Nickols
Francis Malcolm John Nickols, Singapore SG
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20140042845 | APPARATUS AND AN ASSEMBLY FOR EMULATING AN IMPULSE FORCE EXERTED BY A SKELETAL MUSCLE - Various embodiments provide, an apparatus for emulating an impulse force exerted by a skeletal muscle, the apparatus including a mass and an actuator, the actuator being adapted to exert a unidirectional force, a unidirectional torque, a unidirectional moment or a unidirectional couple, on the mass, the apparatus being configured in use to selectively couple together the mass and the actuator so that the unidirectional force, a unidirectional torque, a unidirectional moment or a unidirectional couple exerted on the mass by the actuator emulates the impulse force. | 02-13-2014 |
Josh Nickols, Nashville, TN US
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20120208713 | METHODS AND COMPOSITIONS RELATING TO FUSIONS OF ALK FOR DIAGNOSING AND TREATING CANCER - Disclosed are methods and compositions for detecting the presence of a cancer in a subject and assessing the efficacy of treatments for the same. The disclosed method use reverse transcription polymerase chain reaction (RT-PCR) and multiplex polymerase chain reaction techniques as well as Template Exchange Extension Reaction (TEER) to detect the presence of point mutations, truncations, or fusions of anaplastic lymphoma kinase. | 08-16-2012 |
Joshua Nickols, Nashville, TN US
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20100247651 | PLATELET-DERIVED GROWTH FACTOR COMPOSITIONS AND METHODS FOR THE TREATMENT OF OSTEOCHONDRAL DEFECTS - The present invention provides compositions and methods for treating an osteochondral defect. In one embodiment, provided is a composition for treating an osteochondral defect comprising a biphasic biocompatible matrix and platelet derived growth factor (PDGF), wherein the biphasic biocompatible matrix comprises a scaffolding material and wherein the scaffolding material forms a porous structure comprising an osseous phase and a cartilage phase. In another embodiment, also provided is a method for treating an osteochondral defect in an individual comprising administering to the individual an effective amount of a composition comprising a biphasic biocompatible matrix and PDGF to at least one site of the osteochondral defect, wherein the biphasic biocompatible matrix comprises a scaffolding material and wherein the scaffolding material forms a porous structure comprising an osseous phase and a cartilage phase. | 09-30-2010 |
20130122095 | PLATELET-DERIVED GROWTH FACTOR COMPOSITIONS AND METHODS FOR THE TREATMENT OF OSTEOCHONDRAL DEFECTS - The present invention provides compositions and methods for treating an osteochondral defect. In one embodiment, provided is a composition for treating an osteochondral defect comprising a biphasic biocompatible matrix and platelet derived growth factor (PDGF), wherein the biphasic biocompatible matrix comprises a scaffolding material and wherein the scaffolding material forms a porous structure comprising an osseous phase and a cartilage phase. In another embodiment, also provided is a method for treating an osteochondral defect in an individual comprising administering to the individual an effective amount of a composition comprising a biphasic biocompatible matrix and PDGF to at least one site of the osteochondral defect, wherein the biphasic biocompatible matrix comprises a scaffolding material and wherein the scaffolding material forms a porous structure comprising an osseous phase and a cartilage phase. | 05-16-2013 |
Matthew A. Nickols, Sachse, TX US
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20100088419 | METHOD AND SYSTEM FOR PROVIDING A SETUP TIMER IN A SIP-BASED NETWORK - A system and method for providing a setup timer in a SIP-based network including initiating a session by transmitting one or more messages to a first user. The system and method also comprises starting a first timer upon transmitting the one or more messages, wherein the first timer is configured to expire after a first predetermined time period. The system and method further comprises starting a second timer upon transmitting the one or more messages, wherein the second timer is configured to expire after a second predetermined time period. The system and method furthermore comprises transmitting one or more instructions upon expiration of at least one of the first timer and the second timer, and taking one or more actions based at least in part on the one or more instructions. | 04-08-2010 |
20140140340 | Method and System for Providing a Setup Timer in a SIP-Based Network - A system and method for providing a setup timer in a SIP-based network including initiating a session by transmitting one or more messages to a first user. The system and method also comprises starting a first timer upon transmitting the one or more messages, wherein the first timer is configured to expire after a first predetermined time period. The system and method further comprises starting a second timer upon transmitting the one or more messages, wherein the second timer is configured to expire after a second predetermined time period. The system and method furthermore comprises transmitting one or more instructions upon expiration of at least one of the first timer and the second timer, and taking one or more actions based at least in part on the one or more instructions. | 05-22-2014 |
Matthew A. Nickols, Garland, TX US
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20130007291 | MEDIA INTERWORKING IN IPv4 AND IPv6 SYSTEMS - A device receives a request, from a first endpoint device, to initiate a communication session with a second endpoint device. The device determines whether an IP version that is likely to be used by the second endpoint device, in establishing a media communication session, is compatible with the IP version used by the first endpoint device. The device transmits, when the determination is that the IP version likely to be used by the second endpoint device is compatible with the IP version used by first endpoint device, SIP messages to signal the establishment of a direct media communication session between the first and second endpoint devices. Otherwise, the device may transmit SIP messages to signal the establishment of the media communication session through an intermediary device. | 01-03-2013 |
Nicholas G. Nickols, Van Nuys, CA US
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20080269138 | Polyamides with tail structures - The present invention relates to polyamides with a tail comprising a linker and an end-group. A preferred end-group is isophthalic acid and derivatives thereof. Polyamides of the invention are capable of entering the nucleus of cells. Polyamides of the invention are capable of selectively binding DNA. The invention also relates to methods of using the polyamides in therapy and research. | 10-30-2008 |
20090042965 | Inhibitors for steroid response elements and related methods - The present invention relates to polyamides capable of inhibiting ARE-, GRE- and ERE-mediated gene regulation in cells. The invention also relates to methods to treat diseases related to ARE-, GRE- and ERE-mediated gene regulation. | 02-12-2009 |
20140194483 | INHIBITORS FOR STEROID RESPONSE ELEMENTS AND RNA POLYMERASE II AND RELATED METHODS - The present invention relates to polyamides capable of inhibiting ARE-, GRE- and ERE-mediated gene regulation in cells. The present invention also relates to polyamides capable of modulating the activity of RNA polymerase II and p53. The invention also relates to methods to treat diseases related to ARE-, GRE- and ERE-mediated gene regulation and to RNA polymerase II and p53 activity. | 07-10-2014 |