposited on a fiber of a nanodevice. The bioelectronic cells of the nanodevice act as a gate, allowing current to be transmitted when the bioelectronic cells are exposed to an actuating chemical. The present invention also provides methods for constructing such a device.09-30-2010

Sanjun Niu, Lake Villa, IL US

Patent application numberDescriptionPublished
20090069743INFUSION THERAPY SENSOR SYSTEM - A sensor system for use with an infusion system may include at least one sensor disposed within a catheter, the at least one sensor comprising at least one of an optical sensor, an electrical sensor or a chemical/biochemical sensor. The sensor system may instead include a sample cell that is in fluid communication with the infusion system, which sample cell may be used with an analyzer to determine a patient's condition. The sensor system may be integrated with a control system for an infusion pump to control operation of the pump.03-12-2009

Suyi Niu, Salt Lake City, UT US

Patent application numberDescriptionPublished
20080228151Transdermal drug delivery with controlled heat for treating musculoskeletal pain and/or inflammation - Systems and methods for transdermal drug delivery with controlled heat are provided. Such systems can comprise a heating apparatus that includes an exothermic chemical composition, typically in the form of individual heating elements. The heating apparatus can be exposed to ambient oxygen through a cover. The cover can reduce the amount of ambient oxygen capable of contacting the chemical composition compared to when the cover is not present. In some embodiments, the heating apparatus can include more than one heating element. The systems can further include a drug-containing layer that includes a drug. The drug-containing layer can have a surface area of about 50 cm09-18-2008
20120022158SOLID-FORMING LOCAL ANESTHETIC FORMULATIONS FOR PAIN CONTROL - Solid-forming local anesthetic formulations for pain control can include a lidocaine base and tetracaine base, polyvinyl alcohol, water, and an emulsifier. The formulation can be prepared to be in a semi-solid state prior to application to a skin surface, can form a soft solidified layer after application, and can provide pain relief when applied to a skin surface proximate a pain site.01-26-2012

Patent applications by Suyi Niu, Salt Lake City, UT US

Tianye Niu, Atlanta, GA US

Patent application numberDescriptionPublished
20120263360SCATTER CORRECTION METHODS - Described herein are improved methods for correcting cone beam computed tomography signals to reduce scatter contamination contained therein. Generally, the improved methods involve generating a plurality of two-dimensional projection images of a subject from a three-dimensional multi-detector computed tomography image of the subject. This is followed by subtracting the plurality of two-dimensional projection images from a plurality of two-dimensional cone beam projection images of the subject to produce a plurality of two-dimensional estimated error projections that comprise an estimated error in the plurality of two-dimensional cone beam projection images. The plurality of two-dimensional estimated error projection images are subtracted from the plurality of two-dimensional cone beam projection images to generate a plurality of two-dimensional corrected cone beam projection images. A three-dimensional corrected cone beam computed tomography image of the subject is then constructed from the plurality of two-dimensional corrected cone beam projection images.10-18-2012
20130032715X-RAY COMPTON SCATTER IMAGING ON VOLUMETRIC CT SYSTEMS - Briefly described, in an exemplary form, the present invention discloses a system, method and apparatus for X-ray Compton scatter imaging. In one exemplary embodiment, the present invention uses two detectors in a volumetric CT system. A first detector is positioned generally in-line with the angle of attack of the incoming energy, or, generally in-line of path x, where x is the path of the incoming energy. The first, or primary, detector detects various forms of radiation emanating from an object undergoing testing. In some embodiments, the present invention further comprises a Compton scattering system positioned generally normal to path x. In some embodiments, the Compton scattering subsystem comprises a second detector and a pin-hole collimator. The second detector detects Compton scattering energy from the object being tested.02-07-2013

Wei Niu, Lincoln, NE US

Patent application numberDescriptionPublished
20110045575MICROORGANISMS FOR THE PRODUCTION OF 1,4-BUTANEDIOL AND RELATED METHODS - The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO) pathway comprising at least one exogenous nucleic acid encoding a BDO pathway enzyme expressed in a sufficient amount to produce BDO and further optimized for expression of BDO. The invention additionally provides methods of using such microbial organisms to produce BDO.02-24-2011
20110129899MICROORGANISMS FOR THE PRODUCTION OF 1,4-BUTANEDIOL, 4-HYDROXYBUTANAL, 4-HYDROXYBUTYRYL-COA, PUTRESCINE AND RELATED COMPOUNDS, AND METHODS RELATED THERETO - The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO), 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway comprising at least one exogenous nucleic acid encoding a BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway enzyme expressed in a sufficient amount to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine and further optimized for expression of BDO. The invention additionally provides methods of using such microbial organisms to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine.06-02-2011
20110217742MICROORGANISMS AND METHODS FOR THE COPRODUCTION 1,4-BUTANEDIOL AND GAMMA-BUTYROLACTONE - The invention provides non-naturally occurring microbial organisms comprising 1,4-butanediol (14-BDO) and gamma-butyrolactone (GBL) pathways comprising at least one exogenous nucleic acid encoding a 14-BDO and GBL pathway enzyme expressed in a sufficient amount to produce 14-BDO and GBL. The invention additionally provides methods of using such microbial organisms to produce 14-BDO and GBL.09-08-2011
20110229946MICROORGANISMS FOR THE PRODUCTION OF 1,4-BUTANEDIOL, 4-HYDROXYBUTANAL, 4-HYDROXYBUTYRYL-COA, PUTRESCINE AND RELATED COMPOUNDS, AND METHODS RELATED THERETO - The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO), 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway comprising at least one exogenous nucleic acid encoding a BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway enzyme expressed in a sufficient amount to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine and further optimized for expression of BDO. The invention additionally provides methods of using such microbial organisms to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine.09-22-2011
20120225463MICROORGANISMS FOR THE PRODUCTION OF 1,4-BUTANEDIOL AND RELATED METHODS - The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO) pathway comprising at least one exogenous nucleic acid encoding a BDO pathway enzyme expressed in a sufficient amount to produce BDO and further optimized for expression of BDO. The invention additionally provides methods of using such microbial organisms to produce BDO.09-06-2012
20130029381MICROORGANISMS FOR THE PRODUCTION OF 1,4-BUTANEDIOL, 4-HYDROXYBUTANAL, 4-HYDROXYBUTYRYL-COA, PUTRESCINE AND RELATED COMPOUNDS, AND METHODS RELATED THERETO - The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO), 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway comprising at least one exogenous nucleic acid encoding a BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway enzyme expressed in a sufficient amount to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine and further optimized for expression of BDO. The invention additionally provides methods of using such microbial organisms to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine.01-31-2013
20130189751MICROORGANISMS FOR THE PRODUCTION OF 1,4-BUTANEDIOL, 4-HYDROXYBUTANAL, 4-HYDROXYBUTYRYL-COA, PUTRESCINE AND RELATED COMPOUNDS, AND METHODS RELATED THERETO - The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO), 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway comprising at least one exogenous nucleic acid encoding a BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway enzyme expressed in a sufficient amount to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine and further optimized for expression of BDO. The invention additionally provides methods of using such microbial organisms to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine.07-25-2013
20130196397COMPOSITIONS AND METHODS FOR THE BIOSYNTHESIS OF 1,4-BUTANEDIOL AND ITS PRECURSORS - The invention provides a non-naturally occurring microbial biocatalyst including a microbial organism having a 4-hydroxybutanoic acid (4-HB) biosynthetic pathway having at least one exogenous nucleic acid encoding 4-hydroxybutanoate dehydrogenase, succinyl-CoA synthetase, CoA-dependent succinic semialdehyde dehydrogenase, or α-ketoglutarate decarboxylase, wherein the exogenous nucleic acid is expressed in sufficient amounts to produce monomeric 4-hydroxybutanoic acid (4-HB). Also provided is a non-naturally occurring microbial biocatalyst including a microbial organism having 4-hydroxybutanoic acid (4-HB) and 1,4-butanediol (BDO) biosynthetic pathways, the pathways include at least one exogenous nucleic acid encoding 4-hydroxybutanoate dehydrogenase, succinyl-CoA synthetase, CoA-dependent succinic semialdehyde dehydrogenase, 4-hydroxybutyrate:CoA transferase, 4-butyrate kinase, phosphotransbutyrylase, α-ketoglutarate decarboxylase, aldehyde dehydrogenase, alcohol dehydrogenase or an aldehyde/alcohol dehydrogenase, wherein the exogenous nucleic acid is expressed in sufficient amounts to produce 1,4-butanediol (BDO). Additionally provided are methods for the production of 4-HB and BDO.08-01-2013
20140162327MICROORGANISMS AND METHODS FOR THE COPRODUCTION 1,4-BUTANEDIOL AND GAMMA-BUTYROLACTONE - The invention provides non-naturally occurring microbial organisms comprising 1,4-butanediol (14-BDO) and gamma-butyrolactone (GBL) pathways comprising at least one exogenous nucleic acid encoding a 14-BDO and GBL pathway enzyme expressed in a sufficient amount to produce 14-BDO and GBL. The invention additionally provides methods of using such microbial organisms to produce 14-BDO and GBL.06-12-2014

Patent applications by Wei Niu, Lincoln, NE US

Wei Niu, Wayland, MA US

Patent application numberDescriptionPublished
20100099116Methods for Analysis of Hedgehog Pathway Inhibitors - One aspect of the present invention relates to a method of ascertaining the inhibitory activity in a mammal of a candidate inhibitor of the hedgehog pathway. In certain embodiments, the candidate inhibitor is administered systemically. In certain embodiments, the mammal is a rodent or primate. In certain embodiments, the mammal is a mouse. In certain embodiments, the candidate inhibitor is a small molecule or natural product.04-22-2010

Weijun Niu, Painted Post, NY US

Patent application numberDescriptionPublished
20100305288Fused Thiophenes, Articles, and Methods Thereof - Fused thiophene (FT) compounds, FT polymers, FT containing articles, and methods for making and using the FT compounds and polymers thereof of the formulas, as defined herein.12-02-2010
20110166307FUSED THIOPHENES, ARTICLES, AND METHODS THEREOF - Fused thiophene (FT) compounds, FT polymers, FT containing articles, and methods for making and using the FT compounds and polymers thereof of the formulas, as defined herein.07-07-2011
20110288306METHODS OF MAKING FUSED THIOPHENES - β″-di-R-substituted fused thiophene (DCXFT4) compounds, and a method for making a compound of the formula (V):11-24-2011
20110291054POLYMERIC FUSED THIOPHENE SEMICONDUCTOR FORMULATION - A formulation including: 12-01-2011
20120022116COMPOSITIONS AND METHODS FOR THE TREATMENT OF PATHOLOGICAL CONDITION(S) RELATED TO GPR35 AND/OR GPR35-HERG COMPLEX - Disclosed are compositions and methods for the prevention and/or treatment of diseases which are pathophysiologically related to GPR35, and/or GPR35-hERG signaling complex. For example, disclosed are compounds for preventing and/or treating diseases which are pathophysiologically related to GPR35 in a subject. The compounds having a formula (I), (II) or (III):01-26-2012
20120035375DI-TIN FUSED THIOPHENE COMPOUNDS AND POLYMERS AND METHODS OF MAKING - Di-tin fused thiophene (FT) compounds, FT polymers, such as of the formula -{-(FTx)-(Ar)02-09-2012
20120220748FIVE-RING FUSED HETEROAROMATIC COMPOUNDS AND CONJUGATED POLYMERS THEREOF - Compounds having a core comprised of an aromatic ring and at least two annulated beta-substituted fused thiophene ring systems of the general formula:08-30-2012
20120295965FUSED THIOPHENES AS DUAL INHIBITORS OF EGFR/VEGFR AND THEIR USE IN THE TREATMENT OF CANCER - Disclosed are compositions and methods related to identification of modulators of EGFR and VEGFR.11-22-2012
20120329865MOLECULES RELATED hERG ION CHANNELS AND THE USE THEREOF - Disclosed are compounds having structural formula (I, II) or a pharmaceutically acceptable sale, solvate, clathrate, or prodrug thereof, wherein R12-27-2012
20130085256FUSED THIOPHENES, METHODS OF MAKING FUSED THIOPHENES, AND USES THEREOF - Described herein are compositions including heterocyclic organic compounds based on fused thiophene compounds, polymers based on fused thiophene compounds, and methods for making the monomers and polymer along with uses in thin film-based and other devices.04-04-2013
20130109821CONJUGATED FUSED THIOPHENES, METHODS OF MAKING CONJUGATED FUSED THIOPHENES, AND USES THEREOF05-02-2013
20130178599FIVE-RING FUSED HETEROAROMATIC COMPOUNDS AND CONJUGATED POLYMERS THEREOF - Compounds having a core comprised of an aromatic ring and at least two annulated beta-substituted fused thiophene ring systems of the general formula:07-11-2013
20130302003PRIMARY OPTICAL FIBER COATING COMPOSITION CONTAINING NON-RADIATION CURABLE COMPONENT - A radiation curable composition is disclosed that includes a curable cross-linker essentially free of urethane and urea functional groups, a curable diluent, and a non-radiation curable component comprising (thio)urethane and/or urea groups. Coated optical fibers having a primary coating formed from this radiation curable composition, as well as optical fiber ribbons that contain the coated optical fibers are disclosed. Methods of making the optical fibers and ribbons are also disclosed.11-14-2013
20140341521LOW COST, FAST CURING OPTICAL FIBER COATINGS - A low cost composition that cures rapidly and which is suitable for coating an optical fiber comprises at least one ethylenically unsaturated monomer; at least one photoinitiator; and at least one non-radiation-curable polar polymer having pendent groups that facilitate low energy chemical bonding, hydrogen bonding, dipolar interactions or other interactions with radical compounds formed during polymerization of the monomer. The non-radiation-curable polar polymer(s) are inexpensive and reduce and/or eliminate the need for expensive urethane acrylate oligomers, without sacrificing properties, and while achieving rapid cure speeds.11-20-2014
20140341524OPTICAL FIBER COATING COMPOSITIONS WITH NON-CURABLE REINFORCING AGENTS - A coating composition including a reinforcing agent. The coating composition may include one or more radiation-curable monofunctional monomers, one or more radiation-curable multifunctional monomers or oligomers, a photoinitiator, and a reinforcing agent. The monofunctional monomers, multifunctional monomers, and multifunctional oligomers may include acrylate groups. The reinforcing agent may be an acrylic co-polymer that includes two or more repeat units. At least one of the repeat units includes chemical groups that enable self-association of the acrylic co-polymer. Self-association of the acrylic co-polymer may improve the tensile strength of coatings formed from the coating compositions.11-20-2014
20140357889SYNTHESIS OF POLYFUNCTIONAL POLYOL ACRYLATES - A method of synthesizing urethane-free polyfunctional acrylate compounds. The method includes reaction of a polyol with acrylic acid in the presence of an inhibitor. A catalyst may also be present. The catalyst may be an acid and the inhibitor may be a substituted phenol compound. Excess acid may be removed by adding a salt and excess water may be removed by adding a drying agent. The reaction converts alcohol groups of the polyol to acrylate groups to provide a radiation-curable polyfunctional acrylate compound. The reaction is applicable to polyols generally and provides a scalable high yield process for forming urethane-free polyfunctional acrylates over a wide range of molecular weights. Coatings made from the acrylate products exhibit modulus and tensile strength characteristics favorable for primary fiber coatings.12-04-2014
20150045560NOVEL FUSED NAPHTHALENE CYCLOHETERO RING COMPOUNDS, AND METHODS AND USES THEREOF - Described herein are heterocyclic organic compounds of following formulae: More specifically, described herein are fused heterocyclic naphthalene compounds, polymers based on fused heterocyclic naphthalene compounds, methods for making these compounds, and uses thereof. The compounds described have improved polymerization and stability properties that allow for improved material processibility for use as organic semiconductors (OSCs).02-12-2015
20150057420BORON ESTER FUSED THIOPHENE MONOMERS - A compound of formula (I), formula (II), or a combination thereof, and salts thereof is described.02-26-2015
20150065722FUSED THIOPHENE DITIN MONOMERS - The disclosure relates to thiophene-based ditin compounds and methods of making and using such compounds. The disclosed compounds are novel structures having organotin groups on a conjugated aryl group spaced from and adjacent to a fused thiophene moiety. The formation of trialkyl tin groups spaced away from the fused thiophene moieties is advantageous in that it allows for novel polymerization via Stille coupling.03-05-2015

Patent applications by Weijun Niu, Painted Post, NY US

Xiang Niu, Watertown, MA US

Patent application numberDescriptionPublished
20110046398INTERMEDIATES IN THE SYNTHESIS ZEARALENONE MACROLIDE ANALOGS - Disclosed herein are methods and intermediates useful in the preparation of macrolides, e.g., compounds of formula (IV), wherein R02-24-2011
20110060151REAGENTS AND METHODS FOR THE BETA-KETO AMIDE SYNTHESIS OF A SYNTHETIC PRECURSOR TO IMMUNOLOGICAL ADJUVANT E6020 - This invention relates to the synthesis for a precursor of E6020, compound 26, via a β-keto amide alcohol intermediate, compound 22. The synthesis reacts compound 22 with compound 25 and the resultant intermediate is oxidized to produce compound 26, the precursor to E6020. Compounds 22 and 25, and their crystalline forms, represent separate embodiments of the invention. The invention also relates to compounds of formulas (3) and (4) and processes for their preparation.03-10-2011
20110237805INTERMEDIATES AND METHODS FOR MAKING ZEARALENONE MACROLIDE ANALOGS - Disclosed herein are methods and intermediates useful in the preparation of macrolides, e.g., compounds of formula (IV) wherein R09-29-2011
20130211103INTERMEDIATES AND METHODS FOR MAKING ZEARALENONE MACROLIDE ANALOGS - Disclosed herein are methods and intermediates useful in the preparation of macrolides, e.g., compounds of formula (IV)08-15-2013

Xiang Niu, Malden, MA US

Patent application numberDescriptionPublished
20090187038REAGENTS AND METHODS FOR THE BETA-KETO AMIDE SYNTHESIS OF A SYNTHETIC PRECURSOR TO IMMUNOLOGICAL ADJUVANT E6020 - This invention relates to the synthesis for a precursor of E6020, compound 26, via a β-keto amide alcohol intermediate, compound 22. The synthesis reacts compound 22 with compound 25 and the resultant intermediate is oxidized to produce compound 26, the precursor to E6020. Compounds 22 and 25, and their crystalline forms, represent separate embodiments of the invention. The invention also relates to compounds of formulas (3) and (4) and processes for their preparation.07-23-2009
20120232298COMPOUNDS FOR PREPARING IMMUNOLOGICAL ADJUVANT - The present invention provides methods for preparing TLR-4 receptor agonist E6020:09-13-2012
20140012011COMPOUNDS FOR PREPARING IMMUNOLOGICAL ADJUVANT - The present invention provides methods for preparing TLR-4 receptor agonist E6020:01-09-2014
20140323739COMPOUNDS FOR PREPARING IMMUNOLOGICAL ADJUVANT - The present invention provides methods for preparing TLR-4 receptor agonist E6020:10-30-2014

Patent applications by Xiang Niu, Malden, MA US

Xiaobin Niu, Salt Lake City, UT US

Patent application numberDescriptionPublished
20140027710QUANTUM DOT AND NANOWIRE SYNTHESIS - A self-assembled semiconductor nanostructure includes a core and a shell, wherein one of the core or the shell is rich in a strained component and the other of the core or the shell is rich in an unstrained component, wherein the nanostructure is a quantum dot or a nanowire. A method includes growing a semiconductor alloy structure on a substrate using a growth mode that produces a semiconductor alloy structure having a self-assembled core and shell and allowing the structure to equilibrate such that one of the core or the shell is strained and the other is unstrained. Another method includes growing at least one semiconductor alloy nanostructures on a substrate, wherein the nanostructure comprises a strained component and an unstrained component, and controlling a compositional profile during said growing such that a transition between the strained component and an unstrained component is substantially continuous.01-30-2014

Xiaofeng Niu, Mundelein, IL US

Patent application numberDescriptionPublished
20130304386RANDOM ESTIMATION IN POSITRON EMISSION TOMOGRAPHY WITH TANGENTIAL TIME-OF-FLIGHT MASK - A method of estimating random events in positron emission tomography list mode data, including obtaining time-of-flight (TOF) list mode count data that includes TOF information; converting the obtained TOF list mode count data into four-dimensional (4D) raw sinogram count data, without using the TOF information, wherein the 4D raw sinogram count data includes random count values; interpolating the 4D raw sinogram count data to generate 4D interpolated sinogram count data; low-pass filtering the 4D interpolated sinogram count data to remove noise; converting the low-pass filtered 4D interpolated sinogram count data into filtered 4D raw sinogram count data; and generating, by a processor, five-dimensional (5D) TOF raw sinogram count data from the filtered 4D raw sinogram count data by effectively applying a TOF mask filter to the filtered 4D raw sinogram count data.11-14-2013
20130308873APPARATUS AND METHOD FOR SMOOTHING RANDOM EVENT DATA OBTAINED FROM A POSITRON EMISSION TOMOGRAPHY SCANNER - A method and apparatus for smoothing random event data obtained from a Positron Emission Tomography (PET) scanner. The method includes obtaining initial random event data u(s, φ, t=0)=u11-21-2013
20130311142RANDOM COINCIDENCE REDUCTION IN POSITRON EMISSION TOMOGRAPHY USING TANGENTIAL TIME-OF-FLIGHT MASK - A method and apparatus for reducing random events in positron emission tomography (PET) list mode data, the method including the steps of obtaining, for a PET scanner having a given reconstruction field of view (FOV), time-of-flight (TOF) prompt list-mode count data that includes TOF information, the TOF prompt list-mode count data including a plurality of entries; and filtering the obtained prompt list-mode count data by removing those entries in the obtained prompt list-mode count data that represent emission points lying outside a tangential TOF mask to obtain filtered list-mode count data.11-21-2013
20140095106FIELD-OF-VIEW-DEPENDENT COINCIDENCE WINDOW FOR POSITRON EMISSION TOMOGRAPHY - A method and apparatus for determining a coincidence window for imaging a region of interest of an object using a Positron Emission Tomography (PET) scanner. The method includes determining a diameter of a transverse field of view (FOV) for imaging the region of interest of the object; and calculating the coincidence window based on the determined diameter, a ring diameter of the PET scanner, an axial length of the PET scanner, and a time-of-flight resolution of the PET scanner.04-03-2014

Yanhui Niu, Newark, DE US

Patent application numberDescriptionPublished
20080242831Lower-color polytrimethylene ether glycol using zero-valent metals - The present invention relates to a process for preparing lower-color polytrimethylene ether glycol polymer, comprising contacting said polytrimethylene ether glycol polymer, or its precursor reaction-mixture, with a zero-valent metal during at least one stage of the process of manufacture, or on the polytrimethylene glycol resulting form such process, such that the polytrimethylene ether glycol polymer demonstrates a reduced color (as compared to using no zero-valent metal).10-02-2008
20100204376Rheology Control Agents - The present invention provides for a rheology control agent that includes a following compound represented by the following formula:08-12-2010
20100204436PROCESS FOR PREPARING POLY(TRIMETHYLENE ETHER) GLYCOL AND COPOLYMERS THEREOF - Processes for preparing relatively high molecular weight poly(trimethylene ether)glycol employing a cocatalyst system are provided.08-12-2010
20100204439PROCESSES FOR MAKING POLY(TRIMETHYLENE ETHER) GLYCOL USING ORGANOPHOSPHOROUS COMPOUND - Processes for preparing poly(trimethylene ether)glycol-based polymers using an organophosphorous compound are provided.08-12-2010

Patent applications by Yanhui Niu, Newark, DE US

Youhong Niu, Tampa, FL US

Patent application numberDescriptionPublished
20140004039RGD MIMETIC y-AAPEPTIDES AND METHODS OF USE01-02-2014

Yuhua Niu, Newton, MA US

Patent application numberDescriptionPublished
20100051915POLYMER CHARGE TRANSPORT MATERIAL FOR OPTOELECTRONIC DEVICES - Polymers that enable the use of high work-function metals as a cathode in optoelectronic devices and optoelectronic devices incorporating the polymers as an electron transport layer.03-04-2010

Yuhua Niu, Waltham, MA US

Patent application numberDescriptionPublished
20130009131DEVICE INCLUDING QUANTUM DOTS - A device including an emissive material comprising quantum dots is disclosed. In one embodiment, the device includes a first electrode and a second electrode, a layer comprising quantum dots disposed between the first electrode and the second electrodes, and a first interfacial layer disposed at the interface between a surface of the layer comprising quantum dots and a first layer in the device. In certain embodiments, a second interfacial layer is optionally further disposed on the surface of the layer comprising quantum dots opposite to the first interfacial layer. In certain embodiments, a device comprises a light-emitting device. Other light emitting devices and methods are disclosed.01-10-2013
20150028305LIGHT EMITTING DEVICE INCLUDING BLUE EMITTING QUANTUM DOTS AND METHOD - A method for preparing a light emitting device comprising: disposing an electron-injection layer comprising a metal oxide on a cathode, disposing a first layer adjacent the electron-injection layer, the first layer comprising a small molecule material with a bandgap of at least about 3 eV capable of blocking holes, forming an emissive layer comprising quantum dots capable of emitting blue light upon excitation at a surface of the first layer opposite the electron-injection layer; disposing a second layer comprising a material capable of transporting holes and blocking electrons with a bandgap of at least about 3 eV adjacent a surface of the emissive layer opposite the first layer, and disposing an anode over the second layer. A light-emitting device is also disclosed.01-29-2015

Yu-Hua Niu, Seattle, WA US

Patent application numberDescriptionPublished
20090153021LARGE-BANDGAP HOST MATERIALS FOR PHOSPHORESCENT EMITTERS - Polymers and compounds having high-triplet-energy; guest-host films comprising the polymers or compounds as hosts and phosphorescent compounds as guests; and electroluminescent devices that include the films.06-18-2009
20090278445CROSSLINKABLE HOLE-TRANSPORTING MATERIALS FOR ORGANIC LIGHT-EMITTING DEVICES - Crosslinkable compounds useful for making hole-transporting materials for organic light-emitting devices, hole-transporting layers made from the crosslinkable compounds, and light-emitting devices that include the hole-transporting layers.11-12-2009

Yuping Niu, River Vale, NJ US

Patent application numberDescriptionPublished
20080234340Synthesis and characterization of polymorph form II of 4-(2-(4,4-dimethyl-2-oxooxazolidin-3-YL)thiazol-4-YL)benzonitrile - A polymorph Form II of 4-(2-(4,4-dimethyl-2-oxooxazolidin-3-yl)thiazol-4-yl)benzonitrile and methods of preparing Form II are described. Also provided are methods of contraception, treating or preventing fibroids, uterine leiomyomata, endometriosis, dysfunctional bleeding, polycystic ovary syndrome, and hormone-dependent carcinomas, providing hormone replacement therapy, stimulating food intake, and synchronizing estrus including using polymorph Form II of 4-(2-(4,4-dimethyl-2-oxooxazolidin-3-yl)thiazol-4-yl)benzonitrile.09-25-2008
20080312306POLYMORPHS, SOLVATES, AND HYDRATE OF 5-(4'-FLUORO-2'-OXO-1',2'-DIHYDROSPIRO[CYCLOPROPANE-1,3'-INDOL]-5'-YL)-1-METHYL-1H-PYRROLE-2-CARBONITRILE - Novel polymorph Form II and III, solvate Forms I, II, III, and IV, and the hydrate of 5-(4′-fluoro-2′-oxo-1′,2′-dihydrospiro[cyclopropane-1,3′-indol]-5′-yl)-1-methyl-1H-pyrrole-2-carbonitrile are provided, as are methods for preparing the same. Pharmaceutical compositions and kits containing these novel polymorphs, solvates, and hydrate, and combinations thereof are further provided, as are methods of contraception; treating or preventing fibroids, uterine leiomyomata, endometriosis, dysfunctional bleeding, polycystic ovary syndrome, hormone-dependent carcinomas; treating symptoms of premenstrual syndrome and premenstrual dysphoric disorder; providing hormone replacement therapy; stimulating food intake; synchronizing estrus; or treating symptoms of premenstrual syndrome using one or more of these polymorphs, solvates, or hydrate.12-18-2008
20110281900Crystalline Pharmaceutical - New crystalline forms of lopinavir are disclosed.11-17-2011
20140303369Crystalline Pharmaceutical - New crystalline forms of lopinavir are disclosed.10-09-2014

Patent applications by Yuping Niu, River Vale, NJ US

Zhaoyang Niu, Hanover, NH US

Patent application numberDescriptionPublished
20140308340METHOD FOR SELECTIVELY INHIBITING ACAT1 IN THE TREATMENT OF NEURODEGENERATIVE DISEASES - The present invention features methods for stimulating clearance of misfolded or aggregated proteins or peptides in microglia, and treating neurodegenerative diseases associated with such pathology in brain by selectively inhibiting the expression or activity of Acyl-CoA:Cholesterol Acyltransferase 1, but not Acyl-CoA:Cholesterol Acyltransferase 2.10-16-2014
20150079161METHOD FOR SELECTIVELY INHIBITING ACAT1 IN THE TREATMENT OF NEURODEGENERATIVE DISEASES - The present invention features methods for stimulating clearance of misfolded or aggregated proteins or peptides in microglia or neurons, and treating neurodegenerative diseases associated with such pathology in brain by selectively inhibiting the expression or activity of Acyl-CoA:Cholesterol Acyltransferase 1, but not Acyl-CoA:Cholesterol Acyltransferase 2.03-19-2015
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