Natasa

Natasa Cmiljanovic, Basel CH

Patent application number	Description	Published
20110275762	TRIAZINE, PYRIMIDINE AND PYRIDINE ANALOGS AND THEIR USE AS THERAPEUTIC AGENTS AND DIAGNOSTIC PROBES - The invention relates to novel therapeutic agents and diagnostic probes. The invention also relates to phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) inhibitor triazine-, pyrimidine- and pyridine-based compoundŝ Formula (I), their stereoisomers, geometric isomers, tautomers, solvates, metabolites, N-oxide derivatives, pharmaceutically acceptable salts, and prodrugs thereof compositions of the new compounds; either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, for treating disorders mediated by lipid kinases. •Methods of using compounds of Formula (I) for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed. (Formula I)	11-10-2011
20130040912	PIPERAZINOTRIAZINES AS PI3K INHIBITORS FOR USE IN THE TREATMENT ANTIPROLIFERATIVE DISORDERS - The invention relates to compounds of formula (I) R1 is methyl, n-hexyl, aminoethyl, methylaminoethyl, ethylaminoethyl, dimethylaminoethyl, acryloylaminoethyl, methacryloylaminoethyl, methoxyethyl, ethoxyethyl, d-C4-alkyl-sulfonyl, acryloyl, or methacryloyl; or R1 is aminoethyl, acryloyl or acryloylaminoethyl carrying a linker and a tag, and R2 and R3, independently of each other, are hydrogen or CrC4-alkyl, or R2 and R3 together form a methylene or an ethylene bridge; and tautomers, solvates and pharmaceutically acceptable salts thereof. These compounds are effective in preventing or treating a disease or disorder modulated by PI3 kinases and/or mTOR, in particular treating a hyperproliferative disorder.	02-14-2013
20130040934	SPIROCYCLIC COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS AND DIAGNOSTIC PROBES - The invention relates to new triazines (G=Q=U are N), pyrimidines (two out of G, Q and U are N), and pyridopyrimidines (one of G and U together with R2 forms an anullated pyridine ring) of formula (I) carrying a spirocyclic substituent, wherein E	02-14-2013

Natasa Drnovsek, Ljubljana SI

Patent application number	Description	Published
20130190888	Implant Having a Multilayered Coating and a Process for Preparing Thereof - The present invention relates to an implant having a multilayered coating comprising a porous titanium-based layer on the implant, an optional interface titania layer on and/or in the porous titanium-based layer and a bioactive glass layer on and/or in the porous structure formed by the titanium-based and titania layer(s); as well as to a process for preparing an implant having a multilayered coating.	07-25-2013

Natasa Dzidic, Laguna Beach, CA US

Patent application number	Description	Published
20090088328	Microarray Quality Control - The present invention relates to methods of quality control of manufactured nucleic acid arrays. Fluorescence detection is used to evaluate the quality of a printed nucleic acid array without the need to add or otherwise link a fluorescent compound or dye to the nucleic acid. Nucleic acid arrays suitable for this method are those where the spots of the array are formed by printing a solution that contains the nucleic acid in an ion containing solution. Printing quality may be evaluated by measuring the intensity of fluorescence at the location of each printed sample, and/or by measuring the “morphology” (i.e. shape) of the printed sample. Printed spots can be “imaged” by measuring fluorescence across a spotted sample in two dimensions. The resulting image of a printed spot can be compared with a reference printed image expected for the printing equipment and solid phase used.	04-02-2009

Natasa Dzidic, San Clemente, CA US

Patent application number	Description	Published
20090069191	Rapid Comparative Genome Hybridization - Disclosed is a method for performing nucleic acid hybridization assays, such as assays used for detecting and mapping chromosomal or genetic abnormalities associated with various diseases or associated with predisposition to various diseases. In a particular aspect, the present method relates to the use of rapid nucleic acid hybridization methods for comparing nucleic acid segments of one genome to corresponding nucleic acid segments in another genome(s).	03-12-2009

Natasa Levicar, London GB

Patent application number	Description	Published
20080254460	Method of Fetal Cell Enrichment - The present invention provides a method of enriching fetal cells in a maternal blood sample wherein cells which are CD34+ and capable of adhering to a solid support are selected, an analysable sample of fetal cells obtainable by the methods of the invention and a kit for use in the methods of the invention. There is also provided a method of fetal gender determination and a method of diagnosing a fetal genetic abnormality.	10-16-2008

Natasa Mekic, Denver, CO US

Patent application number	Description	Published
20150013974	FRACTURE EVALUATION THROUGH CASED BOREHOLES - A method of estimating fractures in an earth formation includes: disposing an acoustic tool in a cased borehole in an earth formation, the acoustic tool including a multipole acoustic transmitter and an acoustic receiver; transmitting an acoustic signal into the borehole; measuring deep shear wave (DSW) signals generated from shear body waves reflected in the formation in a far-field region of the formation around the borehole; and estimating at least a location and an orientation of a fracture in the formation based on the DSW signals.	01-15-2015

Natasa Mekic, Houston, TX US

Patent application number	Description	Published
20150109886	ACOUSTIC WAVE IMAGING OF FORMATIONS - An embodiment of a method of estimating characteristics of an earth formation includes: disposing an acoustic tool in a borehole in an earth formation, the acoustic tool including an acoustic multipole transmitter and at least one multipole acoustic receiver; transmitting acoustic signals into the borehole, the acoustic signals generating at least one acoustic body wave that radiates away from the borehole into a far-field formation region; measuring reflected signals including body waves reflected from reflective boundaries in the far-field formation region; identifying a reflective boundary in the formation and reflection attributes associated with the reflective boundary; and estimating at least one of a thickness, distance and a lateral extent of a hydrocarbon formation feature based on the reflected signals and the reflection attributes.	04-23-2015

Natasa Milic-Frayling, Cambridge GB

Patent application number	Description	Published
20080294735	Messaging Service - A messaging service is described which provides application agnostic and cross-platform messaging. Senders compile message content components and specify message preferences. The messaging service calculates a utility and cost of sending the message over different types of communication channel. A communication channel is selected using the cost and utility information and the message service formats the message content components for the particular communication channel. The message is then sent for example, as email, SMS, MMS or other suitable type depending on the selected channel. The utility is calculated using the sender message preferences, communication channel attributes, sending and recipient device attributes and preferably also, but not essentially, preferences of the recipient.	11-27-2008
20100146015	Rich-Context Tagging of Resources - Tagging of resources in order to associate them is described. In an embodiment it is possible to assign tags to resources or switch between resources with different tags, in the context of current work being undertaken by a user. For example, from a single application window that is currently used, a user is able to switch to other resources by tag in an embodiment. Different embodiments illustrate how tags may have multiple purposes and those purposes may evolve thus enabling associated resources to be exposed in different ways. In some embodiments rich metadata about tag usage and/or the use of resource associated with a tag is stored and used to provide additional functionality. Examples are described in which persistence of resources associated with tags is provided and may involve representation of resources such as by duplication of files or by creating alternative representations of resources.	06-10-2010
20100223257	SYSTEMS AND METHODS FOR ENHANCING SEARCH QUERY RESULTS - Embodiments of the present invention leverage search query result page thumbnails and search query result link content evaluations to provide user-dependent enhanced search query results. This provides a simplified means to inform a user of the relevancy of search query results based on the user's preferences, environment, and profile, etc. The present invention allows a user to more adequately determine the value of the search query result via search query result indicators within the thumbnail and in the proximity of a displayed result link. In one embodiment of the present invention, a thumbnail of a query result link is automatically displayed when the link is selected. This provides a tool to view an entire search result page, eliminating the necessity of scrolling through each page to find relevant search terms. In another embodiment of the present invention, indicators are utilized to inform a user of the content of a search result link.	09-02-2010
20100306665	INTELLIGENT BACKWARD RESOURCE NAVIGATION - A system for navigating among resources includes a target detection module detecting whether a first resource has been branched from to two other different resources and a backward navigation module operable to detect selection of a backward navigation button and cause navigation to the first resource. A method includes designating a target resource accessible via a backward navigation button in a first browser session, detecting selection of the backward navigation button in a second browser session, and navigating to the target resource in the second browser session. The method can involve detecting hovering of a pointer icon over the backward navigation button and responsively presenting a thumbnail of a resource associated with the backward navigation button.	12-02-2010
20110314039	Media Item Recommendation - Media item recommendation is described. In one example, a statistical model of media consumption is applied to media session consumption data from a community of users to infer parameters of the model. The model comprises a first probability distribution for each user defining a likelihood of the user having a latent characteristic for a session, and a second probability distribution for each latent characteristic defining a likelihood of a user selecting a media item given the latent characteristic. In another example, the inferred parameters are provided to a recommendation engine arranged to recommend media items. The recommendation engine uses the model with inferred parameters and data describing media items newly consumed by a user to infer a current latent characteristic for a current session of the user, and uses them to generate recommended media items for the user in the current session based on the current latent characteristic.	12-22-2011
20120030317	Capture of Content from Dynamic Resource Services - Methods are described which enable processing of resources originally accessed by a content access operation. An identifier is generated and used to augment all requests for resources which relate to a particular content access operation. A proxy stores the resources associated with the identifier and then sends the resources to the application that requested them (e.g. a browser). The resources may be requested from the proxy by applications using the identifier so that they can be processed (e.g. thumbnail generation, textual analysis) and the processed data may be stored and/or presented to the user.	02-02-2012
20130111483	AUTHORING AND USING PERSONALIZED WORKFLOWS	05-02-2013
20130159426	Dynamic Control of an Electronic Message System - Methods of dynamic control of an electronic message system are described. In an embodiment, a system which is separate from a messaging service within the electronic message system generates an event signal which relates to an event external to the messaging service. The event signal is received by the messaging service and this triggers a dynamic update in one or more electronic messages which are identified based on the event signal received. For example, the dynamic update may result in the message content being displayed in a different manner or the message being delivered or deleted. Examples of external events include a community response to a particular message, based on a subset of information about the message which has been shared, the location of one or more users and a change in membership of a group.	06-20-2013
20140214607	GLOBAL CURRENCY OF CREDIBILITY FOR CROWDSOURCING - A global currency for crowdsourcing which comprises stored credibility values for every buyer (of human intelligence) and seller (of human intelligence) in a crowdsourcing system is described, creating an ecosystem where buyers and sellers are interdependent on each other. This dependence is the property of a global currency of credibility, where a buyer's credibility is a function of the credibility of the sellers who engaged with HITs published by the buyer, while the credibility of a seller is a function of the credibility scores associated with the HITs, which in turn is dependent on the buyer's credibility. The credibility scores are updated with every HIT completion and propagated through a network that connects HITs with buyers, sellers and platforms, as well as sellers with other sellers and buyers with other buyers. Buyers and sellers can bid, auction and refer HITs as a function of their credibility scores.	07-31-2014

Natasa Milicic, Muenchen DE

Patent application number	Description	Published
20150185039	Contact-Analogue Display, in Particular of a Lane Change - A method is disclosed for the contact-analogue display of a navigation instruction for a driving maneuver, particularly a lane change, of a vehicle, wherein the driving maneuver can be carried out at any point of a cohesive driving route of a road. The method includes: contact-analogue stationary displaying of the instruction at the beginning of the driving route for a first distance traveled by the vehicle; adapting the contact-analogue display of the instruction to the change of position of the vehicle, so that the instruction changes its position corresponding to the change of position of the vehicle, for a second distance traveled by the vehicle; and contact-analogue stationary displaying of the instruction at the end of the driving route, for a third distance traveled by the vehicle.	07-02-2015

Natasa Obermajer, Scopolijeva SI

Patent application number	Description	Published
20140255358	GENERATION OF IMMUNOSUPPRESSIVE MYELOID CELLS USING PGE2 - Therapies effective for the treatment and prevention of autoimmune diseases, chronic inflammatory diseases, transplant rejection or Graft versus Host Disease (GvH), using prostaglandin (PG), alternative agonists of PG receptors, EP2 or EP4, or other activators of adenylate cyclase/cAMP/PKA/CREB signaling pathway are disclosed herein. These methods include the administration of a therapeutically effective amount of myeloid cells pre-treated ex vivo with the above-mentioned factors, or the in vivo administration of such agents in combination with the factors attracting myeloid precursor cells, such as myeloid cell-attracting chemokines or their inducers. Such therapies can be applied for the prevention or treatment of autoimmune diseases, spontaneous and specific pathogen-induced inflammatory diseases (including some infectious diseases), premalignant and malignant lesions, and for prevention and treatment of transplant rejection and GvH.	09-11-2014

Natasa Poklar Ulrih, Ljubljana SI

Patent application number	Description	Published
20150140634	METHOD FOR PRODUCING A POLYMER PRODUCT FROM MULTIDIMENSIONAL AGGREGATED COMPONENTS AS BARRIER OR CARRIERS OF LIVING MICROBIAL CELLS AND BIOLOGICAL BARRIERS IN PLASTIC AND TEXTILE - This invention relates to a polymer product comprising the components consisting of a polymer in form of granules; a multidimensional structure containing amphiphilic molecules, such as lipids, surfactants or polymers, wherein said polymer product has an active and/or passive oxygen or CO	05-21-2015

Natasa Radas, Split HR

Patent application number	Description	Published
20100285437	DIDACTIC TOOLS FOR LEARNING MATHEMATICS - Didactic tools for learning mathematics contain a set of jigsaws, inserters, abacuses, three-dimensional arrangeable and separable models, mental maps, arranging pads, Multiplication tables without numbers, cylinders, and other spatially situated mathematical sizes and open the possibility of many combinations for arranging and displaying mathematical contents. These contents range from mathematical basis (relations, numbers and spaces, shapes and quantities) to theorems and rules of higher mathematical levels (multiplication, division, squaring, cubing, Pitagora's and binomial theorem, sum of square sequences and other regularities, some of which are new and unknown). With their inner consistency and coherence, they enable numerous combinations and research, and every tools can function independently in a clear and unambiguous way, based on natural mental abilities of logics and perception, close even to the earliest pre-school age. There is no need for additional instructions and lessons, or the knowledge of mathematical language, because the rules and relations are not proved by formulas, but are shown in a visible and tangible way. All this is achieved with a realistic display of quantities and their relations, the shape, position and colour, with the help of squares and cubeletes. It all enables arranging, categorizing, equalizing, joining, sequencing etc., so that adding or mere counting is sufficient for checking the visible quantities and their relations. They vividly enable discovery and understanding of mathematical laws by direct noting, by themselves. In that way they provide the joy of cognition, which enables more pleasurable, faster and easier understanding, practicing and memorizing.	11-11-2010

Natasa Stambuk Cvitanovic, Split HR

Patent application number	Description	Published
20140373648	SYSTEM AND METHOD FOR AUTOMATIC RECORDING OF A PLURALITY OF MEASUREMENTS AND VERIFICATION OF SPECIMENS IN ROCK MECHANICS - A system and method for automatic recording of a plurality of measurements and verification of specimens in rock mechanics is disclosed. The system may include a server system, a support surface, a motorized stage, a plate, a V-block, one or more digital dial gauges, a measurement system controller, a slide motion controller and a moving frame. The method may include the steps of securing the rock specimens onto a V-block of a system to automatically record a plurality of measurements and verify rock specimens, actuating a linear motorized stage to collect a plurality of rock specimens data, sliding a digital dial gauge tip along one or more of a plurality of chosen lines at the same time on the specimen surface, transmitting a plurality of chosen surface lines data to the system to automatically record a plurality of measurements and verify rock specimens and recording the chosen surface lines data.	12-25-2014

Natasa Strbo, Miami, FL US

Patent application number	Description	Published
20140286991	COMBINED CELL BASED GP96-IG-SIV/HIV, RECOMBINANT GP120 PROTEIN VACCINATION FOR PROTECTION FROM SIV/HIV - Compositions are provided comprising heat shock protein, immunoglobulins and retroviral antigens to induce systemic and mucosal immunity to infection from retroviruses such as Human Immunodeficiency Virus (HIV). Methods of treatment provided comprise administration of the compositions, which boost the immune systems response to the retroviral antigens or immunogens.	09-25-2014

Natasa Strbo, Miami Beach, FL US

Patent application number	Description	Published
20110223196	HIV/SIV VACCINES FOR THE GENERATION OF MUCOSAL AND SYSTEMIC IMMUNITY - Compositions of genetically engineered, secreted gp96 (gp69-Ig) induced strong mucosal and systemic immune responses and CD8 expansion that was independent of CD4 help. Immunization of patients with gp96-Ig immunization is especially attractive for induction of mucosal and systemic immunity to SIV/HIV and other diseases.	09-15-2011
20120029472	TNFR25 AGONISTS TO ENHANCE IMMUNE RESPONSES TO VACCINES - TNFR25 compositions enhance the immune response against antigens. Administration of TNFR25 agonists was found to enhance tumor rejection, responses against viral diseases and other infectious organisms.	02-02-2012
20140037682	HIV/SIV VACCINES FOR THE GENERATION OF MUCOSAL AND SYSTEMIC IMMUNITY - Compositions of genetically engineered, secreted gp96 (gp69-Ig) induced strong mucosal and systemic immune responses and CD8 expansion that was independent of CD4 help. Immunization of patients with gp96-Ig immunization is especially attractive for induction of mucosal and systemic immunity to SIV/HIV and other diseases.	02-06-2014

Natasa Vasiljevic, Charterhouse Square GB

Patent application number	Description	Published
20150051084	METHOD FOR DETERMINING PROGNOSIS OF PROSTATE CANCER IN A SUBJECT - A method for determining the prognosis of prostate cancer in a subject is provided which comprises the assessment of the methylation status of the HSPB1 gene in a prostate cancer sample.	02-19-2015

Natasa Zarovni, Milan IT

Patent application number	Description	Published
20120058492	Method and a Kit To Detect Malignant Tumors and Provide a Prognosis - A method and kit is provided to quantifying and qualifying exosomes in human cell derived samples or in body fluid based on expression of TM9-superfamily proteins on the exosomes. Furthermore, a method and a kit to diagnose malignant tumors is provided. The disclosure also provides a method to monitor tumor growth.	03-08-2012
20120122118	Monclonal antibodies, hybridomas and methods for use - The present invention provides monoclonal antibodies to TM9SF-proteins and hybridoma cell lines that produce the monoclonal antibodies to TM9SF4. This invention also provides a method for determining the level of TM9SF4-protein in biological fluid samples, tissue samples and in microvesicles such as exosomes, comprising kit for determining the level of TM9SF4 protein in human exosomes and other microvesicles, in tissue samples, and in biological fluids.	05-17-2012
20150044695	Method and a Kit To Detect Malignant Tumors and Provide a Prognosis - A method and kit is provided to quantifying and qualifying exosomes in human cell derived samples or in body fluid based on expression of TM9-superfamily proteins on the exosomes. Furthermore, a method and a kit to diagnose malignant tumors is provided. The disclosure also provides a method to monitor tumor growth.	02-12-2015

Natasa Zivic, Siegen DE

Patent application number	Description	Published
20110138257	METHOD FOR TRANSMITTING AND RECEIVING A DATA BLOCK - The invention relates to a method for transmitting a data block (	06-09-2011