Patent application number | Description | Published |
20090318336 | Deuterated Cyclosporine Analogs and Methods of Making the Same - Cyclosporine derivatives are disclosed which possess enhanced efficacy and reduced toxicity over naturally occurring and other presently known cyclosporins and cyclosporine derivatives. The cyclosporine derivatives of the present invention are produced by chemical and isotopic substitution of the cyclosporine A (CsA) molecule by: (1) Chemical substitution and optionally deuterium substitution of amino acid 1; and (2) deuterium substitution at key sites of metabolism of the cyclosporine A molecule such as amino acids 1, 4, 9. Also disclosed are methods of producing the cyclosporine derivatives and method of producing immunosuppression with reduced toxicity with the disclosed cyclosporine derivatives. | 12-24-2009 |
20100047178 | PERYLENEQUINONE DERIVATIVES AND USES THEREOF - The present invention relates to compounds which are perylenequinone derivatives, their stereoisomers and atropisomers. These compounds can be particularly useful as photosensitizers or sononsensitizers in photodynamic or sonodynamic therapy. The invention also relates to various methods for using these compounds in photodynamic and/or sonodynamic therapy. The compounds also are useful as therapeutic agents for treating various hyperproliferative disorders. | 02-25-2010 |
20130304089 | PERYLENEQUINONE DERIVATIVES AND USES THEREOF - The present invention relates to compounds which are perylenequinone derivatives, their stereoisomers and atropisomers. These compounds can be particularly useful as photosensitizers or sononsensitizers in photodynamic or sonodynamic therapy. The invention also relates to various methods for using these compounds in photodynamic and/or sonodynamic therapy. The compounds also are useful as therapeutic agents for treating various hyperproliferative disorders. | 11-14-2013 |
20140072512 | PERYLENEQUINONE DERIVATIVES AND USES THEREOF - The present invention relates to compounds which are perylenequinone derivatives, their stereoisomers and atropisomers. These compounds can be particularly useful as photosensitizers or sononsensitizers in photodynamic or sonodynamic therapy. The invention also relates to various methods for using these compounds in photodynamic and/or sonodynamic therapy. The compounds also are useful as therapeutic agents for treating various hyperproliferative disorders. | 03-13-2014 |
Patent application number | Description | Published |
20090054311 | Novel Cyclosporin Analog Formulations - The present invention relates to formulations containing cyclosporin analogs that are structurally similar to cyclosporin A, in particular isomeric mixtures of cyclosporin analogs that are structurally similar to cyclosporin A. The formulations form stable microemulsion preconcentrates and may provide superior drug bioavailability and/or may reduce one or more adverse effects associated with the administration of cyclosporin. Also disclosed are methods for using and preparing the formulations. | 02-26-2009 |
20100062976 | Synthesis of Cyclosporin Analogs - The invention is directed to isomeric mixtures of cyclosporine analogues that are structurally similar to cyclosporine A. The mixtures possess enhanced efficacy and reduced toxicity over the individual isomers and over naturally occurring and other presently known cyclosporines and cyclosporine derivatives. Embodiments of the present invention are directed toward cis and trans-isomers of cyclosporin A analogs referred to as ISA | 03-11-2010 |
20110092669 | SYNTHESIS OF CYCLOSPORIN ANALOGS - The invention is directed to isomeric mixtures of cyclosporine analogues that are structurally similar to cyclosporine A. The mixtures possess enhanced efficacy and reduced toxicity over the individual isomers and over naturally occurring and other presently known cyclosporines and cyclosporine derivatives. Embodiments of the present invention are directed toward cis and trans-isomers of cyclosporin A analogs referred to as ISA | 04-21-2011 |
20110136744 | CYCLOSPORIN ANALOG FORMULATIONS - The present disclosure relates to formulations containing cyclosporin analogs that are structurally similar to cyclosporin A, in particular isomeric mixtures of cyclosporin analogs that are structurally similar to cyclosporin A. The formulations form stable microemulsion preconcentrates and may provide superior drug bioavailability and/or may reduce one or more adverse effects associated with the administration of cyclosporin. Also disclosed are methods for using and preparing the formulations. | 06-09-2011 |
20130078280 | CYCLOSPORINE ANALOGUE MIXTURES AND THEIR USE AS IMMUNOMODULATING AGENTS - The invention is directed to isomeric mixtures of cyclosporine analogues that are structurally similar to cyclosporine A. The mixtures possess enhanced efficacy and reduced toxicity over the individual isomers and over naturally occurring and other presently known cyclosporines and cyclosporine derivatives. Embodiments of the present invention are directed toward cis and trans-isomers of cyclosporin A analogs referred to as ISA | 03-28-2013 |
20140142277 | CYCLOSPORINE ANALOGUE MIXTURES AND THEIR USE AS IMMUNOMODULATING AGENTS - The invention is directed to isomeric mixtures of cyclosporine analogues that are structurally similar to cyclosporine A. The mixtures possess enhanced efficacy and reduced toxicity over the individual isomers and over naturally occurring and other presently known cyclosporines and cyclosporine derivatives. Embodiments of the present invention are directed toward cis and trans-isomers of cyclosporin A analogs referred to as ISA | 05-22-2014 |
20140235819 | Deuterated Cyclosporine Analogs and Methods of Making the Same - Cyclosporine derivatives are disclosed which possess enhanced efficacy and reduced toxicity over naturally occurring and other presently known cyclosporins and cyclosporine derivatives. The cyclosporine derivatives of the present invention are produced by chemical and isotopic substitution of the cyclosporine A (CsA) molecule by: (1) Chemical substitution and optionally deuterium substitution of amino acid 1; and (2) deuterium substitution at key sites of metabo-lism of the cyclosporine A molecule such as amino acids 1, 4, 9. Also disclosed are methods of producing the cyclosporine derivatives and methods of producing immunosuppression with reduced toxicity using the disclosed cyclosporine derivatives. | 08-21-2014 |
20140249092 | CYCLOSPORIN ANALOG FORMULATIONS - The present disclosure relates to formulations containing cyclosporin analogs that are structurally similar to cyclosporin A, in particular isomeric mixtures of cyclosporin analogs that are structurally similar to cyclosporin A. The formulations form stable microemulsion preconcentrates and may provide superior drug bioavailability and/or may reduce one or more adverse effects associated with the administration of cyclosporin. Also disclosed are methods for using and preparing the formulations. | 09-04-2014 |
20140288266 | Synthesis of Cyclosporin Analogs - The invention is directed to isomeric mixtures of cyclosporine analogues that are structurally similar to cyclosporine A. The mixtures possess enhanced efficacy and reduced toxicity over the individual isomers and over naturally occurring and other presently known cyclosporines and cyclosporine derivatives. Embodiments of the present invention are directed toward cis and trans-isomers of cyclosporin A analogs referred to as ISA | 09-25-2014 |
20140370082 | CYCLOSPORINE ANALOGUE MIXTURES AND THEIR USE AS IMMUNOMODULATING AGENTS - The invention is directed to isomeric mixtures of cyclosporine analogues that are structurally similar to cyclosporine A. The mixtures possess enhanced efficacy and reduced toxicity over the individual isomers and over naturally occurring and other presently known cyclosporines and cyclosporine derivatives. Embodiments of the present invention are directed toward cis and trans-isomers of cyclosporin A analogs referred to as ISA | 12-18-2014 |
Patent application number | Description | Published |
20090036194 | System for Playing a Bingo-Type Game - A system for playing a bingo-type game comprises a number of player stations, a random event generator capable of generating a number of random events upon which an outcome of a game of bingo is based, a secondary display means corresponding to each player station, the secondary display means being instructable by the player station to display a simulation of the turn of the game of bingo, and a primary display means corresponding to each player station, the primary display means being instructable by the player station to display to a player a simulation of a turn of a different entertainment game. Each player station is operable by a player to place a wager on a turn of the game of bingo. The outcome of the turn of the game of bingo is either an unfavourable outcome in which the player forfeits the wager, and at least one favourable outcome in which the player wins a corresponding prize. The turn of the different entertainment game has an outcome that is unfavourable outcome when the outcome of the turn of the game of bingo is an unfavourable outcome, and an outcome that causes the player to win the same corresponding prize as the game of bingo when the outcome of the turn of the game of bingo is a favourable outcome. | 02-05-2009 |
20150141115 | Gaming Machine with Dice Attributes - A machine includes a display; a processor; and a non-transitory computer-readable medium storing program instructions, that when executed by the processor, cause a set of functions to be performed that include: making a determination that a trigger event occurred; displaying a selected symbol table; responsive to making the determination, for each symbol cell in the selected symbol table: randomly selecting a multiplier symbol; adding the selected multiplier symbol to a symbol cell, wherein the selected multiplier symbol corresponds to a displayable image component, wherein the displayable image component is from an image component set, and wherein the image component set corresponds to an image; adding the displayable image component to a selected image component set when the image component is not in the selected image component set; displaying the added displayable image component; and determining whether the selected image component set includes each image component of the image component set. | 05-21-2015 |
Patent application number | Description | Published |
20110092261 | Methods and Devices for Multi-State Card Games with Card Replacement - Players in a multi-state card game, such as blackjack or baccarat, are presented with opportunities to exchange their cards for new cards when the card game is in one or more particular states. These opportunities may include offers to redeal the player's hand of cards or redeal the player's opponent's hand of cards. Additionally, when the player is dealt a new card to be added to the player's hand, the player may be offered options to discard the new card, replace the new card with another new card, or to redeal the player's hand and/or the opponent's hand. In this way, the player may be able to improve his or her position in the card game. At the same time, the game provider may charge the player for acceptance of these offers, thus improving the profit margin of the game provider. | 04-21-2011 |
20110092262 | Methods and Devices for Card Games with Card Replacement - A player of a card game, such as poker, is presented with opportunities to replace one or more of the cards in his or her hand. The first such replacement may be free, but the player may incur a cost for each subsequent replacement. This cost may be based on how much the player is expected to benefit from the replacement. Facilitating these subsequent replacements may allow the player to improve a poor hand, thus enhancing the player's excitement of playing the card game. | 04-21-2011 |