Patent application number | Description | Published |
20100285108 | Method for therapeutic use - The present invention is related to methods for the therapeutic use in the treatment of diseases and disorders where T-helper independent antibody responses are beneficial. In particular, the present invention relates to a method wherein these diseases and disorders above are treated in immunocompromised or autoimmune diseased animals or humans. Even more particular the present invention relates to the treatment of Alzheimer's disease in immunocompromised or autoimmune diseased animals or humans or where inflammatory reactions need to be specifically avoided. | 11-11-2010 |
20110092537 | 2,6-Diaminopyridine Compounds Suitable For Treating Diseases Associated With Amyloid Or Amyloid-Like Proteins Or For Treating Or Preventing Ocular Diseases Or Conditions Associated With A Pathological Abnormality/Change In The Tissue Of The Visual System - The present invention relates to 2,6-diaminopyridine compounds that can be employed in the treatment of a group of disorders and abnormalities associated with amyloid protein and of diseases or conditions associated with amyloid-like proteins. The compounds of the present invention can also be used in the treatment of ocular diseases associated with pathological abnormalities/changes in the tissues of the visual system. | 04-21-2011 |
20110256064 | Novel Compounds for the Treatment of Diseases Associated with Amyloid or Amyloid-like Proteins - The present invention relates to novel compounds that can be employed in the treatment of a group of disorders and abnormalities associated with amyloid protein, such as Alzheimer's disease, and of diseases or conditions associated with amyloid-like proteins. The compounds of the present invention can also be used in the treatment of ocular diseases associated with pathological abnormalities/changes in the tissues of the visual system. The present invention further relates to pharmaceutical compositions comprising these compounds and to the use of these compounds for the preparation of medicaments for treating or preventing diseases or conditions associated with amyloid and/or amyloid-like proteins. A method of treating or preventing diseases or conditions associated with amyloid and/or amyloid-like proteins is also disclosed. | 10-20-2011 |
20110280808 | Novel Compounds for the Treatment of Diseases Associated with Amyloid or Amyloid-Like Proteins - The present invention relates to novel compounds that can be employed in the treatment of a group of disorders and abnormalities associated with amyloid protein, such as Alzheimer's disease, and of diseases or conditions associated with amyloid-like proteins. The compounds of the present invention can also be used in the treatment of ocular diseases associated with pathological abnormalities/changes in the tissues of the visual system. The present invention further relates to pharmaceutical compositions comprising these compounds and to the use of these compounds for the preparation of medicaments for treating or preventing diseases or conditions associated with amyloid and/or amyloid-like proteins. A method of treating or preventing diseases or conditions associated with amyloid and/or amyloid-like proteins is also disclosed. | 11-17-2011 |
Patent application number | Description | Published |
20130224287 | Liposome-Based Construct Comprising a Peptide Modified Through Hydrophobic Moieties - The present invention relates to method for preparing liposome-based constructs comprising a peptide, particularly an antigenic peptide, of interest modified through hydrophobic moieties reconstituted in liposomes and to the antigenic constructs obtained with said method. The invention further relates to the use of said constructs for the therapeutic and diagnostic use in the treatment of diseases and disorders, which are caused by or associated with proteopathy such as Alzheimer's Disease. | 08-29-2013 |
20130287838 | VACCINE ENGINEERING - The method and constructs disclosed and claimed herein allow to control peptide conformation by modulation of the peptide lipidation pattern, spacer and liposome composition, or via co-administration with small molecules. Accordingly, this technology can be applied to the rational design of liposomal vaccines and for the generation of safer and more efficacious therapies for a range of human disease, in particular those based on misfolded proteins. | 10-31-2013 |
20140199323 | Monoclonal Antibody - The present invention is related to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease. The present invention provides novel methods and compositions comprising highly specific and highly effective antibodies having the ability to specifically recognize and bind to specific epitopes from a range of β-amyloid proteins. The antibodies enabled by the teaching of the present invention are particularly useful for the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of diseases and disorders associated with amyloid plaque formation including secondary amyloidosis and age-related amyloidosis including, but not limited to, neurological disorders such as Alzheimer's Disease (AD). | 07-17-2014 |
20140255412 | Pharmaceutical Composition of an Antigenic Tau Peptide Reconstituted in a Liposome and Related Antibodies and Cell Lines - The present invention is related to methods and pharmaceutical compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with neurofibrillary tangles. In particular, the invention relates to pharmaceutical compositions comprising an antigenic peptide, particularly an antigenic phopho-peptide mimicking a major pathological phosphor-epitope of protein tau, for the therapeutic and diagnostic use in the treatment of tauopathies including Alzheimer's Disease. | 09-11-2014 |
20140314837 | Vaccine Therapy - The present invention provides means for treating, alleviating and preventing amyloid-related pathology in young to middle-aged subjects with Down's syndrome (DS). In particular, the present invention provides antigenic peptide fragments derived from amyloid protein or amyloid-like protein for use in the preventive treatment of amyloid-related pathology in young to middle-aged subjects with Down's syndrome. | 10-23-2014 |
20150023950 | 2,6-Diaminopyridine Compounds Suitable for Treating Diseases Associated with Amyloid or Amyloid-Like Proteins or for Treating or Preventing Ocular Diseases or Conditions Associated with a Pathological Abnormality/Change in the Tissue of the Visual System - The present invention relates to 2,6-diaminopyridine compounds that can be employed in the treatment of a group of disorders and abnormalities associated with amyloid protein and of diseases or conditions associated with amyloid-like proteins. The compounds of the present invention can also be used in the treatment of ocular diseases associated with pathological abnormalities/changes in the tissues of the visual system. | 01-22-2015 |
20150175682 | HUMANIZED TAU ANTIBODY - The present invention provides, methods end composites for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with neurofibrillary tangles. In particular, the Invention relates to humanized antibodies, which specifically recognize and bind to phosphorylated pathological protein tau-conformers to methods and compositions involving antibodies for the therapeutic and diagnostic use In the treatment of tauopathies including Alzheimer's Disease (AD). | 06-25-2015 |
20150259406 | Pharmaceutical Composition of an Antigenic Tau Peptide Reconstituted in a Liposome and Related Antibodies and Cell Lines - The present invention is related to methods and pharmaceutical compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with neurofibrillary tangles. In particular, the invention relates to pharmaceutical compositions comprising an antigenic peptide, particularly an antigenic phopho-peptide mimicking a major pathological phosphor-epitope of protein tau, for the therapeutic and diagnostic use in the treatment of tauopathies including Alzheimer's Disease. | 09-17-2015 |
20160000910 | Monoclonal Antibody - The present invention is related to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease. The present invention provides novel methods and compositions comprising highly specific and highly effective antibodies having the ability to specifically recognize and bind to specific epitopes from a range of β-amyloid proteins. The antibodies enabled by the teaching of the present invention are particularly useful for the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of diseases and disorders associated with amyloid plaque formation including secondary amyloidosis and age-related amyloidosis including, but not limited to, neurological disorders such as Alzheimer's Disease (AD). | 01-07-2016 |
20160024193 | ANTI-TAU ANTIBODIES AND METHODS OF USE - The present invention relates to anti-Tau antibodies, such as antibodies that bind to a phosphorylated epitope on human Tau protein with high specificity and/or affinity, and methods of using the same. | 01-28-2016 |
Patent application number | Description | Published |
20110008183 | PUMP SYSTEM WITH VACUUM SOURCE - A self priming pump system that includes a motor coupled to a centrifugal pump for driving the centrifugal pump. A separator having a reservoir is provided for storing a limited amount of pumped fluid in advance of the centrifugal pump. A vacuum source provides a vacuum suction to the reservoir to draw pumped fluid into the reservoir to prime the pump. To increase the reliability of the vacuum pump system, a deflector and/or extension may be provided in the reservoir to help prevent pumped fluid from entering the vacuum pump input. Also, the configuration of a tank used to store liquid for the vacuum pump system may be configured to separate and collect sediments near a drain port, which then can be easily drained. For positive head pressures, one or more valves may be used to prevent pumped fluid from escaping the reservoir, if desired. | 01-13-2011 |
20110044827 | SELF PRIMING PUMP ASSEMBLY WITH A DIRECT DRIVE VACUUM PUMP - A self-priming pump assembly is disclosed. In an illustrative embodiment, the self-priming pump assembly includes a motor, a main pump having a main pump impeller, a vacuum pump having a vacuum pump impeller, and a drive shaft driven by the motor. The main pump impeller and the vacuum pump impeller may be directly coupled to and driven by the drive shaft, and may rotate about the rotation axis of the drive shaft. In some instances, the vacuum pump impeller is situated between the motor and the main pump impeller, while in other instances, the main pump impeller may be situated between the vacuum pump impeller and the motor. In some cases, bearings may be provided at or near the vacuum pump to help support the vacuum pump relative to the drive shaft. | 02-24-2011 |
20120312392 | PUMP SYSTEM WITH VACUUM SOURCE - A self priming pump system that includes a motor coupled to a centrifugal pump for driving the centrifugal pump. A separator having a reservoir is provided for storing a limited amount of pumped fluid in advance of the centrifugal pump. A vacuum source provides a vacuum suction to the reservoir to draw pumped fluid into the reservoir to prime the pump. To increase the reliability of the vacuum pump system, a deflector and/or extension may be provided in the reservoir to help prevent pumped fluid from entering the vacuum pump input. Also, the configuration of a tank used to store liquid for the vacuum pump system may be configured to separate and collect sediments near a drain port, which then can be easily drained. For positive head pressures, one or more valves may be used to prevent pumped fluid from escaping the reservoir, if desired. | 12-13-2012 |
Patent application number | Description | Published |
20100230857 | PROCESS FOR MAKING AN EMBOSSED WEB - A process for making an embossed web. A precursor web is provided between a forming structure and a compliant substrate. The forming structure has a plurality of discrete apertures or depressions. Pressure is provided between the compliant substrate and the forming structure to force the precursor web into the apertures or depressions of forming structure to form the embossed web. The resulting embossed web has a plurality of discrete extended elements. | 09-16-2010 |
20150173956 | METHOD FOR FABRICATING ABSORBENT ARTICLES - The present invention relates to a method for fabricating absorbent article having multiple layers, and deformed zones of targeted performance, and colored regions, the method comprising the steps of forming discrete features on at least one layer, printing colored regions on at least one layer, integrating multiple layers to form an absorbent assembly, and cutting the absorbent assembly into individual absorbent articles, wherein the steps are carried out continuously. | 06-25-2015 |
20150173962 | METHOD FOR FABRICATING ABSORBENT ARTICLES - The present invention relates to a method for fabricating absorbent article having multiple layers, and deformed zones of targeted performance, and colored regions, the method comprising the steps of forming discrete features on at least one layer, printing colored regions on at least one layer, integrating multiple layers to form an absorbent assembly, and cutting the absorbent assembly into individual absorbent articles, wherein the steps are carried out continuously. | 06-25-2015 |
20150173963 | METHOD FOR FABRICATING ABSORBENT ARTICLES - The present invention relates to a method for fabricating absorbent article having multiple layers, and deformed zones of targeted performance, and colored regions, the method comprising the steps of forming discrete features on at least one layer, printing colored regions on at least one layer, integrating multiple layers to form an absorbent assembly, and cutting the absorbent assembly into individual absorbent articles, wherein the steps are carried out continuously. | 06-25-2015 |
Patent application number | Description | Published |
20140136348 | SYSTEM AND METHOD FOR RECEIVING AND MANAGING REMOTELY PLACED ORDERS - A system for enabling the remote ordering of products, primarily for use in a multi-vendor system, is disclosed. Orders are placed remotely, such as through wireless devices connected to a central server. The central server, in turn, is in communication (wireless or otherwise) with a server located at one or more venues within the organization operating the system. The one or more venues provide produces or services available for ordering through the system. Where multiple venues are involved, the system is designed to handle differences in the product or service availability at those different venues, and provides for an ability to make corrections to orders that may be or may become necessary on account of those differences. The system provides for multiple options through which users can pay for and receive orders, and also provides methods for synchronizing the remote ordering system with pre-existing, conventional methods of ordering and product/service order fulfillment. | 05-15-2014 |
20160063585 | SYSTEM AND METHOD FOR RECEIVING AND MANAGING REMOTELY PLACED ORDERS - A system for enabling the remote ordering of products, primarily for use in a multi-vendor system, is disclosed. Orders are placed remotely, such as through wireless devices connected to a central server. The central server, in turn, is in communication (wireless or otherwise) with a server located at one or more venues within the organization operating the system. The one or more venues provide products or services available for ordering through the system. Where multiple venues are involved, the system is designed to handle differences in the product or service availability at those different venues, and provides for an ability to make corrections to orders that may be or may become necessary on account of those differences. The system provides for multiple options through which users can pay for and receive orders, and also provides methods for synchronizing the remote ordering system with pre-existing, conventional methods of ordering and product/service order fulfillment. | 03-03-2016 |