Patent application number | Description | Published |
20090318665 | PHARMACEUTICAL FORMULATIONS - Good bioavailability of desmopressin can be obtained by means of an orodispersible pharmaceutical dosage form. Preferred dosage forms comprise desmopressin and an open matrix network which is an inert water-soluble or water-dispersible carrier material. Desmopressin formulated in this way is useful for voiding postponement, or the treatment or prevention of incontinence, primary noctural enuresis (PNE), nocturia or central diabetes insipidus. Peptides other than desmopressin can also be formulated in this way. | 12-24-2009 |
20120071538 | PHARMACEUTICAL FORMULATONS - Good bioavailability of desmopressin can be obtained by means of an orodispersible pharmaceutical dosage form. Preferred dosage forms comprise desmopressin and an open matrix network which is an inert water-soluble or water-dispersible carrier material. Desmopressin formulated in this way is useful for voiding postponement, or the treatment or prevention of incontinence, primary noctural enuresis (PNE), nocturia or central diabetes insipidus. Peptides other than desmopressin can also be formulated in this way. | 03-22-2012 |
20130281662 | PROCESS FOR THE MANUFACTURE OF DEGARELIX AND ITS INTERMEDIATES - The present invention relates to a liquid (or solution)-phase manufacturing process for preparing the decapeptide Degareiix, its amino-protected precursor, and other useful intermediates. The invention further relates to polypeptides useful in the solution-phase manufacturing process and to the purification of Degareiix itself. The manufacturing process comprises the step of cleaving the ε-amino protecting group Pε from a Degareiix precursor according to formula {P | 10-24-2013 |
20150088902 | Methods And Systems For Data Management And Analysis - Provided are methods comprising receiving a query for information from the database, determining particular data element types and data element values that are the subject of the query, instantiating a query data structure containing the data element types and the data element values that are the subject of the query, identifying records within the database that contain one or more data element types and/or data element values that are included in the query data structure, and instantiating a results data structure comprising information relating to the identified records. | 03-26-2015 |
20150141337 | MANUFACTURE OF DEGARELIX - The present invention provides methods for producing a lyophilized degarelix product which, upon reconstitution with water for injection in an amount of 20 mg/ml, shows a viscosity of up to 15 mPas. The present invention also provides a lyophilized degarelix drug substance which shows, upon dissolution in water in an amount of 20 mg/ml, a viscosity of up to 3.2 mPas, and processes for providing this lyophilized degarelix drug substance. | 05-21-2015 |
20150150938 | PHARMACEUTICAL FORMULATIONS - Good bioavailability of desmopressin can be obtained by means of an orodispersible pharmaceutical dosage form. Preferred dosage forms comprise desmopressin and an open matrix network which is an inert water-soluble or water-dispersible carrier material. Desmopressin formulated in this way is useful for voiding postponement, or the treatment or prevention of incontinence, primary noctural enuresis (PNE), nocturia or central diabetes insipidus. Peptides other than desmopressin can also be formulated in this way. | 06-04-2015 |
Patent application number | Description | Published |
20120174931 | PHARYNX PROTECTOR - A pharynx protector may include a proximal end and a distal end, the distal end being adapted to be inserted into an oesophagus of a patient. The protector may include an elongated tubular part and a distally located receiving portion for receiving a puncture needle during a laryngectomy, wherein the tubular part is substantially flexible. The receiving portion may include a first opening, communicating with a lumen of the tubular part, such that a guide wire may be inserted through the first opening and further passed proximally out of the pharynx protector. A surface of an inner wall may be of a rigid material. | 07-12-2012 |
20140102044 | APPARATUS AND METHOD FOR MANUFACTURE OF A SECONDARY PACKAGE - A method for producing a secondary package, comprising a separate lid and tray, for encasing primary packages, the method comprises folding the lid from a first blank, comprising long side areas along a length of the blank and, at each of opposite short ends of the blank, two cuts are made forming two side flaps and a side cover, separated by the cuts, and folding a tray from a second blank, comprising side areas along a length of the blank. The method comprises folding the side areas of the first blank to form long lid sides; placing the second blank onto a substantially horizontal support rail, between operation flaps; thereby folding the side areas of the second blank to form long tray sides; loading the tray with primary packages; applying the lid to the primary packages, with the long lid sides between the primary packages and the long tray sides. | 04-17-2014 |
Patent application number | Description | Published |
20130181991 | Five-Dimensional Occlusion Queries - A standard occlusion query (OQ) may be generalized to five dimensions, which can be used for motion blurred, defocused, occlusion culling. As such, the occlusion query concept is generalized so that it can be used within 5D rasterization, which is used for rendering of motion blur and depth of field. For 5D rasterization, occlusion culling may be done with OQs as well, applied to solve other rendering related problems. | 07-18-2013 |
20130181992 | TIME-CONTINUOUS COLLISION DETECTION USING 3D RASTERIZATION - We present a technique that utilizes a motion blur (three dimensional) rasterizer to augment the PCS culling technique so that it can be used for continuous collision detection, which to the best of our knowledge has not been done before for motion blur using a graphics processor. | 07-18-2013 |
20130268569 | SELECTING A TILE SIZE FOR THE COMPRESSION OF DEPTH AND/OR COLOR DATA - In accordance with some embodiments, depth and/or color data may be compressed by selecting one of at least two different tile sizes based on considerations of storage requirements and average number of samples per tile. | 10-10-2013 |
20140015835 | Five-Dimensional Rasterization with Conservative Bounds - A per-tile test in the 5D rasterizer outputs intervals for both lens parameters, (u,v), and for time, t, as well as for depth z. These intervals are conservative bounds for the current tile for 1) the visible lens region, 2) the time the triangle overlaps the tile, and 3) the depth range for the triangle inside the tile. | 01-16-2014 |
20140139524 | Depth Buffering - In accordance with some embodiments, depth values may be split into more and less significant bits. By so doing, some processing can be done based only on the more significant bits. Where the number of more significant bits is significantly less than the total number of bits, some memory bandwidth can be preserved. In other words, by only using the more significant bits for some of the depth buffering operations, memory bandwidth usage can be reduced, improving efficiency. | 05-22-2014 |
20140168244 | Color Buffer Caching - A color buffer cache may be implemented in a way that reduces memory bandwidth. In one embodiment this may be done by determining whether a corresponding tile being rendered is completely inside a triangle. If so, the cache lines that correspond to this tile may be marked as “less useful”. As a result of being marked as less useful, those cache lines may be replaced before other cache lines in one embodiment. Thus a color buffer cache is used for those tiles that overlap with at least one triangle edge. The use of such a color buffer cache scheme may be more efficient and therefore may reduce memory bandwidth in some embodiments. | 06-19-2014 |
20140258754 | Reducing Power Consumption During Graphics Rendering - In accordance with some embodiments, the knowledge that a capped frame time is used can be exploited to reduce power consumption. Generally a capped frame time is a pre-allocated amount of time to apply power for rendering in graphics processing. Generally the frame time involves the application of power and some down time in which only idle power is applied pending the next frame time. By making better use of that down time, power consumption reductions can be achieved in some embodiments. | 09-11-2014 |
20140300619 | Programmable Tile Shader - In accordance with some embodiments, a tile shader executes on a group of pixels prior to a pixel shader. The tile of pixels may be rectangular in some embodiments. The tile may be executed hierarchically, refining each tile into smaller subtiles until the pixel or sample level is reached. The tile shader program can be written to discard groups of pixels, thereby quickly removing areas of the bounding triangles that lie outside the shape being rasterized or quickly discarding groups of pixel shader executions that will not contribute to the final image. | 10-09-2014 |
20140313211 | Color Buffer Compression - In accordance with some embodiments, a mask or table may be maintained to record information about whether or not each pixel within a tile is cleared. As used herein, a “cleared” tile is one that is not covered by any other depicted objects. The clear mask may store a bit per pixel or sample to indicate whether the pixel or sample contains a color value or whether it is cleared. As a result, the compression ratio may be increased for partially covered tiles in some embodiments. | 10-23-2014 |
20140340414 | Caching For Reduced Depth And/Or Color Buffer Bandwidth - In accordance with some embodiments, caching may be improved for tiles on shared edges between triangles. In some embodiments, the technique may be used for either color and depth caches or both caches. | 11-20-2014 |
20140375665 | SUBSET BASED COMPRESSION AND DECOMPRESSION OF GRAPHICS DATA - Techniques related to graphics rendering including techniques for compression and/or decompression of graphics data by use of indexed subsets are described. | 12-25-2014 |
20140375666 | COMPRESSION AND DECOMPRESSION OF GRAPHICS DATA USING PIXEL REGION BIT VALUES - Techniques related to graphics rendering including techniques for compression and/or decompression of graphics data by use of pixel region bit values are described. | 12-25-2014 |
20150154772 | Variable Rasterization Order for Motion Blur and Depth of Field - Cache thrashing or over-accessing of a cache can be reduced by reversing the order of traversal of a triangle on different granularities. In the case where triangles are not grouped, the traverse order may be reversed on each triangle. In cases where triangles are grouped, the traversal order may be reversed with each group change. However, when motion is excessive, for example beyond a threshold, then the traversal order reversal may be disabled. | 06-04-2015 |
20150264223 | Color Compression Using A Selective Color Transform - When a tile is evicted from the cache, an attempt is made to compress the tile using any compression algorithm. The difference is that the colors of the tile are compressed as they are, but the colors can also be transformed with a color transform (for example, lossless YCoCg), and after that those colors are compressed with the same compression algorithm. Several different color transforms may be tried, and selection of which one to use can be done in several ways. | 09-17-2015 |
Patent application number | Description | Published |
20110159477 | PRODUCTS AND ANALYTICAL METHOD - The present invention describes product and analysis method for analysis of a substance, a virus, a bacteria or a cell which binds to carbohydrate structures. One or more carbohydrates, or carbohydrate derivatives, is bound to spherical or non-spherical polymer beads (for example microspheres or nanospheres). Formed carbohydrate-polymer beads or carbohydrate-polymer particles, can bind to with more or less specific affinity to the substance, bacteria, virus or cell which shall be detected. The carbohydrate beads is contacted with a sample containing the substance, bacteria, virus or cell (completely or partially isolated, or not purified, in a non-diluted or diluted solution). The resulting mixture is optionally added to a gel, or a column containing a gel, through which the resulting mixture (of carbohydrate beads or carbohydrate particles bound to the substance, virus, bacteria or cell), is allowed to migrate. Detection of aggregates is made visually or using apparatus for detection. | 06-30-2011 |
20140255409 | METHOD FOR EXTRACORPOREAL ELIMINATION OF ONE OR MORE COMPONENTS FROM BLOOD - A method for extracorporeal elimination of one or more components from blood where whole blood or blood plasma is added to a blood treatment device containing an adsorbent which binds the one or more components is disclosed. The adsorbent comprises at least one matrix to which at least one ligand having specific binding affinity to said one or more component is covalently bound. The ligand comprises a glycosidically bound aglycon and at least one saccharide, preferably blood group determinant A, blood group determinant B, blood group H determinant, a P antigen, or a Pk antigen; or said ligand is an amino acid, a peptide or an antibody. Methods for treatment of transplant recipients, and to use a blood treatment device is also disclosed. | 09-11-2014 |
20140284274 | METHOD FOR THE REDUCTION OR ELIMINATION OF ONE OR MORE COMPONENTS FROM A BLOOD PRODUCT - A method for the reduction or elimination of one or more components from a blood product or a fluid is disclosed. The method comprises continuous addition of the blood product to a filter containing an inlet and an outlet for the blood product in which one or more components have been reduced or eliminated. Hollow fiber membranes are arranged with a space between them and with pores through which one or more components and a blood plasma pass outwardly. A loop is arranged between a blood plasma inlet and an outlet. The space between hollow fibers and the loop contains an adsorbent which specifically binds one or more components. Pores of the hollow fibers do not allow passage of the adsorbent into the hollow fiber membranes and the blood plasma is continuously recirculated via the loop back to the space between the hollow fibers. The addition of blood product is stopped when the concentration of one or more components which exits the filter via the outlet reaches a predetermined value. | 09-25-2014 |
20140342377 | METHOD FOR THE DETECTION OF AN ANALYTE IN A SAMPLE - A method for the detection of at least one analyte in a sample is disclosed, wherein it comprises the steps of: a) providing a layer comprising a porous matrix having at least one ligand bound thereto above a filter constituting the bottom of at least one well of an assay plate, wherein said filter does not allow passage of said porous matrix having a ligand bound thereto, b) adding a sample containing said at least one analyte to be detected, said at least one analyte having the ability to specifically bind to said at least one ligand, c) adding a wash solution with a view to washing out non-bound sample components from the assay plate through the filter, d) adding enzyme-linked antibodies or antigens having the ability to specifically bind to said at least one analyte, e) adding a wash solution with a view to washing out non-bound enzyme-linked antibodies or antigens from the analysis plate through the filter, f) adding a substrate specific for the enzyme, wherein a product is formed by a reaction between the enzyme and the substrate, determining the quantity of said at least one analyte by measuring a signal related to the product, as well as method for the diagnosis of an EHEC (enterohemorrhagic | 11-20-2014 |
20150151037 | DEVICE FOR BIO-AFFINITY MATERAL - Apparatus for contacting body fluids with the bio-affinity material is disclosed. The apparatus includes a container having top and bottom lock covers that clip onto the container. | 06-04-2015 |
Patent application number | Description | Published |
20090088085 | Apparatus and Methods for Frequency Control in a Multi-Output Frequency Synthesizer - Methods and circuits for synthesizing two or more signals phase-locked to a common reference frequency signal are disclosed. In one embodiment, a method comprises generating first and second output signals phase-locked to a reference clock signal, using first and second phase-locked loop circuits. In response to a detected frequency error in the first output signal, the first output signal is corrected by adjusting a frequency-division ratio in the first phase-locked loop circuit. The second output signal is corrected, separately from the correction to the first output signal, by adjusting a frequency-division ratio in the second phase-locked loop circuit, using an adjustment parameter calculated from the detected frequency error. In another exemplary method, first and second output signals are generated as described above, using first and second phase-locked loop circuits. The first output signal is corrected by adjusting a frequency-division ratio in the first phase-locked loop circuit and generating a control signal to adjust the frequency of the reference clock signal, in response to detected frequency error in the first output signal. Because the second output signal is derived from the common reference clock signal, adjustments to the reference clock frequency will also adjust the frequency of the second output signal. Additional adjustments to the second output signal may be applied in some embodiments by adjusting a frequency-division ratio in the second phase-locked loop circuits. Circuits for implementing the described methods are also disclosed. | 04-02-2009 |
20090258640 | DEVICE POWER DETECTOR - A communication device includes a transmitter configured to provide a transmitted output signal, and a power detector configured to receive reference signals from a waveform generator associated with the transmitter, and to receive a portion of the transmitted output signal from the transmitter. The power detector is further configured to compare the reference signals with a digital representation of the portion of the transmitted output signal, and calculate a gain associated with the transmitter based on the comparison. The power detector is also configured to receive, from the waveform generator, a root mean square (RMS) value of the reference signals, and generate an estimate of the output power of the transmitter based on the calculated gain and the root mean square (RMS) value of the reference signals. | 10-15-2009 |
20110124302 | Modulation Method and Apparatus - A modulation circuit for use in a radiofrequency transmitter includes a local oscillator circuit configured to generate one or more local oscillator signals at a desired frequency and with a duty cycle at or about twenty-five percent, and a modulator configured to generate one or more modulated signals responsive to the one or more local oscillator signals and one or more baseband information signals. In at least one embodiment, the modulation circuit includes a modulator comprising a combined mixing and transconductance circuit that includes a transistor circuit for each baseband information signal serving as a modulation input to the modulator. Each transistor circuit comprises a first transistor driven by the baseband information signal and coupling a modulator output node to a corresponding transconductance element, and a second transistor driven by one of the one or more local oscillator signals and coupling the corresponding transconductance element to a signal ground node. | 05-26-2011 |
20120129474 | Modulation Method and Apparatus - A modulation circuit for use in a radiofrequency transmitter includes a local oscillator circuit configured to generate one or more local oscillator signals at a desired frequency and with a duty cycle at or about twenty-five percent, and a modulator configured to generate one or more modulated signals responsive to the one or more local oscillator signals and one or more baseband information signals. In at least one embodiment, the modulation circuit includes a modulator comprising a combined mixing and transconductance circuit that includes a transistor circuit for each baseband information signal serving as a modulation input to the modulator. Each transistor circuit comprises a first transistor driven by the baseband information signal and coupling a modulator output node to a corresponding transconductance element, and a second transistor driven by one of the one or more local oscillator signals and coupling the corresponding transconductance element to a signal ground node. | 05-24-2012 |
20120223751 | Generating an Oscillator Signal Having a Desired Frequency in a Continuous Frequency Range - A method of generating a first oscillator signal having a desired frequency in a first frequency range comprises generating in a voltage controlled oscillator unit a second oscillator signal having a frequency in a second frequency range of at least one octave. The method further comprises selecting said second continuous frequency range to have a lower endpoint in said first frequency range and an upper endpoint above said range; and selectively using the oscillator signal unchanged or dividing it by a division ratio selected from integer powers of the number 2 to obtain said first oscillator signal. By centering the VCO higher than otherwise required and using an additional divider, so that the VCO signal can selectively be used unchanged or divided, a sufficient margin below as well as above the desired range for e.g. drift and tolerances of the VCO is achieved. It also simplifies the VCO design. | 09-06-2012 |
20120274372 | Phase Locked Loop Frequency Synthesizer Circuit with Improved Noise Performance - A phase locked loop frequency synthesizer comprises a voltage controlled oscillator; a loop filter for supplying a control voltage to the oscillator; a phase frequency detector arranged to detect a phase difference between a reference signal and a feedback signal generated from the oscillator signal and generate pulses on detector UP signals (UP/DN) dependent on the sign of the phase difference; and a charge pump ( | 11-01-2012 |
20130188756 | Double Conversion Dual-Carrier Radio Frequency Receiver - In a dual-carrier, double-conversion Orthogonal Frequency Division Multiplexing (OFDM) receiver a frequency synthesizer generates a first local oscillator signal for the first down-conversions stage of the receiver. A frequency divider is used to derive a second local oscillator signal from the first local oscillator signal, thus eliminating the need for a separate frequency synthesizer for the second down-conversion stage. A controller determines the frequency of the first local oscillator signal and a divisor M to align subcarrier grids for said first and second baseband signals with DC. | 07-25-2013 |
20140314175 | Wireless Transmission - A wireless communication device ( | 10-23-2014 |
20140376662 | Polar Modulation - A modulator ( | 12-25-2014 |
Patent application number | Description | Published |
20080286331 | COMPOSITION FOR AN INJECTABLE BONE MINERAL SUBSTITUTE MATERIAL - The invention refers to an injectable composition for a bone mineral substitute material, which comprises a dry powder mixed with an aqueous liquid. The powder comprises a first reaction component comprising a calcium sulphate hemihydrate with the capability of being hardened to calcium sulphate dihydrate when reacting with said aqueous liquid; a second reaction component, which comprises a calcium phosphate with the capability of being hardened to a calcium phosphate cement when reacting with said aqueous liquid; and at least one accelerator for the reaction of said first and/or second reaction component with said aqueous liquid. A method of producing an injectable bone mineral substitute material is also provided, wherein the composition is mixed in a closed mixing and delivery system for delivery. | 11-20-2008 |
20090018667 | Composition for an injectable bone mineral substitute material - The invention refers to an injectable composition for a bone mineral substitute material, which comprises a dry powder mixed with an aqueous liquid. The powder comprises a first reaction component comprising a calcium suphate hemihydrate with the capability of being hardened to calcium sulphate dihydrate when reacting with said aqueous liquid; a second reaction component, which comprises a calcium phosphate with the capability of being hardened to a calcium phosphate cement when reacting with said aqueous liquid; and at least one accelerator for the reaction of said first and/or second reaction component with said aqueous liquid. A method of producing an injectable bone mineral substitute material is also provided, wherein the composition is mixed in a closed mixing and delivery system for delivery. | 01-15-2009 |
20090192629 | Composition for an injectable bone mineral substitute material - The invention refers to an injectable composition for a bone mineral substitute material, which comprises a dry powder mixed with an aqueous liquid. The powder comprises a first reaction component comprising a calcium sulphate hemihydrate with the capability of being hardened to calcium sulphate dihydrate when reacting with said aqueous liquid; a second reaction component, which comprises a calcium phosphate with the capability of being hardened to a calcium phosphate cement when reacting with said aqueous liquid; and at least one accelerator for the reaction of said first and/or second reaction component with said aqueous liquid. A method of producing an injectable bone mineral substitute material is also provided, wherein the composition is mixed in a closed mixing and delivery system for delivery. | 07-30-2009 |
Patent application number | Description | Published |
20130068428 | HEAT EXCHANGER WITH IMPROVED CORROSION RESISTANCE - The present invention relates to a plate package for a plate heat exchanger and a plate heat exchanger made of materials with improved anti-corrosion properties for highly corrosive fluids such as hydrochloric acid. | 03-21-2013 |
20140311718 | BLOCK-TYPE PLATE HEAT EXCHANGER WITH ANTI-FOULING PROPERTIES - An block-type plate that has a stack of heat transfer plates which includes a first heat transfer plate and a second heat transfer plate. At least a part of each of the first heat transfer plate and the second heat transfer plate comprises a coating that i) has a layer thickness of 1-30 μm, ii) is prepared by sol-gel processing, iii) comprises silicon oxide (SiOx) having an atomic ratio of O/Si>1, and iv) comprises ≧10 atomic percent carbon (C). | 10-23-2014 |
20140318748 | SPIRAL HEAT EXCHANGER WITH ANTI-FOULING PROPERTIES - The invention relates to a spiral heat exchanger comprising a spiral body formed by at least one spiral sheet wound to form the spiral body forming at least a first spiral-shaped flow channel for a first medium and a second spiral-shaped flow channel for a second medium, wherein the spiral body is enclosed by a substantially cylindrical shell being provided with connecting elements communicating with the first flow channel and the second flow channel. At least a part of the spiral heat exchanger is provided with a coating comprising silicon oxide, SiO | 10-30-2014 |
20140371049 | CENTRIFUGAL SEPARATOR WITH ANTI-FOULING PROPERTIES - A centrifugal separator for continuous separation of a fluid mixture into components includes a rotor, which forms within itself a separation chamber, including in said separation chamber a set of separation discs defining separation passages between adjacent separation discs. The separator further includes an inlet operatively connected to said rotor for continuous supply of a fluid mixture to be separated in the separation chamber, a first outlet for a separated lighter first component of the fluid mixture extending from a radially inner portion of the separation space, and a second outlet for a separated denser second component of the fluid mixture extending from the radially outer portion of the separation space. The separation discs are provided with a coating including silicon oxide, SiO | 12-18-2014 |
Patent application number | Description | Published |
20090258640 | DEVICE POWER DETECTOR - A communication device includes a transmitter configured to provide a transmitted output signal, and a power detector configured to receive reference signals from a waveform generator associated with the transmitter, and to receive a portion of the transmitted output signal from the transmitter. The power detector is further configured to compare the reference signals with a digital representation of the portion of the transmitted output signal, and calculate a gain associated with the transmitter based on the comparison. The power detector is also configured to receive, from the waveform generator, a root mean square (RMS) value of the reference signals, and generate an estimate of the output power of the transmitter based on the calculated gain and the root mean square (RMS) value of the reference signals. | 10-15-2009 |
20130170659 | Speaker Impedance Measurement - An integrated circuit for processing audio and voice signals in a telephone is disclosed. The integrated circuit comprises an audio output port having a first and a second output terminal for connection to a first and a second input terminal, respectively, of a speaker. The integrated circuit further comprises an audio input port having a first and a second input terminal for connection to a first and a second output terminal of an audio input source. The integrated circuit also comprises at least one audio output path and one audio input path. Moreover, the integrated circuit comprises a test impedance, such as a resistor, (RT) for measuring an electrical impedance of the speaker. | 07-04-2013 |
Patent application number | Description | Published |
20080267865 | Targeting of Erb Antigens - A conjugate comprising
| 10-30-2008 |
20100135976 | ADSORPTION DEVICE - The invention relates to an adsorption device for removal and/or reduction of undesirable components from blood, such as whole blood, comprising, porous cross-linked polysaccharide particles or beads, wherein the particles or beads have an average size from about 210±50 μm, at least 30% of the particles have a size from about 180 to about 240 μm, at least 70% of the particles have a size from about 150 to about 300 μm and said particles have at least one immobilised ligand, wherein said immobilised ligand have a size of about 150 kD or less. The invention also relates to kits comprising said adsorption device as well as the use of said adsorption device in different applications such as cleaning of blood. | 06-03-2010 |
20110014151 | MACROMOLECULE CONJUGATE - The invention relates to a macromolecule comprising a polymer central core having at least two atoms to which at least two monomers are attached forming a dendrimeric structure comprising at least three polymer bonds, at least two linear polymers (b) being bond to said polymer bonds, wherein said polymers (b) at least have terminal functional groups for cytotoxic agents and at least on extended polymer (a) having a size of at least 1 carbon atoms longer than said polymers (b) and at least a terminal functional group for a targeting agent. The invention also relates to a macromolecule conjugate as well as a macromolecule biotin conjugate comprising said macromolecule, methods to produce said macromolecules as well as kits or system comprising said macromolecules and method of treating a mammal by said macromolecules. | 01-20-2011 |
20140179877 | MACROMOLECULE CONJUGATE - The invention relates to a macromolecule comprising a polymer central core having at least two atoms to which at least two monomers are attached forming a dendrimeric structure comprising at least three polymer bonds, at least two linear polymers (b) being bond to said polymer bonds, wherein said polymers (b) at least have terminal functional groups for cytotoxic agents and at least on extended polymer (a) having a size of at least 1 carbon atoms longer than said polymers (b) and at least a terminal functional group for a targeting agent. The invention also relates to a macromolecule conjugate as well as a macromolecule biotin conjugate comprising said macromolecule, methods to produce said macromolecules as well as kits or system comprising said macromolecules and method of treating a mammal by said macromolecules. | 06-26-2014 |
Patent application number | Description | Published |
20110130553 | NOVEL SYNTHESIS OF GALACTOSIDE INHIBITORS - Novel synthesis routes for preparation of thiodigalactosides and intermediates are presented. The method includes the use of a 3-azido-galactosyl thiouronium salt derivative, which is activated to the corresponding thiol in situ, which in turn is directly reacted with a 3-azido-galactosyl bromide resulting in the 3,3′-di-azido-thio-di-galactoside before the thiol has a chance to reduce the azido 10 group. Hence, in situ formation of the 3-azido-galactosyl thiol from the thiouronium salt is essential in the synthesis procedure, because any other method that generate the thiol separately results in extensive unwanted azide reduction. | 06-02-2011 |
20140121179 | Novel Galactoside Inhibitor of Galectins - The present invention relates to a compound of the general formula (I): | 05-01-2014 |
20140171630 | NOVEL SYNTHESIS OF GALACTOSIDE INHIBITORS - Novel synthesis routes for preparation of thiodigalactosides and intermediates are presented. The method includes the use of a 3-azido-galactosyl thiouronium salt derivative, which is activated to the corresponding thiol in situ, which in turn is directly reacted with a 3-azido-galactosyl bromide resulting in the 3,3′-di-azido-thio-di-galactoside before the thiol has a chance to reduce the azido 10 group. Hence, in situ formation of the 3-azido-galactosyl thiol from the thiouronium salt is essential in the synthesis procedure, because any other method that generate the thiol separately results in extensive unwanted azide reduction. | 06-19-2014 |
20140336146 | Novel galectoside inhibitors of galectins - The present invention relates to novel compounds prepared from readily accessible 3-O-propargyl-D-galactopyranoside derivatives and having an effect as i.a., galectin inhibitors, the use of said compounds as a medicament as well as for the manufacture of a medicament for treatment of disorders relating to the binding of galectin to ligands in a mammal, wherein said galectin is preferably a galectin-3. The novel compounds are defined by the general formula (I). | 11-13-2014 |
20150274764 | Galactoside Inhibitor of Galectin-3 and its use for Treating Pulmonary Fibrosis - The present invention relates to a compound of the general formula (I) for pulmonary administration. The compound of formula (I) is suitable for treating pulmonary fibrosis, such as Idiopathic pulmonary fibrosis in a mammal. Furthermore the present invention concerns a method for treatment of pulmonary fibrosis, such as Idiopathic pulmonary fibrosis in a human subject. | 10-01-2015 |
Patent application number | Description | Published |
20130011523 | ENHANCING THE APPEARANCE OF FOOD PRODUCTS - This invention provides processes and apparatus for enhancing the appearance of food products. The browning agents are applied or dispensed onto food products ( | 01-10-2013 |
20130011525 | ENHANCING THE AROMA OF FOOD PRODUCTS - This invention provides processes and apparatus for enhancing the aroma of food products. Aroma-enhancing agents are applied or dispensed onto food products during their manufacture by food-grade controlled-droplet dispensing heads (or head). In preferred embodiments, the dispensing heads are controlled by a controller, such as a programmed PC-type computer, in dependence on sensor data, such as electromechanical, optical, or image sensor data. The controller and sensors operate so that different food items can have selected aroma-enhancing agents properly applied or dispensed without waste or overspray. The invention also provides food products, the aroma of which have been enhanced according to the provided processes and apparatus with aroma-enhancing agents. | 01-10-2013 |
20130011529 | ENHANCING THE NUTRITIONAL VALUE OF FOOD PRODUCTS - This invention provides processes and apparatus for enhancing the nutritional value of food products. Nutrition-enhancing agents are applied or dispensed onto or into food products during their manufacture by food-grade controlled-droplet dispensing heads (or head). In preferred embodiments, the dispensing heads are controlled by a controller, such as a programmed PC-type computer, in dependence on sensor data, such as electromechanical, optical, or image sensor data. The controller and sensors operate so that different food items can have selected nutrition-enhancing agents properly applied or dispensed without waste or overspray. The invention also provides food products which have been enhanced according to the provided processes and apparatus with nutrition-enhancing agents. | 01-10-2013 |