Nicole
Nicole Akre, Scottsdale, AZ US
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20110180101 | MULTI-SURFACE ACIDIC BATHROOM CLEANING SYSTEM - A multi-surface bathroom cleaning system is described that allows for easier cleaning of all bathroom surfaces from all angles, especially under the rim of a toilet bowl, and which comprises an acid/nonionic composition contained in and dispensable from a package comprising an angled-neck sprayer bottle fitted with an invertible trigger sprayer assembly, wherein the cleaning system may be used in an entirely upside-down orientation to spray upwards at an acute angle. | 07-28-2011 |
20120234352 | MULTI-SURFACE ACIDIC BATHROOM CLEANING SYSTEM - A multi-surface bathroom cleaning system is described that allows for easier cleaning of all bathroom surfaces from all angles, especially under the rim of a toilet bowl, and which comprises an acid/nonionic composition contained in and dispensable from a package comprising an angled-neck sprayer bottle fitted with an invertible trigger sprayer assembly, wherein the cleaning system may be used in an entirely upside-down orientation to spray upwards at an acute angle. | 09-20-2012 |
Nicole Apetre, Atlanta, GA US
Nicole Auth, Gustavsburg DE
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20100282596 | METHODS AND SYSTEMS FOR REMOVING A MATERIAL FROM A SAMPLE - The present method relates to processes for the removal of a material from a sample by a gas chemical reaction activated by a charged particle beam. The method is a multiple step process wherein in a first step a gas is supplied which, when a chemical reaction between the gas and the material is activated, forms a non-volatile material component such as a metal salt or a metaloxide. In a second consecutive step the reaction product of the first chemical reaction is removed from the sample. | 11-11-2010 |
20110183444 | METHOD FOR ELECTRON BEAM INDUCED ETCHING - The invention relates to a method for electron beam induced etching of a material ( | 07-28-2011 |
20110183517 | METHOD FOR ELECTRON BEAM INDUCED DEPOSITION OF CONDUCTIVE MATERIAL - The invention relates to a method for electron beam induced deposition of electrically conductive material from a metal carbonyl with the method steps of providing at least one electron beam at a position of a substrate ( | 07-28-2011 |
20110183523 | METHOD FOR ELECTRON BEAM INDUCED ETCHING OF LAYERS CONTAMINATED WITH GALLIUM - The invention relates to a method for electron beam induced etching of a layer contaminated with gallium ( | 07-28-2011 |
20140255831 | METHOD AND APPARATUS FOR PROTECTING A SUBSTRATE DURING PROCESSING BY A PARTICLE BEAM - The invention refers to a method and apparatus for protecting a substrate during a processing by at least one particle beam. The method comprises the following steps: (a) applying a locally restrict limited protection layer on the substrate; (b) etching the substrate and/or a layer arranged on the substrate by use of the at least one particle beam and at least one gas; and/or (c) depositing material onto the substrate by use of the at least one particle beam and at least one precursor gas; and (d) removing the locally limited protection layer from the substrate. | 09-11-2014 |
Nicole Baratin, Loury FR
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20080292761 | Steam Cooking Method and Oven with an Improved Water Supply - The inventive steam cooking method is designed to be carried out in a cooking oven ( | 11-27-2008 |
Nicole Bargenda, Bad Laer DE
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20100209480 | GALENICAL FORMULATIONS OF ORGANIC COMPOUNDS - The present invention relates to a pharmaceutical oral fixed dose combination comprising | 08-19-2010 |
Nicole Battail-Poirot, Lyon FR
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20100136571 | I-PLASTIN ASSAY METHOD FOR THE IN VITRO DIAGNOSIS OF COLORECTAL CANCER - A method for the in vitro diagnosis of colorectal cancer by determining the presence of the I-Plastin tumor marker in a biological sample taken from a patient suspected of having colorectal cancer. Said method can be used for early diagnosis, screening, therapeutic follow-up and prognosis, and also for relapse diagnosis in relation to colorectal cancer. | 06-03-2010 |
Nicole Bezay, Hinterbruehl AT
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20090317906 | GENE SILENCING USING SENSE DNA AND ANTISENSE RNA HYBRID CONSTRUCTS COUPLED TO PEPTIDES FACILITATING THE UPTAKE INTO CELLS - The present invention generally relates to gene silencing using sense DNA (sDNA)-antisense RNA (aRNA) hybrids wherein the sense DNA strand is coupled to a peptide which facilitates the uptake of the hybrid into cells. | 12-24-2009 |
Nicole Blazicek, Vestal, NY US
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20100059400 | Consumer package - A consumer package is provided having a container for holding a consumable product. The container has an outer border and at least one surface, which may be planar, curved, irregular, rigid or soft. A medium such as a preprinted pad of written or graphic material is attachable to the surface(s) of the container. Adhesive tape, banding material, glue, or perforated slots are provided for attaching or retaining the medium to the surface(s). The use of the package stimulates consumers' interest, provides entertainment and higher consumer satisfaction which translates into increased sales and a competitive advantage. | 03-11-2010 |
Nicole Blumer, Dusseldorf DE
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20080305089 | Pharmaceutical Composition for Protection from Allergies and Inflammatory Disorders - The present invention relates to a pharmaceutical composition which includes naturally occurring, non-transgenic isolated bacteria from the group of | 12-11-2008 |
Nicole Borth, Vienna AT
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20110136236 | GENETICALLY MODIFIED EUKARYOTIC CELLS - The invention relates to a method of producing genetically modified eukaryotic cells with optimised growth characteristics wherein a recombinant first nucleotide sequence has been integrated into a desired position in the genome. The sequence contains at least one gene encoding a plasma membrane protein with either toxin-receptor or toxic properties and allowing for surface expression based cell sorting to identify a suitable genomic integration locus. The invention also relates to a second exogenous nucleotide sequence containing at least one protein of interest as well as a vector, which aids in the site specific exchange of the first with the second nucleotide sequence. Efficient exchange is achieved by a stringent selection strategy that will kill all cells still expressing the plasma membrane protein. | 06-09-2011 |
Nicole Brausch, Recklinghausen DE
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20110166304 | USE OF FOAM BODIES IN OXIDATION REACTORS FOR PREPARING UNSATURATED ALDEHYDES OR CARBOXYLIC ACIDS - The present invention relates to a process for preparing unsaturated aldehydes or unsaturated carboxylic acids by heterogeneous catalytic gas phase oxidation of unsaturated or saturated hydrocarbons, comprising the process steps of: i) providing a gas mixture comprising a saturated hydrocarbon and catalytically dehydrogenating the saturated hydrocarbon in the gas phase to obtain a gas mixture comprising an unsaturated hydrocarbon in a dehydrogenation reactor having a dehydrogenation catalyst material; or ii) providing a gas mixture comprising oxygen and an unsaturated hydrocarbon; iii) catalytically oxidizing the unsaturated hydrocarbon obtained in process step i) or provided in process step ii) in the gas phase to obtain a gas mixture comprising an unsaturated aldehyde in a first oxidation reactor having a first oxidation catalyst material; wherein at least one of the reactors selected from the dehydrogenation reactor, the first oxidation reactor and the second oxidation reactor comprises at least one foam body. | 07-07-2011 |
20110189072 | PROCESS FOR PREPARING HIGHER HYDRIDOSILANES - Process for preparing higher hydridosilanes of the general formula H—(SiH | 08-04-2011 |
Nicole Breidenassel, Regensburg DE
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20100242519 | HEAT SINK AND LIGHTING DEVICE COMPRISING A HEAT SINK - A heat sink may include a light source region for mounting a light source; a heat spreading and dissipation structure covering at least part of an exterior of the heat sink; wherein the structure comprises vertically aligned fins; wherein the structure comprises an air flow channel leading from a bottom region to a lateral region, the air flow channel being created by a gap between adjacent fins; wherein the light source region comprises an open cavity formed by a cavity wall comprising a light source mounting region adapted to receive the light source; wherein the fins are integrally connected to the exterior of the cavity wall; wherein the heat sink comprises a solid heat sink base extending from the light source mounting region to the exterior and protruding from the cavity wall; and wherein the structure is in thermal connection with the heat sink base. | 09-30-2010 |
20100259935 | HEAT SINK AND LIGHTING DEVICE COMPRISING A HEAT SINK - A heat sink is provided. The heat sink may include an open cavity formed by a cavity wall, a cavity bottom wall thereof including a light source region adapted to have a light source mounted thereon and a lateral cavity wall thereof including a reflection region adapted to reflect light emitted from the light source; a heat spreading and dissipation structure covering at least part of an exterior of the heat sink including a bottom region and a lateral region, the heat spreading and dissipation structure including a plurality of vertically aligned fins; an air guidance structure adapted to separate the heat sink from an air flow generator; and at least one mounting column for attaching the heat sink to a lighting device. | 10-14-2010 |
20110170302 | ILLUMINATION APPARATUS WITH A HEAT SINK - An illumination apparatus is provided. The illumination apparatus may include at least one light-emitting diode; and at least one heat sink for cooling the light-emitting diode, wherein at least one component of the illumination apparatus provided for thermal discharge has an emission coefficient of more than 0.75. | 07-14-2011 |
20120014098 | Cooling element for a lighting device - A cooling element for a lighting device having a plurality of cooling fins, wherein adjacent cooling fins delimit a cooling fin intermediate space with at least one air duct for connecting at least two cooling fin intermediate spaces. | 01-19-2012 |
Nicole Bunselmeyer, Seattle, WA US
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20090155757 | Interactive multimedia instructional systems - The present invention aims at creating an interactive multimedia instructional program that allows inexperienced developers to create multimedia rich and effective learning programs. The present invention uses a commonly used graphics authoring program to pre-program templates that provide instructional frameworks based upon instructional concepts and adult learning theory. A developer uses a template editor to easily modify and customize the instructional templates for a particular use. The final instructional program can be distributed in a wide number of common file formats. | 06-18-2009 |
Nicole Casadevall, Paris FR
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20090162849 | IDENTIFICATION OF A JAK2 MUTATION IN POLYCYTHEMIA VERA - The present invention concerns the V617F variant of the protein-tyrosine kinase JAK2, said variant being responsible for Vaquez Polyglobulia. The invention also relates to a first intention diagnostic method for erythrocytosis and thrombocytosis allowing their association with myeloproliferative disorders, or to the detection of the JAK2 V617F variant in myeloproliferative disorders allowing their reclassification in a new nosological group. | 06-25-2009 |
20120066776 | IDENTIFICATION OF A JAK2 MUTATION INVOLVED IN VAQUEZ POLYGLOBULIA - The present invention concerns the V617F variant of the protein-tyrosine kinase JAK2, said variant being responsible for Vaquez Polyglobulia. The invention also relates to a first intention diagnostic method for erythrocytosis and thrombocytosis allowing their association with myeloproliferative disorders, or to the detection of the JAK2 V617F variant in myeloproliferative disorders allowing their reclassification in a new nosological group. | 03-15-2012 |
20130189683 | IDENTIFICATION OF A JAK2 MUTATION INVOLVED IN VAQUEZ POLYGLOBULIA - The present invention concerns the V617F variant of the protein-tyrosine kinase JAK2, said variant being responsible for Vaquez Polyglobulia. The invention also relates to a first intention diagnostic method for erythrocytosis and thrombocytosis allowing their association with myeloproliferative disorders, or to the detection of the JAK2 V617F variant in myeloproliferative disorders allowing their reclassification in a new nosological group. | 07-25-2013 |
20140249204 | IDENTIFICATION OF A JAK2 MUTATION IN POLYCYTHEMIA VERA - The present invention concerns the V617F variant of the protein-tyrosine kinase JAK2, said variant being responsible for Vaquez Polyglobulia. The invention also relates to a first intention diagnostic method for erythrocytosis and thrombocytosis allowing their association with myeloproliferative disorders, or to the detection of the JAK2 V617F variant in myeloproliferative disorders allowing their reclassification in a new nosological group. | 09-04-2014 |
20150051263 | IDENTIFICATION OF A JAK2 MUTATION IN POLYCYTHEMIA VERA - The present invention concerns the V617F variant of the protein-tyrosine kinase JAK2, said variant being responsible for Vaquez Polyglobulia. The invention also relates to a first intention diagnostic method for erythrocytosis and thrombocytosis allowing their association with myeloproliferative disorders, or to the detection of the JAK2 V617F variant in myeloproliferative disorders allowing their reclassification in a new nosological group. | 02-19-2015 |
Nicole Chaubet, Strasbourg FR
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20090328247 | Isolated DNA sequence capable of serving as regulatory element in a chimeric gene which can be used for the transformation of plants - An isolated DNA sequence capable of serving as regulatory element in a chimeric gene which can be used for the transformation of plants is disclosed. A chimeric gene containing the DNA sequence as a regulatory element for the transformation of plants is also disclosed. The gene comprises at least, in the direction of transcription, a promoter sequence, a transgene and a regulatory element, characterized in that the regulatory element comprises an intron from the noncoding 5′ region of a plant histone gene, allowing the expression of the protein in the zones undergoing rapid growth. The production of transgenic plants is also disclosed. | 12-31-2009 |
Nicole Chenciner, Paris FR
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20090142371 | HIV RECOMBINANT VACCINE - Reagents and methods for making and using HIV recombinant vaccines are disclosed. | 06-04-2009 |
Nicole Dajoux, Ceyrat FR
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20090082534 | Diene elastomer with cyclic vinyl units and processes for obtaining same - The present invention relates to a linear or branched diene elastomer having cyclic vinyl units. A linear diene elastomer according to the invention results from at least one conjugated diene and it comprises cyclic vinyl units in a mass content of greater than or equal to 15% while having a number-average molecular weight falling within a range of from 10,000 to 300,000 g/mol. The invention also relates to a process for the production of such a linear or branched diene elastomer including cyclic vinyl units in the above-stated content and having a number-average molecular weight ranging from 10,000 to 300,000 g/mol, such that said process includes the continuous reaction of at least one conjugated diene monomer in an inert aliphatic or alicyclic hydrocarbon solvent with a catalytic system comprising an organolithium initiator, a polar agent having two or more heteroatoms and an alkali metal salt of an aliphatic or alicyclic alcohol, where: | 03-26-2009 |
Nicole Deglon, Le Plessis Robinson FR
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20100299768 | Reversible siRNA-Based Silencing of Mutant and Endogenous Wild-Type Huntingtin Gene and its Application for the Treatment of Huntington's Disease - Isolated double-stranded short interfering nucleic acid molecules inhibiting the expression of endogenous wild-type and exogenous human mutant huntintin genes in cells of a non-human mammal which are expressing both said huntingtin genes, and their application for the treatment of Huntington's disease as well as to study Huntington's disease in rodent models. | 11-25-2010 |
Nicole Deglon, Curtilles CH
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20100166703 | USE OF IL-6/IL-6 CHIMERA IN HUNTINGTON'S DISEASE - The invention relates to the use of an IL-6R/IL-6 chimera, a mutein, isoform, fused protein, functional derivative, active fraction or circularly permutated derivative or a salt thereof, for the manufacture of a medicament for the treatment and/or prevention of Huntington's disease. | 07-01-2010 |
Nicole Denkinger, Biberach DE
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20090182301 | DUAL CHAMBER CONTAINER WITHOUT BY-PASS - The invention relates to a double chamber container for holding and combining two separate components, at least one of which is liquid, comprising a cylindrical body ( | 07-16-2009 |
Nicole Depine, Graz AT
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20090151774 | Method for Producing Weather-Resistant Laminates for Encapsulating Solar Cell Systems - A process produces weather-resistant laminates ( | 06-18-2009 |
Nicole Depping, Berlin DE
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20090012575 | ACTIVE MEDICAL IMPLANT - The invention consists of a system for remote programming of an implantable medical device such as a heart pacemaker, defibrillator or the like, wherein the system includes a programmable personal device (e.g., an implant) and a service center. The service center has a programming monitoring unit which determines a programming time endpoint which depends on the point in time at which a programming order was sent to the implant, and which cancels or deletes the programming order if the service center has not received a programming confirmation confirming successful receipt, execution, and/or forwarding of the programming order by the implant by the programming time endpoint. | 01-08-2009 |
Nicole Diedrichs, Velbert DE
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20080249133 | Use of Substituted 2-Thio-3,5-Dicyano-4-Phenyl-6-Aminopyridines In the Treatment of Nausea and Vomiting - The present invention relates to the use of substituted 2-thio-3,5-dicyano-4-phenyl-6-amino-pyridines of the formula (I) | 10-09-2008 |
20080269300 | Substituted Phenylaminothiazoles and Use Thereof - The present application relates to novel phenylaminothiazole derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of hypertension and other cardiovascular disorders. | 10-30-2008 |
20090018113 | Novel Cylopenta[B]Benzofuran Derivatives and the Utilization Thereof - The present application relates to a novel cyclopenta[b]benzofuran derivatives, processes for their preparation and their use for the manufacture of medicaments, in particular for the prophylaxis and/or therapy of acute or chronic disorders characterized by elevated cellular stress, by local or systemic inflammatory processes or by hyperproliferation. | 01-15-2009 |
20100048641 | Use of Adenosine A1 and/or Dual A1/2ab Agonists for Production of Medicaments for Treating Diseases - The present invention relates to the use of A1 and/or dual A1/A2 | 02-25-2010 |
20100069363 | SUBSTITUTED 4-AMINO-3,5-DICYANO-2-THIOPYRIDINES AND USE THEREOF - The present application relates to novel substituted 4-amino-3,5-dicyano-2-thiopyridine derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of hypertension and other cardiovascular disorders. | 03-18-2010 |
20100137361 | Tetrahydro-Quinolinylurea Derivatives - This invention relates to tetrahydro-quinolinylurea derivatives and salts thereof which are useful as active ingredients of pharmaceutical preparations. | 06-03-2010 |
20110294718 | DIPEPTOID PRODRUGS AND THE USE THEREOF - The present application relates to prodrug derivatives of 2-amino-6-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}thio)-4-[4-(2-hydroxyethoxy)phenyl]pyridine-3,5-dicarbonitrile, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of cardiovascular disorders. | 12-01-2011 |
20120122820 | PRODRUGS AND THE USE THEREOF - The present application relates to prodrug derivatives of 2-amino-6-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}thio)-4-[4-(2-hydroxyethoxy)phenyl]pyridine-3,5-dicarbonitrile, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of cardiovascular disorders. | 05-17-2012 |
20140206879 | DIPEPTOID PRODRUGS AND THEIR USE - The present application relates to prodrug derivatives of 2-amino-6-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}thio)-4-[4-(2-hydroxyethoxy)phenyl]pyridine-3,5-dicarbonitrile, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of cardiovascular disorders. | 07-24-2014 |
Nicole Dinse, Berlin DE
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20110112172 | SDF-1 Binding Nucleic Acids - The present invention is related to a nucleic acid molecule, preferably binding to SDF-1, selected from the group comprising type A nucleic acid molecules, type B nucleic acid molecules, type C nucleic acid molecules and nucleic acid molecules having a nucleic acid sequence according to any of SEQ ID NO:142, SEQ ID NO:143 or SEQ ID NO:144. | 05-12-2011 |
20110223127 | SDF-1 Binding Nucleic Acids And The Use Thereof - The present invention is related to a nucleic acid molecule binding to SDF-1, whereby the nucleic acid molecule influences migration of cells. | 09-15-2011 |
20130041019 | SDF-1 Binding Nucleic Acids - The present invention is related to an L nucleic acid that binds to an SDF-1. | 02-14-2013 |
20130310442 | SDF-1 Binding Nucleic Acids and the use Thereof in Cancer Treatment - The present invention is related to a nucleic acid molecule capable of binding to SDF-1, preferably capable of inhibiting SDF-1, whereby the nucleic acid molecule is for use in a method for the treatment and/or prevention of a disease or disorder, for use in a method for the treatment of a subject suffering from a disease or disorder or being at risk of developing a disease or disorder as an adjunct therapy, or for use as a medicament for the treatment and/or prevention of a disease or disorder, whereby the disease or disorder is cancer. | 11-21-2013 |
20140370034 | SDF-1 Binding Nucleic Acids and the Use Thereof - The present invention is related to a nucleic acid molecule binding to SDF-1, whereby the nucleic acid molecule influences migration of cells. | 12-18-2014 |
Nicole Ditges, Solingen DE
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20100055474 | Silane Cross-Linking Adhesive or Sealing Compounds, Method for Producing the Same and their Use - The present disclosure relates to silane-crosslinking adhesives or sealants comprising a) at least one polymer of the general formula (I) | 03-04-2010 |
20110034627 | CURABLE COMPOSITIONS CONTAINING SILYLATED POLYURETHANES - Silylated polyurethanes can be manufactured by reacting at least one polyol compound, having a molecular weight from 4000 to 20,000 dalton, with a diisocyanate, with a stoichiometric excess of the diisocyanate compound with respect to the polyol compound or compounds, with the result that a polyurethane prepolymer that is isocyanate-terminated is formed; and by subsequently reacting the polyurethane prepolymer with one or more OH-terminated silanes of formula (1) to yield a polyurethane having predominantly terminal alkoxysilyl groups. In formula (1), m is equal to 0, 1, or 2, R | 02-10-2011 |
20120282444 | LAMINATING ADHESIVE HAVING SILANE CROSS-LINKING - The invention relates to a one-component, moisture-curing adhesive containing at least one polyoxyalkylene and/or poly(methyl)acrylate prepolymer having at least one hydrolyzable silane group, at least one filler, and auxiliary materials and additives, wherein the prepolymer has a molecular weight of 4,000 to 40,000 g/mol and the adhesive has a viscosity of 200 to 10,000 mPas. | 11-08-2012 |
Nicole Duevel, Damme DE
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20100048834 | CABLE SHEATHING - Cable sheathing on the basis of thermoplastic polyurethane based on the reaction of (a) isocyanates with (b) diols, wherein the diol (b) is based on straight-chain or branched diols (i) having from 16 to 45 carbon atoms in an uninterrupted carbon skeleton. | 02-25-2010 |
Nicole Duewelhenke, Berlin DE
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20100216697 | PHARMACEUTICAL COMPOSITION, SUBSTRATE COMPRISING A PHARMACEUTICAL COMPOSITION, AND USE OF A PHARMACEUTICAL COMPOSITION - The invention relates to the use of a pharmaceutical composition for the local treatment or prevention of a tissue infection at an infection site, the pharmaceutical composition comprising at least two different antibiotics of group A or pharmaceutically acceptable derivatives thereof, or an antibiotic of group A and at least one antibiotic of group B or pharmaceutically acceptable derivatives thereof. Group A comprises primarily intracellular active antibiotics working as inhibitor of bacterial RNA polymerase; as inhibitor of gyrase; or as inhibitor of bacterial protein synthesis. Group B comprises primarily extracellular active antibiotics working as inhibitor of bacterial cell wall synthesis; or inhibitor of bacterial protein synthesis; or by direct destabilisation or rupture of the bacterial cell wall. | 08-26-2010 |
Nicole Dusch, Werther DE
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20110053227 | PROCESS FOR PREPARING L-AMINO ACIDS USING IMPROVED STRAINS OF THE ENTEROBACTERIACEAE FAMILY - The invention relates to a process for preparing L-amino acids by fermenting recombinant microorganisms of the Enterobacteriaceae family, characterized in that | 03-03-2011 |
Nicole Düvel, Lembruch DE
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20110165381 | TRANSPARENT, LASER-INSCRIBABLE POLYURETHANE - The present invention relates to a transparent, laser-inscribable, preferably thermoplastic polyurethane, and to the production and use thereof. | 07-07-2011 |
Nicole Fickes, Mattawan, MI US
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20110160723 | BIPOLAR CANNULA FOR USE WITH AN ELECTRODE ASSEMBLY HAVING A SEPARATE SUPPLY ELECTRODE - An electrosurgical system preferably used for denervation procedures of nerve tissue has a control unit and a pluggable electrode assembly. The electrode assembly has a preferably disposable cannula and a preservable supply electrode assembly. The cannula has a tubular body that projects axially from a preferably pointed distal end for piercing tissue to a proximal end engaged to a first coupling assembly of the cannula. The body carries a first contact exposed directly to the nerve tissue and connected electrically to a terminal of the first coupling assembly. The supply electrode assembly has a second coupling assembly and a supply electrode that projects axially and removably into a through-bore of the body when the tool is in an operating state. The second coupling assembly carries a terminal that abuts the first coupling assembly when the coupling assemblies are mated. Preferably the supply electrode carries a temperature sensor for temperature measurement of the targeted tissue and processing by the control unit. Preferably, the electrode assembly also includes a stylet having a rod that fits into the through-bore of the body when the supply electrode assembly is removed and the tool is in a tissue penetrating state. | 06-30-2011 |
Nicole Fuehrler, Schlehdorf DE
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20110034672 | PURIFICATION OF NOT-GLYCOSYLATED POLYPEPTIDES - The current invention reports a method for the purification of a not-glycosylated, heterologous polypeptide, which has been recombinantly produced in a prokaryotic cell, wherein the method comprises three chromatography steps of which the first chromatography step selected from i) hydrophobic charge induction chromatography, or ii) hydrophobic interaction chromatography, or iii) affinity chromatography, or iv) ion exchange chromatography, the second chromatography step is selected from i) anion exchange chromatography, or ii) cation exchange chromatography, or iii) hydroxylapatite chromatography, or iv) hydrophobic interaction chromatography, and the a third chromatography step is selected from i) hydrophobic charge induction chromatography, or ii) anion exchange chromatography, or iii) cation exchange chromatography, or iv) hydrophobic interaction chromatography, whereby the first chromatography step is an affinity chromatography in case of polypeptides capable of interacting with metal ligands, the second chromatography step is not a hydroxylapatite chromatography step in case of polypeptides with an isoelectric point below 6.0, and the third chromatography step can be performed in flow-through mode with polypeptides having a low or high isoelectric point. | 02-10-2011 |
20130059336 | HYDROPHOBIC INTERACTION CHROMATOGRAPHY METHOD - Herein is reported a method for purifying a polypeptide comprising a histidine-tag comprising the steps of i) applying a solution comprising the polypeptide with a histidine-tag to a hydrophobic interaction chromatography material, and ii) recovering the polypeptide comprising a histidine-tag with a solution comprising imidazole or an imidazole-derivative and thereby purifying the polypeptide comprising a histidine-tag, wherein the solution comprising the polypeptide applied to the hydrophobic interaction chromatography material is free of imidazole or an imidazole-derivative and the polypeptide adsorbed to the hydrophobic interaction chromatography material is recovered with a solution comprising imidazole or an imidazole-derivative. | 03-07-2013 |
20140220633 | PURIFICATION OF NOT-GLYCOSYLATED POLYPEPTIDES - The current invention reports a method for the purification of a not-glycosylated, heterologous polypeptide, which has been recombinantly produced in a prokaryotic cell, wherein the method comprises three chromatography steps of which the first chromatography step selected from i) hydrophobic charge induction chromatography, or ii) hydrophobic interaction chromatography, or iii) affinity chromatography, or iv) ion exchange chromatography, the second chromatography step is selected from i) anion exchange chromatography, or ii) cation exchange chromatography, or iii) hydroxylapatite chromatography, or iv) hydrophobic interaction chromatography, and the a third chromatography step is selected from i) hydrophobic charge induction chromatography, or ii) anion exchange chromatography, or iii) cation exchange chromatography, or iv) hydrophobic interaction chromatography, whereby the first chromatography step is an affinity chromatography in case of polypeptides capable of interacting with metal ligands, the second chromatography step is not a hydroxylapatite chromatography step in case of polypeptides with an isoelectric point below 6.0, and the third chromatography step can be performed in flow-through mode with polypeptides having a low or high isoelectric point. | 08-07-2014 |
Nicole Gerow, Surrey CA
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20090038516 | Table covering - A table covering device is provided. Such table covering device includes a table covering member manufactured from a first predetermined material and having a first predetermined shape and a first predetermined size. Such table covering member has at least one aperture disposed therethrough at a predetermined location. Such aperture is a second predetermined size and has a second predetermined shape. A reinforcement means is disposed closely adjacent a perimeter around such at least one aperture. | 02-12-2009 |
Nicole Guiso, Paris FR
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20100112009 | Acellular antibordetella vaccine - The invention relates to an immunogenic composition, characterized in that it comprises an adenyl cyclase-hemolysin (AC-Hly) protein, or an immunogenic portion of this AC-Hly, of a strain of | 05-06-2010 |
20120214206 | VECTORS FOR MOLECULE DELIVERY TO CD11b EXPRESSING CELLS - The invention relates to a novel use of a | 08-23-2012 |
Nicole Harriott, San Diego, CA US
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20110166116 | NEW COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS RELATING THERETO - New compounds are disclosed which have utility in the treatment of a variety of metabolic related conditions in a patient. The compounds of this invention have the structure (I): | 07-07-2011 |
20130065906 | New compounds, pharmaceutical compositions and uses thereof - The present invention relates to compounds of general formula I, | 03-14-2013 |
20130143892 | NEW COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF - The present invention relates to compounds of general formula I, | 06-06-2013 |
20140031369 | N-CYCLOPROPYL-N-PIPERIDINYL-AMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND USES THEREOF - The present invention relates to compounds of general formula I, | 01-30-2014 |
20140045823 | N-CYCLOPROPYL-N-PIPERIDINYL-AMIDES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND USES THEREOF - The present invention relates to compounds of general formula I, | 02-13-2014 |
Nicole Kaftzik, Roslin DE
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20090029401 | Method for detecting biofuel producing microbes - A method for detecting biofuel producing microbes in a colorimetric assay by providing a microbe, a feedstock, and an assay solution. The assay solution contains an alcohol oxidase, a peroxidase, and a peroxidase co-substrate. The microbe is cultured with the feedstock as part of a culture medium that produces a detectable amount of bioalcohol. The culture medium is contacted with the assay solution to produce a colorimetric reaction to screen for a biofuel producing microbe. | 01-29-2009 |
Nicole Kaftzik, Brohl DE
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20080299623 | ENZYME CATALYSIS IN THE PRESENCE OF IONIC LIQUIDS - The invention relates to the implementation of enzyme-catalysed reactions in the presence of ionic liquids. | 12-04-2008 |
Nicole Kaneider, Innsbruck AT
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20080214451 | G Protein Coupled Receptor Agonists and Antagonists and Methods of Use - The invention relates generally to G protein coupled receptors (GPCRs) and in particular to GPCR agonists and antagonists, use of these compounds and their pharmaceutical compositions, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with GPCRs, such as in treating conditions in which chemokine receptors play a role, e.g., sepsis, arthritis, inflammation and autoimmune diseases. | 09-04-2008 |
20110124739 | Use of Sphingosine-1-phosphate (S1P) Receptor Agonists for the Treatment of Brain Degenerative Diseases - Disclosed is the use of sphingosine-1-phosphate (S1P) receptor agonists, preferably 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol, in the treatment of progressive dementia or brain degenerative diseases | 05-26-2011 |
20130281541 | USE IN BRAIN DEGENERATIVE DISEASES - Disclosed is a new use for sphingosine-1-phosphate (S1P) receptor agonists in the treatment of progressive dementia or brain degenerative diseases. | 10-24-2013 |
Nicole Kaulbersch, Leinfelden DE
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20090243264 | Cover for an airbag and method for the production thereof - The invention relates to a cover for covering an airbag in the interior of a motor vehicle, said cover consisting of a material comprising interspaced perforations which fully penetrate the material in the region of the edge of the airbag flap, said perforations having an essentially linear form and a maximum length of 0.8 mm. The invention also relates to a method for producing a cover for covering an airbag in the interior of a motor vehicle. | 10-01-2009 |
Nicole Kester Jones, San Diego, CA US
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20090216729 | SYSTEM AND METHOD OF MONITORING AND CONTROLLING APPLICATION FILES - A system and method for updating, monitoring, and controlling applications on a workstation. The workstation includes a workstation management module configured to detect the launch or request to access a network by an application. A workstation application server receives data associated with the application from the workstation. The application server module can determine one or more policies or categories to associate with the application by referencing an application inventory database. Once the application server module has the category or policy, it forwards a hash/policy table to the workstation management module. Upon receipt of the hash/policy table, the workstation management module applies the policy that is associated with the application to control network access by the application. | 08-27-2009 |
20120191676 | SYSTEM AND METHOD OF MONITORING AND CONTROLLING APPLICATION FILES - A system and method for updating, monitoring, and controlling applications on a workstation. The workstation includes a workstation management module configured to detect the launch or request to access a network by an application. A workstation application server receives data associated with the application from the workstation. The application server module can determine one or more policies or categories to associate with the application by referencing an application inventory database. Once the application server module has the category or policy, it forwards a hash/policy table to the workstation management module. Upon receipt of the hash/policy table, the workstation management module applies the policy that is associated with the application to control network access by the application. | 07-26-2012 |
Nicole Klöden, Ludwigshafen DE
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20110089075 | METHOD FOR COATING GLASS, POLYETHYLENE OR POLYESTER CONTAINERS, AND SUITABLE AQUEOUS FORMULATIONS FOR SAID COATING METHOD - A method of coating containers made of glass, polyethylene or polyester by treatment with a substantially paraffin-free aqueous formulation comprising | 04-21-2011 |
Nicole Klöden, Ludwigshafen DE
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20110089075 | METHOD FOR COATING GLASS, POLYETHYLENE OR POLYESTER CONTAINERS, AND SUITABLE AQUEOUS FORMULATIONS FOR SAID COATING METHOD - A method of coating containers made of glass, polyethylene or polyester by treatment with a substantially paraffin-free aqueous formulation comprising | 04-21-2011 |
Nicole Knüppel, Lembruch DE
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20100237580 | WHEEL GUIDE CONTROL ARM FOR AN ACTIVE CHASSIS - A wheel guide control arm ( | 09-23-2010 |
Nicole Knüppel, Lembruch DE
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20100237580 | WHEEL GUIDE CONTROL ARM FOR AN ACTIVE CHASSIS - A wheel guide control arm ( | 09-23-2010 |
Nicole Kumpfmuller, Munchen DE
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20090120318 | Device for the assembly and disassembly of a fastening device, more preferably a rail fastening device on a support body - The invention describes a device for the assembly and disassembly of a fastening device, more preferably of a rail fastening device on a support body, wherein the device is designed as screw adapter and the screw adapter is to be placed on the rail fastening device. | 05-14-2009 |
Nicole Le, Camarillo, CA US
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20110097336 | Methods for modulating mannose content of recombinant proteins - The present invention relates to methods of modulating (e.g., reducing) the mannose content, particularly high-mannose content of recombinant glycoproteins. | 04-28-2011 |
20130330770 | METHODS FOR MODULATING MANNOSE CONTENT OF RECOMBINANT PROTEINS - The present invention relates to methods of modulating (e.g., reducing) the mannose content, particularly high-mannose content of recombinant glycoproteins. | 12-12-2013 |
Nicole Meier, Mannheim DE
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20100119468 | CATIONIC CONDITIONING AGENT - The present invention relates to compositions comprising at least one polymer a) having cationic and/or cationogenic groups and a molecular weight M | 05-13-2010 |
20100209361 | HIGHLY CATIONIC COPOLYMERS BASED ON QUATERNIZED NITROGEN-CONTAINING MONOMERS - The present invention relates to a copolymer with high cationic charge based on quaternized nitrogen-containing monomers, to cosmetic or pharmaceutical compositions which comprise at least one such copolymer, and to further uses of these copolymers. | 08-19-2010 |
20130068626 | COMPOSITION FOR METAL ELECTROPLATING COMPRISING LEVELING AGENT - A composition comprising a source of metal ions and at least one leveling agent comprising a linear or branched, polymeric imidazolium compound comprising the structural unit of formula L1 (L1) wherein R | 03-21-2013 |
Nicole Mekideche, Ploubazlanec FR
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20090130139 | Cosmetic active ingredient composed of arginine ferrulate and a microalgae extract and its uses - The invention relates to a novel cosmetic active ingredient composed of a microalgae extract and arginine ferrulate, its uses for activating proteasome and the production of thioredoxin, a cosmetic composition containing it and the use of such a cosmetic composition for combating skin ageing. | 05-21-2009 |
20140087448 | PROCESS FOR OBTAINING A BROWN ALGAE LYOPHILISATE, AND COSMETIC PREPARATIONS THEREOF - A process for obtaining a freeze-dried product of gametophytes cells of brown algae, and a cosmetic preparation for tropical use including the freeze-dried product of gametophytes cells of brown algae obtained. | 03-27-2014 |
Nicole Milsap, Walnut Creek, CA US
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20110034548 | Method for Suspending a Flavonoid in a Beverage - Disclosed is a method for suspending microparticulated flavonoid in a beverage by incorporating a microparticulated flavonoid and at least one suspension agent into a beverage. A composition comprising microparticulated quercetin and a suspension agent is also disclosed. | 02-10-2011 |
Nicole Moins, Clermont-Ferrand FR
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20100061928 | LABELLED ANALOGUES OF HALOBENZAMIDES AS RADIOPHARMACEUTICALS - The present invention relates to the use of a compound of formula (I): | 03-11-2010 |
20110044899 | LABELLED ANALOGUES OF HALOBENZAMIDES AS MULTIMODAL RADIOPHARMACEUTICALS AND THEIR PRECURSORS - A compound of formula (I): in which R | 02-24-2011 |
20140093453 | LABELLED ANALOGUES OF HALOBENZAMIDES AS MULTIMODAL RADIOPHARMACEUTICALS AND THEIR PRECURSORS - The present invention relates to the compound of formula (I): | 04-03-2014 |
Nicole Ouis, Renens CH
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20100266669 | MULTI-ZONE FILMS - The invention relates to single-layer oral disintegrating films having at least two distinct zones, which comprise nicotine and allow for effective buccal (=oral mucosal) absorption thereof. | 10-21-2010 |
20130039967 | ORAL DOSAGE FORMS - The invention relates to specific three layer dosage forms for oral administration of pharmaceutical active substances. | 02-14-2013 |
Nicole Pasteur, Montpellier FR
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20080256649 | Novel Acetylcholinesterase Gene Responsible for Insecticide Resistance and Applications Thereof - The invention relates to a novel acetylcholinesterase gene (ace-1) responsible for resistance to organophosphorus and/or carbamates in mosquitoes, which is non-homologous to the | 10-16-2008 |
Nicole Riegler-Kurz, Murr DE
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20110100943 | Mast for a stacker crane - The invention relates to a mast for a stacker crane. | 05-05-2011 |
Nicole Schodel, Munchen DE
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20090253814 | COMPACT REACTOR - The invention relates to a compact reactor that consists of a number of plates that are arranged like stacks and spaced some distance apart, whereby | 10-08-2009 |
20110300046 | METHOD FOR REMOVING IMPURITIES FROM GAS FLOWS COMPRISING OXYGEN - A process for removing impurities, in particular oxides of sulphur (SO | 12-08-2011 |
20120060692 | MEMBRANE TUBE AND REACTOR HAVING A MEMBRANE TUBE - The invention relates to a diaphragm pipe for permeative separation of hydrogen from gas mixtures containing hydrogen, a method for the production thereof as well as a reactor comprising a diaphragm pipe, wherein the diaphragm pipe comprises a porous pipe (S) made of a sintered metal and a diaphragm (M) containing palladium or made of palladium enclosing the outer surface of the sintered metal pipe (5). The sintered metal pipe (S) has at least on one end a fitting (F) made of gasproof material, which is firmly connected with the sintered metal pipe (S). | 03-15-2012 |
20120237422 | METHOD AND PLANT FOR FLUE GAS DE-NOXING - The invention relates to a method for depleting nitrogen oxides from an oxygen-containing gas stream. The gas stream is brought into contact with a scrubbing solution containing ammonia and ammonium sulphite in a NO | 09-20-2012 |
20130197288 | PROCESS FOR THE CONVERSION OF SYNTHESIS GAS TO OLEFINS - The present invention relates to a process for converting a gas mixture comprising CO and H | 08-01-2013 |
20140086813 | PROCESS AND PLANT FOR THE REMOVAL OF NITROGEN OXIDES FROM OXYGEN-CONTAINING GAS STREAMS - The invention relates to a process for the removal of NO and NO | 03-27-2014 |
20140343339 | METHOD FOR OBTAINING OLEFINS FROM FURNACE GASES OF STEEL WORKS - The invention relates to a method for processing furnace gas ( | 11-20-2014 |
20150018582 | DIRECT DIMETHYL ETHER SYNTHESIS FROM SYNTHESIS GAS - The invention concerns processes for preparing dimethyl ether from synthesis gas, comprising a synthesis step, wherein synthesis gas comprising hydrogen and carbon monoxide is converted into dimethyl ether and carbon dioxide, and a separation step, wherein unconverted synthesis gas is separated from carbon dioxide, wherein unconverted synthesis gas is separated from carbon dioxide by a membrane. | 01-15-2015 |
20150018592 | DIRECT SYNTHESIS OF DME AT EQUILIBRIUM - The invention relates to a process for production of DME ( | 01-15-2015 |
20150044129 | METHOD FOR PROCESSING COKE OVEN GAS - The invention relates to a method for processing coke oven gas, said coke oven gas containing hydrogen, wherein the coke oven gas is at least partially integrated into a method for producing dimethyl ether in conjunction with a gas containing carbon monoxide and/or carbon dioxide, whereby a DME-containing product gas is formed. At the outset of the method for the formation of dimethyl ether, a ratio of hydrogen to carbon monoxide, weighted with the carbon dioxide concentration (formula (I)), of 0.9 to 1.1 is set, wherein the DME-containing product gas is integrated into a method for converting dimethyl ether to olefins, whereby an olefin-containing product gas is formed, and wherein olefins, in particular ethylene and/or propylene, is/are separated from the olefin-containing product gas by means of separating methods. | 02-12-2015 |
Nicole Schoedel, Muenchen DE
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20110171118 | Method and device for generating hydrogen - The invention relates to a method and a device for generating hydrogen ( | 07-14-2011 |
20150045456 | METHOD FOR PRODUCING DIMETHYL ETHER FROM METHANE - The invention relates to processes for production of dimethyl ether from methane or natural gas comprising: a dry-reforming step, wherein methane and carbon dioxide are converted into carbon monoxide and hydrogen, and a DME synthesis step, wherein the carbon monoxide and hydrogen formed in the dry-reforming step are converted into dimethyl ether, wherein the dry-reforming step and the synthesis step are carried out at identical pressures or at pressures, which do not differ more than 3 bar, preferably not more than 1 bar. | 02-12-2015 |
Nicole Schoumans, 'S Hertogenbosch NL
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20100323461 | Lithographic Method and Arrangement - A method is described for obtaining information for use in modeling of a lithographic process. A pattern feature is formed on a target portion of a substrate by projecting a beam of radiation onto the target portion of the substrate. For that target portion the lithographic process is characterized by one or both of a first property that varies in a first direction along a surface of the substrate, and a second property that varies in a second direction along a surface of the substrate. A property of the pattern feature is measured. Using the measured property of the pattern feature and at least one of the first and second properties, information is obtained for use in modeling the process. The lithographic process may be or include the projection of the beam of radiation onto the surface of the substrate. | 12-23-2010 |
20130141723 | Alignment Mark Deformation Estimating Method, Substrate Position Predicting Method, Alignment System and Lithographic Apparatus - A method is used to estimate a value representative for a level of alignment mark deformation on a processed substrate using an alignment system. The alignment sensor system is able to emit light at different measuring frequencies to reflect from an alignment mark on the substrate and to detect a diffraction pattern in the reflected light in order to measure an alignment position of the alignment mark. The two or more measuring frequencies are used to measure an alignment position deviation per alignment mark associated with each of the two or more measuring frequencies relative to an expected predetermined alignment position of the alignment mark. A value is determined representative for the spread in the determined alignment position deviations per alignment mark in order to estimate the level of alignment mark deformation. | 06-06-2013 |
20140089870 | Inspection Method and Apparatus and Lithographic Processing Cell - A method of calculating process corrections for a lithographic tool, and associated apparatuses. The method comprises measuring process defect data on a substrate that has been previously exposed using the lithographic tool; fitting a process signature model to the measured process defect data, so as to obtain a model of the process signature for the lithographic tool; and using the process signature model to calculate the process corrections for the lithographic tool. | 03-27-2014 |
Nicole Seiberlich, Shaker Heights, OH US
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20100239143 | REDUCING ACQUISITION TIME - Systems, methods, apparatus, and other embodiments associated with reducing imaging acquisition time are described. One example method includes accessing an under-sampled data set and a library of previously acquired data sets. The method includes producing an approximation of the under-sampled data set by transforming data stored in the library. The method includes producing a sparsified data set from the approximation and the under-sampled data set and then reconstructing the sparsified data set into a sparse image using a reconstruction technique configured to reconstruct sparse data. The method includes producing a fully-sampled approximation of the under-sampled data set and producing a final reconstructed image from the sparse image and the fully sampled approximation. | 09-23-2010 |
20110089946 | THROUGH-TIME NON-CARTESIAN GRAPPA CALIBRATION - Example systems and methods control a parallel magnetic resonance imaging (pMRI) apparatus to acquire non-Cartesian (e.g., spiral) calibration data sets throughout time. Example systems and methods also control the pMRI apparatus to acquire an under-sampled non-Cartesian data set from the object to be imaged. Example systems and methods then control the pMRI apparatus to reconstruct an image of the object to be imaged from the under-sampled non-Cartesian data set. The reconstruction depends, at least in part, on a through-time non-Cartesian GRAPPA calibration where a value for a point missing from k-space in the under-sampled non-Cartesian data set is computed using a GRAPPA weight set calibrated and applied for the missing point. The GRAPPA weight set is computed from data in the non-Cartesian calibration data sets. | 04-21-2011 |
20110093233 | THROUGH-TIME RADIAL GRAPPA CALIBRATION - Example systems and methods control a parallel magnetic resonance imaging (pMRI) apparatus to acquire radial calibration data sets throughout time. Example systems and methods also control the pMRI apparatus to acquire an under-sampled radial data set from the object to be imaged. Example systems and methods then control the pMRI apparatus to reconstruct an image of the object to be imaged from the under-sampled radial data set. The reconstruction depends, at least in part, on a through-time radial GRAPPA calibration where a value for a point missing from k-space in the under-sampled radial data set is computed using a GRAPPA weight set calibrated and applied for the missing point. The GRAPPA weight set is computed from data in the radial calibration data sets. | 04-21-2011 |
20110311158 | MOTION ARTIFACT REMOVAL - Systems, methods, and other embodiments associated with removing motion artifacts from MR images are described. One example method includes controlling an MRI apparatus to acquire a fully sampled, centric-ordered, non-interleaved, data set from an object to be imaged and controlling a Generalized Auto-Calibrating Partially Parallel Acquisition (GRAPPA) logic to produce a GRAPPA duplicate of a single partition through the data set. The method also includes computing, from the GRAPPA duplicate, a GRAPPA navigator for a phase encoding (PE) line in the single partition and computing an error between the PE line in the single partition and a corresponding PE line in the GRAPPA duplicate using the GRAPPA navigator. The method also includes selectively replacing data in the PE line in the single partition with replacement data upon determining that the error exceeds a threshold. The method may include reconstructing an MR image based, at least in part, on the single partition. | 12-22-2011 |
20120235678 | NUCLEAR MAGNETIC RESONANCE (NMR) FINGERPRINTING - Apparatus, methods, and other embodiments associated with NMR fingerprinting are described. One example NMR apparatus includes an NMR logic configured to repetitively and variably sample a (k, t, E) space associated with an object to acquire a set of NMR signals. Members of the set of NMR signals are associated with different points in the (k, t, E) space. Sampling is performed with t and/or E varying in a non-constant way. The varying parameters may include flip angle, echo time, RF amplitude, and other parameters. The NMR apparatus may also include a signal logic configured to produce an NMR signal evolution from the NMR signals, a matching logic configured to compare a signal evolution to a known, simulated or predicted signal evolution, and a characterization logic configured to characterize a resonant species in the object as a result of the signal evolution comparisons. | 09-20-2012 |
20120262165 | RELAXOMETRY - Apparatus, methods, and other embodiments associated with multi-scale orthogonal matching pursuit (OMP) for magnetic resonance imaging (MRI) relaxometry are described. One example method includes controlling a nuclear magnetic resonance (NMR) apparatus to cause selected nuclei in an item to resonate by applying radio frequency (RF) energy to the item and then acquiring multiple series of magnetic resonance (MR) images of the item, the series of MR images having different scales. The example method includes controlling the NMR apparatus to produce a combined signal evolution from a first signal evolution associated with a first series of MR images and a second signal evolution associated with a second series of MR images and to characterize relaxation of the selected nuclei in the item as a function of an OMP that compares the combined signal evolution to a set of combined comparative signal evolutions. | 10-18-2012 |
20120262166 | COMBINED CORRELATION PARAMETER ANALYSIS - Apparatus, methods, and other embodiments associated with combined correlation parameter estimation are described. One example method includes accessing data associated with a magnetic resonance (MR) signal produced by relaxation of nuclei in an item that has experienced nuclear magnetic resonance (NMR) excitation. The MR signal is a function of two or more NMR parameters. The example method also includes accessing data associated with a set of comparative signal evolutions and computing a value for an NMR parameter based on a combined correlation of the data associated with the MR signal to the data associated with the set of comparative signal evolutions. The combined correlation will depend on at least two correlations between the data associated with the MR signal and two different members of the set of comparative signal evolutions. | 10-18-2012 |
20130271137 | Magnetic Resonance Trajectory Correcting - Apparatus, methods, and other embodiments associated with magnetic resonance (MR) trajectory correcting using GRAPPA operator gridding (GROG) are described. One example method includes identifying an on angle or regular portion of a projection in an MR trajectory and then computing base GROG weights for that portion. The example method includes identifying a shift direction and a shift amount for the projection. The shift direction is configured to shift the projection towards a desired point in k-space and the shift amount is configured to shift the projection by a desired amount in the shift direction. With a shift direction and amount available, the example method corrects for a gradient delay by manipulating the MR source signal data using the shift direction and the shift amount. In one embodiment, a gradient delay can be determined and used to calibrate an MRI apparatus. | 10-17-2013 |
20140015527 | Through-Time GRAPPA - Example apparatus and methods control a magnetic resonance imaging (MRI) apparatus to acquire, from an object to be imaged, throughout a period of time, a partitioned non-Cartesian fully-sampled calibration data set. Different groups of lines in the calibration data set are acquired at different points in time under different gradient encoding conditions that yield phase encoding in the direction perpendicular to the non-Cartesian encoded plane. The MRI apparatus is controlled to acquire an under-sampled non-Cartesian data set from the object to be imaged and to reconstruct an image from the under-sampled data set based, at least in part, on a through-time GRAPPA calibration. A GRAPPA weight set can be computed from data in different groups of lines in the calibration data set because different groups of lines can be treated as unique calibration time frames due to phase encoding produced by the different gradient encoding conditions. | 01-16-2014 |
20140292330 | Quantifying Magnetic Resonance Parameters - Example apparatus and methods provide improved spatial and temporal resolution over conventional magnetic resonance imaging (MRI) for a large (e.g., 500 cm | 10-02-2014 |
20140294734 | Magnetic Resonance Imaging (MRI) Based Quantitative Kidney Perfusion Analysis - Example apparatus and methods provide improved spatial and temporal resolution over conventional magnetic resonance renography (MRR). Example apparatus and methods reconstruct under-sampled three-dimensional (3D) data associated with nuclear magnetic resonance (NMR) signals acquired from a kidney. The data is reconstructed using a 3D through-time non-Cartesian generalized auto-calibrating partially parallel acquisitions (GRAPPA) approach. Example apparatus and methods produce a quantized value for a contrast agent concentration in the kidney from a signal intensity in the data based, at least in part, on a two compartment model of the kidney. The two compartment model includes a plasma compartment and a tubular compartment. The quantized value describes a perfusion parameter for the kidney or a filtration parameter for the kidney. Greater precision is achieved for estimates of the perfusion parameter or filtration parameter as a result of the quantization performed on data acquired with greater spatial resolution and temporal resolution. | 10-02-2014 |
20140296700 | Magnetic Resonance Imaging (MRI) Based Quantitative Liver Perfusion Analysis - Example apparatus and methods provide improved spatial and temporal resolution over conventional magnetic resonance imaging (MRI) of the liver. Example apparatus and methods reconstruct under-sampled three-dimensional (3D) data associated with nuclear magnetic resonance (NMR) signals acquired from a liver. The data is reconstructed using a 3D through-time non-Cartesian generalized auto-calibrating partially parallel acquisitions (GRAPPA) approach. Example apparatus and methods produce a quantized value for a contrast agent concentration in the liver from a signal intensity in the data based, at least in part, on a compartment model of the liver. The quantized value describes a perfusion parameter for the liver. Greater precision is achieved for estimates of the perfusion parameter as a result of the quantization performed on data acquired with greater spatial resolution and temporal resolution. | 10-02-2014 |
Nicole Solimini, Quincy, MA US
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20110081362 | TREATMENT OF CANCER - Described herein are methods based, in part, on the discovery of genes or gene products that can be down-modulated to inhibit the growth and survival of a cell, such as a cancer cell. In one embodiment, the genes or gene targets are preferentially expressed in a cell having an activating Ras mutation (e.g., a cancer cell), which permits selective inhibition of growth in cells bearing an activating Ras mutation without affecting cells lacking enhanced Ras activity. In addition, the methods described herein provide for determining cancer prognosis in an individual bearing an activating Ras mutation. | 04-07-2011 |
Nicole Sollazzo, New York, NY US
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20100001019 | PRECISION MEASUREMENT DISPENSER - A storage dispensing unit provides for storage of a granular bulk material in a hermetic storage container. The granular material is held in a storage container which feeds a dispensing section. The dispensing section selectively dispenses the ingredient downward to a base, which optionally includes a weighting tray of a scale. The ingredient is dispensed by weight. The storage dispensing unit may also include a display and keypad for entry of a desired quantity of ingredient to be dispensed, and optionally which of plural ingredients to be dispensed. A controller can convert a requested volumetric measure to an equivalent weight measure, and dispense by weight in place of volume. The storage dispensing unit further optionally includes pressure control on the storage container, i.e., vacuum, an maintains a hermetic seal when not actively dispensing. Optionally, temperature may also be controlled to enhance the shelf life of the stored ingredient. | 01-07-2010 |
Nicole Stackhouse, Bothell, WA US
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20110060290 | STABILIZED PROTEIN COMPOSITIONS - Stabilized compositions of specific binding agents to RANKL, specific binding agents to TNF, and/or specific binding agents to IL-1R1 in containers are provided. Methods of making and using such compositions are also provided. | 03-10-2011 |
Nicole Staniec, Ewing, NJ US
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20110015227 | WARMING SENSATE COMPOSITION - The invention relates to a warming sensate composition of (i) a hot component, (ii) a cooling component, and (iii) optionally a bitter component. The weight ratio of (i):(ii) is from 1:3 to 1:100. If a solvent is provided in the composition, the solvent is present in an amount of less than 10 wt % ethanol, based on the total weight of the composition. Also, the bitter component, when used, is present in an amount of less than 0.15% by weight based on the total weight of the composition. | 01-20-2011 |
Nicole Suciu-Foca, New York, NY US
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20080311073 | Ilt3 Polypeptides and Uses Thereof - This invention provides a first polypeptide comprising all or a portion of the extracellular domain of ILT3, wherein the polypeptide is water-soluble and does not comprise the Fc portion of an immunoglobulin. This invention also provides a second polypeptide comprising (i) all or a portion of the extracellular domain of ILT3 operable affixed to (ii) the Fc portion of an immunoglobulin, wherein the Fc portion of the immunoglobulin comprises a function-enhancing mutation, and wherein the polypeptide is water-soluble. This invention further provides a third polypeptide comprising (i) all or a portion of the extracellular domain of ILT3 operable affixed to (ii) a transmembrane domain. This invention further provides related nucleic acids, expression vectors, host vector systems, compositions, and articles of manufacture and therapeutic and prophylactic methods using the polypeptides of the invention. | 12-18-2008 |
20090202544 | Methods of Treating Diseases by Targeting Silt3 - This invention provides a method of treating a subject afflicted with a disease, comprising withdrawing blood from the subject, treating the withdrawn blood so as to remove sILT3 from the blood, and returning the treated blood to the subject, thereby treating the subject afflicted with the disease. This invention also provides the above method, further comprising administering an anti-ILT3 antibody to the subject. The invention also provides a method of treating a subject afflicted with a disease, comprising administering to the subject an anti-ILT3 antibody, thereby treating the subject. In one embodiment, the disease is chronic viral disease. In another embodiment, the disease is cancer. | 08-13-2009 |
20090274685 | ILT3 POLYPEPTIDES AND USES THEREOF - This invention provides a method for inhibiting the rejection of transplanted islet cells, comprising administering to the subject a polypeptide comprising all or a portion of the extracellular domain of ILT3, wherein the polypeptide is water soluble. This invention further provides a method of treating diabetes, by inhibiting the rejection of transplanted islet cells through the administration of the polypeptide to the subject. | 11-05-2009 |
20090280109 | ILT3 and ILT4-related compositions and methods - This invention provides compositions which comprise at least two of a CD4+CD25+ cell, IL-10, a CD8+CD28− cell and a vitamin D | 11-12-2009 |
20120321623 | ILT3 Polypeptides and Uses Thereof - This invention provides a first polypeptide comprising all or a portion of the extracellular domain of ILT3, wherein the polypeptide is water-soluble and does not comprise the Fc portion of an immunoglobulin. This invention also provides a second polypeptide comprising (i) all or a portion of the extracellular domain of ILT3 operable affixed to (ii) the Fc portion of an immunoglobulin, wherein the Fc portion of the immunoglobulin comprises a function-enhancing mutation, and wherein the polypeptide is water-soluble. This invention further provides a third polypeptide comprising (i) all or a portion of the extracellular domain of ILT3 operable affixed to (ii) a transmembrane domain. This invention further provides related nucleic acids, expression vectors, host vector systems, compositions, and articles of manufacture and therapeutic and prophylactic methods using the polypeptides of the invention. | 12-20-2012 |
20130156763 | ILT3 Polypeptides and Uses Thereof - This invention provides a method for inhibiting the rejection of transplanted islet cells, comprising administering to the subject a polypeptide comprising all or a portion of the extracellular domain of ILT3, wherein the polypeptide is water soluble. This invention further provides a method of treating diabetes, by inhibiting the rejection of transplanted islet cells through the administration of the polypeptide to the subject. | 06-20-2013 |
Nicole Sunaryo, Austin, TX US
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20110163880 | SYSTEM AND METHOD RESPONSIVE TO AN ALARM EVENT DETECTED AT AN INSULIN DELIVERY DEVICE - Embodiments include an alarm unit responsive to an alarm event detected at an insulin delivery device. The alarm unit includes circuitry to select an action to occur remote to the insulin delivery device in response to the alarm event. Embodiments include an alarm center responsive to an alarm event at an insulin delivery device to contact a person in response to the alarm event. | 07-07-2011 |
Nicole Tasiaux, Brussels BE
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20090081127 | Dendritic-like cell/tumor cell hybrids and hybridomas for inducing an anti-tumor response - The present invention relates to a method of producing a plurality of dendritic cell/tumor cell hybrids which induce an anti-tumor response when applied to a patient. The present invention further relates to a method of producing a dendritic cell/tumor cell hybridoma which induces an anti-tumor response when applied to a patient. | 03-26-2009 |
Nicole Tion, Dublin, CA US
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20090249360 | INTEGRATING ENTERPRISE SUPPORT SYSTEMS - Facilitating the exchange of information among applications (e.g., business support systems or operational support systems or a combination thereof) may involve receiving a data object from a first application, using a first controller to route the received data object to a first transformer, using the first transformer to transform the data object from a first format used by the first application into a common format object, publishing the common format object to a communication channel, receiving a request from a subscribing application to subscribe to the communication channel, using a second controller to route the common format object to a second transformer, using the second transformer to transform the common format object into a data object in a second format used by the subscribing application, and sending the data object in the second format to the subscribing application. | 10-01-2009 |
Nicole Van Der Weerden, Brunswick West AU
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20090197809 | ANTIFUNGAL METHODS - A system for reducing the incidence or severity of fungal infection of a plant, comprising a chemical fungicide component, which may be provided by foliar or root (soil or liquid nutrient) application, together with an antifungal plant defensin not in nature expressed in the plant being protected or expressed in lower amounts or in different tissues, provides synergistic improvement in protection against infection by a plant pathogenic fungus which is susceptible to the defensin and the fungicide. The fungicide can be a strobilurin or a triazole, and the defensin can be selected from a wide range of known defensins, for example, NaD1 and others, or it can be a chimeric defensin engineered for low toxicity to the plant. The defensin can be provided as a protein formulation, optionally together with the fungicide, or it can be provided by recombinant expression in the plant to be protected from fungal infection. | 08-06-2009 |
Nicole Van Luijk, Utrecht NL
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20100311132 | PRODUCTION OF ITACONIC ACID - The invention relates to the production of itaconic acid in micro-organisms by introducting into a suitable host cell a gene coding for the enzyme cis-aconitic acid decarboxylase, preferably derived from | 12-09-2010 |
Nicole Walthert, Orleans FR
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20100023293 | DYNAMIC POSTURAL APPARATUS FOR DETECTING A BALANCED BIPED POSTURE - Scales for detecting equilibrium anomalies of a human body include force sensors under a dynamic. A processing unit determines, from signals of the sensors, the total weight of a subject on the plate. The weight is viewed on a display. Deformable members associated with each sensor provide support along an upward direction of the plate relative to a fixed portion of the scales. A module compares data of the sensors received by the processing unit, to detect a poor distribution of the forces. The display is modified when a poor force distribution is measured by the detector module. The subject can thus exercise dynamically to find a balanced position of his/her feet on the plate. | 01-28-2010 |
Nicole Weber, Schwieberdingen DE
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20090321160 | BRAKING STRATEGY FOR A HYBRID DRIVE OF A VEHICLE - Method for operating a hybrid drive, in particular a parallel hybrid drive, of a vehicle. The parallel hybrid drive includes an internal combustion engine and at least one electric drive, at least one energy storage device, and a vehicle transmission. During deceleration phases in which a torque required on the transmission input side is present, the internal combustion engine is operated either in drag mode or at a minimum drive torque. | 12-31-2009 |
20110094590 | Method For Operating a Fluid Valve Via An Oscillating Valve Motion - In a method for operating a fluid valve for controlling or regulating a fluid, having at least one movable valve component is displaceable with the aid of at least one electrical actuating signal which contains at least one first actuating signal portion which causes an oscillating valve motion of the valve component. Pressure oscillations generated in the fluid due to the oscillating valve motion are detected, and are used for regulation of the oscillating valve motion caused by the first actuating signal portion. | 04-28-2011 |
Nicole Werquet, Stuttgart DE
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20110005199 | Method for Reducing Emission of Nitrogen Oxide in a Motor Vehicle Having a Lean Burning Internal Combustion Engine - In a method for reducing the emission of nitrogen dioxide in a motor vehicle having an exhaust gas purification system having an SCR catalytic converter with adsorption centers for nitrogen oxides, an exhaust gas enriched with ammonia is supplied to the SCR catalytic converter above an operating temperature. Below the operating temperature, the exhaust gas supplied to the SCR catalytic converter is enriched with a material such that an adsorption of nitrogen oxides is inhibited at corresponding adsorption centers of the SCR catalytic converter. In order to reduce the overall NO | 01-13-2011 |
Nicole Wilb, Montreal CA
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20090042768 | Purine derivatives and their use for treatment of autoimmune diseases - Compounds useful in the treatment of autoimmune disease are described by the following general formula: | 02-12-2009 |
Nicole Wilb, Laval CA
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20090068169 | 2,4,6-triamino-s-triazine-based compounds which bind to the tail (fc) portion of immunoglobulins and their use - The present invention describes new compounds which are useful for binding to the tail or Fc portion of immunoglobulins and so have utility in those applications which require the non-covalent binding interaction of a molecule with the Fc portion of immunoglobulins. Such applications include the detection and purification of immunoglobulins as well as the treatment of certain autoimmune diseases. | 03-12-2009 |
Nicole Wopfner, Salzburg AT
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20100104606 | ALLERGEN FRAGMENTS - The present invention relates to a peptide derived from the ragweed pollen allergen Amb a (1) and comprising (6 to 50) amino acid residues and pharmaceutical preparations comprising said peptide and uses thereof. | 04-29-2010 |
20110217334 | HYPOALLERGENIC MOLECULES - The present invention relates to a hypoallergenic molecule consisting of Bet v Ia or an allergen having at least 40% identity to Bet v Ia comprising mutations of at least four amino acid residues in the region of amino acids 100 to 125 of Bet v Ia or its corresponding region of the allergen having at least 40% identity to Bet v Ia. | 09-08-2011 |
Nicole Wrubel, Berkeley, CA US
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20090167685 | METHOD AND SYSTEM FOR PROVIDING A COMPUTER ENVIRONMENT FOR CHILDREN - A computer system for providing a simulated computer environment for young children. A console is coupled to a display, e.g., a television set, for storing and processing a plurality of user selectable programs. User selectable program may be stored on a cartridge and received by the console. The user selectable programs are child oriented, educational, interactive and provide feedback responsive to user interaction. A theme-able wireless keyboard adapted for use by young children with keys larger in size than an adult keyboard is coupled with the console, e.g., infrared. The keyboard excludes a subset of adult oriented function and punctuation keys. A theme-able mouse and a mouse pad that is detachably couple to either the left or the right side of the keyboard may be included. An animated character in a GUI and in the programs interacts, gives user instruction and is the focus of reward in reward oriented programs. | 07-02-2009 |
Nicole Wyttenbach, Sissach CH
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20100310659 | Compositions and Uses Thereof - Provided are solid dispersions, solid molecular complexes, salts and crystalline polymorphs involving propane- | 12-09-2010 |
20130172329 | NOVEL SOLID FORMS - The instant invention relates to novel solid forms of the compound of formula (I) | 07-04-2013 |
20140329806 | NOVEL SOLID FORMS - The instant invention relates to novel solid forms of the compound of formula (I) | 11-06-2014 |
Nicole Yacktman, Lakeway, TX US
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20100082063 | Pacifier Tether - A pacifier tether includes a ring or aperture at one end to be interposed between two halves of a fastener such as a button and button hole or two halves of a snap on an infant garment. The tether is connected to the infant garment by completing the buttoning or snap fastening about the ring on the tether to secure the ring between the fastened garment layers. A second ring or aperture at a second tether end is configured to allow passage of the other tether end to form a loop about a pacifier handle. Alternatively, the tether is connected to the pacifier by a hook and loop touch fastener, snap fastener, or snap fit. A snap adapter on the tether can be used to engage each of two halves of a snap on the infant garment. | 04-01-2010 |
Nicole Zitmann, Oxford GB
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20110045021 | SUGAR IMMUNOGENS - Disclosed are compositions and methods useful for inducing an immunogenic response in a subject or host. In particular, the compositions and methods may be directed to carbohydrate HIV vaccines and to methods of producing a carbohydrate HIV vaccine by introducing antigenic sugars into mimics of the glycans of the HIV envelope glycoproteins gp120 and gp41. | 02-24-2011 |
20130195798 | COMBINATION THERAPY FOR TREATMENT OF VIRAL INFECTIONS - One can treat a viral infection by first administering at least one first antiviral compound for a first time period and then, after the end of the first time period, concurrently or subsequently administering the at least one first antiviral compound and at least one second antiviral compound for a second period. In some cases, after the end of the second period, the same at least one second antiviral compound that was administered during the second time period may be administered for a third time period without concurrent or subsequent administration of the at least one first antiviral compound. | 08-01-2013 |
Nicole Zuedel Fernandez, Hamburg DE
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20100047202 | Hair-Conditioning Agents Containing Selected Cationic Polymers and Water-Soluble Silicones - Cosmetic preparations, especially compositions that condition keratin fibers, which comprise at least two different cationic polymers and a water-soluble silicone. Said compositions are especially used to make the hair easy to comb and at the same time add volume to the hair. The compositions are preferably sprayed onto wet or dry keratin fibers, the composition preferably remaining on the keratin fibers until the next wash. | 02-25-2010 |