Patent application number | Description | Published |
20100254945 | Rnai Therapeutic for Respiratory Virus Infection - Disclosed herein is a double stranded siRNA molecule that inhibits production of a respiratory virus, wherein each strand of said siRNA molecule is about 15 to about 50 nucleotides, and wherein one strand of said siRNA molecule comprises a nucleic acid sequence identical to a conserved site, or a variant thereof, within the nucleic acid sequence of the respiratory virus, and uses thereof. | 10-07-2010 |
20110052601 | COMPOSITIONS COMPRISING ANTI-ICAM-1 ANTIBODIES - There is provided a method of preventing a respiratory infection by administering an effective amount of an agent for regulating ICAM-1 expression. Also provided is a composition for the prevention of respiratory infection including an agent which regulates ICAM expression. method of preventing RSV infection by administering an effective amount of an agent that interferes with the binding of RSV to ICAM-1. A method of preventing RSV infection by administering an effective amount of an agent that down regulates the expression of ICAM-1, thereby decreasing RSV binding to ICAM-1 is also provided. There is provided a method of treating RSV infection by administering an effective amount of an agent for down regulating ICAM-1 expression. A method of blocking RSV-ICAM-1 interaction by administering an effective amount of agents for blocking ICAM sites of binding is provided. Also provided is a compound for blocking RSV-ICAM-1 interaction including an agent for blocking ICAM sites of binding. | 03-03-2011 |
20140056931 | GENETIC ADJUVANTS FOR IMMUNOTHERAPY - The present invention pertains to methods and pharmaceutical compositions for modulating an immune response. The method of the present invention involves administration of an effective amount of nucleic acid molecules encoding interleukin-12 (IL-12), interferon-gamma (IFN-γ), or a combination thereof, to a patient in need of such treatment. The pharmaceutical compositions of the invention contain nucleic acid molecules encoding IL-12 and/or IFN-γ and an operably-linked promoter sequence. In another aspect, the present invention concerns expression vectors containing a nucleotide sequence encoding IL-12 and IFN-γ, and an operably-linked promoter sequence. In another aspect, the present invention concerns cells genetically modified with a nucleotide sequence encoding IL-12 and IFN-γ. | 02-27-2014 |
Patent application number | Description | Published |
20090270022 | Climate control duct architecture for a vehicle - A climate control duct architecture having partitions to provide effective distribution of air immediately as it exits the HVAC. By strategic positioning and configuring of the partitions the duct architecture may be tuned to provide maximum console airflow and desired system airflow distribution with a minimum amount of interference to the airflow due to turbulence. | 10-29-2009 |
20100216387 | DUCT ARCHITECTURE FOR REGULATING CLIMATE ZONE IN A VEHICLE - A climate control duct architecture having articulated and controlled interior surfaces to deliver variable and controllable airflow to target zones in the vehicle upon demand. By creating zone climates within the vehicle and providing conditioned airflow to only desired vehicle seating positions, the volume of necessary airflow is minimized, the need for cooling is reduced, and flexibility of the system is created. The interior surface may be mechanically or electrically controlled and may be situated in the common central “octopus” duct. | 08-26-2010 |
20120304670 | Optimized Cooling for Vehicle with Start-Stop Technology - An air conditioning system for a start-stop vehicle employs a compressor with a variable displacement. A controller determines a normal Climate Thermal Load (CTL) value for controlling a variable stroke of the variable displacement compressor. A stop event is detected in response to a speed of the vehicle and the occurrence of a predetermined deceleration. During the stop event, the variable stroke is increased by an amount determined in response to the normal CTL value, the speed of the vehicle, and a measure of the deceleration of the vehicle so that an evaporator temperature within the air conditioning system is allowed to decrease while the vehicle is stopping so that climate comfort can be maintained even while the engine is shut off during the subsequent time that the vehicle is stopped. | 12-06-2012 |
20130092364 | AIRFLOW CONTROL IN FLOOR MODE FOR VEHICLE WITH MULTIPLE SEATING ROWS - A comfort system is provided for a motor vehicle. A seat occupancy sensor determines whether a third row zone is occupied. At least one flow controller is provided in the floor duct for controllably supplying the conditioned airflow to at least the third row outlet. If the third row zone is occupied, then a second row outlet and the third row outlet are turned on to supply a conditioned airflow to a front seat zone, a second row zone, and the third row zone. If the third row zone is not occupied, then the third row outlet is closed off. If the second row zone is not occupied, then the second and third row outlets are closed off. If occupied, then the second row outlet is turned on until a desired comfort level is achieved in the second row zone. | 04-18-2013 |
20130207420 | CLIMATE CONTROL SYSTEM FOR A VEHICLE - A climate control system for a vehicle includes an air conditioner positioned in a rear of the vehicle. A roof panel includes a moonroof opening bounded on at least one side by a moonroof rail. The moonroof rail generally defines an air supply duct between a headliner and the roof panel. The air supply duct is in communication with the air conditioner. A plurality of vents are operably connected to the moonroof rail and relay conditioned air from the air supply duct to an interior of the vehicle. | 08-15-2013 |
20130257106 | Air Ducts Formed in Automotive Structural Members - An air duct for an automotive vehicle is blow molded with an elongated, hollow structural member to be used as a portion of a body of the vehicle. The structural member has an inner wall defining an elongated cavity communicating with first and second access holes at respective longitudinal positions along the structural member. A parison comprised of a thermally insulating material is inserted into the internal cavity. A source of inflation gas is connected to a mouth portion or the parison. The parison is heated and inflated within the internal cavity to an expanded shape to form the air duct disposed against the inner wall and spanning the first and second access holes. The air duct at one of the access holes is configured as an air inlet. The air duct at the other one of the access holes is configured as an air outlet. | 10-03-2013 |
20130303069 | DUCT ARCHITECTURE FOR REGULATING CLIMATE ZONE IN A VEHICLE - A climate control duct architecture having articulated and controlled interior surfaces to deliver variable and controllable airflow to target zones in the vehicle upon demand. By creating zone climates within the vehicle and providing conditioned airflow to only desired vehicle seating positions, the volume of necessary airflow is minimized, the need for cooling is reduced, and flexibility of the system is created. The interior surface may be mechanically or electrically controlled and may be situated in the common central “octopus” duct. | 11-14-2013 |
20140073232 | Laterally Assembled Vehicle Duct Joint - A duct assembly including a first duct and a second duct that are connected by a receptacle and a fitting that are moved in a transverse direction to assemble the first duct to the second duct. The receptacle defines a slot that includes an inner wall and an outer wall. The inner and outer wall define a fitting insertion opening on one lateral side and a fitting seat on the opposite lateral side. A seal is provided on a face wall of the fitting. Triangular side walls extend between the inner and outer walls. A locking tab on a triangular side wall is received within a tab receiver on the outer wall of the fitting. | 03-13-2014 |
20150346041 | MULTI-DIRECTIONAL IN-DUCT COMBINING AIR-TEMPERATURE MONITOR - A combining air-temperature monitor includes a faceted central shaft, a plurality of air-foil rings positioned about the faceted central shaft and a mixing zone proximate the faceted central shaft. The air-foil rings and the faceted central shaft cooperate to direct a plurality of air streams into the mixing zone. A temperature sensor is disposed within the mixing zone. The temperature sensor selectively measures a combined temperature of the plurality of air streams within the mixing zone. The faceted central shaft is adapted for insertion into an air-handling duct, wherein the faceted central shaft is free of a predetermined rotational orientation within the air handling duct. | 12-03-2015 |
Patent application number | Description | Published |
20100082497 | Providing Foundation Application as Enterprise Services - Methods and apparatus, including systems and computer program products, for a services architecture design that provides enterprise services having foundation layer functionality at the level of an enterprise application. The design includes a set of service operations, process components, and optionally deployment units. Suitable business objects are also described. | 04-01-2010 |
20110307263 | MANAGING CONSISTENT INTERFACES FOR PROPERTY LIBRARY, PROPERTY LIST TEMPLATE, QUANTITY CONVERSION VIRTUAL OBJECT, AND SUPPLIER PROPERTY SPECIFICATION BUSINESS OBJECTS ACROSS HETEROGENEOUS SYSTEMS - A business object model, which reflects data that is used during a given business transaction, is utilized to generate interfaces. This business object model facilitates commercial transactions by providing consistent interfaces that are suitable for use across industries, across businesses, and across different departments within a business during a business transaction. In some operations, software creates, updates, or otherwise processes information related to a property library, a property list template, a quantity conversion virtual object, and/or a supplier property specification business object. | 12-15-2011 |
20120047079 | PROVIDING FOUNDATION APPLICATION AS ENTERPRISE SERVICES - Methods and apparatus, including systems and computer program products, for a services architecture design that provides enterprise services having foundation layer functionality at the level of an enterprise application. The design includes a set of service operations, process components, and optionally deployment units. Suitable business objects are also described. | 02-23-2012 |
20140181020 | INTEGRATION SCENARIO FOR MASTER DATA WITH SOFTWARE-AS-A-SERVICE SYSTEM - According to one general aspect, a method may include replicating, to a software-as-a-service application, a plurality of pieces of master data from a physically remote master database. The method may also include converting the plurality of pieces of master data into one or more pieces of local data of the software-as-a-service application. The method may include changing one or more of either the pieces of master data or the pieces of local data. The method may further include synchronizing the changed pieces of either master data or local data between the remote master database and the software-as-a-service application. | 06-26-2014 |
Patent application number | Description | Published |
20090017105 | PROLIPOSOMAL AND LIPOSOMAL COMPOSITIONS OF POORLY WATER SOLUBLE DRUGS - Concentrates or proliposomal compositions of poorly water-soluble drugs and compounds, comprising of one or more membrane forming lipids, a membrane stabilizing agent, in a suitable vehicle, and optionally containing a Polyethylene Glycol (PEG)-coupled phospholipid or a mixture thereof and further, optionally containing pharmaceutically acceptable excipients such as antioxidants, buffering agents, acidifying agents etc. are provided, which have superior long term stability. The concentrates of proliposomal compositions instantly form liposomes of the said poorly water-soluble drugs and compounds on rapid injection to a diluting fluid, the liposomal composition so obtained, characterized by a physical stability more than 24 hours, ≧95% drug encapsulation and having a particle size diameter of less than 100 nm. The liposomal compositions so obtained can further be directly administered to patients in need of treatment of the poorly water-soluble drugs and compounds. | 01-15-2009 |
20090318661 | A BIOCOMPATIBLE, NON-BIODEGRADABLE, NON-TOXIC POLYMER USEFUL FOR NANOPARTICLE PHARMACEUTICAL COMPOSITIONS - The invention relates to a biocompatible, non-biodegradable, and non-toxic polymer of formula (I), comprising of three monomeric units, selected from 1-Vinylpyrrolidone (VP), N-Isopropylacrylamide (NIPAM), and ester of Maleic anhydride and Polyethylene glycol (MPEG), cross-linked with a bi-functional vinyl derivative, of high purity and substantially free of respective toxic monomeric contaminants, and a process for preparation thereof. The invention further relates to nanoparticulate pharmaceutical compositions of poorly water-soluble drugs or compounds comprising the polymer of the invention, which are safe, less-toxic and convenient for bedside administration to patients in need thereof. Furthermore, the invention relates to a highly selective method for preparation of nanoparticulate pharmaceutical compositions of poorly water-soluble drugs or compounds. | 12-24-2009 |