Niestroj
Andre Niestroj, Sennewitz DE
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20090018087 | Novel Inhibitors of Glutaminyl Cyclase - The present invention relates to novel inhibitors of glutaminyl cyclase and combinations thereof for the treatment of neuronal disorders, especially Alzheimer's disease, Down Syndrome, Parkinson disease, Chorea Huntington, pathogenic psychotic conditions, schizophrenia, impaired food intake, sleep-wakefulness, impaired homeostatic regulation of energy metabolism, impaired autonomic function, impaired hormonal balance, impaired regulation, body fluids, hypertension, fever, sleep dysregulation, anorexia, anxiety related disorders including depression, seizures including epilepsy, drug withdrawal and alcoholism, neurodegenerative disorders including cognitive dysfunction and dementia. | 01-15-2009 |
20110224225 | Inhibitors of protein kinases - Compounds of general Formula (I): | 09-15-2011 |
20130345233 | INHIBITORS OF PROTEIN KINASES - Compounds of general Formula (I): | 12-26-2013 |
André J. Niestroj, Sennewitz DE
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20100099721 | NOVEL COMPOUNDS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS - Inhibitors of prolyl endopeptidase of formula 1 | 04-22-2010 |
Andre Johannes Niestroj, Sennewitz DE
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20080286810 | Use of Inhibtors of Glutaminyl Cyclases for Treatment and Prevention of Disease - Novel physiological substrates of mammalian glutaminyl cyclase (QC, EC 2.3.2.5), new effectors of QC, methods for screening for such effectors, and the use of such effectors and pharmaceutical compositions comprising such effectors for the treatment of conditions that can be treated by modulation of QC-activity. Preferred compositions additionally comprise inhibitors of DP IV or DP IV-like enzymes for the treatment or alleviation of conditions that can be treated by modulation of QC- and DP IV-activity. | 11-20-2008 |
20090149394 | USE OF EFFECTORS OF GLUTAMINYL AND GLUTAMATE CYCLASES - The present invention provides novel physiological substrates of mammalian glutaminyl cyclase (QC, EC 2.3.2.5), new effectors of QC and the use of such effectors and pharmaceutical compositions comprising such effectors for the treatment of diseases that can be treated by modulation of QC-activity, e.g. diseases selected from the group consisting of duodenal cancer with or w/o | 06-11-2009 |
20100159032 | COMBINATIONS USEFUL FOR THE TREATMENT OF NEURONAL DISORDERS - The present invention provides a method for the treatment of neuronal disorders, in a mammal such as a human, which method comprises administering an effective, non-toxic and pharmaceutically acceptable amount of at least one QC-inhibitor, optionally in combination with at least one agent, selected from the group consisting of PEP-inhibitors, LiCl, inhibitors of DP IV/DP IV-like enzymes, NPY-receptor ligands, NPY agonists, NPY antagonists, ACE-inhibitors, PIMT enhancers, inhibitors of beta secretases, inhibitors of gamma secretases and inhibitors of neutral endopeptidase, to a mammal in need thereof. | 06-24-2010 |
20150038516 | Inhibitors of Protein Kinases - Compounds of general Formula I: | 02-05-2015 |
André Johannes Niestroj, Sennweitz DE
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20100249149 | Inhibitors of Protein Kinases - are useful as inhibitors of cyclin dependent kinases such as CDK9. | 09-30-2010 |
André Johannes Niestroj, Sennweitz DE
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20100249149 | Inhibitors of Protein Kinases - are useful as inhibitors of cyclin dependent kinases such as CDK9. | 09-30-2010 |
Benjamin Heinrich Niestroj, Konigstein Im Taunus DE
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20140047930 | MONITORING DEVICE FOR MONITORING CLEANING ACTIVITY - A monitoring device for monitoring a user's cleaning activity, comprising a squeezable housing and a sensor housed within the housing, wherein the sensor is configured to sense at least pressure exerted to the monitoring device by the user during the cleaning activity. | 02-20-2014 |
Robert Niestroj, Potsdam Ot Golm DE
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20120237944 | DETECTION DEVICE FOR THE IN VIVO AND/OR IN VITRO ENRICHMENT OF SAMPLE MATERIAL - The present invention refers to a detection device for the in vivo and/or in vitro enrichment of sample material, the detection device comprising a functional surface equipped with detection receptors. To further improve the enrichment of sample material by using a detection device of the aforementioned type, it is provided according to the invention that the functional surface has a three-dimensional structure with mutually facing functional sections which form spaces that can be filled with a sample liquid. Furthermore, the present invention provides for a use and for a method for the use of the detection device. | 09-20-2012 |
Robert Niestroj, Berlin DE
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20130197334 | BIODETECTOR - The invention concerns a Biodetector with a functionalised surface for isolating molecules or cells from the human body. In order to improve a Biodetector of the type mentioned above such that the functionalised surface of the Biodetector or there upon enriched molecules or cells are exposed to a lower abrasion, and the biocompatibility of the Biodetector is improved, the Biodetector is designed to remove a fluid from the human body and absorb it into an inner space of the Biodetector, wherein the functionalised surface is oriented to the inner space of the Biodetector. | 08-01-2013 |
20140357967 | Detection Device for the In Vivo and/or In Vitro Enrichment of Sample Material - The invention relates to a detection device for the in vivo and/or in vitro enrichment of sample material, comprising a functional surface charged with detection receptors. To ensure the diagnosis of different diseases using a detection device of the type mentioned at the outset with less efforts and an improved precision of the diagnosis, it is provided according to the invention that the detection device comprises at least one guide element and at least two functional elements disposed at the guide element, wherein a functional surface charged with detection receptors is formed at each of them, the functional elements being designed for being detachable from each other and/or individually detachable from the guide element. Furthermore, the invention provides a use of and a method for the application of said detection device. | 12-04-2014 |