Niethammer
Andreas G. Niethammer, La Jolla, CA US
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20090253778 | DNA composition against tumor stromal antigen FAP and methods of use thereof - A DNA composition effective for eliciting an immune response against tumor cells and tumor metastases comprising a DNA construct that encodes for at least one epitope of fibroblast activation protein (FAP), which is expressible in immune cells, and which is incorporated in a pharmaceutically acceptable carrier. The composition can encode a single epitope of FAP, a polypeptide comprising two or more epitopes of FAP, the entire FAP protein, or any portion thereof that will elicit the desired immune response. In one preferred embodiment, the composition also includes a DNA construct that encodes an immune effector protein, such as a cytokine. The DNA composition of the invention can be used alone or in combination with a chemotherapeutic agent to treat diseases such as tumors and tumor metastases. | 10-08-2009 |
Andreas G. Niethammer, Heidelberg DE
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20120039931 | DNA COMPOSITION ENCODING AN IMMUNOGENIC VEGF RECEPTOR PEPTIDE AND METHODS OF USE THEREOF - A method of inhibiting endothelial cell proliferation in a mammal is provided. The method comprises the step of administering to the mammal an effective immunological response eliciting amount of a DNA composition comprising a DNA construct operably encoding a VEGF receptor polypeptide and a pharmaceutically acceptable carrier therefor, whereby said mammal exhibits an immune response elicited by vaccine and specific to proliferating endothelial cells. The methods of this invention inhibit vascular endothelial cell proliferation in the tumor micro-environment. Angiogenesis inhibition and subsequent decrease in tumor growth and dissemination is achieved. | 02-16-2012 |
Bernd Niethammer, Schierling DE
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20100219266 | FUEL INJECTOR ASSEMBLY - A control valve includes a main body, the first coil assembly arranged on the first side of the main body and having the first contact surface and the first through hole extending from the first contact surface, the second coil assembly arranged on the second side of the main body and having the second contact surface and the second through hole extending from the second contact surface, and a spool arranged within the main body and configured to move between the first and second contact surfaces. The spool has the third contact surface facing the first contact surface, the fourth contact surface facing the second contact surface, and the third through hole extending from the third contact surface to the fourth contact surface. A surface pattern is formed on one or more of the first, second, third and fourth contact surfaces and includes the first recessed portion substantially extending from an inner circumference to an outer circumference of the corresponding one of the first, second, third and fourth contact surfaces. | 09-02-2010 |
Bernd Niethammer, Blythewood, SC US
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20100108786 | FUEL INJECTOR ASSEMBLY - An oil activated fuel injector includes a clevis having an optimized geometry. The optimized geometry substantially eliminates side loading effects of a plunger during operation, thereby maintaining performance integrity of the fuel injector. The optimized geometry includes a profile larger than a head portion of a plunger in order to allow the plunger to free float. | 05-06-2010 |
Berndt Niethammer, Koningsfeld DE
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20150144445 | Damping valve, in particular for shock absorbers of vehicles, with adjustable damping force - The invention relates to a damping valve, in particular for shock absorbers of vehicles, with an adjustable damping force, in which differently sized outlet openings arranged between an inflow and an outflow can more or less be closed in order to obtain a desired damping effect. To this end, the differently sized outlet openings are more or less sealed off radially by means of a valve slide. In another embodiment, sudden pressure increases in the damping valve are automatically reduced by means of a differential area function. Due to said invention, said damping valve can be produced easily, has low leakage loss, a low tolerance chain and requires little effort for setting the desired damping. | 05-28-2015 |
Hans-Juergen Niethammer, Kirchheimbolanden DE
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20090100210 | Assembly for Permitting Power Over Ethernet Connection - An assembly for permitting “Power-over-Ethernet” (PoE) connection between a PoE control device and the components of a cabling network includes a patch panel or conventional design. The patch panel includes on a front face thereof a plurality of first sockets that are each open on the front face such that a plug inserted into the first socket is connectable to a data cable via a data transmission path forming part of the patch panel. The assembly includes a distribution matrix that is securable onto the front side of the patch panel, the distribution matrix including a plurality of through-going apertures corresponding in number and location to the first sockets of the patch panel such that when the matrix member is secured on the patch panel a said aperture is functionally in register with each of the first sockets. The distribution matrix includes a power bus supported thereby. The assembly includes one or more connector devices, and the power bus is connectable to a PoE controller. | 04-16-2009 |
20090235096 | Network Connection Device - An assembly for transmitting data and/or power comprises a “Power over Ethernet” (PoE) control device having a plurality of connection ports for connection thereto of one or more network connection devices. The assembly includes connected via the ports plural network connection devices that are each capable of transmitting data and/or power over a cabling network, and are each connected to the PoE control device. Each network connection device includes at least one connection thereto of cabling and/or a further device; and the assembly includes one or more PoE modules operatively connected to the PoE control device and/or the network connection device. Each connection port of the PoE control device includes a releasable connection. | 09-17-2009 |
20090305553 | Network Connection Device - A patch panel comprises one or more support members supporting a plurality of cable terminations that are each operatively connectable to a respective data cable for the transmission of data. Each cable termination is operatively connected to a respective first socket that is open on a side of the patch panel such that a plug inserted into the first socket is connectable to a said data cable via a data transmission path forming part of the patch panel. The patch panel additionally includes in at least one of the data transmission paths a further connector that permits the connection in the first data transmission path of one or more additional components, such as a module providing status information or power over Ethernet capabilities. | 12-10-2009 |
Marc Niethammer, Carrboro, NC US
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20100329535 | Methods, Systems and Computer Program Products for Analyzing Histology Slide Images - Methods, systems and computer program products for normalizing histology slide images are provided. A color vector for pixels of the histology slide images is determined. An intensity profile of a stain for the pixels of the histology slide images is normalized. Normalized image data of the histology slide images is provided including the color vector and the normalized intensity profile of a stain for the pixels of the histology slide images. | 12-30-2010 |
20150216496 | SIMULATION-BASED ESTIMATION OF ELASTICITY PARAMETERS AND USE OF SAME FOR NON-INVASIVE CANCER DETECTION AND CANCER STAGING - Simulation-based estimation of elasticity parameters and use of same for non-invasive cancer detection and cancer staging are disclosed. According to one aspect, a method for simulation-based estimation of elasticity parameters includes constructing a 3D model of an object comprising biological tissue, the model having a first shape and an elasticity value. A simulation iteration is then performed, which includes simulating the application of an external force to the model, causing the model to have a second shape, measuring the difference between the second shape and a target shape, and determining whether the measured difference between the second shape and the target shape is within a threshold of error. If the measured difference is not within the threshold of error, the process performs additional iterations using adjusted elasticity or force values until the measured difference is within the threshold of error, at which time the final elasticity and force values are reported. In one embodiment, the elasticity value is mapped to a diagnostic parameter, such as an indication of the possibility, presence, or stage of cancer. | 08-06-2015 |
Matthias Niethammer, Erlangen DE
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20100100089 | Actuation system and actuation method - An actuation system is disclosed for actuating an ablation instrument for an ablation process in a tissue volume. In at least one embodiment, the actuation system includes: an input interface for image data of the tissue volume; an identification unit for identifying a target tissue using the image data; a model production unit for producing process models and/or refined fine process models of expected ablation developments, which is linked to a value derivation unit for deriving model measured values from a process model and/or to a value determination unit for determining measured values representing the ablation progress; a command derivation unit for deriving control commands on the basis of process models and/or for deriving refined control commands on the basis of fine process models; a comparator for comparing measured values and an instrument interface for transmitting control commands and/or refined control commands to the ablation instrument. In at least one embodiment, the invention also relates to an actuation method. | 04-22-2010 |
20110118595 | METHOD AND DEVICE FOR IDENTIFYING AND ASSIGNING CORONARY CALCIFICATION TO A CORONARY VESSEL AND COMPUTER PROGRAM PRODUCT - A method and a device are disclosed for identifying and assigning coronary calcification to at least one coronary vessel of a heart in a patient. In at least one embodiment, coronary calcification is identified on the basis of a | 05-19-2011 |
Matthias Niethammer, Sussen DE
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20160075600 | FAST CURING COMPOSITION FOR THE MANUFACTURE OF POLYURETHANE CEMENTITIOUS HYBRID FLOORING - The present application relates to a multi-component composition comprising a polyol component comprising one or more polyols and water, a polyisocyanate component comprising methylene diphenyl diisocyanate (MDI), a powder component comprising cement, calcium hydroxide and one or more aggregates and less than 0.5 wt.-%, based on the total weight of the polyol, polyisocyanate and the powder component, of a curing accelerator component comprising an amino alcohol and an acid. Polyurethane cementitious hybrid flooring or coating systems having an improved curing speed and enhanced aesthetic properties in that they show substantially no difference in colour shade can be achieved. Blister formation can be avoided. | 03-17-2016 |
Michael Niethammer, Claw DE
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20150375253 | DEVICE FOR WET-TREATING THE LOWER FACE OF SUBSTRATES - A device for the wet treatment of flat substrates (S | 12-31-2015 |
Stefan Niethammer, Schemmerhofen DE
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20100205800 | MACHINE TOOL - A machine tool has, on a machine bed, two stands which can be moved in the horizontal x- and z-direction, on which y-slides carrying tool spindles can be vertically moved. Arranged on one of the stands directly above a bridge projecting over its upper side is at least one tool magazine, with which a tool changer is associated for each stand. The drives for the y-slides are attached below the upper side of the stands to the stands. | 08-19-2010 |